Vanderbilt Center for Matrix Biology

The Vanderbilt Center for Matrix Biology, associated with Vanderbilt University Medical Center, is an interdepartmental group of basic and clinical scientists, whose research involves different aspects of biology of the extracellular matrices. The Center currently includes numerous members from different departments with research interests comprising such areas as angiogenesis, biomaterials, tumor microenvironment, wound repair, diabetic complications, fibrosis, and tissue regeneration.

The mission of the Center is to foster cohesive interactions among scientists to facilitate collaborations and promote excellence in matrix research.

Furthermore, Vanderbilt Center for Matrix Biology aims to support and develop a model science education pipeline with Aspirnaut™, a K-20 STEM Pipeline for Diversity. The goal is to elevate STEM achievement in students from disadvantaged backgrounds as a means to increase the number and diversity of students entering the STEM workforce.

Publications

Featured publications

1. High-Fat, High-Sugar Diet-Induced Subendothelial Matrix Stiffening is Mitigated by Exercise. Kohn JC, Azar J, Seta F, Reinhart-King CA (2018) Cardiovasc Eng Technol 9(1): 84-93
   › Primary publication · 29159794 (PubMed) · PMC5797500 (PubMed Central)
2. Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis. Dear ML, Shilts J, Broadie K (2017) Sci Signal 10(504)
   › Primary publication · 29114039 (PubMed) · PMC5743058 (PubMed Central)
3. The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain. Dohn MR, Kooker CG, Bastarache L, Jessen T, Rinaldi C, Varney S, Mazalouskas MD, Pan H, Oliver KH, Velez Edwards DR, Sutcliffe JS, Denny JC, Carneiro AMD (2017) J Neurosci 37(46): 11271-11284
   › Primary publication · 29038237 (PubMed) · PMC5688530 (PubMed Central)
4. Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development. Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R (2017) Development 144(22): 4148-4158
   › Primary publication · 28993400 (PubMed) · PMC5719244 (PubMed Central)
5. Proteolytic processing of lysyl oxidase-like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV. López-Jiménez AJ, Basak T, Vanacore RM (2017) J Biol Chem 292(41): 16970-16982
   › Primary publication · 28864775 (PubMed) · PMC5641870 (PubMed Central)
6. Building collagen IV smart scaffolds on the outside of cells. Brown KL, Cummings CF, Vanacore RM, Hudson BG (2017) Protein Sci 26(11): 2151-2161
   › Primary publication · 28845540 (PubMed) · PMC5654846 (PubMed Central)
7. The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells. Jerrell RJ, Leih MJ, Parekh A (2020) Small GTPases 11(2): 131-137
   › Primary publication · 28650698 (PubMed) · PMC7053931 (PubMed Central)
8. Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca-Regulated Genes. Stancill JS, Cartailler JP, Clayton HW, O'Connor JT, Dickerson MT, Dadi PK, Osipovich AB, Jacobson DA, Magnuson MA (2017) Diabetes 66(8): 2175-2187
   › Primary publication · 28550109 (PubMed) · PMC5521870 (PubMed Central)
9. Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR (2017) Nature 545(7653): 243-247
   › Primary publication · 28467828 (PubMed) · PMC5903850 (PubMed Central)
10. The Vascular Wall: a Plastic Hub of Activity in Cardiovascular Homeostasis and Disease. Awgulewitsch CP, Trinh LT, Hatzopoulos AK (2017) Curr Cardiol Rep 19(6): 51
    › Primary publication · 28432663 (PubMed)

Community Leaders

• Billy Hudson
  Director, Vanderbilt Center for Matrix Biology
• Ambra Pozzi
  Assistant Director, Vanderbilt Center for Matrix Biology
• Aaron Fidler
  Program Manager, Vanderbilt Center for Matrix Biology, Assistant Professor, Department of Medicine
• Jean-Philippe Cartailler
  Director, Creative Data Solutions

Contact Information

1161 21st Avenue S
Medicine/Nephrology
B-3102 Medical Center North
Nashville, TN 37232-2372
United States

Aaron Fidler
6069232039 (p)
Email

Keywords & MeSH Terms

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Key: MeSH Term Keyword