Dan Roden, M.D.

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Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Androgenic effects on ventricular repolarization: A translational study from the international pharmacovigilance database to iPSC-cardiomyocytes. Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM (2020) Ann Endocrinol (Paris)
    › Primary publication · 32171470 (PubMed)
  2. Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use. Jerome RN, Joly MM, Kennedy N, Shirey-Rice JK, Roden DM, Bernard GR, Holroyd KJ, Denny JC, Pulley JM (2020) Drug Saf 43(6): 567-582
    › Primary publication · 32112228 (PubMed) · PMC7398579 (PubMed Central)
  3. Atropine-induced sinus tachycardia protects against exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Kannankeril PJ, Shoemaker MB, Gayle KA, Fountain D, Roden DM, Knollmann BC (2020) Europace 22(4): 643-648
    › Primary publication · 32091590 (PubMed) · PMC7132542 (PubMed Central)
  4. Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation. Shoemaker MB, Husser D, Roselli C, Al Jazairi M, Chrispin J, Kühne M, Neumann B, Knight S, Sun H, Mohanty S, Shaffer C, Thériault S, Rinke LL, Siland JE, Crawford DM, Ueberham L, Zardkoohi O, Büttner P, Geelhoed B, Blum S, Aeschbacher S, Smith JD, Van Wagoner DR, Freudling R, Müller-Nurasyid M, Montgomery J, Yoneda Z, Wells Q, Issa T, Weeke P, Jacobs V, Van Gelder IC, Hindricks G, Barnard J, Calkins H, Darbar D, Michaud G, Kääb S, Ellinor P, Natale A, Chung M, Nazarian S, Cutler MJ, Sinner MF, Conen D, Rienstra M, Bollmann A, Roden DM, Lubitz S (2020) Circ Arrhythm Electrophysiol 13(3): e007676
    › Primary publication · 32078373 (PubMed) · PMC7080569 (PubMed Central)
  5. Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease. Mosley JD, Gupta DK, Tan J, Yao J, Wells QS, Shaffer CM, Kundu S, Robinson-Cohen C, Psaty BM, Rich SS, Post WS, Guo X, Rotter JI, Roden DM, Gerszten RE, Wang TJ (2020) JAMA 323(7): 627-635
    › Primary publication · 32068817 (PubMed) · PMC7042849 (PubMed Central)
  6. Genomic Medicine Year in Review: 2019. Manolio TA, Bult CJ, Chisholm RL, Deverka PA, Ginsburg GS, Jarvik GP, McLeod HL, Mensah GA, Relling MV, Roden DM, Rowley R, Tamburro C, Williams MS, Green ED (2019) Am J Hum Genet 105(6): 1072-1075
    › Primary publication · 32027834 (PubMed) · PMC7202138 (PubMed Central)
  7. Understanding the use of observational and randomized data in cardiovascular medicine. Bowman L, Baras A, Bombien R, Califf RM, Chen Z, Gale CP, Gaziano JM, Grobbee DE, Maggioni AP, Muse ED, Roden DM, Schroeder S, Wallentin L, Casadei B (2020) Eur Heart J 41(27): 2571-2578
    › Primary publication · 32016367 (PubMed)
  8. Response by Salem et al to Letter Regarding Article, "Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes". Salem JE, Moslehi JJ, Funck Brentano C, Roden DM (2020) Circulation 141(5): e63-e64
    › Primary publication · 32011925 (PubMed) · PMC7041671 (PubMed Central)
  9. Development of a System for Postmarketing Population Pharmacokinetic and Pharmacodynamic Studies Using Real-World Data From Electronic Health Records. Choi L, Beck C, McNeer E, Weeks HL, Williams ML, James NT, Niu X, Abou-Khalil BW, Birdwell KA, Roden DM, Stein CM, Bejan CA, Denny JC, Van Driest SL (2020) Clin Pharmacol Ther 107(4): 934-943
    › Primary publication · 31957870 (PubMed) · PMC7093250 (PubMed Central)
  10. An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition. Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ (2020) Circulation 141(6): 429-439
    › Primary publication · 31941373 (PubMed) · PMC7035205 (PubMed Central)
  11. Deep Mutational Scan of an Voltage Sensor. Glazer AM, Kroncke BM, Matreyek KA, Yang T, Wada Y, Shields T, Salem JE, Fowler DM, Roden DM (2020) Circ Genom Precis Med 13(1): e002786
    › Primary publication · 31928070 (PubMed) · PMC7031040 (PubMed Central)
  12. Real-time visualization of titin dynamics reveals extensive reversible photobleaching in human induced pluripotent stem cell-derived cardiomyocytes. Cadar AG, Feaster TK, Bersell KR, Wang L, Hong T, Balsamo JA, Zhang Z, Chun YW, Nam YJ, Gotthardt M, Knollmann BC, Roden DM, Lim CC, Hong CC (2020) Am J Physiol Cell Physiol 318(1): C163-C173
    › Primary publication · 31747312 (PubMed) · PMC6985833 (PubMed Central)
  13. CYP2C19 Phenotype and Risk of Proton Pump Inhibitor-Associated Infections. Bernal CJ, Aka I, Carroll RJ, Coco JR, Lima JJ, Acra SA, Roden DM, Van Driest SL (2019) Pediatrics 144(6)
    › Primary publication · 31699831 (PubMed) · PMC6889971 (PubMed Central)
  14. Heart failure and atrial tachyarrhythmia on abiraterone: A pharmacovigilance study. Bretagne M, Lebrun-Vignes B, Pariente A, Shaffer CM, Malouf GG, Dureau P, Potey C, Funck-Brentano C, Roden DM, Moslehi JJ, Salem JE (2020) Arch Cardiovasc Dis 113(1): 9-21
    › Primary publication · 31685432 (PubMed) · PMC7158843 (PubMed Central)
  15. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, van Iperen E, Hovingh K, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Lill CM, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott RA, Luan J, Bobak M, Malyutina S, Pająk A, Kubinova R, Tamosiunas A, Pikhart H, Grarup N, Pedersen O, Hansen T, Linneberg A, Jess T, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Lester KH, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, Scott R, Schofield P, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H, Lifelines Cohort authors, Christen T, Mook-Kanamori DO, ICBP Consortium, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Meade T, Christophersen IE, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Roussel R, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Hopewell JC, Seshadri S, METASTROKE Consortium of the ISGC, Dale C, Costa RPE, Ridker PM, Chasman DI, Reiner AP, Ritchie MD, Lange LA, Cornish AJ, Dobbins SE, Hemminki K, Kinnersley B, Sanson M, Labreche K, Simon M, Bondy M, Law P, Speedy H, Allan J, Li N, Went M, Weinhold N, Morgan G, Sonneveld P, Nilsson B, Goldschmidt H, Sud A, Engert A, Hansson M, Hemingway H, Asselbergs FW, Patel RS, Keating BJ, Sattar N, Houlston R, Casas JP, Hingorani AD (2019) BMC Cardiovasc Disord 19(1): 240
    › Primary publication · 31664920 (PubMed) · PMC6820948 (PubMed Central)
  16. Clopidogrel Pharmacogenetics - Why the Wait? Roden DM (2019) N Engl J Med 381(17): 1677-1678
    › Primary publication · 31644850 (PubMed)
  17. Improving the phenotype risk score as a scalable approach to identifying patients with Mendelian disease. Bastarache L, Hughey JJ, Goldstein JA, Bastraache JA, Das S, Zaki NC, Zeng C, Tang LA, Roden DM, Denny JC (2019) J Am Med Inform Assoc 26(12): 1437-1447
    › Primary publication · 31609419 (PubMed) · PMC6857501 (PubMed Central)
  18. Association of Genetic Risk of Obesity with Postoperative Complications Using Mendelian Randomization. Robinson JR, Carroll RJ, Bastarache L, Chen Q, Mou Z, Wei WQ, Connolly JJ, Mentch F, Sleiman P, Crane PK, Hebbring SJ, Stanaway IB, Crosslin DR, Gordon AS, Rosenthal EA, Carrell D, Hayes MG, Wei W, Petukhova L, Namjou B, Zhang G, Safarova MS, Walton NA, Still C, Bottinger EP, Loos RJF, Murphy SN, Jackson GP, Kullo IJ, Hakonarson H, Jarvik GP, Larson EB, Weng C, Roden DM, Denny JC (2020) World J Surg 44(1): 84-94
    › Primary publication · 31605180 (PubMed) · PMC6925615 (PubMed Central)
  19. Cardiovascular Toxicities Associated With Ibrutinib. Salem JE, Manouchehri A, Bretagne M, Lebrun-Vignes B, Groarke JD, Johnson DB, Yang T, Reddy NM, Funck-Brentano C, Brown JR, Roden DM, Moslehi JJ (2019) J Am Coll Cardiol 74(13): 1667-1678
    › Primary publication · 31558250 (PubMed)
  20. John A. Oates: A Founding Father of Clinical Pharmacology. Roden DM (2019) Clin Pharmacol Ther 106(6): 1155-1157
    › Primary publication · 31529489 (PubMed)
  21. Pharmacogenomic polygenic response score predicts ischaemic events and cardiovascular mortality in clopidogrel-treated patients. Lewis JP, Backman JD, Reny JL, Bergmeijer TO, Mitchell BD, Ritchie MD, Déry JP, Pakyz RE, Gong L, Ryan K, Kim EY, Aradi D, Fernandez-Cadenas I, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Gawaz M, Bliden KP, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Schwab M, Klein TE, Shuldiner AR, ICPC Investigators (2020) Eur Heart J Cardiovasc Pharmacother 6(4): 203-210
    › Primary publication · 31504375 (PubMed) · PMC7363022 (PubMed Central)
  22. Acute kidney injury risk-based screening in pediatric inpatients: a pragmatic randomized trial. Van Driest SL, Wang L, McLemore MF, Bridges BC, Fleming GM, McGregor TL, Jones DP, Shirey-Rice J, Gatto CL, Gay JC, Byrne DW, Weitkamp A, Roden DM, Bernard G (2020) Pediatr Res 87(1): 118-124
    › Primary publication · 31454829 (PubMed) · PMC6962531 (PubMed Central)
  23. A Decision-Theoretic Approach to Panel-Based, Preemptive Genotyping. Shi Y, Graves JA, Garbett SP, Zhou Z, Marathi R, Wang X, Harrell FE, Lasko TA, Denny JC, Roden DM, Peterson JF, Schildcrout JS (2019) MDM Policy Pract 4(2): 2381468319864337
    › Primary publication · 31453360 (PubMed) · PMC6699004 (PubMed Central)
  24. CNV Association of Diverse Clinical Phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease. Glessner JT, Li J, Desai A, Palmer M, Kim D, Lucas AM, Chang X, Connolly JJ, Almoguera B, Harley JB, Jarvik GP, Ritchie MD, Sleiman PMA, Roden DM, Crosslin D, Hakonarson H (2020) Int J Cardiol : 107-113
    › Primary publication · 31447229 (PubMed)
  25. Building evidence and measuring clinical outcomes for genomic medicine. Peterson JF, Roden DM, Orlando LA, Ramirez AH, Mensah GA, Williams MS (2019) Lancet 394(10198): 604-610
    › Primary publication · 31395443 (PubMed) · PMC6730663 (PubMed Central)
  26. Genomic medicine for undiagnosed diseases. Wise AL, Manolio TA, Mensah GA, Peterson JF, Roden DM, Tamburro C, Williams MS, Green ED (2019) Lancet 394(10197): 533-540
    › Primary publication · 31395441 (PubMed) · PMC6709871 (PubMed Central)
  27. Pharmacogenomics. Roden DM, McLeod HL, Relling MV, Williams MS, Mensah GA, Peterson JF, Van Driest SL (2019) Lancet 394(10197): 521-532
    › Primary publication · 31395440 (PubMed) · PMC6707519 (PubMed Central)
  28. Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes. Salem JE, Yang T, Moslehi JJ, Waintraub X, Gandjbakhch E, Bachelot A, Hidden-Lucet F, Hulot JS, Knollmann BC, Lebrun-Vignes B, Funck-Brentano C, Glazer AM, Roden DM (2019) Circulation 140(13): 1070-1080
    › Primary publication · 31378084 (PubMed) · PMC6756939 (PubMed Central)
  29. A -Ethnic Genome-Wide Association Study of Uterine Fibroids. Edwards TL, Giri A, Hellwege JN, Hartmann KE, Stewart EA, Jeff JM, Bray MJ, Pendergrass SA, Torstenson ES, Keaton JM, Jones SH, Gogoi RP, Kuivaniemi H, Jackson KL, Kho AN, Kullo IJ, McCarty CA, Im HK, Pacheco JA, Pathak J, Williams MS, Tromp G, Kenny EE, Peissig PL, Denny JC, Roden DM, Velez Edwards DR (2019) Front Genet : 511
    › Primary publication · 31249589 (PubMed) · PMC6582231 (PubMed Central)
