My laboratory is focused on gastrointestinal mucosal inflammation and carcinogenesis. We study the host immune response to the gastric pathogen Helicobacter pylori that causes peptic ulcer disease and gastric cancer. This includes the innate immune response in macrophages and the identification of ways that this response is ineffective. We have also elucidated mechanisms whereby epithelial responses are inappropriate, leading to risk for cancer development. We study novel mechanisms for inflammation and cellular/DNA damage, which leads to increased cancer risk.

We have reported that H. pylori induces the enzyme spermine oxidase (SMOX), originally known as polyamine oxidase 1, which utilizes the polyamine spermine as substrate. Generation of H2O2 by SMOX results in mitochondrial membrane depolarization, cytochrome c release, and apoptosis. Spermine itself contributes to the inadequacy of the host response, by blocking translation of inducible nitric oxide (NO) synthase (iNOS; NOS2) and hence NO production that is needed for the killing of H. pylori. Upregulation of SMOX causes oxidative stress in gastric epithelial cells that leads to both apoptosis and DNA damage. Induction of ornithine decarboxylase (ODC) that generates polyamines also leads to apoptosis of macrophages, contributing to loss of host innate immunity to H. pylori. We have shown that induction of the transcription factor c-Myc by H. pylori enhances ODC transcription and has a causal role in macrophage apoptosis. We have also implicated formation of a specific AP-1 complex in the activation of c-Myc.

We are utilizing clinical material from a large cohort of human subjects from Colombia, South America where H. pylori infection prevalence is very high, but gastric cancer risk is 25-fold higher in the Andean mountains when compared to the coastal region. We have found that SMOX-dependent oxidative stress is increased in gastric epithelial cells in vivo in the subjects at high risk for gastric cancer and that H. pylori clinical strains from these subjects induce more SMOX and oxidative DNA damage both in vitro and in vivo in a gerbil model. Studies are ongoing to pursue the mechanisms involved in the differential induction of SMOX and DNA damage.

We are also pursuing studies on immune dysregulation in inflammatory bowel disease. This includes work on arginine availability/transport, polyamines, and nitric oxide. We have reported that levels of the amino acid L-arginine are increased in the serum of humans with ulcerative colitis. Because L-arginine is important in regulation of epithelial integrity and immune function a defect in the utilization of L-arginine could contribute to the disease pathogenesis. Consistent with this, we have shown that treatment with L-arginine improves colitis in mouse models and that mice lacking an inducible L-arginine transporter have increased disease activity.

Our funded studies are focused on:

1) The role oxidative and nitrosative stress in the development of gastric cancer in Colombia, and the importance of H. pylori strains from regions of low and high gastric cancer risk in modulation of host responses (PI, P01 grant and P01 project).

2) Importance of polyamine metabolism in the immune response and disease progression associated with H. pylori infection (PI, VA Merit Review Grant).

3) Role of EGFR signaling, ornithine decarboxylase/polyamines, and hypusination in myeloid and epithelial dysfunction in H. pylori infection (PI, project on second P01).                                        

4) Novel strategy for prevention of gastric cancer using an electrophile scavenger (Department of Defense grant).

5) Clinical trial of difluoromethylornithine in patients in Latin America with precancerous gastric lesions (R01 grant).

6) Role of the reverse transsulfuration pathway in H. pylori Immunopathogenesis (R21 grant).

7) Crohn's disease Gut Cell Atlas- A combinatorial strategy involving single cell RNAseq, RNA-FISH, multiplex immunofluorescence, digital image analysis/machine learning, and bioinformatics (funded by Helmsley Charitable Trust).

8) Studies on the role of the polyamine spermidine in colitis (funded by Crohn's & Colitis Foundation Senior Research Award).

9) Further studies on spermine oxidase and spermidine in colitis-associated colon cancer (NIH R01 grant).

10) Studies on the role of an electrophile scavenger, 2-HOBA in rodent models of gastric cancer and of colitis-associated cancer (R41 STTR grant).

11) Translational studies about electrophiles and their adducts in colitis-associated colon cancer in patients (new DoD grant).


Multiple other grants pending related to colitis, colorectal cancer, and H. pylori-associated gastric cancer.



