The Vanderbilt University Mass Cytometry Center of Excellence (MCCE) provides a cutting edge environment where users can access mass cytometry equipment, receive advanced training, and learn to standardize mass cytometry applications. MCCE website:
https://my.vanderbilt.edu/mcce/.

Publications

Featured publications

  1. Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy. Barone SM, Paul AG, Muehling LM, Lannigan JA, Kwok WW, Turner RB, Woodfolk JA, Irish JM (2021) Elife
    › Primary publication · 34350827 (PubMed) · PMC8370768 (PubMed Central)
  2. Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine. Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker L, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM (2021) bioRxiv
    › Primary publication · 34341788 (PubMed) · PMC8328055 (PubMed Central)
  3. Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation. Ramsey HE, Stengel K, Pino JC, Johnston G, Childress M, Gorska AE, Arrate PM, Fuller L, Villaume M, Fischer MA, Ferrell PB, Roe CE, Zou J, Lubbock ALR, Stubbs M, Zinkel S, Irish JM, Lopez CF, Hiebert S, Savona MR (2021) Target Oncol 16(5): 663-674
    › Primary publication · 34324169 (PubMed)
  4. HLA-DR cancer cells expression correlates with T cell infiltration and is enriched in lung adenocarcinoma with indolent behavior. Senosain MF, Zou Y, Novitskaya T, Vasiukov G, Balar AB, Rowe DJ, Doxie DB, Lehman JM, Eisenberg R, Maldonado F, Zijlstra A, Novitskiy SV, Irish JM, Massion PP (2021) Sci Rep 11(1): 14424
    › Primary publication · 34257356 (PubMed) · PMC8277797 (PubMed Central)
  5. CMV exposure drives long-term CD57+ CD4 memory T cell inflation following allogeneic stem cell transplant. Yeh AC, Varelias A, Reddy A, Barone SM, Olver S, Chilson K, Onstad L, Ensbey KS, Henden AS, Samson L, Jaeger CA, Bi T, Dahlman K, Kim TK, Zhang P, Degli-Esposti MA, Newell EW, Jagasia M, Irish JM, Lee SJ, Hill GR (2021) Blood
    › Primary publication · 34115118 (PubMed)
  6. Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC (2021) J Immunol 206(6): 1127-1139
    › Primary publication · 33558372 (PubMed) · PMC7946768 (PubMed Central)
  7. CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation. Beckermann KE, Hongo R, Ye X, Young K, Carbonell K, Healey DCC, Siska PJ, Barone S, Roe CE, Smith CC, Vincent BG, Mason FM, Irish JM, Rathmell WK, Rathmell JC (2020) JCI Insight 5(16)
    › Primary publication · 32814710 (PubMed) · PMC7455120 (PubMed Central)
  8. Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy. Barone SM, Paul AGA, Muehling LM, Lannigan JA, Kwok WW, Turner RB, Woodfolk JA, Irish JM (2020) bioRxiv
    › Primary publication · 32766581 (PubMed) · PMC7402038 (PubMed Central)
  9. Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells. Leelatian N, Sinnaeve J, Mistry AM, Barone SM, Brockman AA, Diggins KE, Greenplate AR, Weaver KD, Thompson RC, Chambless LB, Mobley BC, Ihrie RA, Irish JM (2020) Elife
    › Primary publication · 32573435 (PubMed) · PMC7340505 (PubMed Central)
  10. Loss of Myeloid BMPR1a Alters Differentiation and Reduces Mouse Prostate Cancer Growth. Ihle CL, Straign DM, Provera MD, Novitskiy SV, Owens P (2020) Front Oncol : 357
    › Primary publication · 32318332 (PubMed) · PMC7154049 (PubMed Central)

Community Leaders

Contact Information

2220 Pierce Ave
734 Preston Research Building (PRB)
Nashville, TN 37232
United States
(615) 936-3460 (p)

Caroline Roe
615-875-0965 (p)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Alternaria Antibodies, Monoclonal, Humanized Carcinogenesis Cell Line Child, Preschool Core CyTOF Epithelium Fluorescent Dyes Gene Expression Inventions Lateral Ventricles Lung Macrophages Mass cytometry Plasma Cells Precision Medicine Proto-Oncogene Proteins B-raf Reproducibility of Results Sensitivity and Specificity Single-Cell Analysis Treatment Outcome Tumor Necrosis Factor-alpha