The mission of the Vanderbilt Center for Stem Cell Biology is to learn more about the biology of stem cells and mechanisms for directing their differentiation to specific cell fates.

Embryonic stem cells are able to differentiate into any of the many different cell types found in the body. A great deal remains to be learned about them, and how to convert them into various tissue and cell types that can be used to treat a variety of human diseases.

The Vanderbilt Center for Stem Cell Biology is home for the Coordinating Center for the Beta Cell Biology Consortium. A major goal of this consortium of scientists is to learn how to make pancreatic beta cells, which are destroyed in Type 1 diabetes, from embryonic stem cells.

Featured Collections

Publications

Featured publications

  1. Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis. Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E (2017) Cell Death Differ
    › Primary publication · 28211872 (PubMed)
  2. c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis. Sánchez-Arévalo Lobo VJ, Fernández LC, Carrillo-de-Santa-Pau E, Richart L, Cobo I, Cendrowski J, Moreno U, Del Pozo N, Megías D, Bréant B, Wright CV, Magnuson M, Real FX (2017) Gut
    › Primary publication · 28159836 (PubMed)
  3. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC (2016) Genes Dev 30(24): 2669-2683
    › Primary publication · 28087712 (PubMed) · PMC5238727 (PubMed Central)
  4. The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine-cell specification and postnatal β-cell maturation. Yang YP, Magnuson MA, Stein R, Wright CV (2016) Development
    › Primary publication · 27993987 (PubMed)
  5. Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Osipovich AB, Gangula R, Vianna PG, Magnuson MA (2016) Development 143(24): 4595-4607
    › Primary publication · 27864380 (PubMed)
  6. New ideas connecting the cell cycle and pancreatic endocrine-lineage specification. Bechard ME, Wright CV (2016) Cell Cycle
    › Primary publication · 27860540 (PubMed)
  7. Pancreatic Inflammation Redirects Acinar to β Cell Reprogramming. Clayton HW, Osipovich AB, Stancill JS, Schneider JD, Vianna PG, Shanks CM, Yuan W, Gu G, Manduchi E, Stoeckert CJ, Magnuson MA (2016) Cell Rep 17(8): 2028-2041
    › Primary publication · 27851966 (PubMed) · PMC5131369 (PubMed Central)
  8. Zebrafish small molecule screens: Taking the phenotypic plunge. Williams CH, Hong CC (2016) Comput Struct Biotechnol J : 350-356
    › Primary publication · 27721960 (PubMed) · PMC5050293 (PubMed Central)
  9. Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A. Hoang CQ, Hale MA, Azevedo-Pouly AC, Elsässer HP, Deering TG, Willet SG, Pan FC, Magnuson MA, Wright CV, Swift GH, MacDonald RJ (2016) Mol Cell Biol 36(24): 3033-3047
    › Primary publication · 27697859 (PubMed) · PMC5126291 (PubMed Central)
  10. Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells. Bechard ME, Bankaitis ED, Hipkens SB, Ustione A, Piston DW, Yang YP, Magnuson MA, Wright CV (2016) Genes Dev 30(16): 1852-65
    › Primary publication · 27585590 (PubMed) · PMC5024683 (PubMed Central)

Community Leaders

Contact Information

9465 MRB-IV
2213 Garland Avenue
Nashville, TN 37232
United States

Pam Uttz
615-322-7006 (p)
615-322-6645 (f)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Activin Receptors Aging Animals Cell Aging Cell Movement Cell Proliferation cell reprogramming developmental biology differentiation Dose-Response Relationship, Drug Epithelial-Mesenchymal Transition Gene Expression Regulation Glucose HEK293 Cells Insulin Mice NF-kappa B Pericardium Phosphodiesterase 4 Inhibitors Pyrimidinones Smoothened Receptor stem cell Structure-Activity Relationship TOR Serine-Threonine Kinases