  30. SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells. Daniel LL, Yang T, Kroncke B, Hall L, Stroud D, Roden DM (2019) Heart Rhythm 16(11): 1676-1685
    › Primary publication · 31125670 (PubMed) · PMC6825529 (PubMed Central)
  31. Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics. Wells QS, Gupta DK, Smith JG, Collins SP, Storrow AB, Ferguson J, Smith ML, Pulley JM, Collier S, Wang X, Roden DM, Gerszten RE, Wang TJ (2019) J Am Coll Cardiol 73(17): 2195-2205
    › Primary publication · 31047008 (PubMed) · PMC6501811 (PubMed Central)
  32. My Cousin Also Has Atrial Fibrillation: Family Relationships in a Genomic Era. Roden DM, Below JE (2019) JACC Clin Electrophysiol 5(4): 501-503
    › Primary publication · 31000105 (PubMed)
  33. Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network. Hellwege JN, Stallings S, Torstenson ES, Carroll R, Borthwick KM, Brilliant MH, Crosslin D, Gordon A, Hripcsak G, Jarvik GP, Linneman JG, Devi P, Peissig PL, Sleiman PAM, Hakonarson H, Ritchie MD, Verma SS, Shang N, Denny JC, Roden DM, Velez Edwards DR, Edwards TL (2019) Sci Rep 9(1): 6077
    › Primary publication · 30988330 (PubMed) · PMC6465359 (PubMed Central)
  34. Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol. Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM (2019) Clin Pharmacol Ther 106(3): 623-631
    › Primary publication · 30924126 (PubMed) · PMC6941886 (PubMed Central)
  35. Adverse Events Associated with Risperidone Use in Pediatric Patients: A Retrospective Biobank Study. Oshikoya KA, Carroll R, Aka I, Roden DM, Van Driest SL (2019) Drugs Real World Outcomes 6(2): 59-71
    › Primary publication · 30919267 (PubMed) · PMC6520321 (PubMed Central)
  36. Protein structure aids predicting functional perturbation of missense variants in and . Kroncke BM, Mendenhall J, Smith DK, Sanders CR, Capra JA, George AL, Blume JD, Meiler J, Roden DM (2019) Comput Struct Biotechnol J : 206-214
    › Primary publication · 30828412 (PubMed) · PMC6383132 (PubMed Central)
  37. GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish. Unlu G, Gamazon ER, Qi X, Levic DS, Bastarache L, Denny JC, Roden DM, Mayzus I, Breyer M, Zhong X, Konkashbaev AI, Rzhetsky A, Knapik EW, Cox NJ (2019) Am J Hum Genet 104(3): 503-519
    › Primary publication · 30827500 (PubMed) · PMC6407495 (PubMed Central)
  38. A phenome-wide association study to discover pleiotropic effects of , , and . Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, Larson EB, Scrol A, Jarvik GP, Crosslin DR, Leppig K, Rasmussen-Torvik LJ, Pendergrass SA, Sturm AC, Namjou B, Shah AS, Carroll RJ, Chung WK, Wei WQ, Feng Q, Stein CM, Roden DM, Manolio TA, Schaid DJ, Denny JC, Hebbring SJ, de Andrade M, Kullo IJ (2019) NPJ Genom Med : 3
    › Primary publication · 30774981 (PubMed) · PMC6370860 (PubMed Central)
  39. Association of genetic variants previously implicated in coronary artery disease with age at onset of coronary artery disease requiring revascularizations. Andersson C, Lukács Krogager M, Kuhr Skals R, Rosenbaum Appel EV, Theil Have C, Grarup N, Pedersen O, Jeppesen JL, Pedersen OD, Dominguez H, Dixen U, Engstrøm T, Tønder N, Roden DM, Stender S, Gislason GH, Enghusen-Poulsen H, Hansen T, Køber L, Torp-Pedersen C, Weeke PE (2019) PLoS One 14(2): e0211690
    › Primary publication · 30726294 (PubMed) · PMC6364925 (PubMed Central)
  40. A current understanding of drug-induced QT prolongation and its implications for anticancer therapy. Roden DM (2019) Cardiovasc Res 115(5): 895-903
    › Primary publication · 30689740 (PubMed)
  41. Multiple mechanisms underlie increased cardiac late sodium current. Kroncke BM, Yang T, Roden DM (2019) Heart Rhythm 16(7): 1091-1097
    › Primary publication · 30677491 (PubMed) · PMC6655535 (PubMed Central)
  42. Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis. Salem JE, Shoemaker MB, Bastarache L, Shaffer CM, Glazer AM, Kroncke B, Wells QS, Shi M, Straub P, Jarvik GP, Larson EB, Velez Edwards DR, Edwards TL, Davis LK, Hakonarson H, Weng C, Fasel D, Knollmann BC, Wang TJ, Denny JC, Ellinor PT, Roden DM, Mosley JD (2019) JAMA Cardiol 4(2): 136-143
    › Primary publication · 30673079 (PubMed) · PMC6439628 (PubMed Central)
  43. CYP2D6 genotype and adverse events to risperidone in children and adolescents. Oshikoya KA, Neely KM, Carroll RJ, Aka IT, Maxwell-Horn AC, Roden DM, Van Driest SL (2019) Pediatr Res 85(5): 602-606
    › Primary publication · 30661084 (PubMed) · PMC6435416 (PubMed Central)
  44. Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery. Aragam KG, Chaffin M, Levinson RT, McDermott G, Choi SH, Shoemaker MB, Haas ME, Weng LC, Lindsay ME, Smith JG, Newton-Cheh C, Roden DM, London B, Wells QS, Ellinor PT, Kathiresan S, Lubitz SA, GRADE Investigators (2018) Circulation
    › Primary publication · 30586722 (PubMed) · PMC6511334 (PubMed Central)
  45. Probing the Virtual Proteome to Identify Novel Disease Biomarkers. Mosley JD, Benson MD, Smith JG, Melander O, Ngo D, Shaffer CM, Ferguson JF, Herzig MS, McCarty CA, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Kitchner TE, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Kiryluk K, Mentch FD, Sleiman PM, Karlson EW, Verma SS, Zhu Y, Vasan RS, Yang Q, Denny JC, Roden DM, Gerszten RE, Wang TJ (2018) Circulation 138(22): 2469-2481
    › Primary publication · 30571344 (PubMed)
  46. Hypertension genetic risk score is associated with burden of coronary heart disease among patients referred for coronary angiography. Lukács Krogager M, Skals RK, Appel EVR, Schnurr TM, Engelbrechtsen L, Have CT, Pedersen O, Engstrøm T, Roden DM, Gislason G, Poulsen HE, Køber L, Stender S, Hansen T, Grarup N, Andersson C, Torp-Pedersen C, Weeke PE (2018) PLoS One 13(12): e0208645
    › Primary publication · 30566436 (PubMed) · PMC6300273 (PubMed Central)
  47. Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation. Choi SH, Weng LC, Roselli C, Lin H, Haggerty CM, Shoemaker MB, Barnard J, Arking DE, Chasman DI, Albert CM, Chaffin M, Tucker NR, Smith JD, Gupta N, Gabriel S, Margolin L, Shea MA, Shaffer CM, Yoneda ZT, Boerwinkle E, Smith NL, Silverman EK, Redline S, Vasan RS, Burchard EG, Gogarten SM, Laurie C, Blackwell TW, Abecasis G, Carey DJ, Fornwalt BK, Smelser DT, Baras A, Dewey FE, Jaquish CE, Papanicolaou GJ, Sotoodehnia N, Van Wagoner DR, Psaty BM, Kathiresan S, Darbar D, Alonso A, Heckbert SR, Chung MK, Roden DM, Benjamin EJ, Murray MF, Lunetta KL, Lubitz SA, Ellinor PT, DiscovEHR study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium (2018) JAMA 320(22): 2354-2364
    › Primary publication · 30535219 (PubMed) · PMC6436530 (PubMed Central)
  48. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium (2019) Lancet Respir Med 7(3): 227-238
    › Primary publication · 30527956 (PubMed) · PMC6391516 (PubMed Central)
  49. Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study. Salem JE, Manouchehri A, Moey M, Lebrun-Vignes B, Bastarache L, Pariente A, Gobert A, Spano JP, Balko JM, Bonaca MP, Roden DM, Johnson DB, Moslehi JJ (2018) Lancet Oncol 19(12): 1579-1589
    › Primary publication · 30442497 (PubMed) · PMC6287923 (PubMed Central)
  50. Growing Pains in Cardiovascular Genetics. Roden DM (2018) Circulation 138(12): 1206-1209
    › Primary publication · 30354441 (PubMed) · PMC6206881 (PubMed Central)
  51. Coding variants in and increase risk of atrial fibrillation. Thorolfsdottir RB, Sveinbjornsson G, Sulem P, Nielsen JB, Jonsson S, Halldorsson GH, Melsted P, Ivarsdottir EV, Davidsson OB, Kristjansson RP, Thorleifsson G, Helgadottir A, Gretarsdottir S, Norddahl G, Rajamani S, Torfason B, Valgardsson AS, Sverrisson JT, Tragante V, Holmen OL, Asselbergs FW, Roden DM, Darbar D, Pedersen TR, Sabatine MS, Willer CJ, Løchen ML, Halldorsson BV, Jonsdottir I, Hveem K, Arnar DO, Thorsteinsdottir U, Gudbjartsson DF, Holm H, Stefansson K (2018) Commun Biol : 68
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  60. Identification of Central Regulators of Calcium Signaling and ECM-Receptor Interaction Genetically Associated With the Progression and Recurrence of Atrial Fibrillation. Büttner P, Ueberham L, Shoemaker MB, Roden DM, Dinov B, Hindricks G, Bollmann A, Husser D (2018) Front Genet : 162
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  61. Association Between Early Postoperative Acetaminophen Exposure and Acute Kidney Injury in Pediatric Patients Undergoing Cardiac Surgery. Van Driest SL, Jooste EH, Shi Y, Choi L, Darghosian L, Hill KD, Smith AH, Kannankeril PJ, Roden DM, Ware LB (2018) JAMA Pediatr 172(7): 655-663
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  62. Evaluation of a Novel System to Enhance Clinicians' Recognition of Preadmission Adverse Drug Reactions. Smith JC, Chen Q, Denny JC, Roden DM, Johnson KB, Miller RA (2018) Appl Clin Inform 9(2): 313-325
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  63. (Na1.5) Variant Functional Perturbation and Clinical Presentation: Variants of a Certain Significance. Kroncke BM, Glazer AM, Smith DK, Blume JD, Roden DM (2018) Circ Genom Precis Med 11(5): e002095
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  64. Increased long QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors. Grouthier V, Lebrun-Vignes B, Glazer AM, Touraine P, Funck-Brentano C, Pariente A, Courtillot C, Bachelot A, Roden DM, Moslehi JJ, Salem JE (2018) Heart 104(22): 1859-1863
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  65. Arrhythmia genetics: Not dark and lite, but 50 shades of gray. Roden DM, Glazer AM, Kroncke B (2018) Heart Rhythm 15(8): 1231-1232
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  66. LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins. Wei WQ, Li X, Feng Q, Kubo M, Kullo IJ, Peissig PL, Karlson EW, Jarvik GP, Lee MTM, Shang N, Larson EA, Edwards T, Shaffer CM, Mosley JD, Maeda S, Horikoshi M, Ritchie M, Williams MS, Larson EB, Crosslin DR, Bland ST, Pacheco JA, Rasmussen-Torvik LJ, Cronkite D, Hripcsak G, Cox NJ, Wilke RA, Stein CM, Rotter JI, Momozawa Y, Roden DM, Krauss RM, Denny JC (2018) Circulation 138(17): 1839-1849
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  67. Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation. Roden DM, Van Driest SL, Wells QS, Mosley JD, Denny JC, Peterson JF (2018) Circ Res 122(9): 1176-1190
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  68. Anticancer drug-induced cardiac rhythm disorders: Current knowledge and basic underlying mechanisms. Alexandre J, Moslehi JJ, Bersell KR, Funck-Brentano C, Roden DM, Salem JE (2018) Pharmacol Ther : 89-103
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  69. Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC). Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR, ICPC Investigators (2018) Am Heart J : 152-159
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  70. Clinical Features Associated With Nascent Left Ventricular Diastolic Dysfunction in a Population Aged 40 to 55 Years. Mosley JD, Levinson RT, Brittain EL, Gupta DK, Farber-Eger E, Shaffer CM, Denny JC, Roden DM, Wells QS (2018) Am J Cardiol 121(12): 1552-1557
