Profile

My research interest concentrates on genetic and molecular epidemiology of cancer and other complex diseases, with an emphasis on colorectal and pancreatic cancers, melanoma, neuropsycheatric disorders. I try to identify and characterize genetic variants associated with cancer, understand how genetic susceptibility may be modified by environmental exposures and gene-gene interactions, and translate these findings into public health applications. I also have a particular interest in evaluating novel molecular prognostic markers and studying the molecular pathogenesis of cancer as an integrated part of genetic epidemiology. It is becoming increasingly evident that cancer represents a heterogeneous set of diseases with highly specific molecular signatures and phenotypes, and my research strategy is to exploit these specific phenotypes to gain insight into the epidemiology and pathogenesis of cancers.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Interaction of fatty acid genotype and diet on changes in colonic fatty acids in a Mediterranean diet intervention study. Porenta SR, Ko YA, Gruber SB, Mukherjee B, Baylin A, Ren J, Djuric Z (2013) Cancer Prev Res (Phila) 6(11): 1212-21
    › Primary publication · 24022589 (PubMed) · PMC3840911 (PubMed Central)
  2. Distinct molecular features of colorectal cancer in Ghana. Raskin L, Dakubo JC, Palaski N, Greenson JK, Gruber SB (2013) Cancer Epidemiol 37(5): 556-61
    › Primary publication · 23962701 (PubMed) · PMC4267222 (PubMed Central)
  3. Transcriptome profiling identifies HMGA2 as a biomarker of melanoma progression and prognosis. Raskin L, Fullen DR, Giordano TJ, Thomas DG, Frohm ML, Cha KB, Ahn J, Mukherjee B, Johnson TM, Gruber SB (2013) J Invest Dermatol 133(11): 2585-2592
    › Primary publication · 23633021 (PubMed) · PMC4267221 (PubMed Central)
  4. RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. Antoniou AC, Sinilnikova OM, Simard J, Léoné M, Dumont M, Neuhausen SL, Struewing JP, Stoppa-Lyonnet D, Barjhoux L, Hughes DJ, Coupier I, Belotti M, Lasset C, Bonadona V, Bignon YJ, Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers Study (GEMO), Rebbeck TR, Wagner T, Lynch HT, Domchek SM, Nathanson KL, Garber JE, Weitzel J, Narod SA, Tomlinson G, Olopade OI, Godwin A, Isaacs C, Jakubowska A, Lubinski J, Gronwald J, Górski B, Byrski T, Huzarski T, Peock S, Cook M, Baynes C, Murray A, Rogers M, Daly PA, Dorkins H, Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers (EMBRACE), Schmutzler RK, Versmold B, Engel C, Meindl A, Arnold N, Niederacher D, Deissler H, German Consortium for Hereditary Breast and Ovarian Cancer (GCHBOC), Spurdle AB, Chen X, Waddell N, Cloonan N, Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab), Kirchhoff T, Offit K, Friedman E, Kaufmann B, Laitman Y, Galore G, Rennert G, Lejbkowicz F, Raskin L, Andrulis IL, Ilyushik E, Ozcelik H, Devilee P, Vreeswijk MP, Greene MH, Prindiville SA, Osorio A, Benitez J, Zikan M, Szabo CI, Kilpivaara O, Nevanlinna H, Hamann U, Durocher F, Arason A, Couch FJ, Easton DF, Chenevix-Trench G, Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) (2007) Am J Hum Genet 81(6): 1186-200
    › Primary publication · 17999359 (PubMed) · PMC2276351 (PubMed Central)