Profile

The gastrointestinal tract is a dynamic interactive barrier that normally segregates microbial populations from their cognate human hosts. An aberrant consequence of contact between microbes and gut epithelial cells is the development of mucosal inflammation, which, if allowed to become persistent, can initiate carcinogenic pathways. Gastric adenocarcinoma is the second leading cause of cancer-related death in the world, and Helicobacter pylori, a bacterial species that persistently colonizes the human stomach and induces chronic gastritis, is the strongest known risk factor for this malignancy. However, only a fraction of infected persons ever develop cancer, underscoring the importance of defining mechanisms that regulate the biological interactions of H. pylori with their hosts that promote neoplastic transformation. Adherence of H. pylori to gastric epithelial cells is critical for induction of inflammation and injury; therefore, the overarching theme for our research has been delineation of the molecular signaling events initiated by bacterial:epithelial cell contact that regulate phenotypes related to carcinogenesis.

The most important known H. pylori strain-specific determinant associated with cancer is the cag pathogenicity island, and cag+ strains augment the risk for severe gastritis and gastric cancer. Using in vitro models of bacterial:gastric epithelial cell interactions, we have shown that cag island genes are required for pro-inflammatory cytokine release and induction of apoptosis, and that these events are mediated by activation of NF-kB and/or mitogen-activated protein kinases (MAPK). Recently, we have used global proteomics approaches to identify additional H. pylori products that are related to pathogenesis within the gastric niche. Extending these results into rodent models of H. pylori-induced inflammation and carcinogenesis (Mongolian gerbils and mice), we have shown that inactivation of such genes attenuates the development gastric injury and cancer.

In human gastric tissue, however, gastric epithelial cell proliferation is significantly higher but apoptotic indices are lower among persons colonized with cag+ compared to cag- strains or uninfected persons leading us to postulate that reduced rates of cell loss, when accompanied by hyperproliferation, may heighten retention of mutagenized cells, which could predispose towards cancer. Therefore, we have also focused our investigations on host determinants that influence disease outcomes occurring within the context of H. pylori infection. One host effector that may influence carcinogenesis in response to H. pylori is MMP-7, a matrix metalloproteinase that enhances tumor formation in rodents, and is over-expressed in premalignant and malignant lesions within H. pylori-infected human mucosa. Although epithelial cells acutely exposed to matrilysin rapidly undergo apoptosis, constitutive expression of MMP-7 selects for cells with a reduced sensitivity to apoptosis. Our experiments have recently shown that MMP-7 is detected exclusively in human mucosa colonized by cag+ strains, and these same H. pylori strains selectively induce MMP-7 in vitro through cag-mediated activation of NF-kB and MAPK. Based upon these data, we hypothesize that strain-selective activation of NF-kB and/or MAPK by H. pylori cag+ strains regulates MMP-7 expression, which may contribute to the augmentation in carcinogenic risk associated with these strains by attenuating apoptosis within chronically colonized mucosa.

