The Kendall Lab investigates the immunologic pathophysiology of Type 1 diabetes (T1D), with a focus on the role of B lymphocytes. The goal of this work is to understand the cellular and molecular interactions that lead to destruction of pancreatic beta cells, and to apply these discoveries to the prediction, prevention and treatment of T1D.

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Featured publications

  1. Reply. Nyhoff LE, Crofford LJ, Kendall PL (2017) Arthritis Rheumatol 69(2): 475-477
    › Primary publication · 27748073 (PubMed) · PMC5274625 (PubMed Central)
  2. New Players in the Field of T1D: Anti-Peripherin B Lymphocytes. Kendall PL (2016) Diabetes 65(7): 1794-6
    › Primary publication · 27329956 (PubMed) · PMC4915580 (PubMed Central)
  3. Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis. Nyhoff LE, Barron BL, Johnson EM, Bonami RH, Maseda D, Fensterheim BA, Han W, Blackwell TS, Crofford LJ, Kendall PL (2016) Arthritis Rheumatol 68(8): 1856-68
    › Primary publication · 26945549 (PubMed) · PMC5668904 (PubMed Central)
  4. The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy. Crofford LJ, Nyhoff LE, Sheehan JH, Kendall PL (2016) Expert Rev Clin Immunol 12(7): 763-73
    › Primary publication · 26864273 (PubMed) · PMC5070917 (PubMed Central)
  5. The evolving story of human leukocyte antigen and the immunogenetics of peanut allergy. Hemler JA, Phillips EJ, Mallal SA, Kendall PL (2015) Ann Allergy Asthma Immunol 115(6): 471-6
    › Primary publication · 26522257 (PubMed) · PMC5665015 (PubMed Central)
  6. Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury. Riley KG, Pasek RC, Maulis MF, Dunn JC, Bolus WR, Kendall PL, Hasty AH, Gannon M (2015) Mol Metab 4(8): 584-91
    › Primary publication · 26266091 (PubMed) · PMC4529497 (PubMed Central)
  7. Bruton's Tyrosine Kinase Synergizes with Notch2 To Govern Marginal Zone B Cells in Nonobese Diabetic Mice. Case JB, Bonami RH, Nyhoff LE, Steinberg HE, Sullivan AM, Kendall PL (2015) J Immunol 195(1): 61-70
    › Primary publication · 26034172 (PubMed) · PMC4551465 (PubMed Central)
  8. NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells. Bonami RH, Wolfle WT, Thomas JW, Kendall PL (2014) Mol Immunol 62(2): 321-8
    › Primary publication · 24507801 (PubMed) · PMC4125564 (PubMed Central)
  9. Bruton's tyrosine kinase promotes persistence of mature anti-insulin B cells. Bonami RH, Sullivan AM, Case JB, Steinberg HE, Hoek KL, Khan WN, Kendall PL (2014) J Immunol 192(4): 1459-70
    › Primary publication · 24453243 (PubMed) · PMC4083749 (PubMed Central)
  10. B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice. Henry-Bonami RA, Williams JM, Rachakonda AB, Karamali M, Kendall PL, Thomas JW (2013) J Immunol 190(12): 5992-6003
    › Primary publication · 23677466 (PubMed) · PMC3679359 (PubMed Central)

Community Leaders

Contact Information

1161 21st Ave. South
T3207 MCN Medical Center North
Nashville, TN 37232
343-1009 (p)

Crissy Thurman
615-343-1009 (p)

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Autoimmune Diseases Base Sequence Beta cell Cell Nucleus Coculture Techniques Diabetes Diabetes Mellitus, Experimental Disease Progression Female Humans Immunity, Innate Immunology Interleukin-11 Lung Male Mice, Transgenic Mutation pancreas pathophysiology Peanut Hypersensitivity Protein-Tyrosine Kinases Receptors, CXCR5 Receptors, Transforming Growth Factor beta T1D Transgenes Treatment Outcome Type 1 Diabetes