The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Random Multi-Channel Image Synthesis for Multiplexed Immunofluorescence Imaging. Bao S, Tang Y, Lee HH, Gao R, Chiron S, Lyu I, Coburn LA, Wilson KT, Roland JT, Landman BA, Huo Y (2021) Proc Mach Learn Res : 36-46
    › Primary publication · 34993490 (PubMed) · PMC8730359 (PubMed Central)
  2. Protective Role of Spermidine in Colitis and Colon Carcinogenesis. Gobert AP, Latour YL, Asim M, Barry DP, Allaman MM, Finley JL, Smith TM, McNamara KM, Singh K, Sierra JC, Delgado AG, Luis PB, Schneider C, Washington MK, Piazuelo MB, Zhao S, Coburn LA, Wilson KT (2022) Gastroenterology 162(3): 813-827.e8
    › Primary publication · 34767785 (PubMed) · PMC8881368 (PubMed Central)
  3. CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis. Polosukhina D, Singh K, Asim M, Barry DP, Allaman MM, Hardbower DM, Piazuelo MB, Washington MK, Gobert AP, Wilson KT, Coburn LA (2021) Oncogene 40(47): 6540-6546
    › Primary publication · 34625710 (PubMed) · PMC8629429 (PubMed Central)
  4. A cross-platform informatics system for the Gut Cell Atlas: integrating clinical, anatomical and histological data. Bao S, Chiron S, Tang Y, Heiser CN, Southard-Smith AN, Lee HH, Ramirez MA, Huo Y, Washington MK, Scoville EA, Roland JT, Liu Q, Lau KS, Wilson KT, Coburn LA, Landman BA (2021) Proc SPIE Int Soc Opt Eng
    › Primary publication · 34539029 (PubMed) · PMC8445503 (PubMed Central)
  5. Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus. Miller AK, Tavera G, Dominguez RL, Camargo MC, Waterboer T, Wilson KT, Williams SM, Morgan DR (2021) Oncogene 40(40): 5963-5969
    › Primary publication · 34376808 (PubMed) · PMC8692072 (PubMed Central)
  6. Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4 T cells. Hoek KL, Greer MJ, McClanahan KG, Nazmi A, Piazuelo MB, Singh K, Wilson KT, Olivares-Villagómez D (2021) Mucosal Immunol 14(5): 1088-1099
    › Primary publication · 34183776 (PubMed) · PMC8380717 (PubMed Central)
  7. The role of polyamines in gastric cancer. McNamara KM, Gobert AP, Wilson KT (2021) Oncogene 40(26): 4399-4412
    › Primary publication · 34108618 (PubMed) · PMC8262120 (PubMed Central)
  8. HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice. Tyagi RK, Jacobse J, Li J, Allaman MM, Otipoby KL, Sampson ER, Wilson KT, Goettel JA (2021) Front Immunol : 630204
    › Primary publication · 33717161 (PubMed) · PMC7945590 (PubMed Central)
  9. Helicobacter pylori Antimicrobial Resistance and Gene Variants in High- and Low-Gastric-Cancer-Risk Populations. Mannion A, Dzink-Fox J, Shen Z, Piazuelo MB, Wilson KT, Correa P, Peek RM, Camargo MC, Fox JG (2021) J Clin Microbiol 59(5)
    › Primary publication · 33692136 (PubMed) · PMC8091839 (PubMed Central)
  10. Colonic Epithelial-Derived Selenoprotein P Is the Source for Antioxidant-Mediated Protection in Colitis-Associated Cancer. Short SP, Pilat JM, Barrett CW, Reddy VK, Haberman Y, Hendren JR, Marsh BJ, Keating CE, Motley AK, Hill KE, Zemper AE, Washington MK, Shi C, Chen X, Wilson KT, Hyams JS, Denson LA, Burk RF, Rosen MJ, Williams CS (2021) Gastroenterology 160(5): 1694-1708.e3
    › Primary publication · 33388316 (PubMed) · PMC8035252 (PubMed Central)
  11. Hypusination Orchestrates the Antimicrobial Response of Macrophages. Gobert AP, Finley JL, Latour YL, Asim M, Smith TM, Verriere TG, Barry DP, Allaman MM, Delagado AG, Rose KL, Calcutt MW, Schey KL, Sierra JC, Piazuelo MB, Mirmira RG, Wilson KT (2020) Cell Rep 33(11): 108510
    › Primary publication · 33326776 (PubMed) · PMC7812972 (PubMed Central)
  12. The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions. Piazuelo MB, Bravo LE, Mera RM, Camargo MC, Bravo JC, Delgado AG, Washington MK, Rosero A, Garcia LS, Realpe JL, Cifuentes SP, Morgan DR, Peek RM, Correa P, Wilson KT (2021) Gastroenterology 160(4): 1106-1117.e3
    › Primary publication · 33220252 (PubMed) · PMC7956231 (PubMed Central)
  13. Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis. Gobert AP, Boutaud O, Asim M, Zagol-Ikapitte IA, Delgado AG, Latour YL, Finley JL, Singh K, Verriere TG, Allaman MM, Barry DP, McNamara KM, Sierra JC, Amarnath V, Tantawy MN, Bimczok D, Piazuelo MB, Washington MK, Zhao S, Coburn LA, Wilson KT (2021) Gastroenterology 160(4): 1256-1268.e9
    › Primary publication · 33189701 (PubMed) · PMC7956217 (PubMed Central)
  14. Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation. Banerjee A, Herring CA, Chen B, Kim H, Simmons AJ, Southard-Smith AN, Allaman MM, White JR, Macedonia MC, Mckinley ET, Ramirez-Solano MA, Scoville EA, Liu Q, Wilson KT, Coffey RJ, Washington MK, Goettel JA, Lau KS (2020) Gastroenterology 159(6): 2101-2115.e5
    › Primary publication · 32828819 (PubMed) · PMC7725941 (PubMed Central)
  15. Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity. Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J (2020) JCI Insight 5(15)
    › Primary publication · 32759497 (PubMed) · PMC7455083 (PubMed Central)
  16. An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease. Brubaker DK, Kumar MP, Chiswick EL, Gregg C, Starchenko A, Vega PN, Southard-Smith AN, Simmons AJ, Scoville EA, Coburn LA, Wilson KT, Lau KS, Lauffenburger DA (2020) Sci Signal 13(643)
    › Primary publication · 32753478 (PubMed) · PMC7459361 (PubMed Central)
  17. A Summary of the 2020 Gastric Cancer Summit at Stanford University. Huang RJ, Koh H, Hwang JH, Summit Leaders (2020) Gastroenterology 159(4): 1221-1226
    › Primary publication · 32707045 (PubMed) · PMC7577947 (PubMed Central)
  18. Contrasting serum biomarker profiles in two Colombian populations with different risks for progression of premalignant gastric lesions during chronic Helicobacter pylori infection. Whary MT, Avenia JMR, Bravo LE, Lofgren JL, Lertpiriyapong K, Mera-Giler R, Piazuelo MB, Correa P, Peek RM, Wilson KT, Fox JG (2020) Cancer Epidemiol : 101726
    › Primary publication · 32447242 (PubMed) · PMC7755565 (PubMed Central)
  19. Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling. Sierra JC, Piazuelo MB, Luis PB, Barry DP, Allaman MM, Asim M, Sebrell TA, Finley JL, Rose KL, Hill S, Holshouser SL, Casero RA, Cleveland JL, Woster PM, Schey KL, Bimczok D, Schneider C, Gobert AP, Wilson KT (2020) Oncogene 39(22): 4465-4474
    › Primary publication · 32350444 (PubMed) · PMC7260102 (PubMed Central)
  20. Functional Properties of Helicobacter pylori VacA Toxin m1 and m2 Variants. Caston RR, Sierra JC, Foegeding NJ, Truelock MD, Campbell AM, Frick-Cheng AE, Bimczok D, Wilson KT, McClain MS, Cover TL (2020) Infect Immun 88(6)
    › Primary publication · 32284370 (PubMed) · PMC7240096 (PubMed Central)
  21. Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells. Palrasu M, Zaika E, El-Rifai W, Garcia-Buitrago M, Piazuelo MB, Wilson KT, Peek RM, Zaika AI (2020) J Clin Invest 130(5): 2422-2434
    › Primary publication · 32250340 (PubMed) · PMC7190987 (PubMed Central)
  22. Bacterial Pathogens Hijack the Innate Immune Response by Activation of the Reverse Transsulfuration Pathway. Gobert AP, Latour YL, Asim M, Finley JL, Verriere TG, Barry DP, Milne GL, Luis PB, Schneider C, Rivera ES, Lindsey-Rose K, Schey KL, Delgado AG, Sierra JC, Piazuelo MB, Wilson KT (2019) mBio 10(5)
    › Primary publication · 31662455 (PubMed) · PMC6819659 (PubMed Central)
  23. Targeting Gut Microbiome Interactions in Service-Related Gastrointestinal and Liver Diseases of Veterans. Bajaj JS, Sharma A, Dudeja PK, Collaborators (2019) Gastroenterology 157(5): 1180-1183.e1
    › Primary publication · 31404532 (PubMed) · PMC7249241 (PubMed Central)