We have also recently shown that carcinogenic strains of H. pylori can selectively activate B-catenin, and this is due to translocation of CagA into the host epithelial cell. Our current studies therefore, are not only allowing us to investigate discrete interactions that lead to H. pylori-induced neoplasias but also are providing mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Carcinogenic Strains Selectively Dysregulate the Gastric Proteome, Which May Be Associated with Stomach Cancer Progression. Noto JM, Rose KL, Hachey AJ, Delgado AG, Romero-Gallo J, Wroblewski LE, Schneider BG, Shah SC, Cover TL, Wilson KT, Israel DA, Roa JC, Schey KL, Zavros Y, Piazuelo MB, Peek RM (2019) Mol Cell Proteomics 18(2): 352-371
    › Primary publication · 30455363 (PubMed) · PMC6356085 (PubMed Central)
  2. Selective killing of with pH-responsive helix-coil conformation transitionable antimicrobial polypeptides. Xiong M, Bao Y, Xu X, Wang H, Han Z, Wang Z, Liu Y, Huang S, Song Z, Chen J, Peek RM, Yin L, Chen LF, Cheng J (2017) Proc Natl Acad Sci U S A 114(48): 12675-12680
    › Primary publication · 29133389 (PubMed) · PMC5715757 (PubMed Central)
  3. The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer. Noto JM, Peek RM (2017) PLoS Pathog 13(10): e1006573
    › Primary publication · 28982167 (PubMed) · PMC5629027 (PubMed Central)
  4. Pan-genomic analyses identify key pathogenic loci modified by carcinogenic host microenvironments. Noto JM, Chopra A, Loh JT, Romero-Gallo J, Piazuelo MB, Watson M, Leary S, Beckett AC, Wilson KT, Cover TL, Mallal S, Israel DA, Peek RM (2018) Gut 67(10): 1793-1804
    › Primary publication · 28924022 (PubMed) · PMC5857411 (PubMed Central)
  5. Dynamics of infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Mera RM, Bravo LE, Camargo MC, Bravo JC, Delgado AG, Romero-Gallo J, Yepez MC, Realpe JL, Schneider BG, Morgan DR, Peek RM, Correa P, Wilson KT, Piazuelo MB (2018) Gut 67(7): 1239-1246
    › Primary publication · 28647684 (PubMed) · PMC5742304 (PubMed Central)
  6. Epidermal growth factor receptor inhibition downregulates -induced epithelial inflammatory responses, DNA damage and gastric carcinogenesis. Sierra JC, Asim M, Verriere TG, Piazuelo MB, Suarez G, Romero-Gallo J, Delgado AG, Wroblewski LE, Barry DP, Peek RM, Gobert AP, Wilson KT (2018) Gut 67(7): 1247-1260
    › Primary publication · 28473630 (PubMed) · PMC5671361 (PubMed Central)
  7. Correction: Helicobacter pylori bab Paralog Distribution and Association with cagA, vacA, and homA/B Genotypes in American and South Korean Clinical Isolates. Kim A, Servetas SL, Kang J, Kim J, Jang S, Cha HJ, Lee WJ, Kim J, Romero-Gallo J, Peek RM, Merrell DS, Cha JH (2017) PLoS One 12(4): e0176468
    › Primary publication · 28426827 (PubMed) · PMC5398676 (PubMed Central)
  8. Draft Genome Sequences of 13 Colombian Strains Isolated from Pacific Coast and Andean Residents. Pazos A, Kodaman N, Piazuelo MB, Romero-Gallo J, Sobota RS, Israel DA, Bravo LE, Morgan DR, Wilson KT, Correa P, Peek RM, Williams SM, Schneider BG (2017) Genome Announc 5(15)
    › Primary publication · 28408665 (PubMed) · PMC5391403 (PubMed Central)
  9. Genetic Manipulation of Virulence Function by Host Carcinogenic Phenotypes. Suarez G, Romero-Gallo J, Sierra JC, Piazuelo MB, Krishna US, Gomez MA, Wilson KT, Peek RM (2017) Cancer Res 77(9): 2401-2412
    › Primary publication · 28209611 (PubMed) · PMC5413443 (PubMed Central)
  10. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR (2016) Cell Mol Gastroenterol Hepatol 2(4): 391-393
