Mass Cytometry Center of Excellence

The Vanderbilt University Mass Cytometry Center of Excellence (MCCE) provides a cutting edge environment where users can access mass cytometry equipment, receive advanced training, and learn to standardize mass cytometry applications. MCCE website:
https://my.vanderbilt.edu/mcce/.

Publications

Featured publications

  1. Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis. Rushing GV, Brockman AA, Bollig MK, Leelatian N, Mobley BC, Irish JM, Ess KC, Fu C, Ihrie RA (2019) Life Sci Alliance 2(2)
    › Primary publication · 30910807 (PubMed) · PMC6435042 (PubMed Central)
  2. Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response. Huse K, Wogsland CE, Polikowsky HG, Diggins KE, Smeland EB, Myklebust JH, Irish JM (2019) Cytometry A 95(4): 442-449
    › Primary publication · 30838773 (PubMed) · PMC6711772 (PubMed Central)
  3. Computational Immune Monitoring Reveals Abnormal Double-Negative T Cells Present across Human Tumor Types. Greenplate AR, McClanahan DD, Oberholtzer BK, Doxie DB, Roe CE, Diggins KE, Leelatian N, Rasmussen ML, Kelley MC, Gama V, Siska PJ, Rathmell JC, Ferrell PB, Johnson DB, Irish JM (2019) Cancer Immunol Res 7(1): 86-99
    › Primary publication · 30413431 (PubMed) · PMC6318034 (PubMed Central)
  4. BRAF and MEK inhibitor therapy eliminates Nestin-expressing melanoma cells in human tumors. Doxie DB, Greenplate AR, Gandelman JS, Diggins KE, Roe CE, Dahlman KB, Sosman JA, Kelley MC, Irish JM (2018) Pigment Cell Melanoma Res 31(6): 708-719
    › Primary publication · 29778085 (PubMed) · PMC6188784 (PubMed Central)
  5. Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Earl DC, Ferrell PB, Leelatian N, Froese JT, Reisman BJ, Irish JM, Bachmann BO (2018) Nat Commun 9(1): 39
    › Primary publication · 29295987 (PubMed) · PMC5750220 (PubMed Central)
  6. Unsupervised Trajectory Analysis of Single-Cell RNA-Seq and Imaging Data Reveals Alternative Tuft Cell Origins in the Gut. Herring CA, Banerjee A, McKinley ET, Simmons AJ, Ping J, Roland JT, Franklin JL, Liu Q, Gerdes MJ, Coffey RJ, Lau KS (2018) Cell Syst 6(1): 37-51.e9
    › Primary publication · 29153838 (PubMed) · PMC5799016 (PubMed Central)
  7. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC (2017) JCI Insight 2(12)
    › Primary publication · 28614802 (PubMed) · PMC5470888 (PubMed Central)
  8. Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow. Roussel M, Ferrell PB, Greenplate AR, Lhomme F, Le Gallou S, Diggins KE, Johnson DB, Irish JM (2017) J Leukoc Biol 102(2): 437-447
    › Primary publication · 28400539 (PubMed) · PMC6608074 (PubMed Central)
  9. Characterizing cell subsets using marker enrichment modeling. Diggins KE, Greenplate AR, Leelatian N, Wogsland CE, Irish JM (2017) Nat Methods 14(3): 275-278
    › Primary publication · 28135256 (PubMed) · PMC5330853 (PubMed Central)
  10. Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. Simmons AJ, Scurrah CR, McKinley ET, Herring CA, Irish JM, Washington MK, Coffey RJ, Lau KS (2016) Sci Signal 9(449): rs11
    › Primary publication · 27729552 (PubMed) · PMC5111815 (PubMed Central)

Community Leaders

Contact Information

2220 Pierce Ave
734 Preston Research Building (PRB)
Nashville, TN 37232
United States
(615) 936-3460 (p)

Caroline Roe
615-875-0965 (p)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Anemia, Aplastic Antibodies, Monoclonal, Humanized Carcinogenesis Cell Line Cell Separation Core CyTOF Epithelium Gene Expression Immunomodulation Immunophenotyping Interleukin-2 Lanthanoid Series Elements Macrophages Mass cytometry Mass Spectrometry Models, Theoretical Paraffin Embedding Plasma Cells Proto-Oncogene Proteins B-raf Single-Cell Analysis Treatment Outcome Tumor Necrosis Factor-alpha