The major research areas in the Sung lab are polymeric biomaterials-based matrix engineering, cellular engineering, tissue engineering, and therapeutic engineering which involve a multifaceted approach that combines state of the art biomaterial systems, engineering tools, and chemical/biochemical/biological methodologies.  

The research goal of the Sung LAB is to identify the underlying mechanisms by which cells and tissues interact with polymeric matrix from nano to organ scales and coordinate dynamic physicochemical/biological signals to change their microenvironments, and to apply this knowledge to develop the next generation of polymeric biomaterials for regenerative medicine and medical device technologies.

The combinatorial design of our polymer and engineering systems 1) enables control of each parameter without influencing the others (“Decoupling”) and 2) creates an unlimited variation in the system properties, thereby controlling the properties in a “user-specified” manner. This design concept is applied to develop advanced therapeutic tools, including injury-responsive injectable cardiac patch for cell delivery, heart machinery for patient-specific stem cell differentiation, shape memory vascular patch, minimally-invasive vascular bypass grafting, nanoparticles for hemodynamic targeting, and nanoneedle/pore gradient arrays.

 

Publications

Most recent publications

  1. Pro-angiogenic and anti-inflammatory regulation by functional peptides loaded in polymeric implants for soft tissue regeneration. Zachman AL, Crowder SW, Ortiz O, Zienkiewicz KJ, Bronikowski CM, Yu SS, Giorgio TD, Guelcher SA, Kohn J, Sung HJ (2013) Tissue Eng Part A 19(3-4): 437-47
    › Citation · 22953721 (PubMed) · PMC3542873 (PubMed Central)
  2. Decoupling polymer properties to elucidate mechanisms governing cell behavior. Wang X, Boire TC, Bronikowski C, Zachman AL, Crowder SW, Sung HJ (2012) Tissue Eng Part B Rev 18(5): 396-404
    › Citation · 22536977 (PubMed) · PMC3458619 (PubMed Central)
  3. Combinatorial polymer electrospun matrices promote physiologically-relevant cardiomyogenic stem cell differentiation. Gupta MK, Walthall JM, Venkataraman R, Crowder SW, Jung DK, Yu SS, Feaster TK, Wang X, Giorgio TD, Hong CC, Baudenbacher FJ, Hatzopoulos AK, Sung HJ (2011) PLoS One 6(12): e28935
    › Citation · 22216144 (PubMed) · PMC3246450 (PubMed Central)
  4. Modular polymer design to regulate phenotype and oxidative response of human coronary artery cells for potential stent coating applications. Crowder SW, Gupta MK, Hofmeister LH, Zachman AL, Sung HJ (2012) Acta Biomater 8(2): 559-69
    › Citation · 22019760 (PubMed) · PMC3253951 (PubMed Central)
  5. Physiologically relevant oxidative degradation of oligo(proline) cross-linked polymeric scaffolds. Yu SS, Koblin RL, Zachman AL, Perrien DS, Hofmeister LH, Giorgio TD, Sung HJ (2011) Biomacromolecules 12(12): 4357-66
    › Citation · 22017359 (PubMed) · PMC3237771 (PubMed Central)
  6. Emerging applications of nanotechnology for the diagnosis and management of vulnerable atherosclerotic plaques. Yu SS, Ortega RA, Reagan BW, McPherson JA, Sung HJ, Giorgio TD (2011) Wiley Interdiscip Rev Nanomed Nanobiotechnol 3(6): 620-46
    › Citation · 21834059 (PubMed)
  7. Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds. Hafeman AE, Zienkiewicz KJ, Zachman AL, Sung HJ, Nanney LB, Davidson JM, Guelcher SA (2011) Biomaterials 32(2): 419-29
    › Citation · 20864156 (PubMed) · PMC2997347 (PubMed Central)

Community Leaders

  • Hak-Joon Sung
    Assistant Professor of Biomedical Engineering, Assistant Professor of Medicine-Cardiovascular Medicine

Contact Information

1225 Stevenson Center
5824 Science & Eng. Bldg.
Nashville, TN 37240
USA
615-322-3521 (p)

No contact person provided

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Angiogenic Proteins Animals Anti-Inflammatory Agents Biocompatible Materials Cell Differentiation Cells Coated Materials, Biocompatible Combinatorial Biomaterials and Biointerface Engineering Aspect of Cardiovascular Medicine Graft Rejection Guided Tissue Regeneration Hydrogen Peroxide Lysine Microscopy, Electron, Scanning Nanomedicine Oxidation-Reduction Phenotype Polyurethanes Rats Stem Cell Engineering Thymosin Tissue Engineering Water Wound Healing