    › Primary publication · 28174724 (PubMed) · PMC5042602 (PubMed Central)
  11. DNA Transfer and Toll-like Receptor Modulation by Helicobacter pylori. Varga MG, Peek RM (2017) Curr Top Microbiol Immunol : 169-193
    › Primary publication · 28124154 (PubMed) · PMC5540360 (PubMed Central)
  12. TLR9 activation suppresses inflammation in response to Helicobacter pylori infection. Varga MG, Piazuelo MB, Romero-Gallo J, Delgado AG, Suarez G, Whitaker ME, Krishna US, Patel RV, Skaar EP, Wilson KT, Algood HM, Peek RM (2016) Am J Physiol Gastrointest Liver Physiol 311(5): G852-G858
    › Primary publication · 27758771 (PubMed) · PMC5130555 (PubMed Central)
  13. Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration. Beckett AC, Piazuelo MB, Noto JM, Peek RM, Washington MK, Algood HM, Cover TL (2016) Infect Immun 84(12): 3338-3349
    › Primary publication · 27620719 (PubMed) · PMC5116712 (PubMed Central)
  14. induced cell death is counteracted by NF-κB-mediated transcription of DARPP-32. Zhu S, Soutto M, Chen Z, Peng D, Romero-Gallo J, Krishna US, Belkhiri A, Washington MK, Peek R, El-Rifai W (2017) Gut 66(5): 761-762
    › Primary publication · 27590997 (PubMed) · PMC5334457 (PubMed Central)
  15. Helicobacter pylori, Cancer, and the Gastric Microbiota. Wroblewski LE, Peek RM (2016) Adv Exp Med Biol : 393-408
    › Primary publication · 27573782 (PubMed)
  16. The Role of the Microbiome in Gastrointestinal Cancer. Wroblewski LE, Peek RM, Coburn LA (2016) Gastroenterol Clin North Am 45(3): 543-56
    › Primary publication · 27546848 (PubMed) · PMC4994977 (PubMed Central)
  17. Hydrogen Metabolism in Helicobacter pylori Plays a Role in Gastric Carcinogenesis through Facilitating CagA Translocation. Wang G, Romero-Gallo J, Benoit SL, Piazuelo MB, Dominguez RL, Morgan DR, Peek RM, Maier RJ (2016) MBio 7(4)
    › Primary publication · 27531909 (PubMed) · PMC4992972 (PubMed Central)
  18. Activation of Epidermal Growth Factor Receptor in Macrophages Mediates Feedback Inhibition of M2 Polarization and Gastrointestinal Tumor Cell Growth. Zhao G, Liu L, Peek RM, Hao X, Polk DB, Li H, Yan F (2016) J Biol Chem 291(39): 20462-72
    › Primary publication · 27507810 (PubMed) · PMC5034042 (PubMed Central)
  19. EGFR regulates macrophage activation and function in bacterial infection. Hardbower DM, Singh K, Asim M, Verriere TG, Olivares-Villagómez D, Barry DP, Allaman MM, Washington MK, Peek RM, Piazuelo MB, Wilson KT (2016) J Clin Invest 126(9): 3296-312
    › Primary publication · 27482886 (PubMed) · PMC5004944 (PubMed Central)
  20. An LGG-derived protein promotes IgA production through upregulation of APRIL expression in intestinal epithelial cells. Wang Y, Liu L, Moore DJ, Shen X, Peek RM, Acra SA, Li H, Ren X, Polk DB, Yan F (2017) Mucosal Immunol 10(2): 373-384
    › Primary publication · 27353252 (PubMed) · PMC5199635 (PubMed Central)
  21. New Biology to New Treatment of Helicobacter pylori-Induced Gastric Cancer. Peek RM (2016) Dig Dis 34(5): 510-6
    › Primary publication · 27332886 (PubMed) · PMC4930673 (PubMed Central)
  22. The Mongolian Gerbil: A Robust Model of Helicobacter pylori-Induced Gastric Inflammation and Cancer. Noto JM, Romero-Gallo J, Piazuelo MB, Peek RM (2016) Methods Mol Biol : 263-80
    › Primary publication · 27246040 (PubMed) · PMC5915618 (PubMed Central)
  23. The Dawning of a New Editorial Board for Gastroenterology. Corley DA, Peek RM (2016) Gastroenterology 151(1): 4-8