  24. Preventing Gastric Cancer Development by Inhibiting the Virulence of H. pylori Infection. Wilson KT (2019) Oncology (Williston Park) 33(6): 227-31
    › Primary publication · 31219607 (PubMed) · PMC6685684 (PubMed Central)
  25. Geospatial analyses identify regional hot spots of diffuse gastric cancer in rural Central America. Dominguez RL, Cherry CB, Estevez-Ordonez D, Mera R, Escamilla V, Pawlita M, Waterboer T, Wilson KT, Peek RM, Tavera G, Williams SM, Gulley ML, Emch M, Morgan DR (2019) BMC Cancer 19(1): 545
    › Primary publication · 31174492 (PubMed) · PMC6554991 (PubMed Central)
  26. Resolution of Gastric Cancer-Promoting Inflammation: A Novel Strategy for Anti-cancer Therapy. Piazuelo MB, Riechelmann RP, Wilson KT, Algood HMS (2019) Curr Top Microbiol Immunol : 319-359
    › Primary publication · 31123895 (PubMed) · PMC6602908 (PubMed Central)
  27. Helicobacter pylori antimicrobial resistance and antibiotic consumption in the low-resource Central America setting. Ortiz V, Estevez-Ordonez D, Montalvan-Sanchez E, Urrutia-Argueta S, Israel D, Krishna US, Romero-Gallo J, Wilson KT, Peek RM, Dominguez R, Morgan DR (2019) Helicobacter 24(4): e12595
    › Primary publication · 31111610 (PubMed) · PMC6619433 (PubMed Central)
  28. Correction: Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma. Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS (2019) Oncogene 38(25): 5107
    › Primary publication · 31068667 (PubMed)
  29. The role of polyamines in the regulation of macrophage polarization and function. Latour YL, Gobert AP, Wilson KT (2020) Amino Acids 52(2): 151-160
    › Primary publication · 31016375 (PubMed) · PMC6812587 (PubMed Central)
  30. Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome. Singh K, Gobert AP, Coburn LA, Barry DP, Allaman M, Asim M, Luis PB, Schneider C, Milne GL, Boone HH, Shilts MH, Washington MK, Das SR, Piazuelo MB, Wilson KT (2019) Front Cell Infect Microbiol : 66
    › Primary publication · 30972302 (PubMed) · PMC6443829 (PubMed Central)
  31. Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma. Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS (2019) Oncogene 38(25): 5091-5106
    › Primary publication · 30858547 (PubMed) · PMC6586520 (PubMed Central)
  32. Serum Polyunsaturated Fatty Acids Correlate with Serum Cytokines and Clinical Disease Activity in Crohn's Disease. Scoville EA, Allaman MM, Adams DW, Motley AK, Peyton SC, Ferguson SL, Horst SN, Williams CS, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA (2019) Sci Rep 9(1): 2882
    › Primary publication · 30814550 (PubMed) · PMC6393448 (PubMed Central)
  33. α-Difluoromethylornithine reduces gastric carcinogenesis by causing mutations in . Sierra JC, Suarez G, Piazuelo MB, Luis PB, Baker DR, Romero-Gallo J, Barry DP, Schneider C, Morgan DR, Peek RM, Gobert AP, Wilson KT (2019) Proc Natl Acad Sci U S A 116(11): 5077-5085
    › Primary publication · 30804204 (PubMed) · PMC6421409 (PubMed Central)
  34. Nod1 Imprints Inflammatory and Carcinogenic Responses toward the Gastric Pathogen . Suarez G, Romero-Gallo J, Piazuelo MB, Sierra JC, Delgado AG, Washington MK, Shah SC, Wilson KT, Peek RM (2019) Cancer Res 79(7): 1600-1611
    › Primary publication · 30696658 (PubMed) · PMC6445772 (PubMed Central)
  35. Carcinogenic Strains Selectively Dysregulate the Gastric Proteome, Which May Be Associated with Stomach Cancer Progression. Noto JM, Rose KL, Hachey AJ, Delgado AG, Romero-Gallo J, Wroblewski LE, Schneider BG, Shah SC, Cover TL, Wilson KT, Israel DA, Roa JC, Schey KL, Zavros Y, Piazuelo MB, Peek RM (2019) Mol Cell Proteomics 18(2): 352-371
    › Primary publication · 30455363 (PubMed) · PMC6356085 (PubMed Central)
  36. Helicobacter: Inflammation, immunology, and vaccines. Blosse A, Lehours P, Wilson KT, Gobert AP (2018) Helicobacter : e12517
    › Primary publication · 30277626 (PubMed) · PMC6310010 (PubMed Central)
  37. Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis. Coburn LA, Singh K, Asim M, Barry DP, Allaman MM, Al-Greene NT, Hardbower DM, Polosukhina D, Williams CS, Delgado AG, Piazuelo MB, Washington MK, Gobert AP, Wilson KT (2019) Oncogene 38(7): 1067-1079
    › Primary publication · 30202097 (PubMed) · PMC6377304 (PubMed Central)
  38. Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. Means AL, Freeman TJ, Zhu J, Woodbury LG, Marincola-Smith P, Wu C, Meyer AR, Weaver CJ, Padmanabhan C, An H, Zi J, Wessinger BC, Chaturvedi R, Brown TD, Deane NG, Coffey RJ, Wilson KT, Smith JJ, Sawyers CL, Goldenring JR, Novitskiy SV, Washington MK, Shi C, Beauchamp RD (2018) Cell Mol Gastroenterol Hepatol 6(3): 257-276
    › Primary publication · 30109253 (PubMed) · PMC6083016 (PubMed Central)
  39. Distinct Immunomodulatory Effects of Spermine Oxidase in Colitis Induced by Epithelial Injury or Infection. Gobert AP, Al-Greene NT, Singh K, Coburn LA, Sierra JC, Verriere TG, Luis PB, Schneider C, Asim M, Allaman MM, Barry DP, Cleveland JL, Destefano Shields CE, Casero RA, Washington MK, Piazuelo MB, Wilson KT (2018) Front Immunol : 1242
    › Primary publication · 29922289 (PubMed) · PMC5996034 (PubMed Central)
  40. BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability. Choksi YA, Reddy VK, Singh K, Barrett CW, Short SP, Parang B, Keating CE, Thompson JJ, Verriere TG, Brown RE, Piazuelo MB, Bader DM, Washington MK, Mittal MK, Brand T, Gobert AP, Coburn LA, Wilson KT, Williams CS (2018) Mucosal Immunol 11(5): 1363-1374
    › Primary publication · 29907869 (PubMed) · PMC6162166 (PubMed Central)
  41. Supplementation of p40, a Lactobacillus rhamnosus GG-derived protein, in early life promotes epidermal growth factor receptor-dependent intestinal development and long-term health outcomes. Shen X, Liu L, Peek RM, Acra SA, Moore DJ, Wilson KT, He F, Polk DB, Yan F (2018) Mucosal Immunol 11(5): 1316-1328
    › Primary publication · 29875401 (PubMed) · PMC6162144 (PubMed Central)
  42. Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Singh K, Coburn LA, Asim M, Barry DP, Allaman MM, Shi C, Washington MK, Luis PB, Schneider C, Delgado AG, Piazuelo MB, Cleveland JL, Gobert AP, Wilson KT (2018) Cancer Res 78(15): 4303-4315
    › Primary publication · 29853605 (PubMed) · PMC6072585 (PubMed Central)
  43. Alterations in Lipid, Amino Acid, and Energy Metabolism Distinguish Crohn's Disease from Ulcerative Colitis and Control Subjects by Serum Metabolomic Profiling. Scoville EA, Allaman MM, Brown CT, Motley AK, Horst SN, Williams CS, Koyama T, Zhao Z, Adams DW, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA (2018) Metabolomics 14(1): 17
    › Primary publication · 29681789 (PubMed) · PMC5907923 (PubMed Central)
  44. Pan-genomic analyses identify key pathogenic loci modified by carcinogenic host microenvironments. Noto JM, Chopra A, Loh JT, Romero-Gallo J, Piazuelo MB, Watson M, Leary S, Beckett AC, Wilson KT, Cover TL, Mallal S, Israel DA, Peek RM (2018) Gut 67(10): 1793-1804
    › Primary publication · 28924022 (PubMed) · PMC5857411 (PubMed Central)
  45. MTG16 is a tumor suppressor in colitis-associated carcinoma. McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS (2017) JCI Insight 2(16)
    › Primary publication · 28814670 (PubMed) · PMC5621889 (PubMed Central)
  46. Dynamics of infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Mera RM, Bravo LE, Camargo MC, Bravo JC, Delgado AG, Romero-Gallo J, Yepez MC, Realpe JL, Schneider BG, Morgan DR, Peek RM, Correa P, Wilson KT, Piazuelo MB (2018) Gut 67(7): 1239-1246
    › Primary publication · 28647684 (PubMed) · PMC5742304 (PubMed Central)
  47. Effect of CO on Peroxynitrite-Mediated Bacteria Killing: Response to Tsikas et al. Gobert AP, Wilson KT (2017) Trends Microbiol 25(8): 602-603