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  71. Phenotype risk scores identify patients with unrecognized Mendelian disease patterns. Bastarache L, Hughey JJ, Hebbring S, Marlo J, Zhao W, Ho WT, Van Driest SL, McGregor TL, Mosley JD, Wells QS, Temple M, Ramirez AH, Carroll R, Osterman T, Edwards T, Ruderfer D, Velez Edwards DR, Hamid R, Cogan J, Glazer A, Wei WQ, Feng Q, Brilliant M, Zhao ZJ, Cox NJ, Roden DM, Denny JC (2018) Science 359(6381): 1233-1239
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  72. Inhibition of the -Subunit of Phosphoinositide 3-Kinase in Heart Increases Late Sodium Current and Is Arrhythmogenic. Yang T, Meoli DF, Moslehi J, Roden DM (2018) J Pharmacol Exp Ther 365(3): 460-466
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  73. Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects. Volpi S, Bult CJ, Chisholm RL, Deverka PA, Ginsburg GS, Jacob HJ, Kasapi M, McLeod HL, Roden DM, Williams MS, Green ED, Rodriguez LL, Aronson S, Cavallari LH, Denny JC, Dressler LG, Johnson JA, Klein TE, Leeder JS, Piquette-Miller M, Perera M, Rasmussen-Torvik LJ, Rehm HL, Ritchie MD, Skaar TC, Wagle N, Weinshilboum R, Weitzel KW, Wildin R, Wilson J, Manolio TA, Relling MV (2018) Clin Pharmacol Ther 103(5): 778-786
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  74. Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications. Goldstein JA, Bastarache LA, Denny JC, Roden DM, Pulley JM, Aronoff DM (2018) Pharmacol Res : 44-51
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  75. Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing. Giudicessi JR, Roden DM, Wilde AAM, Ackerman MJ (2018) Circulation 137(6): 619-630
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  76. Benefit of Preemptive Pharmacogenetic Information on Clinical Outcome. Roden DM, Van Driest SL, Mosley JD, Wells QS, Robinson JR, Denny JC, Peterson JF (2018) Clin Pharmacol Ther 103(5): 787-794
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  77. Exploiting ion channel structure to assess rare variant pathogenicity. Kroncke BM, Yang T, Kannankeril P, Shoemaker MB, Roden DM (2018) Heart Rhythm 15(6): 890-894
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  78. Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors. Jerome RN, Pulley JM, Roden DM, Shirey-Rice JK, Bastarache LA, R Bernard G, B Ekstrom L, Lancaster WJ, Denny JC (2018) Drug Saf 41(3): 303-311
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  79. The Influence of Big (Clinical) Data and Genomics on Precision Medicine and Drug Development. Denny JC, Van Driest SL, Wei WQ, Roden DM (2018) Clin Pharmacol Ther 103(3): 409-418
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  80. Genome-wide and Phenome-wide Approaches to Understand Variable Drug Actions in Electronic Health Records. Robinson JR, Denny JC, Roden DM, Van Driest SL (2018) Clin Transl Sci 11(2): 112-122
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  81. Exome-wide association study of plasma lipids in >300,000 individuals. Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC, Boehnke M, Boerwinkle E, Bork-Jensen J, Bottinger EP, Brandslund I, Brown M, Busonero F, Caulfield MJ, Chambers JC, Chasman DI, Chen YE, Chen YI, Chowdhury R, Christensen C, Chu AY, Connell JM, Cucca F, Cupples LA, Damrauer SM, Davies G, Deary IJ, Dedoussis G, Denny JC, Dominiczak A, Dubé MP, Ebeling T, Eiriksdottir G, Esko T, Farmaki AE, Feitosa MF, Ferrario M, Ferrieres J, Ford I, Fornage M, Franks PW, Frayling TM, Frikke-Schmidt R, Fritsche LG, Frossard P, Fuster V, Ganesh SK, Gao W, Garcia ME, Gieger C, Giulianini F, Goodarzi MO, Grallert H, Grarup N, Groop L, Grove ML, Gudnason V, Hansen T, Harris TB, Hayward C, Hirschhorn JN, Holmen OL, Huffman J, Huo Y, Hveem K, Jabeen S, Jackson AU, Jakobsdottir J, Jarvelin MR, Jensen GB, Jørgensen ME, Jukema JW, Justesen JM, Kamstrup PR, Kanoni S, Karpe F, Kee F, Khera AV, Klarin D, Koistinen HA, Kooner JS, Kooperberg C, Kuulasmaa K, Kuusisto J, Laakso M, Lakka T, Langenberg C, Langsted A, Launer LJ, Lauritzen T, Liewald DCM, Lin LA, Linneberg A, Loos RJF, Lu Y, Lu X, Mägi R, Malarstig A, Manichaikul A, Manning AK, Mäntyselkä P, Marouli E, Masca NGD, Maschio A, Meigs JB, Melander O, Metspalu A, Morris AP, Morrison AC, Mulas A, Müller-Nurasyid M, Munroe PB, Neville MJ, Nielsen JB, Nielsen SF, Nordestgaard BG, Ordovas JM, Mehran R, O'Donnell CJ, Orho-Melander M, Molony CM, Muntendam P, Padmanabhan S, Palmer CNA, Pasko D, Patel AP, Pedersen O, Perola M, Peters A, Pisinger C, Pistis G, Polasek O, Poulter N, Psaty BM, Rader DJ, Rasheed A, Rauramaa R, Reilly DF, Reiner AP, Renström F, Rich SS, Ridker PM, Rioux JD, Robertson NR, Roden DM, Rotter JI, Rudan I, Salomaa V, Samani NJ, Sanna S, Sattar N, Schmidt EM, Scott RA, Sever P, Sevilla RS, Shaffer CM, Sim X, Sivapalaratnam S, Small KS, Smith AV, Smith BH, Somayajula S, Southam L, Spector TD, Speliotes EK, Starr JM, Stirrups KE, Stitziel N, Strauch K, Stringham HM, Surendran P, Tada H, Tall AR, Tang H, Tardif JC, Taylor KD, Trompet S, Tsao PS, Tuomilehto J, Tybjaerg-Hansen A, van Zuydam NR, Varbo A, Varga TV, Virtamo J, Waldenberger M, Wang N, Wareham NJ, Warren HR, Weeke PE, Weinstock J, Wessel J, Wilson JG, Wilson PWF, Xu M, Yaghootkar H, Young R, Zeggini E, Zhang H, Zheng NS, Zhang W, Zhang Y, Zhou W, Zhou Y, Zoledziewska M, Charge Diabetes Working Group, EPIC-InterAct Consortium, EPIC-CVD Consortium, GOLD Consortium, VA Million Veteran Program, Howson JMM, Danesh J, McCarthy MI, Cowan CA, Abecasis G, Deloukas P, Musunuru K, Willer CJ, Kathiresan S (2017) Nat Genet 49(12): 1758-1766
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  82. A Missense Variant in PLEC Increases Risk of Atrial Fibrillation. Thorolfsdottir RB, Sveinbjornsson G, Sulem P, Helgadottir A, Gretarsdottir S, Benonisdottir S, Magnusdottir A, Davidsson OB, Rajamani S, Roden DM, Darbar D, Pedersen TR, Sabatine MS, Jonsdottir I, Arnar DO, Thorsteinsdottir U, Gudbjartsson DF, Holm H, Stefansson K (2017) J Am Coll Cardiol 70(17): 2157-2168
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  83. Erratum to: A multi-stage genome-wide association study of uterine fibroids in African Americans. Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR (2017) Hum Genet 136(11-12): 1497-1498
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  85. Rare variants in genes encoding the cardiac sodium channel and associated compounds and their impact on outcome of catheter ablation of atrial fibrillation. Husser D, Ueberham L, Hindricks G, Büttner P, Ingram C, Weeke P, Shoemaker MB, Adams V, Arya A, Sommer P, Darbar D, Roden DM, Bollmann A (2017) PLoS One 12(8): e0183690
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  86. A multi-stage genome-wide association study of uterine fibroids in African Americans. Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, Jones SF, Torstenson ES, Dickinson S, Ruiz-Narváez EA, Rohland N, Allen A, Reich D, Tandon A, Pasaniuc B, Mancuso N, Im HK, Hinds DA, Palmer JR, Rosenberg L, Denny JC, Roden DM, Stewart EA, Morton CC, Kenny EE, Edwards TL, Velez Edwards DR (2017) Hum Genet 136(10): 1363-1373
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  87. A comparative study of different methods for automatic identification of clopidogrel-induced bleedings in electronic health records. Lee HJ, Jiang M, Wu Y, Shaffer CM, Cleator JH, Friedman EA, Lewis JP, Roden DM, Denny J, Xu H (2017) AMIA Jt Summits Transl Sci Proc : 185-192
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  88. New Pharmacogenomics Research Network: An Open Community Catalyzing Research and Translation in Precision Medicine. Relling MV, Krauss RM, Roden DM, Klein TE, Fowler DM, Terada N, Lin L, Riel-Mehan M, Do TP, Kubo M, Yee SW, Johnson GT, Giacomini KM (2017) Clin Pharmacol Ther 102(6): 897-902
    › Primary publication · 28795399 (PubMed) · PMC5706548 (PubMed Central)
  89. Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä I, Malik R, R V R Horimoto A, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen YI, Sandhu RK, Li M, Boerwinkle E, Eisele L, Lannfelt L, Rost N, Anderson CD, Taylor KD, Campbell A, Magnusson PK, Porteous D, Hocking LJ, Vlachopoulou E, Pedersen NL, Nikus K, Orho-Melander M, Hamsten A, Heeringa J, Denny JC, Kriebel J, Darbar D, Newton-Cheh C, Shaffer C, Macfarlane PW, Heilmann-Heimbach S, Almgren P, Huang PL, Sotoodehnia N, Soliman EZ, Uitterlinden AG, Hofman A, Franco OH, Völker U, Jöckel KH, Sinner MF, Lin HJ, Guo X, METASTROKE Consortium of the ISGC, Neurology Working Group of the CHARGE Consortium, Dichgans M, Ingelsson E, Kooperberg C, Melander O, J F Loos R, Laurikka J, Conen D, Rosand J, van der Harst P, Lokki ML, Kathiresan S, Pereira A, Jukema JW, Hayward C, Rotter JI, März W, Lehtimäki T, Stricker BH, Chung MK, Felix SB, Gudnason V, Alonso A, Roden DM, Kääb S, Chasman DI, Heckbert SR, Benjamin EJ, Tanaka T, Lunetta KL, Lubitz SA, Ellinor PT, AFGen Consortium (2017) Nat Genet 49(8): 1286
    › Primary publication · 28747752 (PubMed)
  90. Influence of Human Leukocyte Antigen (HLA) Alleles and Killer Cell Immunoglobulin-Like Receptors (KIR) Types on Heparin-Induced Thrombocytopenia (HIT). Karnes JH, Shaffer CM, Cronin R, Bastarache L, Gaudieri S, James I, Pavlos R, Steiner HE, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM (2017) Pharmacotherapy 37(9): 1164-1171
    › Primary publication · 28688202 (PubMed) · PMC5600645 (PubMed Central)
  91. Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record. Wei WQ, Bastarache LA, Carroll RJ, Marlo JE, Osterman TJ, Gamazon ER, Cox NJ, Roden DM, Denny JC (2017) PLoS One 12(7): e0175508
    › Primary publication · 28686612 (PubMed) · PMC5501393 (PubMed Central)
  92. Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association. Hill JA, Ardehali R, Clarke KT, Del Zoppo GJ, Eckhardt LL, Griendling KK, Libby P, Roden DM, Sadek HA, Seidman CE, Vaughan DE, American Heart Association Council on Basic Cardiovascular Sciences; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Stroke Council (2017) Circ Res 121(3): e2-e8
    › Primary publication · 28652256 (PubMed)
  93. Reprint of Editiorial Commentary: Genomics and drug discovery: The next frontier in precision medicine. Roden DM (2017) Trends Cardiovasc Med 27(5): 360-362
    › Primary publication · 28601251 (PubMed)
  94. Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults. Wells QS, Veatch OJ, Fessel JP, Joon AY, Levinson RT, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke PE, Glazer AM, Bersell KR, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, Roden DM (2017) Pharmacogenet Genomics 27(7): 247-254
    › Primary publication · 28542097 (PubMed) · PMC5502740 (PubMed Central)
