Mass Cytometry Center of Excellence

The Vanderbilt University Mass Cytometry Center of Excellence (MCCE) provides a cutting edge environment where users can access mass cytometry equipment, receive advanced training, and learn to standardize mass cytometry applications. MCCE website:
https://my.vanderbilt.edu/mcce/.

Publications

Featured publications

  1. CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation. Beckermann KE, Hongo R, Ye X, Young K, Carbonell K, Healey DCC, Siska PJ, Barone S, Roe CE, Smith CC, Vincent BG, Mason FM, Irish JM, Rathmell WK, Rathmell JC (2020) JCI Insight 5(16)
    › Primary publication · 32814710 (PubMed) · PMC7455120 (PubMed Central)
  2. Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy. Barone SM, Paul AGA, Muehling LM, Lannigan JA, Kwok WW, Turner RB, Woodfolk JA, Irish JM (2020) bioRxiv
    › Primary publication · 32766581 (PubMed) · PMC7402038 (PubMed Central)
  3. Unsupervised machine learning reveals risk stratifying glioblastoma tumor cells. Leelatian N, Sinnaeve J, Mistry AM, Barone SM, Brockman AA, Diggins KE, Greenplate AR, Weaver KD, Thompson RC, Chambless LB, Mobley BC, Ihrie RA, Irish JM (2020) Elife
    › Primary publication · 32573435 (PubMed) · PMC7340505 (PubMed Central)
  4. Loss of Myeloid BMPR1a Alters Differentiation and Reduces Mouse Prostate Cancer Growth. Ihle CL, Straign DM, Provera MD, Novitskiy SV, Owens P (2020) Front Oncol : 357
    › Primary publication · 32318332 (PubMed) · PMC7154049 (PubMed Central)
  5. High-Dimensional Data Analysis Algorithms Yield Comparable Results for Mass Cytometry and Spectral Flow Cytometry Data. Ferrer-Font L, Mayer JU, Old S, Hermans IF, Irish J, Price KM (2020) Cytometry A 97(8): 824-831
    › Primary publication · 32293794 (PubMed) · PMC7682594 (PubMed Central)
  6. Training Novices in Generation and Analysis of High-Dimensional Human Cell Phospho-Flow Cytometry Data. Roe CE, Hayes MJ, Barone SM, Irish JM (2020) Curr Protoc Cytom 93(1): e71
    › Primary publication · 32250555 (PubMed) · PMC7682619 (PubMed Central)
  7. Mass cytometry defines distinct immune profile in germinal center B-cell lymphomas. Roussel M, Lhomme F, Roe CE, Bartkowiak T, Gravelle P, Laurent C, Fest T, Irish JM (2020) Cancer Immunol Immunother 69(3): 407-420
    › Primary publication · 31919622 (PubMed) · PMC7764565 (PubMed Central)
  8. Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis. Rushing GV, Brockman AA, Bollig MK, Leelatian N, Mobley BC, Irish JM, Ess KC, Fu C, Ihrie RA (2019) Life Sci Alliance 2(2)
    › Primary publication · 30910807 (PubMed) · PMC6435042 (PubMed Central)
  9. Human Germinal Center B Cells Differ from Naïve and Memory B Cells in CD40 Expression and CD40L-Induced Signaling Response. Huse K, Wogsland CE, Polikowsky HG, Diggins KE, Smeland EB, Myklebust JH, Irish JM (2019) Cytometry A 95(4): 442-449
    › Primary publication · 30838773 (PubMed) · PMC6711772 (PubMed Central)
  10. NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines. van Montfoort N, Borst L, Korrer MJ, Sluijter M, Marijt KA, Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, André P, Wagtmann N, Welters MJP, Kim YJ, Piersma SJ, van der Burg SH, van Hall T (2018) Cell 175(7): 1744-1755.e15
    › Primary publication · 30503208 (PubMed) · PMC6354585 (PubMed Central)

Community Leaders

Contact Information

2220 Pierce Ave
734 Preston Research Building (PRB)
Nashville, TN 37232
United States
(615) 936-3460 (p)

Caroline Roe
615-875-0965 (p)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Anemia, Aplastic Antibodies, Monoclonal, Humanized Carcinogenesis CD40 Ligand Cell Line Child, Preschool Core CyTOF Epithelium Gene Expression Inventions Lateral Ventricles Macrophages Mass cytometry Models, Theoretical Plasma Cells Precision Medicine Proto-Oncogene Proteins B-raf Reproducibility of Results Sensitivity and Specificity Single-Cell Analysis Treatment Outcome Tumor Necrosis Factor-alpha