    › Primary publication · 28610877 (PubMed) · PMC5628050 (PubMed Central)
  48. Epidermal growth factor receptor inhibition downregulates -induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Sierra JC, Asim M, Verriere TG, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado AG, Wroblewski LE, Barry DP, Peek RM, Gobert AP, Wilson KT (2018) Gut 67(7): 1247-1260
    › Primary publication · 28473630 (PubMed) · PMC5671361 (PubMed Central)
  49. Increased expression of deleted in malignant brain tumors (DMBT1) gene in precancerous gastric lesions: Findings from human and animal studies. Garay J, Piazuelo MB, Lopez-Carrillo L, Leal YA, Majumdar S, Li L, Cruz-Rodriguez N, Serrano-Gomez SJ, Busso CS, Schneider BG, Delgado AG, Bravo LE, Crist AM, Meadows SM, Camargo MC, Wilson KT, Correa P, Zabaleta J (2017) Oncotarget 8(29): 47076-47089
    › Primary publication · 28423364 (PubMed) · PMC5564545 (PubMed Central)
  50. Draft Genome Sequences of 13 Colombian Strains Isolated from Pacific Coast and Andean Residents. Pazos A, Kodaman N, Piazuelo MB, Romero-Gallo J, Sobota RS, Israel DA, Bravo LE, Morgan DR, Wilson KT, Correa P, Peek RM, Williams SM, Schneider BG (2017) Genome Announc 5(15)
    › Primary publication · 28408665 (PubMed) · PMC5391403 (PubMed Central)
  51. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS (2017) Gut 66(5): 852-862
    › Primary publication · 28389570 (PubMed) · PMC5385850 (PubMed Central)
  52. EGFR-mediated macrophage activation promotes colitis-associated tumorigenesis. Hardbower DM, Coburn LA, Asim M, Singh K, Sierra JC, Barry DP, Gobert AP, Piazuelo MB, Washington MK, Wilson KT (2017) Oncogene 36(27): 3807-3819
    › Primary publication · 28263971 (PubMed) · PMC5501754 (PubMed Central)
  53. Genetic Manipulation of Virulence Function by Host Carcinogenic Phenotypes. Suarez G, Romero-Gallo J, Sierra JC, Piazuelo MB, Krishna US, Gomez MA, Wilson KT, Peek RM (2017) Cancer Res 77(9): 2401-2412
    › Primary publication · 28209611 (PubMed) · PMC5413443 (PubMed Central)
  54. Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients. Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA (2017) Gastroenterology 152(6): 1345-1357.e7
    › Primary publication · 28132889 (PubMed) · PMC5406257 (PubMed Central)
  55. Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases. Gobert AP, Wilson KT (2017) Curr Top Microbiol Immunol : 27-52
    › Primary publication · 28124148 (PubMed) · PMC5316293 (PubMed Central)
  56. Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Hardbower DM, Asim M, Luis PB, Singh K, Barry DP, Yang C, Steeves MA, Cleveland JL, Schneider C, Piazuelo MB, Gobert AP, Wilson KT (2017) Proc Natl Acad Sci U S A 114(5): E751-E760
    › Primary publication · 28096401 (PubMed) · PMC5293075 (PubMed Central)
  57. The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. Singh K, Al-Greene NT, Verriere TG, Coburn LA, Asim M, Barry DP, Allaman MM, Hardbower DM, Delgado AG, Piazuelo MB, Vallance BA, Gobert AP, Wilson KT (2016) PLoS Pathog 12(10): e1005984
    › Primary publication · 27783672 (PubMed) · PMC5081186 (PubMed Central)
  58. TLR9 activation suppresses inflammation in response to Helicobacter pylori infection. Varga MG, Piazuelo MB, Romero-Gallo J, Delgado AG, Suarez G, Whitaker ME, Krishna US, Patel RV, Skaar EP, Wilson KT, Algood HM, Peek RM (2016) Am J Physiol Gastrointest Liver Physiol 311(5): G852-G858
    › Primary publication · 27758771 (PubMed) · PMC5130555 (PubMed Central)
  59. Polyamine- and NADPH-dependent generation of ROS during Helicobacter pylori infection: A blessing in disguise. Gobert AP, Wilson KT (2017) Free Radic Biol Med : 16-27
    › Primary publication · 27682363 (PubMed) · PMC5366100 (PubMed Central)
  60. EGFR regulates macrophage activation and function in bacterial infection. Hardbower DM, Singh K, Asim M, Verriere TG, Olivares-Villagómez D, Barry DP, Allaman MM, Washington MK, Peek RM, Piazuelo MB, Wilson KT (2016) J Clin Invest 126(9): 3296-312
    › Primary publication · 27482886 (PubMed) · PMC5004944 (PubMed Central)
  61. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S (2017) Mucosal Immunol 10(2): 493-507
    › Primary publication · 27435104 (PubMed) · PMC5250617 (PubMed Central)
  62. Erratum to: Epigenetic and genetic variation in GATA5 is associated with gastric disease risk. Sobota RS, Kodaman N, Mera R, Piazuelo MB, Bravo LE, Pazos A, Zabaleta J, Delgado AG, El-Rifai W, Morgan DR, Wilson KT, Correa P, Williams SM, Schneider BG (2016) Hum Genet 135(8): 907-908
    › Primary publication · 27417435 (PubMed) · PMC8967415 (PubMed Central)
  63. Myeloid translocation genes differentially regulate colorectal cancer programs. Parang B, Bradley AM, Mittal MK, Short SP, Thompson JJ, Barrett CW, Naik RD, Bilotta AJ, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Hiebert SW, Williams CS (2016) Oncogene 35(49): 6341-6349
    › Primary publication · 27270437 (PubMed) · PMC5140770 (PubMed Central)
  64. Serum Fatty Acids Are Correlated with Inflammatory Cytokines in Ulcerative Colitis. Wiese DM, Horst SN, Brown CT, Allaman MM, Hodges ME, Slaughter JC, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT, Coburn LA (2016) PLoS One 11(5): e0156387
    › Primary publication · 27227540 (PubMed) · PMC4882051 (PubMed Central)
  65. Epigenetic and genetic variation in GATA5 is associated with gastric disease risk. Sobota RS, Kodaman N, Mera R, Piazuelo MB, Bravo LE, Pazos A, Zabaleta J, Delgado AG, El-Rifai W, Morgan DR, Wilson KT, Correa P, Williams SM, Schneider BG (2016) Hum Genet 135(8): 895-906
    › Primary publication · 27225266 (PubMed) · PMC4947561 (PubMed Central)
  66. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM (2016) Oncogene 35(48): 6262-6269
    › Primary publication · 27157617 (PubMed) · PMC5102820 (PubMed Central)
  67. L-Arginine Availability and Metabolism Is Altered in Ulcerative Colitis. Coburn LA, Horst SN, Allaman MM, Brown CT, Williams CS, Hodges ME, Druce JP, Beaulieu DB, Schwartz DA, Wilson KT (2016) Inflamm Bowel Dis 22(8): 1847-58
    › Primary publication · 27104830 (PubMed) · PMC4956554 (PubMed Central)
  68. Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection. Hardbower DM, Asim M, Murray-Stewart T, Casero RA, Verriere T, Lewis ND, Chaturvedi R, Piazuelo MB, Wilson KT (2016) Amino Acids 48(10): 2375-88
    › Primary publication · 27074721 (PubMed) · PMC5042810 (PubMed Central)
  69. Epigenetic silencing of miR-124 prevents spermine oxidase regulation: implications for Helicobacter pylori-induced gastric cancer. Murray-Stewart T, Sierra JC, Piazuelo MB, Mera RM, Chaturvedi R, Bravo LE, Correa P, Schneider BG, Wilson KT, Casero RA (2016) Oncogene 35(42): 5480-5488
    › Primary publication · 27041578 (PubMed) · PMC5050049 (PubMed Central)
  70. The Immune Battle against Helicobacter pylori Infection: NO Offense. Gobert AP, Wilson KT (2016) Trends Microbiol 24(5): 366-376
    › Primary publication · 26916789 (PubMed) · PMC4841705 (PubMed Central)
  71. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S (2016) Sci Rep : 18594
    › Primary publication · 26729566 (PubMed) · PMC4700446 (PubMed Central)
  72. The homing receptor CD44 is involved in the progression of precancerous gastric lesions in patients infected with Helicobacter pylori and in development of mucous metaplasia in mice. Garay J, Piazuelo MB, Majumdar S, Li L, Trillo-Tinoco J, Del Valle L, Schneider BG, Delgado AG, Wilson KT, Correa P, Zabaleta J (2016) Cancer Lett 371(1): 90-8
    › Primary publication · 26639196 (PubMed) · PMC4714604 (PubMed Central)