  95. Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial. Kannankeril PJ, Moore JP, Cerrone M, Priori SG, Kertesz NJ, Ro PS, Batra AS, Kaufman ES, Fairbrother DL, Saarel EV, Etheridge SP, Kanter RJ, Carboni MP, Dzurik MV, Fountain D, Chen H, Ely EW, Roden DM, Knollmann BC (2017) JAMA Cardiol 2(7): 759-766
    › Primary publication · 28492868 (PubMed) · PMC5548393 (PubMed Central)
  96. Commotio cordis due to high-velocity projectile ejected from an industrial lawnmower. Montgomery JA, Roden DM (2015) HeartRhythm Case Rep 1(4): 172-175
    › Primary publication · 28491541 (PubMed) · PMC5419247 (PubMed Central)
  97. Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants. Karnes JH, Bastarache L, Shaffer CM, Gaudieri S, Xu Y, Glazer AM, Mosley JD, Zhao S, Raychaudhuri S, Mallal S, Ye Z, Mayer JG, Brilliant MH, Hebbring SJ, Roden DM, Phillips EJ, Denny JC (2017) Sci Transl Med 9(389)
    › Primary publication · 28490672 (PubMed) · PMC5563969 (PubMed Central)
  98. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä I, Malik R, Horimoto ARVR, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen YI, Sandhu RK, Li M, Boerwinkle E, Eisele L, Lannfelt L, Rost N, Anderson CD, Taylor KD, Campbell A, Magnusson PK, Porteous D, Hocking LJ, Vlachopoulou E, Pedersen NL, Nikus K, Orho-Melander M, Hamsten A, Heeringa J, Denny JC, Kriebel J, Darbar D, Newton-Cheh C, Shaffer C, Macfarlane PW, Heilmann-Heimbach S, Almgren P, Huang PL, Sotoodehnia N, Soliman EZ, Uitterlinden AG, Hofman A, Franco OH, Völker U, Jöckel KH, Sinner MF, Lin HJ, Guo X, METASTROKE Consortium of the ISGC, Neurology Working Group of the CHARGE Consortium, Dichgans M, Ingelsson E, Kooperberg C, Melander O, Loos RJF, Laurikka J, Conen D, Rosand J, van der Harst P, Lokki ML, Kathiresan S, Pereira A, Jukema JW, Hayward C, Rotter JI, März W, Lehtimäki T, Stricker BH, Chung MK, Felix SB, Gudnason V, Alonso A, Roden DM, Kääb S, Chasman DI, Heckbert SR, Benjamin EJ, Tanaka T, Lunetta KL, Lubitz SA, Ellinor PT, AFGen Consortium (2017) Nat Genet 49(6): 946-952
    › Primary publication · 28416818 (PubMed) · PMC5585859 (PubMed Central)
  99. Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes. Mosley JD, Shoemaker MB, Wells QS, Darbar D, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Witte JS, Denny JC, Roden DM (2017) Circ Cardiovasc Genet 10(2)
    › Primary publication · 28416512 (PubMed) · PMC5434456 (PubMed Central)
  100. Azithromycin Causes a Novel Proarrhythmic Syndrome. Yang Z, Prinsen JK, Bersell KR, Shen W, Yermalitskaya L, Sidorova T, Luis PB, Hall L, Zhang W, Du L, Milne G, Tucker P, George AL, Campbell CM, Pickett RA, Shaffer CM, Chopra N, Yang T, Knollmann BC, Roden DM, Murray KT (2017) Circ Arrhythm Electrophysiol 10(4)
    › Primary publication · 28408648 (PubMed) · PMC5396181 (PubMed Central)
  101. Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics. Pulley JM, Shirey-Rice JK, Lavieri RR, Jerome RN, Zaleski NM, Aronoff DM, Bastarache L, Niu X, Holroyd KJ, Roden DM, Skaar EP, Niswender CM, Marnett LJ, Lindsley CW, Ekstrom LB, Bentley AR, Bernard GR, Hong CC, Denny JC (2017) Assay Drug Dev Technol 15(3): 113-119
    › Primary publication · 28379727 (PubMed) · PMC5399743 (PubMed Central)
  102. Apolipoprotein L1 Variants and Blood Pressure Traits in African Americans. Nadkarni GN, Galarneau G, Ellis SB, Nadukuru R, Zhang J, Scott SA, Schurmann C, Li R, Rasmussen-Torvik LJ, Kho AN, Hayes MG, Pacheco JA, Manolio TA, Chisholm RL, Roden DM, Denny JC, Kenny EE, Bottinger EP (2017) J Am Coll Cardiol 69(12): 1564-1574
    › Primary publication · 28335839 (PubMed) · PMC5479565 (PubMed Central)
  103. Phenome-wide association studies: a new method for functional genomics in humans. Roden DM (2017) J Physiol 595(12): 4109-4115
    › Primary publication · 28229460 (PubMed) · PMC5471509 (PubMed Central)
  104. Genome-wide study of resistant hypertension identified from electronic health records. Dumitrescu L, Ritchie MD, Denny JC, El Rouby NM, McDonough CW, Bradford Y, Ramirez AH, Bielinski SJ, Basford MA, Chai HS, Peissig P, Carrell D, Pathak J, Rasmussen LV, Wang X, Pacheco JA, Kho AN, Hayes MG, Matsumoto M, Smith ME, Li R, Cooper-DeHoff RM, Kullo IJ, Chute CG, Chisholm RL, Jarvik GP, Larson EB, Carey D, McCarty CA, Williams MS, Roden DM, Bottinger E, Johnson JA, de Andrade M, Crawford DC (2017) PLoS One 12(2): e0171745
    › Primary publication · 28222112 (PubMed) · PMC5319785 (PubMed Central)
  105. Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk: A Pilot Study. Strauss DG, Vicente J, Johannesen L, Blinova K, Mason JW, Weeke P, Behr ER, Roden DM, Woosley R, Kosova G, Rosenberg MA, Newton-Cheh C (2017) Circulation 135(14): 1300-1310
    › Primary publication · 28213480 (PubMed) · PMC5380476 (PubMed Central)
  106. Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy. Zhang B, Novitskaya T, Wheeler DG, Xu Z, Chepurko E, Huttinger R, He H, Varadharaj S, Zweier JL, Song Y, Xu M, Harrell FE, Su YR, Absi T, Kohr MJ, Ziolo MT, Roden DM, Shaffer CM, Galindo CL, Wells QS, Gumina RJ (2017) Circ Heart Fail 10(2)
    › Primary publication · 28209764 (PubMed) · PMC5319711 (PubMed Central)
  107. Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Webb TR, Erdmann J, Stirrups KE, Stitziel NO, Masca NG, Jansen H, Kanoni S, Nelson CP, Ferrario PG, König IR, Eicher JD, Johnson AD, Hamby SE, Betsholtz C, Ruusalepp A, Franzén O, Schadt EE, Björkegren JL, Weeke PE, Auer PL, Schick UM, Lu Y, Zhang H, Dube MP, Goel A, Farrall M, Peloso GM, Won HH, Do R, van Iperen E, Kruppa J, Mahajan A, Scott RA, Willenborg C, Braund PS, van Capelleveen JC, Doney AS, Donnelly LA, Asselta R, Merlini PA, Duga S, Marziliano N, Denny JC, Shaffer C, El-Mokhtari NE, Franke A, Heilmann S, Hengstenberg C, Hoffmann P, Holmen OL, Hveem K, Jansson JH, Jöckel KH, Kessler T, Kriebel J, Laugwitz KL, Marouli E, Martinelli N, McCarthy MI, Van Zuydam NR, Meisinger C, Esko T, Mihailov E, Escher SA, Alver M, Moebus S, Morris AD, Virtamo J, Nikpay M, Olivieri O, Provost S, AlQarawi A, Robertson NR, Akinsansya KO, Reilly DF, Vogt TF, Yin W, Asselbergs FW, Kooperberg C, Jackson RD, Stahl E, Müller-Nurasyid M, Strauch K, Varga TV, Waldenberger M, Wellcome Trust Case Control Consortium, Zeng L, Chowdhury R, Salomaa V, Ford I, Jukema JW, Amouyel P, Kontto J, MORGAM Investigators, Nordestgaard BG, Ferrières J, Saleheen D, Sattar N, Surendran P, Wagner A, Young R, Howson JM, Butterworth AS, Danesh J, Ardissino D, Bottinger EP, Erbel R, Franks PW, Girelli D, Hall AS, Hovingh GK, Kastrati A, Lieb W, Meitinger T, Kraus WE, Shah SH, McPherson R, Orho-Melander M, Melander O, Metspalu A, Palmer CN, Peters A, Rader DJ, Reilly MP, Loos RJ, Reiner AP, Roden DM, Tardif JC, Thompson JR, Wareham NJ, Watkins H, Willer CJ, Samani NJ, Schunkert H, Deloukas P, Kathiresan S, Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators (2017) J Am Coll Cardiol 69(7): 823-836
    › Primary publication · 28209224 (PubMed) · PMC5314135 (PubMed Central)
  108. Comparison of HLA allelic imputation programs. Karnes JH, Shaffer CM, Bastarache L, Gaudieri S, Glazer AM, Steiner HE, Mosley JD, Mallal S, Denny JC, Phillips EJ, Roden DM (2017) PLoS One 12(2): e0172444
    › Primary publication · 28207879 (PubMed) · PMC5312875 (PubMed Central)
  109. Identification of unique venous thromboembolism-susceptibility variants in African-Americans. Heit JA, Armasu SM, McCauley BM, Kullo IJ, Sicotte H, Pathak J, Chute CG, Gottesman O, Bottinger EP, Denny JC, Roden DM, Li R, Ritchie MD, de Andrade M (2017) Thromb Haemost 117(4): 758-768
    › Primary publication · 28203683 (PubMed) · PMC5831339 (PubMed Central)
  110. Torsades de pointes with high-dose loperamide. Kozak PM, Harris AE, McPherson JA, Roden DM (2017) J Electrocardiol 50(3): 355-357
    › Primary publication · 28109524 (PubMed)
  111. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems. Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, O'Donnell PH, Altman RB, Pereira N, Ratain MJ, Roden DM, Embi PJ, Sadee W, Klein TE, Johnson JA, Relling MV, Wang L, Weinshilboum RM, Shuldiner AR, Freimuth RR, Pharmacogenomics Research Network Translational Pharmacogenetics Program (2017) Clin Pharmacol Ther 102(3): 502-510
    › Primary publication · 28090649 (PubMed) · PMC5511786 (PubMed Central)
  112. Pharmacogenetic Implementation Lessons From the "Real World". Roden DM (2017) Clin Pharmacol Ther 102(1): 25-27
    › Primary publication · 27981579 (PubMed) · PMC5474210 (PubMed Central)
  113. PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL, Hyppönen E, Power C, Moldovan M, van Iperen E, Hovingh GK, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Liu T, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott R, Luan J, Bobak M, Malyutina S, Pająk A, Kubinova R, Tamosiunas A, Pikhart H, Husemoen LL, Grarup N, Pedersen O, Hansen T, Linneberg A, Simonsen KS, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Kirchner HL, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H, LifeLines Cohort study group, Christen T, Mook-Kanamori DO, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Smith DJ, Meade T, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Balkau B, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Ridker PM, Chasman DI, Reiner AP, Lange LA, Ritchie MD, Asselbergs FW, Casas JP, Keating BJ, Preiss D, Hingorani AD, UCLEB consortium, Sattar N (2017) Lancet Diabetes Endocrinol 5(2): 97-105
    › Primary publication · 27908689 (PubMed) · PMC5266795 (PubMed Central)
  114. STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION. Wiley LK, Vanhouten JP, Samuels DC, Aldrich MC, Roden DM, Peterson JF, Denny JC (2017) Pac Symp Biocomput : 545-556
    › Primary publication · 27897005 (PubMed) · PMC5389380 (PubMed Central)
  115. On the Potential of Preemptive Genotyping Towards Preventing Medication-Related Adverse Events: Results from the South Korean National Health Insurance Database. Schildcrout JS, Denny JC, Roden DM (2017) Drug Saf 40(1): 1-2
    › Primary publication · 27873192 (PubMed) · PMC5225656 (PubMed Central)
  116. Genomic contributors to atrial electroanatomical remodeling and atrial fibrillation progression: Pathway enrichment analysis of GWAS data. Husser D, Ueberham L, Dinov B, Kosiuk J, Kornej J, Hindricks G, Shoemaker MB, Roden DM, Bollmann A, Büttner P (2016) Sci Rep : 36630
    › Primary publication · 27857207 (PubMed) · PMC5114680 (PubMed Central)
  117. Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart. Stroud DM, Yang T, Bersell K, Kryshtal DO, Nagao S, Shaffer C, Short L, Hall L, Atack TC, Zhang W, Knollmann BC, Baudenbacher F, Roden DM (2016) J Am Heart Assoc 5(11)
    › Primary publication · 27806966 (PubMed) · PMC5210363 (PubMed Central)
  118. Fulminant Myocarditis with Combination Immune Checkpoint Blockade. Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA, Anders RA, Sosman JA, Moslehi JJ (2016) N Engl J Med 375(18): 1749-1755
    › Primary publication · 27806233 (PubMed) · PMC5247797 (PubMed Central)
