The PMM (Proteolysis. Metastasis and Microenvironment) group comprises the laboratory groups headed by Barbara Fingleton, Oliver McIntyre, Lee Gorden and Michael VanSaun. Our overarching interest is in understanding the impact of the microenvironment on tumor progression and metastasis in GI cancers (colon, liver, pancreas) and breast cancer. We have particular expertise in MMP biology and functional imaging, which is enhanced by extensive collaborations here at Vanderbilt. Another major focus area is the contributions of inflammatory cells, and the cytokines they release, to tumor progression and metastasis, including chemoresistance.


Featured publications

  1. IL4 receptor ILR4α regulates metastatic colonization by mammary tumors through multiple signaling pathways. Venmar KT, Carter KJ, Hwang DG, Dozier EA, Fingleton B (2014) Cancer Res 74(16): 4329-40
    › Primary publication · 24947041 (PubMed) · PMC4134711 (PubMed Central)
  2. Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Petersen CP, Weis VG, Nam KT, Sousa JF, Fingleton B, Goldenring JR (2014) Gastroenterology 146(7): 1727-38.e8
    › Primary publication · 24534633 (PubMed) · PMC4035414 (PubMed Central)
  3. Hepatocellular proliferation correlates with inflammatory cell and cytokine changes in a murine model of nonalchoholic fatty liver disease. Vansaun MN, Mendonsa AM, Lee Gorden D (2013) PLoS One 8(9): e73054
    › Primary publication · 24039859 (PubMed) · PMC3767686 (PubMed Central)
  4. Synthesis and in vitro efficacy of MMP9-activated NanoDendrons. Samuelson LE, Scherer RL, Matrisian LM, McIntyre JO, Bornhop DJ (2013) Mol Pharm 10(8): 3164-74
    › Primary publication · 23750801 (PubMed) · PMC4824186 (PubMed Central)
  5. Molecular pathways: adiponectin and leptin signaling in cancer. Vansaun MN (2013) Clin Cancer Res 19(8): 1926-32
    › Primary publication · 23355630 (PubMed) · PMC3630242 (PubMed Central)
  6. Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation. auf dem Keller U, Prudova A, Eckhard U, Fingleton B, Overall CM (2013) Sci Signal 6(258): rs2
    › Primary publication · 23322905 (PubMed) · PMC3872078 (PubMed Central)
  7. Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13. Hallett MA, Venmar KT, Fingleton B (2012) Cancer Res 72(24): 6338-43
    › Primary publication · 23222300 (PubMed) · PMC3531868 (PubMed Central)
  8. Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Koller FL, Dozier EA, Nam KT, Swee M, Birkland TP, Parks WC, Fingleton B (2012) Lab Invest 92(12): 1749-59
    › Primary publication · 23044923 (PubMed) · PMC3510327 (PubMed Central)
  9. Increased metastases are associated with inflammation and matrix metalloproteinase-9 activity at incision sites in a murine model of peritoneal dissemination of colorectal cancer. Lee IK, Vansaun MN, Shim JH, Matrisian LM, Gorden DL (2013) J Surg Res 180(2): 252-9
    › Primary publication · 22763216 (PubMed)
  10. Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. Gorden DL, Ivanova PT, Myers DS, McIntyre JO, VanSaun MN, Wright JK, Matrisian LM, Brown HA (2011) PLoS One 6(8): e22775
    › Primary publication · 21857953 (PubMed) · PMC3153459 (PubMed Central)

Community Leaders

Contact Information

2220 Pierce Ave
738 PRB
Nashville, TN 37232-6840
6159362911 (p)

Barbara Fingleton
615-936 5877 (p)
615-936 2912 (f)

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Amino Acid Sequence Carbocyanines Cell Polarity Diverticulitis, Colonic Histocytochemistry Inflammatory Bowel Diseases Interleukin-4 Receptor alpha Subunit Matrix metalloproteinases (MMPs) Metalloendopeptidases Metastasis Mice, Mutant Strains Models, Biological Molecular Sequence Data Neovascularization, Pathologic Nucleosides Proteoglycans Pyrazoles Rats, Inbred F344 Receptor Activator of Nuclear Factor-kappa B Saliva Skin Diseases Tissue Donors Tumor microenvironment