Thomas E Yankeelov, Ph.D.

Profile

The requirement to study cancer in its native environment has lead to the development of imaging technologies that can non-invasively and quantitatively interrogate both primary and metastatic disease. This involves mathematical modeling, application of these models in small animal tumors systems, and ultimately applying the most promising techniques in human breast cancer. The overall goal of Dr. Yankeelov's research is to develop advanced imaging methods for the characterization of human tumors and to evaluate their role as potential surrogate biomarkers of treatment responses and tissue status for use in clinical trials and drug discovery.

Publications

The following timeline graph is generated from all co-authored publications.

1. Toward a science of tumor forecasting for clinical oncology. Yankeelov TE, Quaranta V, Evans KJ, Rericha EC (2015) Cancer Res 75(6): 918-23
   › Primary publication · 25592148 (PubMed) · PMC4359948 (PubMed Central)
2. Techniques and applications of dynamic contrast enhanced magnetic resonance imaging in cancer. Barnes SL, Whisenant JG, Xia Li , Yankeelov TE (2014) Conf Proc IEEE Eng Med Biol Soc : 4264-7
   › Primary publication · 25570934 (PubMed) · PMC4428286 (PubMed Central)
3. Detection of breast cancer microcalcification using (99m)Tc-MDP SPECT or Osteosense 750EX FMT imaging. Felix DD, Gore JC, Yankeelov TE, Peterson TE, Barnes S, Whisenant J, Weis J, Shoukouhi S, Virostko J, Nickels M, McIntyre JO, Sanders M, Abramson V, Tantawy MN (2015) Nucl Med Biol 42(3): 269-73
   › Primary publication · 25533764 (PubMed) · PMC4889014 (PubMed Central)
4. Evaluating treatment response using DW-MRI and DCE-MRI in trastuzumab responsive and resistant HER2-overexpressing human breast cancer xenografts. Whisenant JG, Sorace AG, McIntyre JO, Kang H, Sánchez V, Loveless ME, Yankeelov TE (2014) Transl Oncol 7(6): 768-79
   › Primary publication · 25500087 (PubMed) · PMC4311041 (PubMed Central)
5. Methods and challenges in quantitative imaging biomarker development. Abramson RG, Burton KR, Yu JP, Scalzetti EM, Yankeelov TE, Rosenkrantz AB, Mendiratta-Lala M, Bartholmai BJ, Ganeshan D, Lenchik L, Subramaniam RM (2015) Acad Radiol 22(1): 25-32
   › Primary publication · 25481515 (PubMed) · PMC4258641 (PubMed Central)
6. Clinical utility of quantitative imaging. Rosenkrantz AB, Mendiratta-Lala M, Bartholmai BJ, Ganeshan D, Abramson RG, Burton KR, Yu JP, Scalzetti EM, Yankeelov TE, Subramaniam RM, Lenchik L (2015) Acad Radiol 22(1): 33-49
   › Primary publication · 25442800 (PubMed) · PMC4259826 (PubMed Central)
7. Multiparametric magnetic resonance imaging for predicting pathological response after the first cycle of neoadjuvant chemotherapy in breast cancer. Li X, Abramson RG, Arlinghaus LR, Kang H, Chakravarthy AB, Abramson VG, Farley J, Mayer IA, Kelley MC, Meszoely IM, Means-Powell J, Grau AM, Sanders M, Yankeelov TE (2015) Invest Radiol 50(4): 195-204
   › Primary publication · 25360603 (PubMed) · PMC4471951 (PubMed Central)
8. Optimization of 7-T chemical exchange saturation transfer parameters for validation of glycosaminoglycan and amide proton transfer of fibroglandular breast tissue. Dula AN, Dewey BE, Arlinghaus LR, Williams JM, Klomp D, Yankeelov TE, Smith S (2015) Radiology 275(1): 255-61
   › Primary publication · 25353249 (PubMed) · PMC4455672 (PubMed Central)
9. Modeling the effect of intra-voxel diffusion of contrast agent on the quantitative analysis of dynamic contrast enhanced magnetic resonance imaging. Barnes SL, Quarles CC, Yankeelov TE (2014) PLoS One 9(9): e108726
   › Primary publication · 25275536 (PubMed) · PMC4183533 (PubMed Central)
10. Quantitative multimodality imaging in cancer research and therapy. Yankeelov TE, Abramson RG, Quarles CC (2014) Nat Rev Clin Oncol 11(11): 670-80
    › Primary publication · 25113842 (PubMed) · PMC4909117 (PubMed Central)
11. Utility of [18 F]FLT-PET to assess treatment response in trastuzumab-resistant and trastuzumab-sensitive HER2-overexpressing human breast cancer xenografts. Whisenant JG, McIntyre JO, Peterson TE, Kang H, Sánchez V, Manning HC, Arteaga CL, Yankeelov TE (2015) Mol Imaging Biol 17(1): 119-28
    › Primary publication · 25034624 (PubMed) · PMC4311727 (PubMed Central)
12. Sequence design and evaluation of the reproducibility of water-selective diffusion-weighted imaging of the breast at 3 T. Zhu H, Arlinghaus LR, Whisenant JG, Li M, Gore JC, Yankeelov TE (2014) NMR Biomed 27(9): 1030-6
    › Primary publication · 24986756 (PubMed) · PMC4134406 (PubMed Central)