    › Primary publication · 27215655 (PubMed)
  24. Not all mice are the same: Standardization of animal research data presentation. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR (2016) Hepatology 63(6): 1752-4
    › Primary publication · 27205897 (PubMed)
  25. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Omary MB, Cohen DE, El-Omar E, Jalan R, Low M, Nathanson M, Peek R, Turner J (2016) Gut 65(6): 894-5
    › Primary publication · 27197119 (PubMed)
  26. Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease. Krishna U, Romero-Gallo J, Suarez G, Azah A, Krezel AM, Varga MG, Forsyth MH, Peek RM (2016) J Infect Dis 214(4): 644-8
    › Primary publication · 27190191 (PubMed) · PMC4957439 (PubMed Central)
  27. Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system. Varga MG, Shaffer CL, Sierra JC, Suarez G, Piazuelo MB, Whitaker ME, Romero-Gallo J, Krishna US, Delgado A, Gomez MA, Good JA, Almqvist F, Skaar EP, Correa P, Wilson KT, Hadjifrangiskou M, Peek RM (2016) Oncogene 35(48): 6262-6269
    › Primary publication · 27157617 (PubMed) · PMC5102820 (PubMed Central)
  28. The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines. Riquelme I, Tapia O, Espinoza JA, Leal P, Buchegger K, Sandoval A, Bizama C, Araya JC, Peek RM, Roa JC (2016) Pathol Oncol Res 22(4): 797-805
    › Primary publication · 27156070 (PubMed) · PMC5890336 (PubMed Central)
  29. Helicobacter pylori: Pathogenic enablers - toxic relationships in the stomach. Wroblewski LE, Peek RM (2016) Nat Rev Gastroenterol Hepatol 13(6): 317-8
    › Primary publication · 27147493 (PubMed) · PMC5035680 (PubMed Central)
  30. Characterization of progressive metaplasia in the gastric corpus mucosa of Mongolian gerbils infected with Helicobacter pylori. Shimizu T, Choi E, Petersen CP, Noto JM, Romero-Gallo J, Piazuelo MB, Washington MK, Peek RM, Goldenring JR (2016) J Pathol 239(4): 399-410
    › Primary publication · 27125972 (PubMed) · PMC4958595 (PubMed Central)
  31. Neonatal colonization of mice with LGG promotes intestinal development and decreases susceptibility to colitis in adulthood. Yan F, Liu L, Cao H, Moore DJ, Washington MK, Wang B, Peek RM, Acra SA, Polk DB (2017) Mucosal Immunol 10(1): 117-127
    › Primary publication · 27095077 (PubMed) · PMC5073052 (PubMed Central)
  32. BET Inhibition Attenuates Helicobacter pylori-Induced Inflammatory Response by Suppressing Inflammatory Gene Transcription and Enhancer Activation. Chen J, Wang Z, Hu X, Chen R, Romero-Gallo J, Peek RM, Chen LF (2016) J Immunol 196(10): 4132-42
    › Primary publication · 27084101 (PubMed) · PMC4868794 (PubMed Central)
  33. Not All Mice Are the Same: Standardization of Animal Research Data Presentation. Omary MB, Cohen DE, El-Omar EM, Jalan R, Low MJ, Nathanson MH, Peek RM, Turner JR (2016) Gastroenterology 150(7): 1503-1504
    › Primary publication · 27063865 (PubMed)
  34. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S (2016) Sci Rep : 18594
    › Primary publication · 26729566 (PubMed) · PMC4700446 (PubMed Central)
  35. Helicobacter pylori and CagA under conditions of iron deficiency. Noto JM, Peek RM (2015) Gut Microbes 6(6): 377-81
    › Primary publication · 26727420 (PubMed) · PMC4826123 (PubMed Central)
  36. Micronutrients: A double-edged sword in microbial-induced gastric carcinogenesis. Noto JM, Peek RM (2015) Trends Cancer 1(2): 136-144
    › Primary publication · 26623443 (PubMed) · PMC4662415 (PubMed Central)