  73. Dual role of arginine metabolism in establishing pathogenesis. Gogoi M, Datey A, Wilson KT, Chakravortty D (2016) Curr Opin Microbiol : 43-8
    › Primary publication · 26610300 (PubMed) · PMC4755812 (PubMed Central)
  74. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function. Waddell A, Vallance JE, Moore PD, Hummel AT, Wu D, Shanmukhappa SK, Fei L, Washington MK, Minar P, Coburn LA, Nakae S, Wilson KT, Denson LA, Hogan SP, Rosen MJ (2015) Inflamm Bowel Dis 21(12): 2737-46
    › Primary publication · 26313694 (PubMed) · PMC4654638 (PubMed Central)
  75. DNA Methylation Predicts Progression of Human Gastric Lesions. Schneider BG, Mera R, Piazuelo MB, Bravo JC, Zabaleta J, Delgado AG, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P (2015) Cancer Epidemiol Biomarkers Prev 24(10): 1607-13
    › Primary publication · 26269563 (PubMed) · PMC4592454 (PubMed Central)
  76. Hepatic TLR4 signaling in obese NAFLD. Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR (2015) Am J Physiol Gastrointest Liver Physiol 309(4): G270-8
    › Primary publication · 26113297 (PubMed) · PMC4537925 (PubMed Central)
  77. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R (2015) Genome Announc 3(3)
    › Primary publication · 26067974 (PubMed) · PMC4463538 (PubMed Central)
  78. Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS (2015) J Clin Invest 125(7): 2646-60
    › Primary publication · 26053663 (PubMed) · PMC4563672 (PubMed Central)
  79. Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury. Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS (2015) Am J Physiol Gastrointest Liver Physiol 308(6): G562-71
    › Primary publication · 25573176 (PubMed) · PMC4360050 (PubMed Central)
  80. CD8αα⁺ innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Van Kaer L, Algood HMS, Singh K, Parekh VV, Greer MJ, Piazuelo MB, Weitkamp JH, Matta P, Chaturvedi R, Wilson KT, Olivares-Villagómez D (2014) Immunity 41(3): 451-464
    › Primary publication · 25220211 (PubMed) · PMC4169715 (PubMed Central)
  81. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT (2015) Oncogene 34(26): 3429-40
    › Primary publication · 25174398 (PubMed) · PMC4345146 (PubMed Central)
  82. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM (2015) Gut 64(5): 720-30
    › Primary publication · 25123931 (PubMed) · PMC4329117 (PubMed Central)
  83. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM, Chaturvedi R, Wilson KT (2014) J Immunol 193(6): 3013-22
    › Primary publication · 25108023 (PubMed) · PMC4171064 (PubMed Central)
  84. Systems modeling of the role of interleukin-21 in the maintenance of effector CD4+ T cell responses during chronic Helicobacter pylori infection. Carbo A, Olivares-Villagómez D, Hontecillas R, Bassaganya-Riera J, Chaturvedi R, Piazuelo MB, Delgado A, Washington MK, Wilson KT, Algood HM (2014) mBio 5(4): e01243-14
    › Primary publication · 25053783 (PubMed) · PMC4120195 (PubMed Central)
  85. At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. Hardbower DM, Peek RM, Wilson KT (2014) J Leukoc Biol 96(2): 201-12
    › Primary publication · 24868089 (PubMed) · PMC4101087 (PubMed Central)
  86. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Krakowiak MS, Noto JM, Piazuelo MB, Hardbower DM, Romero-Gallo J, Delgado A, Chaturvedi R, Correa P, Wilson KT, Peek RM (2015) Oncogene 34(14): 1865-71
    › Primary publication · 24837365 (PubMed) · PMC4237684 (PubMed Central)
  87. Peroxisome proliferator-activated receptor δ promotes colonic inflammation and tumor growth. Wang D, Fu L, Ning W, Guo L, Sun X, Dey SK, Chaturvedi R, Wilson KT, DuBois RN (2014) Proc Natl Acad Sci U S A 111(19): 7084-9
    › Primary publication · 24763687 (PubMed) · PMC4024916 (PubMed Central)
  88. Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis. Ahmad R, Chaturvedi R, Olivares-Villagómez D, Habib T, Asim M, Shivesh P, Polk DB, Wilson KT, Washington MK, Van Kaer L, Dhawan P, Singh AB (2014) Mucosal Immunol 7(6): 1340-53
    › Primary publication · 24670427 (PubMed) · PMC4221190 (PubMed Central)
  89. Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. Shi C, Washington MK, Chaturvedi R, Drosos Y, Revetta FL, Weaver CJ, Buzhardt E, Yull FE, Blackwell TS, Sosa-Pineda B, Whitehead RH, Beauchamp RD, Wilson KT, Means AL (2014) Lab Invest 94(4): 409-21
    › Primary publication · 24535260 (PubMed) · PMC3992484 (PubMed Central)
  90. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KT (2014) Gastroenterology 146(7): 1739-51.e14
    › Primary publication · 24530706 (PubMed) · PMC4035375 (PubMed Central)
  91. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Wilson KT, Cover TL, Williams SM, Correa P (2014) Proc Natl Acad Sci U S A 111(4): 1455-60
    › Primary publication · 24474772 (PubMed) · PMC3910595 (PubMed Central)
  92. Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis. Lu N, Wang L, Cao H, Liu L, Van Kaer L, Washington MK, Rosen MJ, Dubé PE, Wilson KT, Ren X, Hao X, Polk DB, Yan F (2014) J Immunol 192(3): 1013-23
    › Primary publication · 24391216 (PubMed) · PMC4006992 (PubMed Central)
  93. High-throughput multi-analyte Luminex profiling implicates eotaxin-1 in ulcerative colitis. Coburn LA, Horst SN, Chaturvedi R, Brown CT, Allaman MM, Scull BP, Singh K, Piazuelo MB, Chitnavis MV, Hodges ME, Rosen MJ, Williams CS, Slaughter JC, Beaulieu DB, Schwartz DA, Wilson KT (2013) PLoS One 8(12): e82300
    › Primary publication · 24367513 (PubMed) · PMC3867379 (PubMed Central)
  94. Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1. Noto JM, Piazuelo MB, Chaturvedi R, Bartel CA, Thatcher EJ, Delgado A, Romero-Gallo J, Wilson KT, Correa P, Patton JG, Peek RM (2013) Am J Physiol Gastrointest Liver Physiol 305(11): G786-96
    › Primary publication · 24136787 (PubMed) · PMC3882435 (PubMed Central)
  95. Virulence of infecting Helicobacter pylori strains and intensity of mononuclear cell infiltration are associated with levels of DNA hypermethylation in gastric mucosae. Schneider BG, Piazuelo MB, Sicinschi LA, Mera R, Peng DF, Roa JC, Romero-Gallo J, Delgado AG, de Sablet T, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P (2013) Epigenetics 8(11): 1153-61
    › Primary publication · 24128875 (PubMed) · PMC3927747 (PubMed Central)
  96. Draft Genome Sequences of Helicobacter pylori Strains Isolated from Regions of Low and High Gastric Cancer Risk in Colombia. Sheh A, Piazuelo MB, Wilson KT, Correa P, Fox JG (2013) Genome Announc 1(5)
    › Primary publication · 24051318 (PubMed) · PMC3778201 (PubMed Central)
  97. Outcomes following infliximab therapy for pediatric patients hospitalized with refractory colitis-predominant IBD. Falaiye TO, Mitchell KR, Lu Z, Saville BR, Horst SN, Moulton DE, Schwartz DA, Wilson KT, Rosen MJ (2014) J Pediatr Gastroenterol Nutr 58(2): 213-9
    › Primary publication · 24048170 (PubMed) · PMC3946904 (PubMed Central)
  98. Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS (2013) PLoS One 8(7): e67845
    › Primary publication · 23861820 (PubMed) · PMC3701622 (PubMed Central)
  99. Spermine oxidase is a regulator of macrophage host response to Helicobacter pylori: enhancement of antimicrobial nitric oxide generation by depletion of spermine. Chaturvedi R, Asim M, Barry DP, Frye JW, Casero RA, Wilson KT (2014) Amino Acids 46(3): 531-42
    › Primary publication · 23820617 (PubMed) · PMC3812355 (PubMed Central)
  100. Chronic inflammation and oxidative stress: the smoking gun for Helicobacter pylori-induced gastric cancer? Hardbower DM, de Sablet T, Chaturvedi R, Wilson KT (2013) Gut Microbes 4(6): 475-81
    › Primary publication · 23811829 (PubMed) · PMC3928159 (PubMed Central)