  119. Genetic Risk Prediction of Atrial Fibrillation. Lubitz SA, Yin X, Lin HJ, Kolek M, Smith JG, Trompet S, Rienstra M, Rost NS, Teixeira PL, Almgren P, Anderson CD, Chen LY, Engström G, Ford I, Furie KL, Guo X, Larson MG, Lunetta KL, Macfarlane PW, Psaty BM, Soliman EZ, Sotoodehnia N, Stott DJ, Taylor KD, Weng LC, Yao J, Geelhoed B, Verweij N, Siland JE, Kathiresan S, Roselli C, Roden DM, van der Harst P, Darbar D, Jukema JW, Melander O, Rosand J, Rotter JI, Heckbert SR, Ellinor PT, Alonso A, Benjamin EJ, AFGen Consortium (2017) Circulation 135(14): 1311-1320
    › Primary publication · 27793994 (PubMed) · PMC5380586 (PubMed Central)
  120. Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data. Mosley JD, van Driest SL, Wells QS, Shaffer CM, Edwards TL, Bastarache L, McCarty CA, Thompson W, Chute CG, Jarvik GP, Crosslin DR, Larson EB, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Linneman JG, Denny JC, Roden DM (2016) Circ Cardiovasc Genet 9(6): 521-530
    › Primary publication · 27780847 (PubMed) · PMC5177499 (PubMed Central)
  121. Transcription factor ETV1 is essential for rapid conduction in the heart. Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, Fishman GI, Park DS (2016) J Clin Invest 126(12): 4444-4459
    › Primary publication · 27775552 (PubMed) · PMC5127680 (PubMed Central)
  122. Editiorial Commentary: Genomics and drug discovery: The next frontier in precision medicine. Roden DM (2017) Trends Cardiovasc Med 27(3): 203-206
    › Primary publication · 27771237 (PubMed)
  123. Finding a Needle in a QT Interval Big Data Haystack: The Role for Orthogonal Datasets. Roden DM, Mosley JD, Denny JC (2016) J Am Coll Cardiol 68(16): 1765-1768
    › Primary publication · 27737743 (PubMed)
  124. Evaluation of a Prediction Model for the Development of Atrial Fibrillation in a Repository of Electronic Medical Records. Kolek MJ, Graves AJ, Xu M, Bian A, Teixeira PL, Shoemaker MB, Parvez B, Xu H, Heckbert SR, Ellinor PT, Benjamin EJ, Alonso A, Denny JC, Moons KG, Shintani AK, Harrell FE, Roden DM, Darbar D (2016) JAMA Cardiol 1(9): 1007-1013
    › Primary publication · 27732699 (PubMed) · PMC5293184 (PubMed Central)
  125. KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting. Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G (2016) Nat Commun : 12795
    › Primary publication · 27731317 (PubMed) · PMC5064022 (PubMed Central)
  126. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association. Mital S, Musunuru K, Garg V, Russell MW, Lanfear DE, Gupta RM, Hickey KT, Ackerman MJ, Perez MV, Roden DM, Woo D, Fox CS, Ware S, American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Stroke Council; Council on Lifestyle and Cardiometabolic Health; and Council on Quality of Care and Outcomes Research (2016) Circ Cardiovasc Genet 9(5): 448-467
    › Primary publication · 27672144 (PubMed)
  127. Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans. Daneshjou R, Cavallari LH, Weeke PE, Karczewski KJ, Drozda K, Perera MA, Johnson JA, Klein TE, Bustamante CD, Roden DM, Shaffer C, Denny JC, Zehnder JL, Altman RB (2016) Mol Genet Genomic Med 4(5): 513-20
    › Primary publication · 27652279 (PubMed) · PMC5023936 (PubMed Central)
  128. Genetic determinants of variability in warfarin response after the dose-titration phase. Iwuchukwu OF, Ramirez AH, Shi Y, Bowton EA, Kawai VK, Schildcrout JS, Roden DM, Denny JC, Stein CM (2016) Pharmacogenet Genomics 26(11): 510-516
    › Primary publication · 27632229 (PubMed) · PMC5300764 (PubMed Central)
  129. Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes. Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, Wilde AA, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue BS, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden DM, Makita N (2016) J Am Heart Assoc 5(9)
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  130. Evaluating electronic health record data sources and algorithmic approaches to identify hypertensive individuals. Teixeira PL, Wei WQ, Cronin RM, Mo H, VanHouten JP, Carroll RJ, LaRose E, Bastarache LA, Rosenbloom ST, Edwards TL, Roden DM, Lasko TA, Dart RA, Nikolai AM, Peissig PL, Denny JC (2017) J Am Med Inform Assoc 24(1): 162-171
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  131. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JD, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM (2016) Clin Pharmacol Ther 100(5): 537-547
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  132. The Future of Cardiovascular Therapeutics. MacRae CA, Roden DM, Loscalzo J (2016) Circulation 133(25): 2610-7
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  134. Partial Duplication and Poly(A) Insertion in KCNQ1 Not Detected by Next-Generation Sequencing in Jervell and Lange-Nielsen Syndrome. Bersell K, Montgomery JA, Kanagasundram AN, Campbell CM, Chung WK, Macaya D, Konecki D, Venter E, Shoemaker MB, Roden DM (2016) Circ Arrhythm Electrophysiol 9(6)
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  135. Pharmacogenetics of Potassium Channel Blockers. Roden DM (2016) Card Electrophysiol Clin 8(2): 385-93
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  136. Phenome-Wide Association Studies as a Tool to Advance Precision Medicine. Denny JC, Bastarache L, Roden DM (2016) Annu Rev Genomics Hum Genet : 353-73
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  137. Identifying genetically driven clinical phenotypes using linear mixed models. Mosley JD, Witte JS, Larkin EK, Bastarache L, Shaffer CM, Karnes JH, Stein CM, Phillips E, Hebbring SJ, Brilliant MH, Mayer J, Ye Z, Roden DM, Denny JC (2016) Nat Commun : 11433
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  138. Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies. Joshi AD, Andersson C, Buch S, Stender S, Noordam R, Weng LC, Weeke PE, Auer PL, Boehm B, Chen C, Choi H, Curhan G, Denny JC, De Vivo I, Eicher JD, Ellinghaus D, Folsom AR, Fuchs C, Gala M, Haessler J, Hofman A, Hu F, Hunter DJ, Janssen HL, Kang JH, Kooperberg C, Kraft P, Kratzer W, Lieb W, Lutsey PL, Darwish Murad S, Nordestgaard BG, Pasquale LR, Reiner AP, Ridker PM, Rimm E, Rose LM, Shaffer CM, Schafmayer C, Tamimi RM, Uitterlinden AG, Völker U, Völzke H, Wakabayashi Y, Wiggs JL, Zhu J, Roden DM, Stricker BH, Tang W, Teumer A, Hampe J, Tybjærg-Hansen A, Chasman DI, Chan AT, Johnson AD (2016) Gastroenterology 151(2): 351-363.e28
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  139. PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability. Kirby JC, Speltz P, Rasmussen LV, Basford M, Gottesman O, Peissig PL, Pacheco JA, Tromp G, Pathak J, Carrell DS, Ellis SB, Lingren T, Thompson WK, Savova G, Haines J, Roden DM, Harris PA, Denny JC (2016) J Am Med Inform Assoc 23(6): 1046-1052
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  140. Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association. Hall JL, Ryan JJ, Bray BE, Brown C, Lanfear D, Newby LK, Relling MV, Risch NJ, Roden DM, Shaw SY, Tcheng JE, Tenenbaum J, Wang TN, Weintraub WS, American Heart Association Professional and Public Education and Publications Committee of the Council on Functional Genomics and Translational Biology, Council on Clinical Cardiology, Council on Epidemiology and Prevention, Council on Quality of Care and Outcomes Research, and Stroke Council (2016) Circ Cardiovasc Genet 9(2): 193-202
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  142. The phenotypic legacy of admixture between modern humans and Neandertals. Simonti CN, Vernot B, Bastarache L, Bottinger E, Carrell DS, Chisholm RL, Crosslin DR, Hebbring SJ, Jarvik GP, Kullo IJ, Li R, Pathak J, Ritchie MD, Roden DM, Verma SS, Tromp G, Prato JD, Bush WS, Akey JM, Denny JC, Capra JA (2016) Science 351(6274): 737-41
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  143. Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network. Bush WS, Crosslin DR, Owusu-Obeng A, Wallace J, Almoguera B, Basford MA, Bielinski SJ, Carrell DS, Connolly JJ, Crawford D, Doheny KF, Gallego CJ, Gordon AS, Keating B, Kirby J, Kitchner T, Manzi S, Mejia AR, Pan V, Perry CL, Peterson JF, Prows CA, Ralston J, Scott SA, Scrol A, Smith M, Stallings SC, Veldhuizen T, Wolf W, Volpi S, Wiley K, Li R, Manolio T, Bottinger E, Brilliant MH, Carey D, Chisholm RL, Chute CG, Haines JL, Hakonarson H, Harley JB, Holm IA, Kullo IJ, Jarvik GP, Larson EB, McCarty CA, Williams MS, Denny JC, Rasmussen-Torvik LJ, Roden DM, Ritchie MD (2016) Clin Pharmacol Ther 100(2): 160-9
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  144. Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records. Van Driest SL, Wells QS, Stallings S, Bush WS, Gordon A, Nickerson DA, Kim JH, Crosslin DR, Jarvik GP, Carrell DS, Ralston JD, Larson EB, Bielinski SJ, Olson JE, Ye Z, Kullo IJ, Abul-Husn NS, Scott SA, Bottinger E, Almoguera B, Connolly J, Chiavacci R, Hakonarson H, Rasmussen-Torvik LJ, Pan V, Persell SD, Smith M, Chisholm RL, Kitchner TE, He MM, Brilliant MH, Wallace JR, Doheny KF, Shoemaker MB, Li R, Manolio TA, Callis TE, Macaya D, Williams MS, Carey D, Kapplinger JD, Ackerman MJ, Ritchie MD, Denny JC, Roden DM (2016) JAMA 315(1): 47-57
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  145. CMTR1 is associated with increased asthma exacerbations in patients taking inhaled corticosteroids. Dahlin A, Denny J, Roden DM, Brilliant MH, Ingram C, Kitchner TE, Linneman JG, Shaffer CM, Weeke P, Xu H, Kubo M, Tamari M, Clemmer GL, Ziniti J, McGeachie MJ, Tantisira KG, Weiss ST, Wu AC (2015) Immun Inflamm Dis 3(4): 350-9
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  146. Physician response to implementation of genotype-tailored antiplatelet therapy. Peterson JF, Field JR, Unertl KM, Schildcrout JS, Johnson DC, Shi Y, Danciu I, Cleator JH, Pulley JM, McPherson JA, Denny JC, Laposata M, Roden DM, Johnson KB (2016) Clin Pharmacol Ther 100(1): 67-74
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  147. Integrating electronic health record genotype and phenotype datasets to transform patient care. Roden DM, Denny JC (2016) Clin Pharmacol Ther 99(3): 298-305
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  148. Predicting drug-induced QT prolongation and torsades de pointes. Roden DM (2016) J Physiol 594(9): 2459-68
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  149. A prognostic model based on readily available clinical data enriched a pre-emptive pharmacogenetic testing program. Schildcrout JS, Shi Y, Danciu I, Bowton E, Field JR, Pulley JM, Basford MA, Gregg W, Cowan JD, Harrell FE, Roden DM, Peterson JF, Denny JC (2016) J Clin Epidemiol : 107-15
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  150. Practical considerations in genomic decision support: The eMERGE experience. Herr TM, Bielinski SJ, Bottinger E, Brautbar A, Brilliant M, Chute CG, Cobb BL, Denny JC, Hakonarson H, Hartzler AL, Hripcsak G, Kannry J, Kohane IS, Kullo IJ, Lin S, Manzi S, Marsolo K, Overby CL, Pathak J, Peissig P, Pulley J, Ralston J, Rasmussen L, Roden DM, Tromp G, Uphoff T, Weng C, Wolf W, Williams MS, Starren J (2015) J Pathol Inform : 50