  37. Identification of alanyl aminopeptidase (CD13) as a surface marker for isolation of mature gastric zymogenic chief cells. Moore BD, Jin RU, Osaki L, Romero-Gallo J, Noto J, Peek RM, Mills JC (2015) Am J Physiol Gastrointest Liver Physiol 309(12): G955-64
    › Primary publication · 26514774 (PubMed) · PMC4683299 (PubMed Central)
  38. Helical antimicrobial polypeptides with radial amphiphilicity. Xiong M, Lee MW, Mansbach RA, Song Z, Bao Y, Peek RM, Yao C, Chen LF, Ferguson AL, Wong GC, Cheng J (2015) Proc Natl Acad Sci U S A 112(43): 13155-60
    › Primary publication · 26460016 (PubMed) · PMC4629321 (PubMed Central)
  39. miR-101-2, miR-125b-2 and miR-451a act as potential tumor suppressors in gastric cancer through regulation of the PI3K/AKT/mTOR pathway. Riquelme I, Tapia O, Leal P, Sandoval A, Varga MG, Letelier P, Buchegger K, Bizama C, Espinoza JA, Peek RM, Araya JC, Roa JC (2016) Cell Oncol (Dordr) 39(1): 23-33
    › Primary publication · 26458815 (PubMed) · PMC4751587 (PubMed Central)
  40. Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Amieva M, Peek RM (2016) Gastroenterology 150(1): 64-78
    › Primary publication · 26385073 (PubMed) · PMC4691563 (PubMed Central)
  41. Microbial Regulation of p53 Tumor Suppressor. Zaika AI, Wei J, Noto JM, Peek RM (2015) PLoS Pathog 11(9): e1005099
    › Primary publication · 26379246 (PubMed) · PMC4574736 (PubMed Central)
  42. Trefoil factor 1 expression suppresses Helicobacter pylori-induced inflammation in gastric carcinogenesis. Soutto M, Chen Z, Katsha AM, Romero-Gallo J, Krishna US, Piazuelo MB, Washington MK, Peek RM, Belkhiri A, El-Rifai WM (2015) Cancer 121(24): 4348-58
    › Primary publication · 26372254 (PubMed) · PMC4670586 (PubMed Central)
  43. Helicobacter pylori bab Paralog Distribution and Association with cagA, vacA, and homA/B Genotypes in American and South Korean Clinical Isolates. Kim A, Servetas SL, Kang J, Kim J, Jang S, Cha HJ, Lee WJ, Kim J, Romero-Gallo J, Peek RM, Merrell DS, Cha JH (2015) PLoS One 10(8): e0137078
    › Primary publication · 26317221 (PubMed) · PMC4552749 (PubMed Central)
  44. Quality indicators for the management of Barrett's esophagus, dysplasia, and esophageal adenocarcinoma: international consensus recommendations from the American Gastroenterological Association Symposium. Sharma P, Katzka DA, Gupta N, Ajani J, Buttar N, Chak A, Corley D, El-Serag H, Falk GW, Fitzgerald R, Goldblum J, Gress F, Ilson DH, Inadomi JM, Kuipers EJ, Lynch JP, McKeon F, Metz D, Pasricha PJ, Pech O, Peek R, Peters JH, Repici A, Seewald S, Shaheen NJ, Souza RF, Spechler SJ, Vennalaganti P, Wang K (2015) Gastroenterology 149(6): 1599-606
    › Primary publication · 26296479 (PubMed) · PMC4820399 (PubMed Central)
  45. DNA Methylation Predicts Progression of Human Gastric Lesions. Schneider BG, Mera R, Piazuelo MB, Bravo JC, Zabaleta J, Delgado AG, Bravo LE, Wilson KT, El-Rifai W, Peek RM, Correa P (2015) Cancer Epidemiol Biomarkers Prev 24(10): 1607-13
    › Primary publication · 26269563 (PubMed) · PMC4592454 (PubMed Central)
  46. Toll-Like Receptor 9 Contributes to Defense against Acinetobacter baumannii Infection. Noto MJ, Boyd KL, Burns WJ, Varga MG, Peek RM, Skaar EP (2015) Infect Immun 83(10): 4134-41
    › Primary publication · 26238713 (PubMed) · PMC4567622 (PubMed Central)
  47. Hepatic TLR4 signaling in obese NAFLD. Sharifnia T, Antoun J, Verriere TG, Suarez G, Wattacheril J, Wilson KT, Peek RM, Abumrad NN, Flynn CR (2015) Am J Physiol Gastrointest Liver Physiol 309(4): G270-8