  101. Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Singh K, Coburn LA, Barry DP, Asim M, Scull BP, Allaman MM, Lewis ND, Washington MK, Rosen MJ, Williams CS, Chaturvedi R, Wilson KT (2013) Am J Physiol Gastrointest Liver Physiol 305(3): G225-40
    › Primary publication · 23703655 (PubMed) · PMC3742860 (PubMed Central)
  102. Induction of COX-2 expression by Helicobacter pylori is mediated by activation of epidermal growth factor receptor in gastric epithelial cells. Sierra JC, Hobbs S, Chaturvedi R, Yan F, Wilson KT, Peek RM, Polk DB (2013) Am J Physiol Gastrointest Liver Physiol 305(2): G196-203
    › Primary publication · 23681474 (PubMed) · PMC3725681 (PubMed Central)
  103. Phylogeographic origin of Helicobacter pylori determines host-adaptive responses upon coculture with gastric epithelial cells. Sheh A, Chaturvedi R, Merrell DS, Correa P, Wilson KT, Fox JG (2013) Infect Immun 81(7): 2468-77
    › Primary publication · 23630959 (PubMed) · PMC3697613 (PubMed Central)
  104. Helicobacter pylori promotes the expression of Krüppel-like factor 5, a mediator of carcinogenesis, in vitro and in vivo. Noto JM, Khizanishvili T, Chaturvedi R, Piazuelo MB, Romero-Gallo J, Delgado AG, Khurana SS, Sierra JC, Krishna US, Suarez G, Powell AE, Goldenring JR, Coffey RJ, Yang VW, Correa P, Mills JC, Wilson KT, Peek RM (2013) PLoS One 8(1): e54344
    › Primary publication · 23372710 (PubMed) · PMC3553174 (PubMed Central)
  105. Activated invariant NKT cells control central nervous system autoimmunity in a mechanism that involves myeloid-derived suppressor cells. Parekh VV, Wu L, Olivares-Villagómez D, Wilson KT, Van Kaer L (2013) J Immunol 190(5): 1948-60
    › Primary publication · 23345328 (PubMed) · PMC3577977 (PubMed Central)
  106. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. Rosen MJ, Chaturvedi R, Washington MK, Kuhnhein LA, Moore PD, Coggeshall SS, McDonough EM, Weitkamp JH, Singh AB, Coburn LA, Williams CS, Yan F, Van Kaer L, Peebles RS, Wilson KT (2013) J Immunol 190(4): 1849-58
    › Primary publication · 23303670 (PubMed) · PMC3563924 (PubMed Central)
  107. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. Noto JM, Gaddy JA, Lee JY, Piazuelo MB, Friedman DB, Colvin DC, Romero-Gallo J, Suarez G, Loh J, Slaughter JC, Tan S, Morgan DR, Wilson KT, Bravo LE, Correa P, Cover TL, Amieva MR, Peek RM (2013) J Clin Invest 123(1): 479-92
    › Primary publication · 23257361 (PubMed) · PMC3533289 (PubMed Central)
  108. Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters. Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS (2012) PLoS One 7(12): e51205
    › Primary publication · 23251453 (PubMed) · PMC3521008 (PubMed Central)
  109. Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS (2013) Cancer Res 73(3): 1245-55
    › Primary publication · 23221387 (PubMed) · PMC3563732 (PubMed Central)
  110. Haem oxygenase-1 inhibits phosphorylation of the Helicobacter pylori oncoprotein CagA in gastric epithelial cells. Gobert AP, Verriere T, de Sablet T, Peek RM, Chaturvedi R, Wilson KT (2013) Cell Microbiol 15(1): 145-56
    › Primary publication · 23051580 (PubMed) · PMC3524338 (PubMed Central)
  111. MTG16 contributes to colonic epithelial integrity in experimental colitis. Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM, Wilson KT, Hiebert SW (2013) Gut 62(10): 1446-55
    › Primary publication · 22833394 (PubMed) · PMC3663894 (PubMed Central)
  112. Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression. Loh JT, Friedman DB, Piazuelo MB, Bravo LE, Wilson KT, Peek RM, Correa P, Cover TL (2012) Infect Immun 80(9): 3094-106
    › Primary publication · 22710874 (PubMed) · PMC3418733 (PubMed Central)
  113. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt MW, Hu T, Ren X, Wilson KT, Polk DB, Yan F (2012) PLoS One 7(5): e36418
    › Primary publication · 22574158 (PubMed) · PMC3344856 (PubMed Central)
  114. Spermine oxidase, a polyamine catabolic enzyme that links Helicobacter pylori CagA and gastric cancer risk. Chaturvedi R, de Sablet T, Peek RM, Wilson KT (2012) Gut Microbes 3(1): 48-56
    › Primary publication · 22555547 (PubMed) · PMC3337125 (PubMed Central)
  115. Editorial: Orchestration of macrophage polarization by polyamines. Gobert AP, Wilson KT (2012) J Leukoc Biol 91(5): 677-9
    › Primary publication · 22547131 (PubMed) · PMC3336771 (PubMed Central)
  116. L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis. Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MM, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA, Chaturvedi R, Zhao Z, Wilson KT (2012) PLoS One 7(3): e33546
    › Primary publication · 22428068 (PubMed) · PMC3299802 (PubMed Central)
  117. Non-invasive genotyping of Helicobacter pylori cagA, vacA, and hopQ from asymptomatic children. Sicinschi LA, Correa P, Bravo LE, Peek RM, Wilson KT, Loh JT, Yepez MC, Gold BD, Thompson DT, Cover TL, Schneider BG (2012) Helicobacter 17(2): 96-106
    › Primary publication · 22404439 (PubMed) · PMC3305281 (PubMed Central)
  118. L-arginine uptake by cationic amino acid transporter 2 is essential for colonic epithelial cell restitution. Singh K, Coburn LA, Barry DP, Boucher JL, Chaturvedi R, Wilson KT (2012) Am J Physiol Gastrointest Liver Physiol 302(9): G1061-73
    › Primary publication · 22361732 (PubMed) · PMC3362080 (PubMed Central)
  119. Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection. Barry DP, Asim M, Scull BP, Piazuelo MB, de Sablet T, Lewis ND, Coburn LA, Singh K, Ellies LG, Gobert AP, Chaturvedi R, Wilson KT (2011) PLoS One 6(12): e29046
    › Primary publication · 22194986 (PubMed) · PMC3237590 (PubMed Central)
  120. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk DB (2012) Am J Physiol Gastrointest Liver Physiol 302(5): G504-14
    › Primary publication · 22173918 (PubMed) · PMC3311435 (PubMed Central)
  121. Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells. Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A, El-Rifai W (2012) Gut 61(9): 1250-60
    › Primary publication · 22157330 (PubMed) · PMC3419307 (PubMed Central)
  122. Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1. Gobert AP, Asim M, Piazuelo MB, Verriere T, Scull BP, de Sablet T, Glumac A, Lewis ND, Correa P, Peek RM, Chaturvedi R, Wilson KT (2011) J Immunol 187(10): 5370-9
    › Primary publication · 21987660 (PubMed) · PMC3208050 (PubMed Central)
  123. Intestinal epithelial cells modulate CD4 T cell responses via the thymus leukemia antigen. Olivares-Villagómez D, Algood HM, Singh K, Parekh VV, Ryan KE, Piazuelo MB, Wilson KT, Van Kaer L (2011) J Immunol 187(8): 4051-60
    › Primary publication · 21900182 (PubMed) · PMC3186831 (PubMed Central)
  124. Arginine and polyamines in Helicobacter pylori-induced immune dysregulation and gastric carcinogenesis. Chaturvedi R, de Sablet T, Coburn LA, Gobert AP, Wilson KT (2012) Amino Acids 42(2-3): 627-40
    › Primary publication · 21874531 (PubMed) · PMC3258477 (PubMed Central)
  125. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT (2011) Gastroenterology 141(5): 1696-708.e1-2
    › Primary publication · 21839041 (PubMed) · PMC3202654 (PubMed Central)
  126. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB (2011) J Clin Invest 121(6): 2242-53
    › Primary publication · 21606592 (PubMed) · PMC3104743 (PubMed Central)
  127. Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. Barry DP, Asim M, Leiman DA, de Sablet T, Singh K, Casero RA, Chaturvedi R, Wilson KT (2011) PLoS One 6(2): e17510
    › Primary publication · 21386987 (PubMed) · PMC3046249 (PubMed Central)
