Profile

The Parekh Laboratory is focused on mechanobiology research in cancer and wound healing. Proper cell and extracellular matrix (ECM) interactions are responsible for maintaining functional homeostasis in tissues and organs. Alterations in this reciprocal relationship following disease or injury are guided by changes in the local ECM mechanical environment as well as signaling molecules and interactions with other cell types. These changes drive the ensuing disease state and tissue repair response by altering cellular phenotypes resulting in outcomes such as cancer cell invasion and pathological remodeling of healing wounds, respectively. In order to modulate these mechanobiological responses, a fundamental understanding of the biochemical and biophysical factors that influence these processes are required. These factors dictate cellular phenotypes and thus determine the manner in which cells further interact with their ECM microenvironment. Clinical modalities can be developed by identifying therapeutic targets that drive these pathological responses toward a more favorable outcome by interfering with these cell/ECM interactions. Therefore, our general research goal is to understand how mechanical forces drive pathologic cellular phenotypes in cancer and wound healing by utilizing biochemical and biomechanical approaches that include in vitro, ex vivo, in vivo, and in silico techniques and/or models.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. The Contractile Phenotype of Dermal Fetal Fibroblasts in Scarless Wound Healing. Parekh A, Hebda PA (2017) Curr Pathobiol Rep 5(3): 271-277
    › Primary publication · 29038745 (PubMed) · PMC5640269 (PubMed Central)
  2. The ROCK isoforms differentially regulate the morphological characteristics of carcinoma cells. Jerrell RJ, Leih MJ, Parekh A (2017) Small GTPases : 1-7
    › Primary publication · 28650698 (PubMed)
  3. Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2. Jerrell RJ, Parekh A (2016) Biomaterials : 119-129
    › Primary publication · 26826790 (PubMed) · PMC4755854 (PubMed Central)
  4. Regulation of invadopodia by mechanical signaling. Parekh A, Weaver AM (2016) Exp Cell Res 343(1): 89-95
    › Primary publication · 26546985 (PubMed) · PMC4851576 (PubMed Central)
  5. Polyacrylamide gels for invadopodia and traction force assays on cancer cells. Jerrell RJ, Parekh A (2015) J Vis Exp (95): 52343
    › Primary publication · 25590238 (PubMed) · PMC4354498 (PubMed Central)
  6. Cellular traction stresses mediate extracellular matrix degradation by invadopodia. Jerrell RJ, Parekh A (2014) Acta Biomater 10(5): 1886-96
    › Primary publication · 24412623 (PubMed) · PMC3976707 (PubMed Central)
  7. Synthetic and tissue-derived models for studying rigidity effects on invadopodia activity. Weaver AM, Page JM, Guelcher SA, Parekh A (2013) Methods Mol Biol : 171-89
    › Primary publication · 23868588 (PubMed)
  8. Strain history and TGF-β1 induce urinary bladder wall smooth muscle remodeling and elastogenesis. Heise RL, Parekh A, Joyce EM, Chancellor MB, Sacks MS (2012) Biomech Model Mechanobiol 11(1-2): 131-45
    › Primary publication · 21384200 (PubMed) · PMC3155650 (PubMed Central)
  9. Sensing and modulation of invadopodia across a wide range of rigidities. Parekh A, Ruppender NS, Branch KM, Sewell-Loftin MK, Lin J, Boyer PD, Candiello JE, Merryman WD, Guelcher SA, Weaver AM (2011) Biophys J 100(3): 573-582
    › Primary publication · 21281571 (PubMed) · PMC3030182 (PubMed Central)
  10. Ex vivo deformations of the urinary bladder wall during whole bladder filling: contributions of extracellular matrix and smooth muscle. Parekh A, Cigan AD, Wognum S, Heise RL, Chancellor MB, Sacks MS (2010) J Biomech 43(9): 1708-16