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  151. CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease. Hoh BL, Gong Y, McDonough CW, Waters MF, Royster AJ, Sheehan TO, Burkley B, Langaee TY, Mocco J, Zuckerman SL, Mummareddy N, Stephens ML, Ingram C, Shaffer CM, Denny JC, Brilliant MH, Kitchner TE, Linneman JG, Roden DM, Johnson JA (2016) J Neurosurg 124(6): 1746-51
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  152. Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding in patients who have undergone percutaneous coronary intervention. Friedman EA, Texeira L, Delaney J, Weeke PE, Lynch DR, Kasasbeh E, Song Y, Harrell FE, Denny JC, Hamm HE, Roden DM, Cleator JH (2016) J Thromb Thrombolysis 41(4): 656-62
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  153. Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network. Gallego CJ, Burt A, Sundaresan AS, Ye Z, Shaw C, Crosslin DR, Crane PK, Fullerton SM, Hansen K, Carrell D, Kuivaniemi H, Derr K, de Andrade M, McCarty CA, Kitchner TE, Ragon BK, Stallings SC, Papa G, Bochenek J, Smith ME, Aufox SA, Pacheco JA, Patel V, Friesema EM, Erwin AL, Gottesman O, Gerhard GS, Ritchie M, Motulsky AG, Kullo IJ, Larson EB, Tromp G, Brilliant MH, Bottinger E, Denny JC, Roden DM, Williams MS, Jarvik GP (2015) Am J Hum Genet 97(4): 512-20
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  154. Desiderata for computable representations of electronic health records-driven phenotype algorithms. Mo H, Thompson WK, Rasmussen LV, Pacheco JA, Jiang G, Kiefer R, Zhu Q, Xu J, Montague E, Carrell DS, Lingren T, Mentch FD, Ni Y, Wehbe FH, Peissig PL, Tromp G, Larson EB, Chute CG, Pathak J, Denny JC, Speltz P, Kho AN, Jarvik GP, Bejan CA, Williams MS, Borthwick K, Kitchner TE, Roden DM, Harris PA (2015) J Am Med Inform Assoc 22(6): 1220-30
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  155. Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia. Karol SE, Yang W, Van Driest SL, Chang TY, Kaste S, Bowton E, Basford M, Bastarache L, Roden DM, Denny JC, Larsen E, Winick N, Carroll WL, Cheng C, Pei D, Fernandez CA, Liu C, Smith C, Loh ML, Raetz EA, Hunger SP, Scheet P, Jeha S, Pui CH, Evans WE, Devidas M, Mattano LA, Relling MV (2015) Blood 126(15): 1770-6
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  156. Attitudes of clinicians following large-scale pharmacogenomics implementation. Peterson JF, Field JR, Shi Y, Schildcrout JS, Denny JC, McGregor TL, Van Driest SL, Pulley JM, Lubin IM, Laposata M, Roden DM, Clayton EW (2016) Pharmacogenomics J 16(4): 393-8
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  157. Cardiovascular pharmacogenomics: current status and future directions. Roden DM (2016) J Hum Genet 61(1): 79-85
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  158. A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, Linneman JG, Brilliant MH, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Baldwin E, Ralston J, Larson EB, Grafton J, Scrol A, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Carey DJ, Ritchie MD, Bradford Y, Verma SS, Chute CG, Veluchamy A, Siddiqui MK, Palmer CN, Doney A, MahmoudPour SH, Maitland-van der Zee AH, Morris AD, Denny JC, Roden DM (2016) Pharmacogenomics J 16(3): 231-7
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  159. Clinical and Genetic Factors Associated with Cutaneous Squamous Cell Carcinoma in Kidney and Heart Transplant Recipients. Sanders ML, Karnes JH, Denny JC, Roden DM, Ikizler TA, Birdwell KA (2015) Transplant Direct 1(4)
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  160. Phenotype-Driven Plasma Biobanking Strategies and Methods. Bowton EA, Collier SP, Wang X, Sutcliffe CB, Van Driest SL, Couch LJ, Herrera M, Jerome RN, Slebos RJ, Alborn WE, Liebler DC, McNaughton CD, Mernaugh RL, Wells QS, Brown NJ, Roden DM, Pulley JM (2015) J Pers Med 5(2): 140-52
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  161. Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action. Sun J, Zhao M, Jia P, Wang L, Wu Y, Iverson C, Zhou Y, Bowton E, Roden DM, Denny JC, Aldrich MC, Xu H, Zhao Z (2015) PLoS Comput Biol 11(6): e1004202
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  162. CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies. McGeachie MJ, Wu AC, Tse SM, Clemmer GL, Sordillo J, Himes BE, Lasky-Su J, Chase RP, Martinez FD, Weeke P, Shaffer CM, Xu H, Denny JC, Roden DM, Panettieri RA, Raby BA, Weiss ST, Tantisira KG (2015) J Allergy Clin Immunol 136(6): 1503-1510
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  163. Global implementation of genomic medicine: We are not alone. Manolio TA, Abramowicz M, Al-Mulla F, Anderson W, Balling R, Berger AC, Bleyl S, Chakravarti A, Chantratita W, Chisholm RL, Dissanayake VH, Dunn M, Dzau VJ, Han BG, Hubbard T, Kolbe A, Korf B, Kubo M, Lasko P, Leego E, Mahasirimongkol S, Majumdar PP, Matthijs G, McLeod HL, Metspalu A, Meulien P, Miyano S, Naparstek Y, O'Rourke PP, Patrinos GP, Rehm HL, Relling MV, Rennert G, Rodriguez LL, Roden DM, Shuldiner AR, Sinha S, Tan P, Ulfendahl M, Ward R, Williams MS, Wong JE, Green ED, Ginsburg GS (2015) Sci Transl Med 7(290): 290ps13
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  164. Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy. Van Driest SL, McGregor TL, Velez Edwards DR, Saville BR, Kitchner TE, Hebbring SJ, Brilliant M, Jouni H, Kullo IJ, Creech CB, Kannankeril PJ, Vear SI, Brothers KB, Bowton EA, Shaffer CM, Patel N, Delaney JT, Bradford Y, Wilson S, Olson LM, Crawford DC, Potts AL, Ho RH, Roden DM, Denny JC (2015) PLoS One 10(6): e0127791
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  165. Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2. Kolder ICRM, Tanck MWT, Postema PG, Barc J, Sinner MF, Zumhagen S, Husemann A, Stallmeyer B, Koopmann TT, Hofman N, Pfeufer A, Lichtner P, Meitinger T, Beckmann BM, Myerburg RJ, Bishopric NH, Roden DM, Kääb S, Wilde AAM, Schott JJ, Schulze-Bahr E, Bezzina CR (2015) Circ Cardiovasc Genet 8(3): 447-456
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  166. Creation and Validation of an EMR-based Algorithm for Identifying Major Adverse Cardiac Events while on Statins. Wei WQ, Feng Q, Weeke P, Bush W, Waitara MS, Iwuchukwu OF, Roden DM, Wilke RA, Stein CM, Denny JC (2014) AMIA Jt Summits Transl Sci Proc : 112-9
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  167. Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study. Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E, Prins BP, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, Ackerman MJ, Haunso S, Leenhardt A, Kääb S, Probst V, Redon R, Sharma S, Wilde A, Tfelt-Hansen J, Schwartz P, Roden DM, Bezzina CR, Olesen M, Darbar D, Guicheney P, Crotti L, UK10K Consortium, Jamshidi Y (2015) Cardiovasc Res 106(3): 520-9
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  168. Common genetic variants and response to atrial fibrillation ablation. Shoemaker MB, Bollmann A, Lubitz SA, Ueberham L, Saini H, Montgomery J, Edwards T, Yoneda Z, Sinner MF, Arya A, Sommer P, Delaney J, Goyal SK, Saavedra P, Kanagasundram A, Whalen SP, Roden DM, Hindricks G, Ellis CR, Ellinor PT, Darbar D, Husser D (2015) Circ Arrhythm Electrophysiol 8(2): 296-302
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  169. The AFFORD clinical decision aid to identify emergency department patients with atrial fibrillation at low risk for 30-day adverse events. Barrett TW, Storrow AB, Jenkins CA, Abraham RL, Liu D, Miller KF, Moser KM, Russ S, Roden DM, Harrell FE, Darbar D (2015) Am J Cardiol 115(6): 763-70
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  170. Replication of Associations with Electrocardio-graphic Traits in African Americans from Clinical and Epidemiologic Studies. Jeff JM, Brown-Gentry K, Goodloe R, Ritchie MD, Denny JC, Kho AN, Armstrong LL, McClellan B, Mayo P, Allen M, Jin H, Gillani NB, Schnetz-Boutaud N, Dilks HH, Basford MA, Pacheco JA, Jarvik GP, Chisholm RL, Roden DM, Hayes MG, Crawford DC (2014) Evol Comput Mach Learn Data Min Bioinform : 939-951
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  171. Genetic and clinical risk prediction model for postoperative atrial fibrillation. Kolek MJ, Muehlschlegel JD, Bush WS, Parvez B, Murray KT, Stein CM, Shoemaker MB, Blair MA, Kor KC, Roden DM, Donahue BS, Fox AA, Shernan SK, Collard CD, Body SC, Darbar D (2015) Circ Arrhythm Electrophysiol 8(1): 25-31
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  172. Multiplex ligation-dependent probe amplification copy number variant analysis in patients with acquired long QT syndrome. Williams VS, Cresswell CJ, Ruspi G, Yang T, Atak TC, McLoughlin M, Ingram CD, Ramirez AH, Roden D, Armstrong M (2015) Europace 17(4): 635-41
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  173. Genotype and risk of major bleeding during warfarin treatment. Kawai VK, Cunningham A, Vear SI, Van Driest SL, Oginni A, Xu H, Jiang M, Li C, Denny JC, Shaffer C, Bowton E, Gage BF, Ray WA, Roden DM, Stein CM (2014) Pharmacogenomics 15(16): 1973-83
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  174. A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record. Karnes JH, Cronin RM, Rollin J, Teumer A, Pouplard C, Shaffer CM, Blanquicett C, Bowton EA, Cowan JD, Mosley JD, Van Driest SL, Weeke PE, Wells QS, Bakchoul T, Denny JC, Greinacher A, Gruel Y, Roden DM (2015) Thromb Haemost 113(4): 772-81
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  175. Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting. Iwuchukwu OF, Feng Q, Wei WQ, Jiang L, Jiang M, Xu H, Denny JC, Wilke RA, Krauss RM, Roden DM, Stein CM (2014) Pharmacogenomics 15(14): 1739-1747
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  176. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013. Van Wagoner DR, Piccini JP, Albert CM, Anderson ME, Benjamin EJ, Brundel B, Califf RM, Calkins H, Chen PS, Chiamvimonvat N, Darbar D, Eckhardt LL, Ellinor PT, Exner DV, Fogel RI, Gillis AM, Healey J, Hohnloser SH, Kamel H, Lathrop DA, Lip GY, Mehra R, Narayan SM, Olgin J, Packer D, Peters NS, Roden DM, Ross HM, Sheldon R, Wehrens XH (2015) Heart Rhythm 12(1): e5-e29
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  177. Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network. Malinowski JR, Denny JC, Bielinski SJ, Basford MA, Bradford Y, Peissig PL, Carrell D, Crosslin DR, Pathak J, Rasmussen L, Pacheco J, Kho A, Newton KM, Li R, Kullo IJ, Chute CG, Chisholm RL, Jarvik GP, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M, Ritchie MD, Crawford DC (2014) PLoS One 9(12): e111301
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  178. Examining rare and low-frequency genetic variants previously associated with lone or familial forms of atrial fibrillation in an electronic medical record system: a cautionary note. Weeke P, Denny JC, Basterache L, Shaffer C, Bowton E, Ingram C, Darbar D, Roden DM (2015) Circ Cardiovasc Genet 8(1): 58-63