  128. Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Dhawan P, Ahmad R, Chaturvedi R, Smith JJ, Midha R, Mittal MK, Krishnan M, Chen X, Eschrich S, Yeatman TJ, Harris RC, Washington MK, Wilson KT, Beauchamp RD, Singh AB (2011) Oncogene 30(29): 3234-47
    › Primary publication · 21383692 (PubMed) · PMC3591522 (PubMed Central)
  129. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk. de Sablet T, Piazuelo MB, Shaffer CL, Schneider BG, Asim M, Chaturvedi R, Bravo LE, Sicinschi LA, Delgado AG, Mera RM, Israel DA, Romero-Gallo J, Peek RM, Cover TL, Correa P, Wilson KT (2011) Gut 60(9): 1189-95
    › Primary publication · 21357593 (PubMed) · PMC3133872 (PubMed Central)
  130. Methods to evaluate alterations in polyamine metabolism caused by Helicobacter pylori infection. Gobert AP, Chaturvedi R, Wilson KT (2011) Methods Mol Biol : 409-25
    › Primary publication · 21318889 (PubMed) · PMC3069756 (PubMed Central)
  131. STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Rosen MJ, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta FL, Wilson KT, Polk DB (2011) Inflamm Bowel Dis 17(11): 2224-34
    › Primary publication · 21308881 (PubMed) · PMC3120916 (PubMed Central)
  132. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model. Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS (2011) Cancer Res 71(4): 1302-12
    › Primary publication · 21303973 (PubMed) · PMC3150168 (PubMed Central)
  133. Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II. Lewis ND, Asim M, Barry DP, de Sablet T, Singh K, Piazuelo MB, Gobert AP, Chaturvedi R, Wilson KT (2011) J Immunol 186(6): 3632-41
    › Primary publication · 21296975 (PubMed) · PMC3069806 (PubMed Central)
  134. Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania. Rana T, Misra S, Mittal MK, Farrow AL, Wilson KT, Linton MF, Fazio S, Willis IM, Chaudhuri G (2011) J Biol Chem 286(8): 6614-26
    › Primary publication · 21149457 (PubMed) · PMC3057815 (PubMed Central)
  135. The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. Singh K, Chaturvedi R, Barry DP, Coburn LA, Asim M, Lewis ND, Piazuelo MB, Washington MK, Vitek MP, Wilson KT (2011) J Biol Chem 286(5): 3839-50
    › Primary publication · 21115487 (PubMed) · PMC3030385 (PubMed Central)
  136. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Wroblewski LE, Peek RM, Wilson KT (2010) Clin Microbiol Rev 23(4): 713-39
    › Primary publication · 20930071 (PubMed) · PMC2952980 (PubMed Central)
  137. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-γ production. Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB (2011) Gastroenterology 140(1): 265-74
    › Primary publication · 20875416 (PubMed) · PMC3008308 (PubMed Central)
  138. Role of innate immunity in Helicobacter pylori-induced gastric malignancy. Peek RM, Fiske C, Wilson KT (2010) Physiol Rev 90(3): 831-58
    › Primary publication · 20664074 (PubMed) · PMC2990353 (PubMed Central)
  139. Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production. Chaturvedi R, Asim M, Hoge S, Lewis ND, Singh K, Barry DP, de Sablet T, Piazuelo MB, Sarvaria AR, Cheng Y, Closs EI, Casero RA, Gobert AP, Wilson KT (2010) Gastroenterology 139(5): 1686-98, 1698.e1-6
    › Primary publication · 20600019 (PubMed) · PMC2967614 (PubMed Central)
  140. Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages. Asim M, Chaturvedi R, Hoge S, Lewis ND, Singh K, Barry DP, Algood HS, de Sablet T, Gobert AP, Wilson KT (2010) J Biol Chem 285(26): 20343-57
    › Primary publication · 20410304 (PubMed) · PMC2888446 (PubMed Central)
  141. Pathology of gastric intestinal metaplasia: clinical implications. Correa P, Piazuelo MB, Wilson KT (2010) Am J Gastroenterol 105(3): 493-8
    › Primary publication · 20203636 (PubMed) · PMC2895407 (PubMed Central)
  142. Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer. Schneider BG, Peng DF, Camargo MC, Piazuelo MB, Sicinschi LA, Mera R, Romero-Gallo J, Delgado AG, Bravo LE, Wilson KT, Peek RM, Correa P, El-Rifai W (2010) Int J Cancer 127(11): 2588-97
    › Primary publication · 20178103 (PubMed) · PMC2916942 (PubMed Central)
  143. Increased expression and cellular localization of spermine oxidase in ulcerative colitis and relationship to disease activity. Hong SK, Chaturvedi R, Piazuelo MB, Coburn LA, Williams CS, Delgado AG, Casero RA, Schwartz DA, Wilson KT (2010) Inflamm Bowel Dis 16(9): 1557-66
    › Primary publication · 20127992 (PubMed) · PMC2894261 (PubMed Central)
  144. Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages. Lewis ND, Asim M, Barry DP, Singh K, de Sablet T, Boucher JL, Gobert AP, Chaturvedi R, Wilson KT (2010) J Immunol 184(5): 2572-82
    › Primary publication · 20097867 (PubMed) · PMC2841360 (PubMed Central)
  145. Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice. Ogden SR, Noto JM, Allen SS, Patel DA, Romero-Gallo J, Washington MK, Fingleton B, Israel DA, Lewis ND, Wilson KT, Chaturvedi R, Zhao Z, Shyr Y, Peek RM (2010) Cancer Res 70(1): 30-5
    › Primary publication · 20048070 (PubMed) · PMC2804939 (PubMed Central)
  146. Increased serum levels of L-arginine in ulcerative colitis and correlation with disease severity. Hong SK, Maltz BE, Coburn LA, Slaughter JC, Chaturvedi R, Schwartz DA, Wilson KT (2010) Inflamm Bowel Dis 16(1): 105-11
    › Primary publication · 19637336 (PubMed) · PMC2795785 (PubMed Central)
  147. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk DB (2009) Gastroenterology 136(4): 1297-1307, e1-3
    › Primary publication · 19250983 (PubMed) · PMC2878739 (PubMed Central)
  148. Regulation of the Helicobacter pylori cellular receptor decay-accelerating factor. O'Brien DP, Romero-Gallo J, Schneider BG, Chaturvedi R, Delgado A, Harris EJ, Krishna U, Ogden SR, Israel DA, Wilson KT, Peek RM (2008) J Biol Chem 283(35): 23922-30
    › Primary publication · 18579524 (PubMed) · PMC2527108 (PubMed Central)
  149. The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. Singh K, Chaturvedi R, Asim M, Barry DP, Lewis ND, Vitek MP, Wilson KT (2008) J Biol Chem 283(24): 16752-61
    › Primary publication · 18417477 (PubMed) · PMC2423260 (PubMed Central)
  150. Host response to Helicobacter pylori infection before initiation of the adaptive immune response. Algood HM, Gallo-Romero J, Wilson KT, Peek RM, Cover TL (2007) FEMS Immunol Med Microbiol 51(3): 577-86
    › Primary publication · 17919297 (PubMed)
  151. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Wilson KT, Crabtree JE (2007) Gastroenterology 133(1): 288-308
    › Primary publication · 17631150 (PubMed)
  152. L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori. Chaturvedi R, Asim M, Lewis ND, Algood HM, Cover TL, Kim PY, Wilson KT (2007) Infect Immun 75(9): 4305-15
    › Primary publication · 17562760 (PubMed) · PMC1951193 (PubMed Central)
  153. Treatment of gastrointestinal infections. Malamud A, Wilson KT (2000) Curr Opin Gastroenterol 16(1): 51-5
    › Primary publication · 17024016 (PubMed)
  154. Pathogenesis of Helicobacter pylori infection. Wilson KT, Fantry GT (1999) Curr Opin Gastroenterol 15(1): 66-71
    › Primary publication · 17023920 (PubMed)
  155. Low multiplicity of infection of Helicobacter pylori suppresses apoptosis of B lymphocytes. Bussiere FI, Chaturvedi R, Asim M, Hoek KL, Cheng Y, Gainor J, Scholz A, Khan WN, Wilson KT (2006) Cancer Res 66(13): 6834-42
    › Primary publication · 16818661 (PubMed)
  156. Narcotic use in patients with Crohn's disease. Cross RK, Wilson KT, Binion DG (2005) Am J Gastroenterol 100(10): 2225-9
    › Primary publication · 16181373 (PubMed)
  157. Cellular responses to attaching and effacing bacteria: activation and implication of the innate immune system. Gobert AP, Wilson KT, Martin C (2005) Arch Immunol Ther Exp (Warsz) 53(3): 234-44
