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Mass Cytometry Center of Excellence

The Vanderbilt University Mass Cytometry Center of Excellence (MCCE) provides a cutting edge environment where users can access mass cytometry equipment, receive advanced training, and learn to standardize mass cytometry applications. MCCE website:
https://my.vanderbilt.edu/mcce/.

Publications

Featured publications

  1. Generating Quantitative Cell Identity Labels with Marker Enrichment Modeling (MEM). Diggins KE, Gandelman JS, Roe CE, Irish JM (2018) Curr Protoc Cytom : 10.21.1-10.21.28
    › Primary publication · 29345329 (PubMed) · PMC5774653 (PubMed Central)
  2. Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Earl DC, Ferrell PB, Leelatian N, Froese JT, Reisman BJ, Irish JM, Bachmann BO (2018) Nat Commun 9(1): 39
    › Primary publication · 29295987 (PubMed) · PMC5750220 (PubMed Central)
  3. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC (2017) JCI Insight 2(12)
    › Primary publication · 28614802 (PubMed) · PMC5470888 (PubMed Central)
  4. Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow. Roussel M, Ferrell PB, Greenplate AR, Lhomme F, Le Gallou S, Diggins KE, Johnson DB, Irish JM (2017) J Leukoc Biol 102(2): 437-447
    › Primary publication · 28400539 (PubMed)
  5. Preparing Viable Single Cells from Human Tissue and Tumors for Cytomic Analysis. Leelatian N, Doxie DB, Greenplate AR, Sinnaeve J, Ihrie RA, Irish JM (2017) Curr Protoc Mol Biol : 25C.1.1-25C.1.23
    › Primary publication · 28369679 (PubMed) · PMC5518778 (PubMed Central)
  6. Characterizing cell subsets using marker enrichment modeling. Diggins KE, Greenplate AR, Leelatian N, Wogsland CE, Irish JM (2017) Nat Methods 14(3): 275-278
    › Primary publication · 28135256 (PubMed) · PMC5330853 (PubMed Central)
  7. Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations. Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K (2017) Cytometry B Clin Cytom 92(1): 79-87
    › Primary publication · 27933753 (PubMed) · PMC5506779 (PubMed Central)
  8. Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. Simmons AJ, Scurrah CR, McKinley ET, Herring CA, Irish JM, Washington MK, Coffey RJ, Lau KS (2016) Sci Signal 9(449): rs11
    › Primary publication · 27729552 (PubMed) · PMC5111815 (PubMed Central)
  9. Single cell analysis of human tissues and solid tumors with mass cytometry. Leelatian N, Doxie DB, Greenplate AR, Mobley BC, Lehman JM, Sinnaeve J, Kauffmann RM, Werkhaven JA, Mistry AM, Weaver KD, Thompson RC, Massion PP, Hooks MA, Kelley MC, Chambless LB, Ihrie RA, Irish JM (2017) Cytometry B Clin Cytom 92(1): 68-78
    › Primary publication · 27598832 (PubMed) · PMC5459378 (PubMed Central)
  10. Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo. Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS (2016) Mol Syst Biol 12(8): 881
    › Primary publication · 27574014 (PubMed) · PMC5119492 (PubMed Central)

Community Leaders

Contact Information

2220 Pierce Ave
734 Preston Research Building (PRB)
Nashville, TN 37232
United States
(615) 936-3460 (p)

Caroline Roe
615-875-0965 (p)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Antibodies, Monoclonal, Humanized Apoptosis Carcinogenesis Cell Line Computational Biology Core CyTOF Disease Progression Female Gene Expression Humans Immunomodulation Lymphocytes Lymphoma, B-Cell Macrophages Male Mass cytometry Myeloid-Derived Suppressor Cells Phosphorylation Plasma Cells Single-Cell Analysis Treatment Outcome Tumor Necrosis Factor-alpha