Our research focuses on the use of functional genomic and epigenetic approaches to understand gene regulation. Our interests range from detailed mechanistic studies of the interferon-gamma gene, a key cytokine produced by cells of the innate and adaptive immune system, a critical cytokine required to induce cell-mediated inflammation to the use of these approaches to gain new insights into human disease, including diseases of the endocrine system. These include recent studies evaluating relationships among gene expression signatures in atherosclerosis, type 2 diabetes and metabolic syndrome and study of copy number polymorphisms in type 1 diabetes, type 2 diabetes, and multiple sclerosis.


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Regulation of the Th1 genomic locus from Ifng through Tmevpg1 by T-bet. Collier SP, Henderson MA, Tossberg JT, Aune TM (2014) J Immunol 193(8): 3959-65
    › Primary publication · 25225667 (PubMed) · PMC4185266 (PubMed Central)
  2. Expression of IL-33 and its epigenetic regulation in Multiple Sclerosis. Zhang F, Tossberg JT, Spurlock CF, Yao SY, Aune TM, Sriram S (2014) Ann Clin Transl Neurol 1(5): 307-318
    › Primary publication · 25215310 (PubMed) · PMC4157667 (PubMed Central)
  3. Methotrexate-mediated inhibition of nuclear factor κB activation by distinct pathways in T cells and fibroblast-like synoviocytes. Spurlock CF, Gass HM, Bryant CJ, Wells BC, Olsen NJ, Aune TM (2015) Rheumatology (Oxford) 54(1): 178-87
    › Primary publication · 25118313 (PubMed) · PMC4269792 (PubMed Central)
  4. Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction. Spurlock CF, Tossberg JT, Matlock BK, Olsen NJ, Aune TM (2014) Arthritis Rheumatol 66(11): 2947-57
    › Primary publication · 25077978 (PubMed) · PMC4211976 (PubMed Central)
  5. KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production. Pabbisetty SK, Rabacal W, Maseda D, Cendron D, Collins PL, Hoek KL, Parekh VV, Aune TM, Sebzda E (2014) Proc Natl Acad Sci U S A 111(26): 9579-84
    › Primary publication · 24979767 (PubMed) · PMC4084438 (PubMed Central)
  6. Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Olsen NJ, Spurlock CF, Aune TM (2014) Arthritis Res Ther 16(1): R17
    › Primary publication · 24444433 (PubMed) · PMC3978848 (PubMed Central)
  7. Epigenetic Activation and Silencing of the Gene that Encodes IFN-γ. Aune TM, Collins PL, Collier SP, Henderson MA, Chang S (2013) Front Immunol : 112
    › Primary publication · 23720660 (PubMed) · PMC3655339 (PubMed Central)
  8. Using gene expression data to identify certain gastro-intestinal diseases. Crooke PS, Tossberg JT, Horst SN, Tauscher JL, Henderson MA, Beaulieu DB, Schwartz DA, Olsen NJ, Aune TM (2012) J Clin Bioinforma 2(1): 20
    › Primary publication · 23171526 (PubMed) · PMC3599448 (PubMed Central)
  9. Gene-expression signatures: biomarkers toward diagnosing multiple sclerosis. Tossberg JT, Crooke PS, Henderson MA, Sriram S, Mrelashvili D, Chitnis S, Polman C, Vosslamber S, Verweij CL, Olsen NJ, Aune TM (2012) Genes Immun 13(2): 146-54
    › Primary publication · 21938015 (PubMed) · PMC3291793 (PubMed Central)