Irish Lab
Vanderbilt University

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A central goal of our research at Vanderbilt is to understand how changes at the single cell level alter signaling in healthy cells and lead to therapy resistant populations in human diseases.

In the Irish Lab, we use new tools and computational approaches to do basic and translational research in human cancer and immunology.

In addition to making discoveries at the frontier of human genetics and immunology, we aspire to use knowledge of cell signaling to create therapeutic technologies and to guide clinical decisions.  In the long term, great potential exists to detect disease earlier and to tailor a patient’s therapy to the biological alterations detected in the cells of their disease.  By better understanding biological systems which control development and cell-cell interactions in healthy and diseased contexts, we can learn to program cells to become therapeutic agents or target malignant signaling events to specifically kill cancer cells.

-Jonathan IrishThe Irish Lab

Publications

Featured publications

  1. Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response. Huse K, Wogsland CE, Polikowsky HG, Diggins KE, Smeland EB, Myklebust JH, Irish JM (2019) Cytometry A 95(4): 442-449
    › Primary publication · 30838773 (PubMed) · PMC6711772 (PubMed Central)
  2. Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types. Greenplate AR, McClanahan DD, Oberholtzer BK, Doxie DB, Roe CE, Diggins KE, Leelatian N, Rasmussen ML, Kelley MC, Gama V, Siska PJ, Rathmell JC, Ferrell PB, Johnson DB, Irish JM (2019) Cancer Immunol Res 7(1): 86-99
    › Primary publication · 30413431 (PubMed) · PMC6318034 (PubMed Central)
  3. Machine learning reveals chronic graft--host disease phenotypes and stratifies survival after stem cell transplant for hematologic malignancies. Gandelman JS, Byrne MT, Mistry AM, Polikowsky HG, Diggins KE, Chen H, Lee SJ, Arora M, Cutler C, Flowers M, Pidala J, Irish JM, Jagasia MH (2019) Haematologica 104(1): 189-196
    › Primary publication · 30237265 (PubMed) · PMC6312024 (PubMed Central)
  4. BRAF and MEK inhibitor therapy eliminates Nestin-expressing melanoma cells in human tumors. Doxie DB, Greenplate AR, Gandelman JS, Diggins KE, Roe CE, Dahlman KB, Sosman JA, Kelley MC, Irish JM (2018) Pigment Cell Melanoma Res 31(6): 708-719
    › Primary publication · 29778085 (PubMed) · PMC6188784 (PubMed Central)
  5. Generating Quantitative Cell Identity Labels with Marker Enrichment Modeling (MEM). Diggins KE, Gandelman JS, Roe CE, Irish JM (2018) Curr Protoc Cytom : 10.21.1-10.21.28
    › Primary publication · 29345329 (PubMed) · PMC5774653 (PubMed Central)
  6. Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Earl DC, Ferrell PB, Leelatian N, Froese JT, Reisman BJ, Irish JM, Bachmann BO (2018) Nat Commun 9(1): 39
    › Primary publication · 29295987 (PubMed) · PMC5750220 (PubMed Central)
  7. Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow. Roussel M, Ferrell PB, Greenplate AR, Lhomme F, Le Gallou S, Diggins KE, Johnson DB, Irish JM (2017) J Leukoc Biol 102(2): 437-447
    › Primary publication · 28400539 (PubMed) · PMC6608074 (PubMed Central)
  8. Preparing Viable Single Cells from Human Tissue and Tumors for Cytomic Analysis. Leelatian N, Doxie DB, Greenplate AR, Sinnaeve J, Ihrie RA, Irish JM (2017) Curr Protoc Mol Biol : 25C.1.1-25C.1.23
    › Primary publication · 28369679 (PubMed) · PMC5518778 (PubMed Central)
  9. Characterizing cell subsets using marker enrichment modeling. Diggins KE, Greenplate AR, Leelatian N, Wogsland CE, Irish JM (2017) Nat Methods 14(3): 275-278
    › Primary publication · 28135256 (PubMed) · PMC5330853 (PubMed Central)
  10. Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations. Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K (2017) Cytometry B Clin Cytom 92(1): 79-87
    › Primary publication · 27933753 (PubMed) · PMC5506779 (PubMed Central)