The major research areas in the Sung lab are polymeric biomaterials-based matrix engineering, cellular engineering, tissue engineering, and therapeutic engineering which involve a multifaceted approach that combines state of the art biomaterial systems, engineering tools, and chemical/biochemical/biological methodologies.
The research goal of the Sung LAB is to identify the underlying mechanisms by which cells and tissues interact with polymeric matrix from nano to organ scales and coordinate dynamic physicochemical/biological signals to change their microenvironments, and to apply this knowledge to develop the next generation of polymeric biomaterials for regenerative medicine and medical device technologies.
The combinatorial design of our polymer and engineering systems 1) enables control of each parameter without influencing the others (“Decoupling”) and 2) creates an unlimited variation in the system properties, thereby controlling the properties in a “user-specified” manner. This design concept is applied to develop advanced therapeutic tools, including injury-responsive injectable cardiac patch for cell delivery, heart machinery for patient-specific stem cell differentiation, shape memory vascular patch, minimally-invasive vascular bypass grafting, nanoparticles for hemodynamic targeting, and nanoneedle/pore gradient arrays.
- Hak-Joon Sung
Assistant Professor of Biomedical Engineering, Assistant Professor of Medicine-Cardiovascular Medicine
1225 Stevenson Center
5824 Science & Eng. Bldg.
Nashville, TN 37240
No contact person provided
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordAngiogenic Proteins Animals Base Sequence Cell Line Coated Materials, Biocompatible Combinatorial Biomaterials and Biointerface Engineering Aspect of Cardiovascular Medicine Guided Tissue Regeneration Hydrogen Peroxide Immunohistochemistry Macrophages Magnetic Resonance Spectroscopy Microscopy, Electron, Scanning Myocytes, Smooth Muscle Nanomedicine Peptides Polyethylene Glycols Polyurethanes Stem Cell Engineering Stem Cells Thymosin Tissue Engineering Treatment Outcome