    › Primary publication · 26113297 (PubMed) · PMC4537925 (PubMed Central)
  48. Draft Genome Sequence of Gerbil-Adapted Carcinogenic Helicobacter pylori Strain 7.13. Asim M, Chikara SK, Ghosh A, Vudathala S, Romero-Gallo J, Krishna US, Wilson KT, Israel DA, Peek RM, Chaturvedi R (2015) Genome Announc 3(3)
    › Primary publication · 26067974 (PubMed) · PMC4463538 (PubMed Central)
  49. Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion. Hammond CE, Beeson C, Suarez G, Peek RM, Backert S, Smolka AJ (2015) Am J Physiol Gastrointest Liver Physiol 309(3): G193-201
    › Primary publication · 26045613 (PubMed) · PMC4525105 (PubMed Central)
  50. Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis. Soutto M, Romero-Gallo J, Krishna U, Piazuelo MB, Washington MK, Belkhiri A, Peek RM, El-Rifai W (2015) Oncotarget 6(20): 17911-22
    › Primary publication · 25980439 (PubMed) · PMC4627225 (PubMed Central)
  51. Modification of Helicobacter pylori Peptidoglycan Enhances NOD1 Activation and Promotes Cancer of the Stomach. Suarez G, Romero-Gallo J, Piazuelo MB, Wang G, Maier RJ, Forsberg LS, Azadi P, Gomez MA, Correa P, Peek RM (2015) Cancer Res 75(8): 1749-59
    › Primary publication · 25732381 (PubMed) · PMC4401661 (PubMed Central)
  52. CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. Bertaux-Skeirik N, Feng R, Schumacher MA, Li J, Mahe MM, Engevik AC, Javier JE, Peek RM, Ottemann K, Orian-Rousseau V, Boivin GP, Helmrath MA, Zavros Y (2015) PLoS Pathog 11(2): e1004663
    › Primary publication · 25658601 (PubMed) · PMC4450086 (PubMed Central)
  53. Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway. Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika AI (2015) Oncotarget 6(3): 1531-43
    › Primary publication · 25605238 (PubMed) · PMC4359312 (PubMed Central)
  54. Regulation of Helicobacter pylori Virulence Within the Context of Iron Deficiency. Noto JM, Lee JY, Gaddy JA, Cover TL, Amieva MR, Peek RM (2015) J Infect Dis 211(11): 1790-4
    › Primary publication · 25505301 (PubMed) · PMC4447831 (PubMed Central)
  55. The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration. Gaddy JA, Radin JN, Loh JT, Piazuelo MB, Kehl-Fie TE, Delgado AG, Ilca FT, Peek RM, Cover TL, Chazin WJ, Skaar EP, Scott Algood HM (2014) PLoS Pathog 10(10): e1004450
    › Primary publication · 25330071 (PubMed) · PMC4199781 (PubMed Central)
  56. Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase. Chaturvedi R, de Sablet T, Asim M, Piazuelo MB, Barry DP, Verriere TG, Sierra JC, Hardbower DM, Delgado AG, Schneider BG, Israel DA, Romero-Gallo J, Nagy TA, Morgan DR, Murray-Stewart T, Bravo LE, Peek RM, Fox JG, Woster PM, Casero RA, Correa P, Wilson KT (2015) Oncogene 34(26): 3429-40
    › Primary publication · 25174398 (PubMed) · PMC4345146 (PubMed Central)
  57. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM (2015) Gut 64(5): 720-30
    › Primary publication · 25123931 (PubMed) · PMC4329117 (PubMed Central)
  58. Heme oxygenase-1 dysregulates macrophage polarization and the immune response to Helicobacter pylori. Gobert AP, Verriere T, Asim M, Barry DP, Piazuelo MB, de Sablet T, Delgado AG, Bravo LE, Correa P, Peek RM, Chaturvedi R, Wilson KT (2014) J Immunol 193(6): 3013-22
    › Primary publication · 25108023 (PubMed) · PMC4171064 (PubMed Central)
  59. Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Wei J, Noto JM, Zaika E, Romero-Gallo J, Piazuelo MB, Schneider B, El-Rifai W, Correa P, Peek RM, Zaika AI (2015) Gut 64(7): 1040-8