13. Letter to cancer center directors: Progress in quantitative imaging as a means to predict and/or measure tumor response in cancer therapy trials. Mountz JM, Yankeelov TE, Rubin DL, Buatti JM, Erikson BJ, Fennessy FM, Gillies RJ, Huang W, Jacobs MA, Kinahan PE, Laymon CM, Linden HM, Mankoff DA, Schwartz LH, Shim H, Wahl RL (2014) J Clin Oncol 32(19): 2115-6
    › Primary publication · 24868025 (PubMed) · PMC4861229 (PubMed Central)
14. An Approach to Breast Cancer Diagnosis via PET Imaging of Microcalcifications Using (18)F-NaF. Wilson GH, Gore JC, Yankeelov TE, Barnes S, Peterson TE, True JM, Shokouhi S, McIntyre JO, Sanders M, Abramson V, Ngyuen TQ, Mahadevan-Jansen A, Tantawy MN (2014) J Nucl Med 55(7): 1138-43
    › Primary publication · 24833491 (PubMed) · PMC4320039 (PubMed Central)
15. Longitudinal, intermodality registration of quantitative breast PET and MRI data acquired before and during neoadjuvant chemotherapy: preliminary results. Atuegwu NC, Li X, Arlinghaus LR, Abramson RG, Williams JM, Chakravarthy AB, Abramson VG, Yankeelov TE (2014) Med Phys 41(5): 052302
    › Primary publication · 24784395 (PubMed) · PMC4000383 (PubMed Central)
16. Multi-parametric MRI characterization of inflammation in murine skeletal muscle. Bryant ND, Li K, Does MD, Barnes S, Gochberg DF, Yankeelov TE, Park JH, Damon BM (2014) NMR Biomed 27(6): 716-25
    › Primary publication · 24777935 (PubMed) · PMC4134016 (PubMed Central)
17. Variations of dynamic contrast-enhanced magnetic resonance imaging in evaluation of breast cancer therapy response: a multicenter data analysis challenge. Huang W, Li X, Chen Y, Li X, Chang MC, Oborski MJ, Malyarenko DI, Muzi M, Jajamovich GH, Fedorov A, Tudorica A, Gupta SN, Laymon CM, Marro KI, Dyvorne HA, Miller JV, Barbodiak DP, Chenevert TL, Yankeelov TE, Mountz JM, Kinahan PE, Kikinis R, Taouli B, Fennessy F, Kalpathy-Cramer J (2014) Transl Oncol 7(1): 153-66
    › Primary publication · 24772219 (PubMed) · PMC3998693 (PubMed Central)
18. Analyzing Spatial Heterogeneity in DCE- and DW-MRI Parametric Maps to Optimize Prediction of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer. Li X, Kang H, Arlinghaus LR, Abramson RG, Chakravarthy AB, Abramson VG, Farley J, Sanders M, Yankeelov TE (2014) Transl Oncol 7(1): 14-22
    › Primary publication · 24772203 (PubMed) · PMC3998687 (PubMed Central)
19. A comparison of two methods for estimating DCE-MRI parameters via individual and cohort based AIFs in prostate cancer: a step towards practical implementation. Fedorov A, Fluckiger J, Ayers GD, Li X, Gupta SN, Tempany C, Mulkern R, Yankeelov TE, Fennessy FM (2014) Magn Reson Imaging 32(4): 321-9
    › Primary publication · 24560287 (PubMed) · PMC3965600 (PubMed Central)
20. A comparison of individual and population-derived vascular input functions for quantitative DCE-MRI in rats. Hormuth DA, Skinner JT, Does MD, Yankeelov TE (2014) Magn Reson Imaging 32(4): 397-401
    › Primary publication · 24556502 (PubMed) · PMC3965603 (PubMed Central)
21. Integrating Imaging Data into Predictive Biomathematical and Biophysical Models of Cancer. Yankeelov TE (2012) ISRN Biomath
    › Primary publication · 23914302 (PubMed) · PMC3729405 (PubMed Central)
22. Arterial input functions determined from MR signal magnitude and phase for quantitative dynamic contrast-enhanced MRI in the human pelvis. Cron GO, Foottit C, Yankeelov TE, Avruch LI, Schweitzer ME, Cameron I (2011) Magn Reson Med 66(2): 498-504
    › Primary publication · 21360747 (PubMed) · PMC5556949 (PubMed Central)
23. Current and future trends in magnetic resonance imaging assessments of the response of breast tumors to neoadjuvant chemotherapy. Arlinghaus LR, Li X, Levy M, Smith D, Welch EB, Gore JC, Yankeelov TE (2010) J Oncol
    › Primary publication · 20953332 (PubMed) · PMC2952974 (PubMed Central)
24. NCCN clinical practice guidelines in oncology: breast cancer screening and diagnosis. Bevers TB, Anderson BO, Bonaccio E, Buys S, Buys S, Daly MB, Dempsey PJ, Farrar WB, Fleming I, Garber JE, Harris RE, Heerdt AS, Helvie M, Huff JG, Khakpour N, Khan SA, Krontiras H, Lyman G, Rafferty E, Shaw S, Smith ML, Tsangaris TN, Williams C, Yankeelov T, Yaneeklov T, National Comprehensive Cancer Network (2009) J Natl Compr Canc Netw 7(10): 1060-96
    › Primary publication · 19930975 (PubMed)
25. Dynamic Contrast Enhanced Magnetic Resonance Imaging in Oncology: Theory, Data Acquisition, Analysis, and Examples. Yankeelov TE, Gore JC (2009) Curr Med Imaging Rev 3(2): 91-107
    › Primary publication · 19829742 (PubMed) · PMC2760951 (PubMed Central)
26. Variation of the relaxographic "shutter-speed" for transcytolemmal water exchange affects the CR bolus-tracking curve shape. Yankeelov TE, Rooney WD, Li X, Springer CS (2003) Magn Reson Med 50(6): 1151-69
    › Primary publication · 14648563 (PubMed)

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