    › Primary publication · 15995584 (PubMed)
  158. Polypharmacy and Crohn's disease. Cross RK, Wilson KT, Binion DG (2005) Aliment Pharmacol Ther 21(10): 1211-6
    › Primary publication · 15882241 (PubMed)
  159. Helicobacter pylori-induced macrophage apoptosis requires activation of ornithine decarboxylase by c-Myc. Cheng Y, Chaturvedi R, Asim M, Bussière FI, Scholz A, Xu H, Casero RA, Wilson KT (2005) J Biol Chem 280(23): 22492-6
    › Primary publication · 15843384 (PubMed)
  160. Helicobacter pylori infection: pathogenesis. Panchal PC, Forman JS, Blumberg DR, Wilson KT (2003) Curr Opin Gastroenterol 19(1): 4-10
    › Primary publication · 15699887 (PubMed)
  161. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, Potosky D, Meltzer SJ, Rhee JG, Kim SS, Moss SF, Hacker A, Wang Y, Casero RA, Wilson KT (2004) Cancer Res 64(23): 8521-5
    › Primary publication · 15574757 (PubMed)
  162. Spermine causes loss of innate immune response to Helicobacter pylori by inhibition of inducible nitric-oxide synthase translation. Bussière FI, Chaturvedi R, Cheng Y, Gobert AP, Asim M, Blumberg DR, Xu H, Kim PY, Hacker A, Casero RA, Wilson KT (2005) J Biol Chem 280(4): 2409-12
    › Primary publication · 15548540 (PubMed)
  163. Protective role of arginase in a mouse model of colitis. Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, Hacker A, Casero RA, Wilson KT (2004) J Immunol 173(3): 2109-17
    › Primary publication · 15265947 (PubMed)
  164. Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization. Chaturvedi R, Cheng Y, Asim M, Bussière FI, Xu H, Gobert AP, Hacker A, Casero RA, Wilson KT (2004) J Biol Chem 279(38): 40161-73
    › Primary publication · 15247269 (PubMed)
  165. Promoter methylation regulates cyclooxygenase expression in breast cancer. Ma X, Yang Q, Wilson KT, Kundu N, Meltzer SJ, Fulton AM (2004) Breast Cancer Res 6(4): R316-21
    › Primary publication · 15217498 (PubMed) · PMC468630 (PubMed Central)
  166. Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect. Duleu S, Vincendeau P, Courtois P, Semballa S, Lagroye I, Daulouède S, Boucher JL, Wilson KT, Veyret B, Gobert AP (2004) J Immunol 172(10): 6298-303
    › Primary publication · 15128819 (PubMed)
  167. Cutting edge: cyclooxygenase-2 activation suppresses Th1 polarization in response to Helicobacter pylori. Meyer F, Ramanujam KS, Gobert AP, James SP, Wilson KT (2003) J Immunol 171(8): 3913-7
    › Primary publication · 14530307 (PubMed)
  168. Nitric oxide in inflammatory bowel disease. Cross RK, Wilson KT (2003) Inflamm Bowel Dis 9(3): 179-89
    › Primary publication · 12792224 (PubMed)
  169. Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. Paradoxical proinflammatory effect on the microvascular endothelium. Rafiee P, Johnson CP, Li MS, Ogawa H, Heidemann J, Fisher PJ, Lamirand TH, Otterson MF, Wilson KT, Binion DG (2002) J Biol Chem 277(38): 35605-15
    › Primary publication · 12110686 (PubMed)
  170. Angiogenic markers, neovascularization and malignant deformation of Barrett's esophagus. Wilson KT (2002) Dis Esophagus 15(1): 16-21
    › Primary publication · 12060038 (PubMed)
  171. Cutting edge: urease release by Helicobacter pylori stimulates macrophage inducible nitric oxide synthase. Gobert AP, Mersey BD, Cheng Y, Blumberg DR, Newton JC, Wilson KT (2002) J Immunol 168(12): 6002-6
    › Primary publication · 12055207 (PubMed)
  172. Helicobacter pylori induces macrophage apoptosis by activation of arginase II. Gobert AP, Cheng Y, Wang JY, Boucher JL, Iyer RK, Cederbaum SD, Casero RA, Newton JC, Wilson KT (2002) J Immunol 168(9): 4692-700
    › Primary publication · 11971019 (PubMed)
  173. Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: a strategy for bacterial survival. Gobert AP, McGee DJ, Akhtar M, Mendz GL, Newton JC, Cheng Y, Mobley HL, Wilson KT (2001) Proc Natl Acad Sci U S A 98(24): 13844-9
    › Primary publication · 11717441 (PubMed) · PMC61129 (PubMed Central)
  174. Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. Fleisher AS, Esteller M, Tamura G, Rashid A, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Nishizuka S, James SP, Wilson KT, Herman JG, Meltzer SJ (2001) Oncogene 20(3): 329-35
    › Primary publication · 11313962 (PubMed)
  175. Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells. Akhtar M, Cheng Y, Magno RM, Ashktorab H, Smoot DT, Meltzer SJ, Wilson KT (2001) Cancer Res 61(6): 2399-403
    › Primary publication · 11289104 (PubMed)
  176. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT, Johnson CP, Otterson MF, Telford GL, Wilson KT (2000) Free Radic Biol Med 29(9): 881-8
    › Primary publication · 11063913 (PubMed)
  177. Modulation of innate cytokine responses by products of Helicobacter pylori. Meyer F, Wilson KT, James SP (2000) Infect Immun 68(11): 6265-72
    › Primary publication · 11035734 (PubMed) · PMC97708 (PubMed Central)
  178. Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Fleisher AS, Esteller M, Harpaz N, Leytin A, Rashid A, Xu Y, Liang J, Stine OC, Yin J, Zou TT, Abraham JM, Kong D, Wilson KT, James SP, Herman JG, Meltzer SJ (2000) Cancer Res 60(17): 4864-8
    › Primary publication · 10987299 (PubMed)
  179. Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia. Tsuchiya T, Tamura G, Sato K, Endoh Y, Sakata K, Jin Z, Motoyama T, Usuba O, Kimura W, Nishizuka S, Wilson KT, James SP, Yin J, Fleisher AS, Zou T, Silverberg SG, Kong D, Meltzer SJ (2000) Oncogene 19(32): 3642-6
    › Primary publication · 10951570 (PubMed)
  180. E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas. Tamura G, Yin J, Wang S, Fleisher AS, Zou T, Abraham JM, Kong D, Smolinski KN, Wilson KT, James SP, Silverberg SG, Nishizuka S, Terashima M, Motoyama T, Meltzer SJ (2000) J Natl Cancer Inst 92(7): 569-73
    › Primary publication · 10749913 (PubMed)
  181. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis. Fu S, Ramanujam KS, Wong A, Fantry GT, Drachenberg CB, James SP, Meltzer SJ, Wilson KT (1999) Gastroenterology 116(6): 1319-29
    › Primary publication · 10348815 (PubMed)
  182. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Fleisher AS, Esteller M, Wang S, Tamura G, Suzuki H, Yin J, Zou TT, Abraham JM, Kong D, Smolinski KN, Shi YQ, Rhyu MG, Powell SM, James SP, Wilson KT, Herman JG, Meltzer SJ (1999) Cancer Res 59(5): 1090-5
    › Primary publication · 10070967 (PubMed)
  183. Decreased prevalence of Helicobacter pylori infection in gastroesophageal reflux disease. Varanasi RV, Fantry GT, Wilson KT (1998) Helicobacter 3(3): 188-94
    › Primary publication · 9731990 (PubMed)
  184. iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Binion DG, Fu S, Ramanujam KS, Chai YC, Dweik RA, Drazba JA, Wade JG, Ziats NP, Erzurum SC, Wilson KT (1998) Am J Physiol 275(3): G592-603
    › Primary publication · 9724273 (PubMed)
  185. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Wilson KT, Fu S, Ramanujam KS, Meltzer SJ (1998) Cancer Res 58(14): 2929-34
    › Primary publication · 9679948 (PubMed)
  186. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line. Wilson KT, Ramanujam KS, Mobley HL, Musselman RF, James SP, Meltzer SJ (1996) Gastroenterology 111(6): 1524-33
    › Primary publication · 8942731 (PubMed)
  187. Production and localization of cGMP and PGE2 in nitroprusside-stimulated rat colonic ion transport. Wilson KT, Vaandrager AB, De Vente J, Musch MW, De Jonge HR, Chang EB (1996) Am J Physiol 270(3 Pt 1): C832-40
    › Primary publication · 8638664 (PubMed)
  188. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. Wilson KT, Xie Y, Musch MW, Chang EB (1993) J Pharmacol Exp Ther 266(1): 224-30
    › Primary publication · 8331560 (PubMed)