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  179. Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs. Roden DM (2014) Card Electrophysiol Clin 6(4): 695-704
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  180. Inactivating mutations in NPC1L1 and protection from coronary heart disease. Myocardial Infarction Genetics Consortium Investigators, Stitziel NO, Won HH, Morrison AC, Peloso GM, Do R, Lange LA, Fontanillas P, Gupta N, Duga S, Goel A, Farrall M, Saleheen D, Ferrario P, König I, Asselta R, Merlini PA, Marziliano N, Notarangelo MF, Schick U, Auer P, Assimes TL, Reilly M, Wilensky R, Rader DJ, Hovingh GK, Meitinger T, Kessler T, Kastrati A, Laugwitz KL, Siscovick D, Rotter JI, Hazen SL, Tracy R, Cresci S, Spertus J, Jackson R, Schwartz SM, Natarajan P, Crosby J, Muzny D, Ballantyne C, Rich SS, O'Donnell CJ, Abecasis G, Sunaev S, Nickerson DA, Buring JE, Ridker PM, Chasman DI, Austin E, Kullo IJ, Weeke PE, Shaffer CM, Bastarache LA, Denny JC, Roden DM, Palmer C, Deloukas P, Lin DY, Tang ZZ, Erdmann J, Schunkert H, Danesh J, Marrugat J, Elosua R, Ardissino D, McPherson R, Watkins H, Reiner AP, Wilson JG, Altshuler D, Gibbs RA, Lander ES, Boerwinkle E, Gabriel S, Kathiresan S (2014) N Engl J Med 371(22): 2072-82
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  181. Electrophysiologic substrate in congenital Long QT syndrome: noninvasive mapping with electrocardiographic imaging (ECGI). Vijayakumar R, Silva JNA, Desouza KA, Abraham RL, Strom M, Sacher F, Van Hare GF, Haïssaguerre M, Roden DM, Rudy Y (2014) Circulation 130(22): 1936-1943
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  182. A polymorphism in HLA-G modifies statin benefit in asthma. Naidoo D, Wu AC, Brilliant MH, Denny J, Ingram C, Kitchner TE, Linneman JG, McGeachie MJ, Roden DM, Shaffer CM, Shah A, Weeke P, Weiss ST, Xu H, Medina MW (2015) Pharmacogenomics J 15(3): 272-7
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  183. Rheumatoid arthritis is associated with IgG antibodies to human endogenous retrovirus gag matrix: a potential pathogenic mechanism of disease? Nelson PN, Roden D, Nevill A, Freimanis GL, Trela M, Ejtehadi HD, Bowman S, Axford J, Veitch AM, Tugnet N, Rylance PB (2014) J Rheumatol 41(10): 1952-60
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  184. Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Cronin RM, Field JR, Bradford Y, Shaffer CM, Carroll RJ, Mosley JD, Bastarache L, Edwards TL, Hebbring SJ, Lin S, Hindorff LA, Crane PK, Pendergrass SA, Ritchie MD, Crawford DC, Pathak J, Bielinski SJ, Carrell DS, Crosslin DR, Ledbetter DH, Carey DJ, Tromp G, Williams MS, Larson EB, Jarvik GP, Peissig PL, Brilliant MH, McCarty CA, Chute CG, Kullo IJ, Bottinger E, Chisholm R, Smith ME, Roden DM, Denny JC (2014) Front Genet : 250
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  185. SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation. Savio-Galimberti E, Weeke P, Muhammad R, Blair M, Ansari S, Short L, Atack TC, Kor K, Vanoye CG, Olesen MS, LuCamp , Yang T, George AL, Roden DM, Darbar D (2014) Cardiovasc Res 104(2): 355-63
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  186. Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality. Xu H, Aldrich MC, Chen Q, Liu H, Peterson NB, Dai Q, Levy M, Shah A, Han X, Ruan X, Jiang M, Li Y, Julien JS, Warner J, Friedman C, Roden DM, Denny JC (2015) J Am Med Inform Assoc 22(1): 179-91
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  187. Size matters: how population size influences genotype-phenotype association studies in anonymized data. Heatherly R, Denny JC, Haines JL, Roden DM, Malin BA (2014) J Biomed Inform : 243-50
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  188. A genome-wide association study to identify genomic modulators of rate control therapy in patients with atrial fibrillation. Kolek MJ, Edwards TL, Muhammad R, Balouch A, Shoemaker MB, Blair MA, Kor KC, Takahashi A, Kubo M, Roden DM, Tanaka T, Darbar D (2014) Am J Cardiol 114(4): 593-600
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  189. eMERGEing progress in genomics-the first seven years. Crawford DC, Crosslin DR, Tromp G, Kullo IJ, Kuivaniemi H, Hayes MG, Denny JC, Bush WS, Haines JL, Roden DM, McCarty CA, Jarvik GP, Ritchie MD (2014) Front Genet : 184
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  190. Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Rasmussen-Torvik LJ, Stallings SC, Gordon AS, Almoguera B, Basford MA, Bielinski SJ, Brautbar A, Brilliant MH, Carrell DS, Connolly JJ, Crosslin DR, Doheny KF, Gallego CJ, Gottesman O, Kim DS, Leppig KA, Li R, Lin S, Manzi S, Mejia AR, Pacheco JA, Pan V, Pathak J, Perry CL, Peterson JF, Prows CA, Ralston J, Rasmussen LV, Ritchie MD, Sadhasivam S, Scott SA, Smith M, Vega A, Vinks AA, Volpi S, Wolf WA, Bottinger E, Chisholm RL, Chute CG, Haines JL, Harley JB, Keating B, Holm IA, Kullo IJ, Jarvik GP, Larson EB, Manolio T, McCarty CA, Nickerson DA, Scherer SE, Williams MS, Roden DM, Denny JC (2014) Clin Pharmacol Ther 96(4): 482-9
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  191. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, Waggott D, Lyytikäinen LP, Hicks AA, Eisele L, Ellinghaus D, Hayward C, Navarro P, Ulivi S, Tanaka T, Tester DJ, Chatel S, Gustafsson S, Kumari M, Morris RW, Naluai ÅT, Padmanabhan S, Kluttig A, Strohmer B, Panayiotou AG, Torres M, Knoflach M, Hubacek JA, Slowikowski K, Raychaudhuri S, Kumar RD, Harris TB, Launer LJ, Shuldiner AR, Alonso A, Bader JS, Ehret G, Huang H, Kao WH, Strait JB, Macfarlane PW, Brown M, Caulfield MJ, Samani NJ, Kronenberg F, Willeit J, CARe Consortium, COGENT Consortium, Smith JG, Greiser KH, Meyer Zu Schwabedissen H, Werdan K, Carella M, Zelante L, Heckbert SR, Psaty BM, Rotter JI, Kolcic I, Polašek O, Wright AF, Griffin M, Daly MJ, DCCT/EDIC, Arnar DO, Hólm H, Thorsteinsdottir U, eMERGE Consortium, Denny JC, Roden DM, Zuvich RL, Emilsson V, Plump AS, Larson MG, O'Donnell CJ, Yin X, Bobbo M, D'Adamo AP, Iorio A, Sinagra G, Carracedo A, Cummings SR, Nalls MA, Jula A, Kontula KK, Marjamaa A, Oikarinen L, Perola M, Porthan K, Erbel R, Hoffmann P, Jöckel KH, Kälsch H, Nöthen MM, HRGEN Consortium, den Hoed M, Loos RJ, Thelle DS, Gieger C, Meitinger T, Perz S, Peters A, Prucha H, Sinner MF, Waldenberger M, de Boer RA, Franke L, van der Vleuten PA, Beckmann BM, Martens E, Bardai A, Hofman N, Wilde AA, Behr ER, Dalageorgou C, Giudicessi JR, Medeiros-Domingo A, Barc J, Kyndt F, Probst V, Ghidoni A, Insolia R, Hamilton RM, Scherer SW, Brandimarto J, Margulies K, Moravec CE, del Greco M F, Fuchsberger C, O'Connell JR, Lee WK, Watt GC, Campbell H, Wild SH, El Mokhtari NE, Frey N, Asselbergs FW, Mateo Leach I, Navis G, van den Berg MP, van Veldhuisen DJ, Kellis M, Krijthe BP, Franco OH, Hofman A, Kors JA, Uitterlinden AG, Witteman JC, Kedenko L, Lamina C, Oostra BA, Abecasis GR, Lakatta EG, Mulas A, Orrú M, Schlessinger D, Uda M, Markus MR, Völker U, Snieder H, Spector TD, Ärnlöv J, Lind L, Sundström J, Syvänen AC, Kivimaki M, Kähönen M, Mononen N, Raitakari OT, Viikari JS, Adamkova V, Kiechl S, Brion M, Nicolaides AN, Paulweber B, Haerting J, Dominiczak AF, Nyberg F, Whincup PH, Hingorani AD, Schott JJ, Bezzina CR, Ingelsson E, Ferrucci L, Gasparini P, Wilson JF, Rudan I, Franke A, Mühleisen TW, Pramstaller PP, Lehtimäki TJ, Paterson AD, Parsa A, Liu Y, van Duijn CM, Siscovick DS, Gudnason V, Jamshidi Y, Salomaa V, Felix SB, Sanna S, Ritchie MD, Stricker BH, Stefansson K, Boyer LA, Cappola TP, Olsen JV, Lage K, Schwartz PJ, Kääb S, Chakravarti A, Ackerman MJ, Pfeufer A, de Bakker PI, Newton-Cheh C (2014) Nat Genet 46(8): 826-36
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  192. The Brugada ECG and schizophrenia. Roden DM (2014) Circ Arrhythm Electrophysiol 7(3): 365-7
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  193. Integrating EMR-linked and in vivo functional genetic data to identify new genotype-phenotype associations. Mosley JD, Van Driest SL, Weeke PE, Delaney JT, Wells QS, Bastarache L, Roden DM, Denny JC (2014) PLoS One 9(6): e100322
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  194. The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update. Ramsey LB, Johnson SG, Caudle KE, Haidar CE, Voora D, Wilke RA, Maxwell WD, McLeod HL, Krauss RM, Roden DM, Feng Q, Cooper-DeHoff RM, Gong L, Klein TE, Wadelius M, Niemi M (2014) Clin Pharmacol Ther 96(4): 423-8
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  195. Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current. Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM (2014) Circulation 130(3): 224-34
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  196. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM (2014) Clin Pharmacol Ther 96(3): 370-9
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  197. Biobanks and electronic medical records: enabling cost-effective research. Bowton E, Field JR, Wang S, Schildcrout JS, Van Driest SL, Delaney JT, Cowan J, Weeke P, Mosley JD, Wells QS, Karnes JH, Shaffer C, Peterson JF, Denny JC, Roden DM, Pulley JM (2014) Sci Transl Med 6(234): 234cm3
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  198. Whole-exome sequencing in familial atrial fibrillation. Weeke P, Muhammad R, Delaney JT, Shaffer C, Mosley JD, Blair M, Short L, Stubblefield T, Roden DM, Darbar D, National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project (2014) Eur Heart J 35(36): 2477-83
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  199. Personalized medicine to treat arrhythmias. Roden DM (2014) Curr Opin Pharmacol : 61-7
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  200. Response to "clinically actionable genotypes among Brazilians". Van Driest SL, Roden DM (2014) Clin Pharmacol Ther 96(1): 26
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  201. Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans. Jeff JM, Armstrong LL, Ritchie MD, Denny JC, Kho AN, Basford MA, Wolf WA, Pacheco JA, Li R, Chisholm RL, Roden DM, Hayes MG, Crawford DC (2014) PLoS One 9(3): e86931
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  202. Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome. Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Roden DM (2014) J Am Coll Cardiol 63(14): 1430-7
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  203. Atrial fibrillation genomics: time to take the next step. Roden DM (2014) J Am Coll Cardiol 63(12): 1211-1213
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  204. Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process. Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, Gong L, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agundez JA, Freimuth RR, Huser V, Lee MT, Iwuchukwu OF, Crews KR, Scott SA, Wadelius M, Swen JJ, Tyndale RF, Stein CM, Roden D, Relling MV, Williams MS, Johnson SG (2014) Curr Drug Metab 15(2): 209-17
    › Primary publication · 24479687 (PubMed) · PMC3977533 (PubMed Central)
