The Vanderbilt University Mass Cytometry Center of Excellence (MCCE) provides a cutting edge environment where users can access mass cytometry equipment, receive advanced training, and learn to standardize mass cytometry applications. MCCE website:
https://my.vanderbilt.edu/mcce/.

Publications

Featured publications

  1. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC (2017) JCI Insight 2(12)
    › Primary publication · 28614802 (PubMed)
  2. Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow. Roussel M, Ferrell PB, Greenplate AR, Lhomme F, Le Gallou S, Diggins KE, Johnson DB, Irish JM (2017) J Leukoc Biol
    › Primary publication · 28400539 (PubMed)
  3. Preparing Viable Single Cells from Human Tissue and Tumors for Cytomic Analysis. Leelatian N, Doxie DB, Greenplate AR, Sinnaeve J, Ihrie RA, Irish JM (2017) Curr Protoc Mol Biol : 25C.1.1-25C.1.23
    › Primary publication · 28369679 (PubMed)
  4. Characterizing cell subsets using marker enrichment modeling. E Diggins K, R Greenplate A, Leelatian N, E Wogsland C, M Irish J (2017) Nat Methods
    › Primary publication · 28135256 (PubMed)
  5. Mass cytometry of follicular lymphoma tumors reveals intrinsic heterogeneity in proteins including HLA-DR and a deficit in non-malignant plasmablast and germinal center B cell populations. Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K (2016) Cytometry B Clin Cytom
    › Primary publication · 27933753 (PubMed)
  6. Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. Simmons AJ, Scurrah CR, McKinley ET, Herring CA, Irish JM, Washington MK, Coffey RJ, Lau KS (2016) Sci Signal 9(449): rs11
    › Primary publication · 27729552 (PubMed) · PMC5111815 (PubMed Central)
  7. Single cell analysis of human tissues and solid tumors with mass cytometry. Leelatian N, Doxie DB, Greenplate AR, Mobley BC, Lehman JM, Sinnaeve J, Kauffmann RM, Werkhaven JA, Mistry AM, Weaver KD, Thompson RC, Massion PP, Hooks MA, Kelley MC, Chambless LB, Ihrie RA, Irish JM (2016) Cytometry B Clin Cytom
    › Primary publication · 27598832 (PubMed)
  8. Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo. Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS (2016) Mol Syst Biol 12(8): 881
    › Primary publication · 27574014 (PubMed) · PMC5119492 (PubMed Central)
  9. High-Dimensional Analysis of Acute Myeloid Leukemia Reveals Phenotypic Changes in Persistent Cells during Induction Therapy. Ferrell PB, Diggins KE, Polikowsky HG, Mohan SR, Seegmiller AC, Irish JM (2016) PLoS One 11(4): e0153207
    › Primary publication · 27074138 (PubMed) · PMC4830605 (PubMed Central)
  10. Myelodysplastic Syndrome Revealed by Systems Immunology in a Melanoma Patient Undergoing Anti-PD-1 Therapy. Greenplate AR, Johnson DB, Roussel M, Savona MR, Sosman JA, Puzanov I, Ferrell PB, Irish JM (2016) Cancer Immunol Res 4(6): 474-80
    › Primary publication · 26966176 (PubMed) · PMC4891280 (PubMed Central)

Community Leaders

Contact Information

2220 Pierce Ave
734 Preston Research Building (PRB)
Nashville, TN 37232
United States
(615) 936-3460 (p)

Caroline Roe
615-875-0965 (p)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Aged Apoptosis Cell Line Computational Biology Core CyTOF Female Flow Cytometry Gene Expression Humans Immunophenotyping Lanthanoid Series Elements Leukocytes, Mononuclear Machine Learning Male Mass cytometry Mass Spectrometry Oxidation-Reduction Palatine Tonsil Phosphorylation Single-Cell Analysis Treatment Outcome Tumor Necrosis Factor-alpha