The Vanderbilt University Cancer & Immunology Core (CIC) provides fee-for-service mass cytometry and other advanced cytometry services using well-established CIC Panels of metal-conjugated antibodies and standardized protocols. We also have a website at: https://my.vanderbilt.edu/cancerimmunology/.

Publications

Featured publications

  1. Computational immune monitoring reveals abnormal double negative T cells present across human tumor types. Greenplate AR, McClanahan DD, Oberholtzer BK, Doxie DB, Roe CE, Diggins KE, Leelatian N, Rasmussen ML, Kelley MC, Gama V, Siska PJ, Rathmell JC, Ferrell PB, Johnson DB, Irish JM (2018) Cancer Immunol Res
    › Primary publication · 30413431 (PubMed)
  2. Machine learning reveals chronic graft-versus-host disease phenotypes and stratifies survival after stem cell transplant for hematologic malignancies. Gandelman JS, Byrne MT, Mistry AM, Polikowsky HG, Diggins KE, Chen H, Lee SJ, Arora M, Cutler C, Flowers M, Pidala J, Irish JM, Jagasia MH (2018) Haematologica
    › Primary publication · 30237265 (PubMed)
  3. Genomic Profiling of T-Cell Neoplasms Reveals Frequent and Mutations With Clonal Evasion From Targeted Therapies. Greenplate A, Wang K, Tripathi RM, Palma N, Ali SM, Stephens PJ, Miller VA, Shyr Y, Guo Y, Reddy NM, Kozhaya L, Unutmaz D, Chen X, Irish JM, Davé UP (2018) JCO Precis Oncol
    › Primary publication · 30079384 (PubMed)
  4. Discovery of human cell selective effector molecules using single cell multiplexed activity metabolomics. Earl DC, Ferrell PB, Leelatian N, Froese JT, Reisman BJ, Irish JM, Bachmann BO (2018) Nat Commun 9(1): 39
    › Primary publication · 29295987 (PubMed) · PMC5750220 (PubMed Central)
  5. Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma. Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC (2017) JCI Insight 2(12)
    › Primary publication · 28614802 (PubMed) · PMC5470888 (PubMed Central)
  6. Mass cytometry deep phenotyping of human mononuclear phagocytes and myeloid-derived suppressor cells from human blood and bone marrow. Roussel M, Ferrell PB, Greenplate AR, Lhomme F, Le Gallou S, Diggins KE, Johnson DB, Irish JM (2017) J Leukoc Biol 102(2): 437-447
    › Primary publication · 28400539 (PubMed)
  7. Preparing Viable Single Cells from Human Tissue and Tumors for Cytomic Analysis. Leelatian N, Doxie DB, Greenplate AR, Sinnaeve J, Ihrie RA, Irish JM (2017) Curr Protoc Mol Biol : 25C.1.1-25C.1.23
    › Primary publication · 28369679 (PubMed) · PMC5518778 (PubMed Central)
  8. Characterizing cell subsets using marker enrichment modeling. Diggins KE, Greenplate AR, Leelatian N, Wogsland CE, Irish JM (2017) Nat Methods 14(3): 275-278
    › Primary publication · 28135256 (PubMed) · PMC5330853 (PubMed Central)
  9. Mass Cytometry of Follicular Lymphoma Tumors Reveals Intrinsic Heterogeneity in Proteins Including HLA-DR and a Deficit in Nonmalignant Plasmablast and Germinal Center B-Cell Populations. Wogsland CE, Greenplate AR, Kolstad A, Myklebust JH, Irish JM, Huse K (2017) Cytometry B Clin Cytom 92(1): 79-87
    › Primary publication · 27933753 (PubMed) · PMC5506779 (PubMed Central)
  10. Single cell analysis of human tissues and solid tumors with mass cytometry. Leelatian N, Doxie DB, Greenplate AR, Mobley BC, Lehman JM, Sinnaeve J, Kauffmann RM, Werkhaven JA, Mistry AM, Weaver KD, Thompson RC, Massion PP, Hooks MA, Kelley MC, Chambless LB, Ihrie RA, Irish JM (2017) Cytometry B Clin Cytom 92(1): 68-78
    › Primary publication · 27598832 (PubMed) · PMC5459378 (PubMed Central)

Community Leaders

Contact Information

2220 Pierce Ave
734 Preston Research Building (PRB)
Nashville, TN 37232
United States
(615) 936-3460 (p)

Caroline Roe
(615) 936-3460 (p)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Algorithms Biomarkers, Tumor Bone Marrow Brain Neoplasms Chromatography, Liquid Cryopreservation Dendritic Cells Germinal Center Induction Chemotherapy Jurkat Cells Lymphoma, Follicular Melanoma Metabolome Middle Aged Monocytes Multivariate Analysis Neoplasms Signal Transduction Streptomyces Young Adult