The Vanderbilt Center for Matrix Biology, associated with Vanderbilt University Medical Center, is an interdepartmental group of basic and clinical scientists, whose research involves different aspects of biology of the extracellular matrices. The Center currently includes numerous members from different departments with research interests comprising such areas as angiogenesis, biomaterials, tumor microenvironment, wound repair, diabetic complications, fibrosis, and tissue regeneration.

The mission of the Center is to foster cohesive interactions among scientists to facilitate collaborations and promote excellence in matrix research.

Furthermore, Vanderbilt Center for Matrix Biology aims to support and develop a model science education pipeline with Aspirnaut™, a K-20 STEM Pipeline for Diversity. The goal is to elevate STEM achievement in students from disadvantaged backgrounds as a means to increase the number and diversity of students entering the STEM workforce.


Featured publications

  1. Progression of chronic kidney disease: too much cellular talk causes damage. Gewin L, Zent R, Pozzi A (2016) Kidney Int
    › Primary publication · 27773427 (PubMed)
  2. Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane. Añazco C, López-Jiménez AJ, Rafi M, Vega-Montoto L, Zhang MZ, Hudson BG, Vanacore RM (2016) J Biol Chem 291(50): 25999-26012
    › Primary publication · 27770022 (PubMed)
  3. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming. Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG (2016) Matrix Biol
    › Primary publication · 27619726 (PubMed)
  4. Extracellular chloride signals collagen IV network assembly during basement membrane formation. Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, Stothers C, Ero-Tolliver IA, McCall AS, Vanacore R, Bhave G, Santoro S, Blackwell TS, Zent R, Pozzi A, Hudson BG (2016) J Cell Biol 213(4): 479-94
    › Primary publication · 27216258 (PubMed) · PMC4878091 (PubMed Central)
  5. Integrin α1β1 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling. Shin SY, Pozzi A, Boyd SK, Clark AL (2016) Osteoarthritis Cartilage 24(10): 1795-806
    › Primary publication · 27211864 (PubMed)
  6. Integrin-Linked Kinase in Muscle Is Necessary for the Development of Insulin Resistance in Diet-Induced Obese Mice. Kang L, Mokshagundam S, Reuter B, Lark DS, Sneddon CC, Hennayake C, Williams AS, Bracy DP, James FD, Pozzi A, Zent R, Wasserman DH (2016) Diabetes 65(6): 1590-600
    › Primary publication · 27207548 (PubMed) · PMC4878430 (PubMed Central)
  7. Antibodies to α5 chain of collagen IV are pathogenic in Goodpasture's disease. Cui Z, Zhao MH, Jia XY, Wang M, Hu SY, Wang SX, Yu F, Brown KL, Hudson BG, Pedchenko V (2016) J Autoimmun : 1-11
    › Primary publication · 27117167 (PubMed)
  8. Serum Metabolite Profiles Are Altered by Erlotinib Treatment and the Integrin α1-Null Genotype but Not by Post-Traumatic Osteoarthritis. Mickiewicz B, Shin SY, Pozzi A, Vogel HJ, Clark AL (2016) J Proteome Res 15(3): 815-25
    › Primary publication · 26784366 (PubMed) · PMC4779398 (PubMed Central)
  9. Cell Receptor-Basement Membrane Interactions in Health and Disease: A Kidney-Centric View. Borza CM, Chen X, Zent R, Pozzi A (2015) Curr Top Membr : 231-53
    › Primary publication · 26610916 (PubMed) · PMC4913201 (PubMed Central)
  10. Comprehensive Characterization of Glycosylation and Hydroxylation of Basement Membrane Collagen IV by High-Resolution Mass Spectrometry. Basak T, Vega-Montoto L, Zimmerman LJ, Tabb DL, Hudson BG, Vanacore RM (2016) J Proteome Res 15(1): 245-58
    › Primary publication · 26593852 (PubMed) · PMC4771517 (PubMed Central)