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The Vanderbilt Center for Stem Cell Biology facilitates studies of the basic biology of stem and progenitor cells through partnerships with the Program in Developmental Biology (PDB) and the Department of Cell and Developmental Biology.  It is home to two shared resources, the Vanderbilt Genome Editing Resource (VGER) and Creative Data Solutions (CDS), and oversees the Stem and Progenitor Cell Interest Group (SPRING) meetings.

 

Featured Collections

Publications

Featured publications

  1. Myt Transcription Factors Prevent Stress-Response Gene Overactivation to Enable Postnatal Pancreatic β Cell Proliferation, Function, and Survival. Hu R, Walker E, Huang C, Xu Y, Weng C, Erickson GE, Coldren A, Yang X, Brissova M, Kaverina I, Appakalai BN, Wright CVE, Li Y, Stein R, Gu G (2020) Dev Cell 53(4): 390-405.e10
    › Primary publication · 32359405 (PubMed)
  2. Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-cells. Osipovich AB, Stancill JS, Cartailler JP, Dudek KD, Magnuson MA (2020) Diabetes
    › Primary publication · 32332159 (PubMed)
  3. Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CVE, Van de Casteele M, German MS, Bouwens L, Heimberg H (2020) Nat Biotechnol 38(3): 374
    › Primary publication · 32066957 (PubMed) · PMC7175803 (PubMed Central)
  4. Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis. Katholnig K, Schütz B, Fritsch SD, Schörghofer D, Linke M, Sukhbaatar N, Matschinger JM, Unterleuthner D, Hirtl M, Lang M, Herac M, Spittler A, Bergthaler A, Schabbauer G, Bergmann M, Dolznig H, Hengstschläger M, Magnuson MA, Mikula M, Weichhart T (2019) JCI Insight 4(20)
    › Primary publication · 31619583 (PubMed) · PMC6824305 (PubMed Central)
  5. Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism. Krah NM, Narayanan SM, Yugawa DE, Straley JA, Wright CVE, MacDonald RJ, Murtaugh LC (2019) Dev Cell 50(6): 744-754.e4
    › Primary publication · 31422917 (PubMed) · PMC6776997 (PubMed Central)
  6. Differential Cell Susceptibilities to Kras in the Setting of Obstructive Chronic Pancreatitis. Shi C, Pan FC, Kim JN, Washington MK, Padmanabhan C, Meyer CT, Kopp JL, Sander M, Gannon M, Beauchamp RD, Wright CV, Means AL (2019) Cell Mol Gastroenterol Hepatol 8(4): 579-594
    › Primary publication · 31310834 (PubMed) · PMC6889613 (PubMed Central)
  7. Regulation of Glucose-Dependent Golgi-Derived Microtubules by cAMP/EPAC2 Promotes Secretory Vesicle Biogenesis in Pancreatic β Cells. Trogden KP, Zhu X, Lee JS, Wright CVE, Gu G, Kaverina I (2019) Curr Biol 29(14): 2339-2350.e5
    › Primary publication · 31303487 (PubMed) · PMC6698911 (PubMed Central)
  8. Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis. Wen HJ, Gao S, Wang Y, Ray M, Magnuson MA, Wright CVE, Di Magliano MP, Frankel TL, Crawford HC (2019) Cell Mol Gastroenterol Hepatol 8(2): 173-192
    › Primary publication · 31125624 (PubMed) · PMC6661420 (PubMed Central)
  9. Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue. Prentice BM, Hart NJ, Phillips N, Haliyur R, Judd A, Armandala R, Spraggins JM, Lowe CL, Boyd KL, Stein RW, Wright CV, Norris JL, Powers AC, Brissova M, Caprioli RM (2019) Diabetologia 62(6): 1036-1047
    › Primary publication · 30955045 (PubMed) · PMC6553460 (PubMed Central)
  10. Point mutations in the PDX1 transactivation domain impair human β-cell development and function. Wang X, Sterr M, Ansarullah , Burtscher I, Böttcher A, Beckenbauer J, Siehler J, Meitinger T, Häring HU, Staiger H, Cernilogar FM, Schotta G, Irmler M, Beckers J, Wright CVE, Bakhti M, Lickert H (2019) Mol Metab : 80-97
    › Primary publication · 30930126 (PubMed) · PMC6531841 (PubMed Central)

Community Leaders

Contact Information

9465 MRB-IV
2213 Garland Avenue
Nashville, TN 37232
United States

Pam Uttz
615-322-7006 (p)
615-322-6645 (f)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Cell Culture Techniques cell reprogramming Cells, Cultured Cytosol developmental biology Diabetes Mellitus, Type 2 differentiation Energy Metabolism Enhancer Elements, Genetic Fluorescent Antibody Technique Gangliosides Glucose Gonads Insulin Membrane Proteins Mice, Knockout Pancreatitis Protein Binding Retina Retinal Ganglion Cells Sex Factors Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization stem cell Sweetening Agents