    › Primary publication · 25080447 (PubMed) · PMC4312278 (PubMed Central)
  60. At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. Hardbower DM, Peek RM, Wilson KT (2014) J Leukoc Biol 96(2): 201-12
    › Primary publication · 24868089 (PubMed) · PMC4101087 (PubMed Central)
  61. Matrix metalloproteinase 7 restrains Helicobacter pylori-induced gastric inflammation and premalignant lesions in the stomach by altering macrophage polarization. Krakowiak MS, Noto JM, Piazuelo MB, Hardbower DM, Romero-Gallo J, Delgado A, Chaturvedi R, Correa P, Wilson KT, Peek RM (2015) Oncogene 34(14): 1865-71
    › Primary publication · 24837365 (PubMed) · PMC4237684 (PubMed Central)
  62. Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Epplein M, Zheng W, Li H, Peek RM, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Xiang YB, Shu XO (2014) Nutr Cancer 66(4): 550-7
    › Primary publication · 24666234 (PubMed) · PMC4068395 (PubMed Central)
  63. Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage. Chaturvedi R, Asim M, Piazuelo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Morgan DR, Peek RM, Wilson KT (2014) Gastroenterology 146(7): 1739-51.e14
    › Primary publication · 24530706 (PubMed) · PMC4035375 (PubMed Central)
  64. Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase α-subunit gene expression by miRNA. Zhang YM, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RM, Smolka AJ (2014) Am J Physiol Gastrointest Liver Physiol 306(7): G606-13
    › Primary publication · 24503769 (PubMed) · PMC4116396 (PubMed Central)
  65. Human and Helicobacter pylori coevolution shapes the risk of gastric disease. Kodaman N, Pazos A, Schneider BG, Piazuelo MB, Mera R, Sobota RS, Sicinschi LA, Shaffer CL, Romero-Gallo J, de Sablet T, Harder RH, Bravo LE, Peek RM, Wilson KT, Cover TL, Williams SM, Correa P (2014) Proc Natl Acad Sci U S A 111(4): 1455-60
    › Primary publication · 24474772 (PubMed) · PMC3910595 (PubMed Central)
  66. Helicobacter pylori: expect the unexpected. Suarez G, Peek RM (2014) Mol Microbiol 91(5): 858-61
    › Primary publication · 24471732 (PubMed) · PMC3966957 (PubMed Central)
  67. Gastrointestinal malignancy and the microbiome. Abreu MT, Peek RM (2014) Gastroenterology 146(6): 1534-1546.e3
    › Primary publication · 24406471 (PubMed) · PMC3995897 (PubMed Central)
  68. Helicobacter pylori Biomarkers and Risk of Colorectal Oncogenesis--Response. Epplein M, Peek RM, Blot WJ (2014) Cancer Epidemiol Biomarkers Prev 23(2): 366
    › Primary publication · 24285842 (PubMed) · PMC3946073 (PubMed Central)
  69. Introduction. Helicobacter pylori. Peek RM (2013) Gut Microbes 4(6): 425
    › Primary publication · 24262863 (PubMed) · PMC3928155 (PubMed Central)
  70. The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation. Capoccia BJ, Jin RU, Kong YY, Peek RM, Fassan M, Rugge M, Mills JC (2013) J Clin Invest 123(4): 1475-91
    › Primary publication · 23478405 (PubMed) · PMC3613919 (PubMed Central)
  71. Functional plasticity in the type IV secretion system of Helicobacter pylori. Barrozo RM, Cooke CL, Hansen LM, Lam AM, Gaddy JA, Johnson EM, Cariaga TA, Suarez G, Peek RM, Cover TL, Solnick JV (2013) PLoS Pathog 9(2): e1003189
    › Primary publication · 23468628 (PubMed) · PMC3585145 (PubMed Central)
  72. Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. Wang L, Cao H, Lu N, Liu L, Wang B, Hu T, Israel DA, Peek RM, Polk DB, Yan F (2013) PLoS One 8(2): e56666
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