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A central goal of our research at Vanderbilt is to understand how changes at the single cell level alter signaling in healthy cells and lead to therapy resistant populations in human diseases.
In the Irish Lab, we use new tools and computational approaches to do basic and translational research in human cancer and immunology.
In addition to making discoveries at the frontier of human genetics and immunology, we aspire to use knowledge of cell signaling to create therapeutic technologies and to guide clinical decisions. In the long term, great potential exists to detect disease earlier and to tailor a patient’s therapy to the biological alterations detected in the cells of their disease. By better understanding biological systems which control development and cell-cell interactions in healthy and diseased contexts, we can learn to program cells to become therapeutic agents or target malignant signaling events to specifically kill cancer cells.
PRB 740B / Irish Lab
740B Preston Research Building (PRB)
Nashville, TN 37220
(615) 875-0965 (p)
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordAgammaglobulinaemia Tyrosine Kinase Algorithms B cells Cancer Cell Biology Cell Proliferation Cell Transformation, Neoplastic Chromatography, Liquid Computational Biology CyTOF Databases as Topic Dendritic Cells fas Receptor Flow Cytometry Genes, MHC Class II Glioblastoma Graft vs Host Disease Histocompatibility Antigens Class II Human Subjects Research Immunology Janus Kinase 2 lung cancer Lymphoma MAP Kinase Signaling System Mass Cytometry Melanoma Mice, Inbred C57BL Monitoring, Immunologic Myeloproliferative Disorders Neoplastic Stem Cells Nivolumab Personalized Medicine Phospho-Flow Cytometry Point Mutation Primary Cells Signaling Small Cell Lung Carcinoma STAT6 Transcription Factor Stem Cells T cells