The mission of the Vanderbilt Center for Stem Cell Biology is to learn more about the biology of stem cells and mechanisms for directing their differentiation to specific cell fates.

Embryonic stem cells are able to differentiate into any of the many different cell types found in the body. A great deal remains to be learned about them, and how to convert them into various tissue and cell types that can be used to treat a variety of human diseases.

The Vanderbilt Center for Stem Cell Biology is home for the Coordinating Center for the Beta Cell Biology Consortium. A major goal of this consortium of scientists is to learn how to make pancreatic beta cells, which are destroyed in Type 1 diabetes, from embryonic stem cells.

Featured Collections

Publications

Featured publications

  1. Defining a Novel Role for the PDX1 Transcription Factor in Islet β Cell Maturation and Proliferation During Weaning. Spaeth JM, Gupte M, Perelis M, Yang YP, Cyphert H, Guo S, Liu JH, Guo M, Bass J, Magnuson MA, Wright C, Stein R (2017) Diabetes
    › Primary publication · 28705881 (PubMed)
  2. Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated Genes. Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA (2017) Diabetes
    › Primary publication · 28550109 (PubMed)
  3. Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction. Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM (2017) J Clin Invest 127(6): 2262-2276
    › Primary publication · 28463231 (PubMed)
  4. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC (2017) Assay Drug Dev Technol
    › Primary publication · 28379727 (PubMed)
  5. Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis. Tassone B, Saoncella S, Neri F, Ala U, Brusa D, Magnuson MA, Provero P, Oliviero S, Riganti C, Calautti E (2017) Cell Death Differ
    › Primary publication · 28211872 (PubMed)
  6. c-Myc downregulation is required for preacinar to acinar maturation and pancreatic homeostasis. Sánchez-Arévalo Lobo VJ, Fernández LC, Carrillo-de-Santa-Pau E, Richart L, Cobo I, Cendrowski J, Moreno U, Del Pozo N, Megías D, Bréant B, Wright CV, Magnuson M, Real FX (2017) Gut
    › Primary publication · 28159836 (PubMed)
  7. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC (2016) Genes Dev 30(24): 2669-2683
    › Primary publication · 28087712 (PubMed) · PMC5238727 (PubMed Central)
  8. The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine-cell specification and postnatal β-cell maturation. Yang YP, Magnuson MA, Stein R, Wright CV (2016) Development
    › Primary publication · 27993987 (PubMed)
  9. Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Osipovich AB, Gangula R, Vianna PG, Magnuson MA (2016) Development 143(24): 4595-4607
    › Primary publication · 27864380 (PubMed)
  10. New ideas connecting the cell cycle and pancreatic endocrine-lineage specification. Bechard ME, Wright CV (2016) Cell Cycle
    › Primary publication · 27860540 (PubMed)

Community Leaders

Contact Information

9465 MRB-IV
2213 Garland Avenue
Nashville, TN 37232
United States

Pam Uttz
615-322-7006 (p)
615-322-6645 (f)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Cell Aging Cell Line Cell Movement cell reprogramming developmental biology differentiation Dose-Response Relationship, Drug Epithelial-Mesenchymal Transition Gene Expression Regulation Glucose HEK293 Cells Insulin Insulin-Secreting Cells Mice Mice, Transgenic Molecular Structure NF-kappa B Phosphodiesterase 4 Inhibitors PPAR gamma Pyrimidinones Receptors, Transforming Growth Factor beta stem cell Structure-Activity Relationship TOR Serine-Threonine Kinases