My lab utilizes a combined approach of molecular genetics, biochemistry, cell and developmental biology to understand the gene-environment interactions underlying neurodegenerative diseases.  We employ a diverse range of model systems including patient-derived induced pluripotent stem cells (iPSCs), neuronal culture and mouse models of Huntington's disease, Down syndrome/Alzheimer's disease and other diseases.  We aim to define mechanisms of neuronal dysfunction and understand the basis of selective neuropathology, by characterizing the molecular function of disease genes and their interaction with environmental agents under both normal and pathological conditions.  We are primarily studying interactions between metal and other toxicant exposures and neurodegenerative disease states.

Publications

Featured publications

  1. Untargeted metabolic profiling identifies interactions between Huntington's disease and neuronal manganese status. Kumar KK, Goodwin CR, Uhouse MA, Bornhorst J, Schwerdtle T, Aschner M, McLean JA, Bowman AB (2015) Metallomics 7(2): 363-70
    › Primary publication · 25599126 (PubMed) · PMC4326616 (PubMed Central)
  2. A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease. Tidball AM, Bryan MR, Uhouse MA, Kumar KK, Aboud AA, Feist JE, Ess KC, Neely MD, Aschner M, Bowman AB (2015) Hum Mol Genet 24(7): 1929-44
    › Primary publication · 25489053 (PubMed) · PMC4355025 (PubMed Central)
  3. Cellular manganese content is developmentally regulated in human dopaminergic neurons. Kumar KK, Lowe EW, Aboud AA, Neely MD, Redha R, Bauer JA, Odak M, Weaver CD, Meiler J, Aschner M, Bowman AB (2014) Sci Rep : 6801
    › Primary publication · 25348053 (PubMed) · PMC4210885 (PubMed Central)
  4. SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity. Leyva-Illades D, Chen P, Zogzas CE, Hutchens S, Mercado JM, Swaim CD, Morrisett RA, Bowman AB, Aschner M, Mukhopadhyay S (2014) J Neurosci 34(42): 14079-95
    › Primary publication · 25319704 (PubMed) · PMC4198546 (PubMed Central)
  5. PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper. Aboud AA, Tidball AM, Kumar KK, Neely MD, Han B, Ess KC, Hong CC, Erikson KM, Hedera P, Bowman AB (2015) Neurobiol Dis : 204-12
    › Primary publication · 25315681 (PubMed) · PMC4394022 (PubMed Central)
  6. Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension. West JD, Austin ED, Gaskill C, Marriott S, Baskir R, Bilousova G, Jean JC, Hemnes AR, Menon S, Bloodworth NC, Fessel JP, Kropski JA, Irwin D, Ware LB, Wheeler L, Hong CC, Meyrick B, Loyd JE, Bowman AB, Ess KC, Klemm DJ, Young PP, Merryman WD, Kotton D, Majka SM (2014) Am J Physiol Cell Physiol 307(5): C415-30
    › Primary publication · 24871858 (PubMed) · PMC4154073 (PubMed Central)
  7. Considerations on manganese (Mn) treatments for in vitro studies. Bowman AB, Aschner M (2014) Neurotoxicology : 141-2
    › Primary publication · 24509086 (PubMed) · PMC4004588 (PubMed Central)
  8. Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation. Srinivasakumar N, Zaboikin M, Tidball AM, Aboud AA, Neely MD, Ess KC, Bowman AB, Schuening FG (2013) PeerJ : e224
    › Primary publication · 24392288 (PubMed) · PMC3869187 (PubMed Central)
  9. Optimization of fluorescence assay of cellular manganese status for high throughput screening. Kumar KK, Aboud AA, Patel DK, Aschner M, Bowman AB (2013) J Biochem Mol Toxicol 27(1): 42-9
    › Primary publication · 23169769 (PubMed) · PMC3774111 (PubMed Central)
  10. Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects. Aboud AA, Tidball AM, Kumar KK, Neely MD, Ess KC, Erikson KM, Bowman AB (2012) Neurotoxicology 33(6): 1443-9
    › Primary publication · 23099318 (PubMed) · PMC3518601 (PubMed Central)