The Young Laboratory is focused on understanding the biology of adult stem cells within the context of two broad biological processes--malignancy and regeneration. The role of adult stem cells to modulate repair and regeneration is of great interest. Our work focuses on gaining a better understanding of bone marrow derived stem cells using both mouse and human cells. Specifically, we are committed to understanding the characteristics of stem cell progenitors, their differentiation, the mechanism by which stem cells mediate regeneration and also the host/stem cell interactions.
Project 1- Mesenchymal stem cells hold much promise as tools to mediate repair. We have recently identified that Wnt pathway inhibition regulates MSC biology. We use mouse models of myocardial infarction or pressure overload hypertrophy (as a heart failure model) to study the role of wnt modulation in MSC-mediated repair. Other projects are focused on understanding the unique metabolism of stem cells that enable engraftment in wound sites and improving our knowledge of the paracrine profile of stem cells that mediate tissue repair. Our hope is to understand how to modulate endogenous MSCs after injury to control repair and regeneration.
Project 2-Bone marrow derived endothelial progenitor cells (EPCs) are derived from both committed and uncommitted hematopoietic cells. We have characterized myeloid to endothelial plasticity over the last few years and have focused our attention on the mechanism of this plasticity. We have recently identified TNF as a modulator of endothelial differentiation. Moreover, we have also begun to better understand the role of these myelod/endothelial cells in cancer and regeneration.
Project 3 -Our vascular system is impacted by both physiologic and pathologic biomechanical stress. We have identified that SPRR3 is a mechanosensitive protein expressed by vascular smooth muscle cells and have begun to study its role in the cardiovascular system using a mouse knockout model
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MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordAdult angiogenesis Animals Blood Group Incompatibility Blotting, Western Bone Neoplasms cancer cardiac function cardiac regeneration Cell Growth Processes Cell Line, Tumor Cell Proliferation cellular adaptation to biomechanical stress developmental biology Endothelial Cells endothelial progenitor cells (EPCs) gene therapy heart Heart Transplantation Macrophage Migration-Inhibitory Factors Mechanotransduction, Cellular mesenchymal stem cells (MSCs) Middle Aged Monocytes mouse Osteosarcoma pathology physiology stem cells Protein Isoforms regeneneration Saphenous Vein Skin Spider Venoms Stress, Mechanical transplantation vascular biology tumor-host interactions vasculogenesis