    › Primary publication · 20398903 (PubMed)
  11. Assessing the effects of transforming growth factor-beta1 on bladder smooth muscle cell phenotype. II. Modulation of collagen organization. Parekh A, Long RA, Chancellor MB, Sacks MS (2009) J Urol 182(3): 1216-21
    › Primary publication · 19625051 (PubMed)
  12. Assessing the effects of transforming growth factor-beta1 on bladder smooth muscle cell phenotype. I. Modulation of in vitro contractility. Parekh A, Long RA, Iannone EC, Chancellor MB, Sacks MS (2009) J Urol 182(3): 1210-5
    › Primary publication · 19625042 (PubMed)
  13. Generating elastin-rich small intestinal submucosa-based smooth muscle constructs utilizing exogenous growth factors and cyclic mechanical stimulation. Heise RL, Ivanova J, Parekh A, Sacks MS (2009) Tissue Eng Part A 15(12): 3951-60
    › Primary publication · 19569874 (PubMed) · PMC2792073 (PubMed Central)
  14. Regulation of cancer invasiveness by the physical extracellular matrix environment. Parekh A, Weaver AM (2009) Cell Adh Migr 3(3): 288-92
    › Primary publication · 19458499 (PubMed) · PMC2712813 (PubMed Central)
  15. Repair of the tympanic membrane with urinary bladder matrix. Parekh A, Mantle B, Banks J, Swarts JD, Badylak SF, Dohar JE, Hebda PA (2009) Laryngoscope 119(6): 1206-13
    › Primary publication · 19358244 (PubMed) · PMC3003594 (PubMed Central)
  16. Prostaglandin E2 differentially regulates contraction and structural reorganization of anchored collagen gels by human adult and fetal dermal fibroblasts. Parekh A, Sandulache VC, Singh T, Cetin S, Sacks MS, Dohar JE, Hebda PA (2009) Wound Repair Regen 17(1): 88-98
    › Primary publication · 19152655 (PubMed) · PMC3000117 (PubMed Central)
  17. Extracellular matrix rigidity promotes invadopodia activity. Alexander NR, Branch KM, Parekh A, Clark ES, Iwueke IC, Guelcher SA, Weaver AM (2008) Curr Biol 18(17): 1295-1299
    › Primary publication · 18718759 (PubMed) · PMC2555969 (PubMed Central)
  18. Fetal dermal fibroblasts retain a hyperactive migratory and contractile phenotype under 2-and 3-dimensional constraints compared to normal adult fibroblasts. Sandulache VC, Parekh A, Dohar JE, Hebda PA (2007) Tissue Eng 13(11): 2791-801
    › Primary publication · 17764403 (PubMed)
  19. Differences in tissue-remodeling potential of aortic and pulmonary heart valve interstitial cells. Merryman WD, Liao J, Parekh A, Candiello JE, Lin H, Sacks MS (2007) Tissue Eng 13(9): 2281-9
    › Primary publication · 17596117 (PubMed)
  20. Differential regulation of free-floating collagen gel contraction by human fetal and adult dermal fibroblasts in response to prostaglandin E2 mediated by an EP2/cAMP-dependent mechanism. Parekh A, Sandulache VC, Lieb AS, Dohar JE, Hebda PA (2007) Wound Repair Regen 15(3): 390-8
    › Primary publication · 17537126 (PubMed)
  21. Collagen gel anisotropy measured by 2-D laser trap microrheometry. Parekh A, Velegol D (2007) Ann Biomed Eng 35(7): 1231-46
    › Primary publication · 17380393 (PubMed)
  22. Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)-beta1-induced collagen synthesis. Sandulache VC, Parekh A, Li-Korotky H, Dohar JE, Hebda PA (2007) Wound Repair Regen 15(1): 122-33
    › Primary publication · 17244328 (PubMed)
  23. Prostaglandin E2 differentially modulates human fetal and adult dermal fibroblast migration and contraction: implication for wound healing. Sandulache VC, Parekh A, Li-Korotky HS, Dohar JE, Hebda PA (2006) Wound Repair Regen 14(5): 633-43
    › Primary publication · 17014677 (PubMed)