Irish Lab
Vanderbilt University

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A central goal of our research at Vanderbilt is to understand how changes at the single cell level alter signaling in healthy cells and lead to therapy resistant populations in human diseases.

In the Irish Lab, we use new tools and computational approaches to do basic and translational research in human cancer and immunology.

In addition to making discoveries at the frontier of human genetics and immunology, we aspire to use knowledge of cell signaling to create therapeutic technologies and to guide clinical decisions.  In the long term, great potential exists to detect disease earlier and to tailor a patient’s therapy to the biological alterations detected in the cells of their disease.  By better understanding biological systems which control development and cell-cell interactions in healthy and diseased contexts, we can learn to program cells to become therapeutic agents or target malignant signaling events to specifically kill cancer cells.

-Jonathan IrishThe Irish Lab

Publications

Featured publications

  1. Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow. Roussel M, Ferrell PB, Greenplate AR, Lhomme F, Le Gallou S, Diggins KE, Johnson DB, Irish JM (2017) J Leukoc Biol
    › Primary publication · 28400539 (PubMed)
  2. Preparing Viable Single Cells from Human Tissue and Tumors for Cytomic Analysis. Leelatian N, Doxie DB, Greenplate AR, Sinnaeve J, Ihrie RA, Irish JM (2017) Curr Protoc Mol Biol : 25C.1.1-25C.1.23
    › Primary publication · 28369679 (PubMed)
  3. Characterizing cell subsets using marker enrichment modeling. E Diggins K, R Greenplate A, Leelatian N, E Wogsland C, M Irish J (2017) Nat Methods
    › Primary publication · 28135256 (PubMed)
  4. Mass cytometry of follicular lymphoma tumors reveals intrinsic heterogeneity in proteins including HLA-DR and a deficit in non-malignant plasmablast and germinal center B cell populations. Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K (2016) Cytometry B Clin Cytom
    › Primary publication · 27933753 (PubMed)
  5. Single cell analysis of human tissues and solid tumors with mass cytometry. Leelatian N, Doxie DB, Greenplate AR, Mobley BC, Lehman JM, Sinnaeve J, Kauffmann RM, Werkhaven JA, Mistry AM, Weaver KD, Thompson RC, Massion PP, Hooks MA, Kelley MC, Chambless LB, Ihrie RA, Irish JM (2016) Cytometry B Clin Cytom
    › Primary publication · 27598832 (PubMed)
  6. Systems immune monitoring in cancer therapy. Greenplate AR, Johnson DB, Ferrell PB, Irish JM (2016) Eur J Cancer : 77-84
    › Primary publication · 27155446 (PubMed) · PMC4885747 (PubMed Central)
  7. High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy. Ferrell PB, Diggins KE, Polikowsky HG, Mohan SR, Seegmiller AC, Irish JM (2016) PLoS One 11(4): e0153207
    › Primary publication · 27074138 (PubMed) · PMC4830605 (PubMed Central)
  8. Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy. Greenplate AR, Johnson DB, Roussel M, Savona MR, Sosman JA, Puzanov I, Ferrell PB, Irish JM (2016) Cancer Immunol Res 4(6): 474-80
    › Primary publication · 26966176 (PubMed) · PMC4891280 (PubMed Central)
  9. Characterizing Phenotypes and Signaling Networks of Single Human Cells by Mass Cytometry. Leelatian N, Diggins KE, Irish JM (2015) Methods Mol Biol : 99-113
    › Primary publication · 26542718 (PubMed) · PMC4656023 (PubMed Central)
  10. Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B Cells. Polikowsky HG, Wogsland CE, Diggins KE, Huse K, Irish JM (2015) J Immunol 195(4): 1364-7
    › Primary publication · 26157177 (PubMed) · PMC4530023 (PubMed Central)