The mission of the Vanderbilt Center for Stem Cell Biology is to learn more about the biology of stem cells and mechanisms for directing their differentiation to specific cell fates.

Embryonic stem cells are able to differentiate into any of the many different cell types found in the body. A great deal remains to be learned about them, and how to convert them into various tissue and cell types that can be used to treat a variety of human diseases.

The Vanderbilt Center for Stem Cell Biology is home for the Coordinating Center for the Beta Cell Biology Consortium. A major goal of this consortium of scientists is to learn how to make pancreatic beta cells, which are destroyed in Type 1 diabetes, from embryonic stem cells.

Featured Collections

Publications

Featured publications

  1. Stochastic priming and spatial cues orchestrate heterogeneous clonal contribution to mouse pancreas organogenesis. Larsen HL, Martín-Coll L, Nielsen AV, Wright CVE, Trusina A, Kim YH, Grapin-Botton A (2017) Nat Commun 8(1): 605
    › Primary publication · 28928395 (PubMed) · PMC5605525 (PubMed Central)
  2. Production of Single Contracting Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Matrigel Mattress Technique. Cadar AG, Feaster TK, Durbin MD, Hong CC (2017) Curr Protoc Stem Cell Biol : 4A.14.1-4A.14.7
    › Primary publication · 28806851 (PubMed) · PMC5577013 (PubMed Central)
  3. FUCCI tracking shows cell-cycle-dependent Neurog3 variation in pancreatic progenitors. Bechard ME, Bankaitis ED, Ustione A, Piston DW, Magnuson MA, Wright CVE (2017) Genesis
    › Primary publication · 28772022 (PubMed)
  4. Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning. Spaeth JM, Gupte M, Perelis M, Yang YP, Cyphert H, Guo S, Liu JH, Guo M, Bass J, Magnuson MA, Wright C, Stein R (2017) Diabetes
    › Primary publication · 28705881 (PubMed)
  5. Hypoplastic Left Heart Syndrome Sequencing Reveals a Novel NOTCH1 Mutation in a Family with Single Ventricle Defects. Durbin MD, Cadar AG, Williams CH, Guo Y, Bichell DP, Su YR, Hong CC (2017) Pediatr Cardiol 38(6): 1232-1240
    › Primary publication · 28608148 (PubMed) · PMC5577922 (PubMed Central)
  6. Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA (2017) Diabetes
    › Primary publication · 28550109 (PubMed)
  7. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM (2017) J Clin Invest 127(6): 2262-2276
    › Primary publication · 28463231 (PubMed)
  8. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC (2017) Assay Drug Dev Technol
    › Primary publication · 28379727 (PubMed)
  9. Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis. Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E (2017) Cell Death Differ
    › Primary publication · 28211872 (PubMed)
  10. c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis. Sánchez-Arévalo Lobo VJ, Fernández LC, Carrillo-de-Santa-Pau E, Richart L, Cobo I, Cendrowski J, Moreno U, Del Pozo N, Megías D, Bréant B, Wright CV, Magnuson M, Real FX (2017) Gut
    › Primary publication · 28159836 (PubMed)

Community Leaders

Contact Information

9465 MRB-IV
2213 Garland Avenue
Nashville, TN 37232
United States

Pam Uttz
615-322-7006 (p)
615-322-6645 (f)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Aged Breast Neoplasms Carrier Proteins Case-Control Studies cell reprogramming Codon, Nonsense developmental biology differentiation Enhancer Elements, Genetic Female Gene Expression Regulation, Neoplastic Genetic Predisposition to Disease Germ-Line Mutation Heart Ventricles Humans Infant, Newborn Male MCF-7 Cells Middle Aged Polymorphism, Single Nucleotide Receptor, Notch1 Sequence Analysis, DNA stem cell Young Adult