  205. Dantrolene: from better bacon to a treatment for ventricular fibrillation. Roden DM, Knollmann BC (2014) Circulation 129(8): 834-6
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  206. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Becker JR, Chatterjee S, Robinson TY, Bennett JS, Panáková D, Galindo CL, Zhong L, Shin JT, Coy SM, Kelly AE, Roden DM, Lim CC, MacRae CA (2014) Development 141(2): 335-45
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  207. Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data. Mosley JD, Van Driest SL, Larkin EK, Weeke PE, Witte JS, Wells QS, Karnes JH, Guo Y, Bastarache L, Olson LM, McCarty CA, Pacheco JA, Jarvik GP, Carrell DS, Larson EB, Crosslin DR, Kullo IJ, Tromp G, Kuivaniemi H, Carey DJ, Ritchie MD, Denny JC, Roden DM (2013) PLoS One 8(12): e81503
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  208. Genetic variation in the β1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery. Jeff JM, Donahue BS, Brown-Gentry K, Roden DM, Crawford DC, Stein CM, Kurnik D (2014) Am Heart J 167(1): 101-108.e1
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  209. Using systems approaches to address challenges for clinical implementation of pharmacogenomics. Karnes JH, Van Driest S, Bowton EA, Weeke PE, Mosley JD, Peterson JF, Denny JC, Roden DM (2014) Wiley Interdiscip Rev Syst Biol Med 6(2): 125-35
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  210. Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients. Oetjens M, Bush WS, Birdwell KA, Dilks HH, Bowton EA, Denny JC, Wilke RA, Roden DM, Crawford DC (2014) Pac Symp Biocomput : 253-64
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  211. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Denny JC, Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM, Ramirez AH, Bowton E, Basford MA, Carrell DS, Peissig PL, Kho AN, Pacheco JA, Rasmussen LV, Crosslin DR, Crane PK, Pathak J, Bielinski SJ, Pendergrass SA, Xu H, Hindorff LA, Li R, Manolio TA, Chute CG, Chisholm RL, Larson EB, Jarvik GP, Brilliant MH, McCarty CA, Kullo IJ, Haines JL, Crawford DC, Masys DR, Roden DM (2013) Nat Biotechnol 31(12): 1102-10
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  212. Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing. Van Driest SL, Shi Y, Bowton EA, Schildcrout JS, Peterson JF, Pulley J, Denny JC, Roden DM (2014) Clin Pharmacol Ther 95(4): 423-31
    › Primary publication · 24253661 (PubMed) · PMC3961508 (PubMed Central)
  213. Characterization of statin dose response in electronic medical records. Wei WQ, Feng Q, Jiang L, Waitara MS, Iwuchukwu OF, Roden DM, Jiang M, Xu H, Krauss RM, Rotter JI, Nickerson DA, Davis RL, Berg RL, Peissig PL, McCarty CA, Wilke RA, Denny JC (2014) Clin Pharmacol Ther 95(3): 331-8
    › Primary publication · 24096969 (PubMed) · PMC3944214 (PubMed Central)
  214. Genomic medicine, precision medicine, personalized medicine: what's in a name? Roden DM, Tyndale RF (2013) Clin Pharmacol Ther 94(2): 169-72
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  215. Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Oetjens MT, Denny JC, Ritchie MD, Gillani NB, Richardson DM, Restrepo NA, Pulley JM, Dilks HH, Basford MA, Bowton E, Masys DR, Wilke RA, Roden DM, Crawford DC (2013) Pharmacogenomics 14(7): 735-44
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  216. Proliferation of embryonic cardiomyocytes in zebrafish requires the sodium channel scn5Lab. Bennett JS, Stroud DM, Becker JR, Roden DM (2013) Genesis 51(8): 562-74
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  217. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation. Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE, Pharmacogenomics Research Network Translational Pharmacogenetics Program Group, Shuldiner AR, Vesely M, Robinson SW, Ambulos N, Stass SA, Kelemen MD, Brown LA, Pollin TI, Beitelshees AL, Zhao RY, Pakyz RE, Palmer K, Alestock T, O'Neill C, Maloney K, Branham A, Sewell D, Relling MV, Crews K, Hoffman J, Cross S, Haidar C, Baker D, Hicks JK, Bell G, Greeson F, Gaur A, Reiss U, Huettel A, Cheng C, Gajjar A, Pappo A, Howard S, Hudson M, Pui CH, Jeha S, Evans WE, Broeckel U, Altman RB, Gong L, Whirl-Carrillo M, Klein TE, Sadee W, Manickam K, Sweet KM, Embi PJ, Roden D, Peterson J, Denny J, Schildcrout J, Bowton E, Pulley J, Beller M, Mitchell J, Danciu I, Price L, Pereira NL, Weinshilboum R, Wang L, Johnson JA, Nelson D, Clare-Salzler M, Elsey A, Burkley B, Langaee T, Liu F, Nessl D, Dong HJ, Lesko L, Freimuth RR, Chute CG (2013) Clin Pharmacol Ther 94(2): 207-10
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  218. Data re-identification: societal safeguards. Altman RB, Clayton EW, Kohane IS, Malin BA, Roden DM (2013) Science 339(6123): 1032-3
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  219. Implementing genomic medicine in the clinic: the future is here. Manolio TA, Chisholm RL, Ozenberger B, Roden DM, Williams MS, Wilson R, Bick D, Bottinger EP, Brilliant MH, Eng C, Frazer KA, Korf B, Ledbetter DH, Lupski JR, Marsh C, Mrazek D, Murray MF, O'Donnell PH, Rader DJ, Relling MV, Shuldiner AR, Valle D, Weinshilboum R, Green ED, Ginsburg GS (2013) Genet Med 15(4): 258-67
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  220. Response to "Doubt about the feasibility of preemptive genotyping". Denny JC, Schildcrout JS, Pulley JM, Roden DM (2013) Clin Pharmacol Ther 93(3): 234
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  221. Cardiovascular pharmacogenomics: the future of cardiovascular therapeutics? Roden DM (2013) Can J Cardiol 29(1): 58-66
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  222. An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1. Yang T, Smith JA, Leake BF, Sanders CR, Meiler J, Roden DM (2013) Mol Pharmacol 83(2): 481-9
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  223. Relation of morbid obesity and female gender to risk of procedural complications in patients undergoing atrial fibrillation ablation. Shoemaker MB, Muhammad R, Farrell M, Parvez B, White BW, Streur M, Stubblefield T, Rytlewski J, Parvathaneni S, Nagarakanti R, Roden DM, Saavedra P, Ellis C, Whalen SP, Darbar D (2013) Am J Cardiol 111(3): 368-73
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  224. Cardiovascular pharmacogenomics: current status and future directions-report of a national heart, lung, and blood institute working group. Musunuru K, Roden DM, Boineau R, Bristow MR, McCaffrey TA, Newton-Cheh C, Paltoo DN, Rosenberg Y, Wohlgemuth JG, Zineh I, Hasan AA (2012) J Am Heart Assoc 1(2): e000554
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  225. Systems biology and cardiac arrhythmias. Grace AA, Roden DM (2012) Lancet 380(9852): 1498-508
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  226. Drug-induced arrhythmia: pharmacogenomic prescribing? Behr ER, Roden D (2013) Eur Heart J 34(2): 89-95
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  227. High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Rasmussen-Torvik LJ, Pacheco JA, Wilke RA, Thompson WK, Ritchie MD, Kho AN, Muthalagu A, Hayes MG, Armstrong LL, Scheftner DA, Wilkins JT, Zuvich RL, Crosslin D, Roden DM, Denny JC, Jarvik GP, Carlson CS, Kullo IJ, Bielinski SJ, McCarty CA, Li R, Manolio TA, Crawford DC, Chisholm RL (2012) Clin Transl Sci 5(5): 394-9
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  228. Leveraging the electronic health record to implement genomic medicine. Kullo IJ, Jarvik GP, Manolio TA, Williams MS, Roden DM (2013) Genet Med 15(4): 270-1
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  229. Strategies for personalized medicine-based research and implementation in the clinical workflow. Lieb W, Völzke H, Pulley JM, Roden DM, Kroemer HK (2012) Clin Pharmacol Ther 92(4): 443-5
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  230. Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation. Ritchie MD, Rowan S, Kucera G, Stubblefield T, Blair M, Carter S, Roden DM, Darbar D (2012) J Am Coll Cardiol 60(13): 1173-81
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  231. The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes. Behr ER, January C, Schulze-Bahr E, Grace AA, Kääb S, Fiszman M, Gathers S, Buckman S, Youssef A, Pirmohamed M, Roden D (2013) Eur Heart J 34(26): 1958-63
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  232. Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation. Parvez B, Vaglio J, Rowan S, Muhammad R, Kucera G, Stubblefield T, Carter S, Roden D, Darbar D (2012) J Am Coll Cardiol 60(6): 539-45
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  233. Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM (2012) Circ Res 111(3): 322-32
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  234. Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia. Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER (2012) J Am Coll Cardiol 60(9): 841-50
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  235. Genetics and cardiovascular disease: a policy statement from the American Heart Association. Ashley EA, Hershberger RE, Caleshu C, Ellinor PT, Garcia JG, Herrington DM, Ho CY, Johnson JA, Kittner SJ, Macrae CA, Mudd-Martin G, Rader DJ, Roden DM, Scholes D, Sellke FW, Towbin JA, Van Eyk J, Worrall BB, American Heart Association Advocacy Coordinating Committee (2012) Circulation 126(1): 142-57
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  236. The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Wilke RA, Ramsey LB, Johnson SG, Maxwell WD, McLeod HL, Voora D, Krauss RM, Roden DM, Feng Q, Cooper-Dehoff RM, Gong L, Klein TE, Wadelius M, Niemi M, Clinical Pharmacogenomics Implementation Consortium (CPIC) (2012) Clin Pharmacol Ther 92(1): 112-7
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  237. Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, Ramirez AH, Delaney JT, Bowton E, Brothers K, Johnson K, Crawford DC, Schildcrout J, Masys DR, Dilks HH, Wilke RA, Clayton EW, Shultz E, Laposata M, McPherson J, Jirjis JN, Roden DM (2012) Clin Pharmacol Ther 92(1): 87-95
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  238. Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes. Ramirez AH, Shaffer CM, Delaney JT, Sexton DP, Levy SE, Rieder MJ, Nickerson DA, George AL, Roden DM (2013) Pharmacogenomics J 13(4): 325-9
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  239. Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice. Lowe JS, Stroud DM, Yang T, Hall L, Atack TC, Roden DM (2012) Cardiovasc Res 95(3): 300-7
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  240. A KCNJ8 mutation associated with early repolarization and atrial fibrillation. Delaney JT, Muhammad R, Blair MA, Kor K, Fish FA, Roden DM, Darbar D (2012) Europace 14(10): 1428-32
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  241. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Ellinor PT, Lunetta KL, Albert CM, Glazer NL, Ritchie MD, Smith AV, Arking DE, Müller-Nurasyid M, Krijthe BP, Lubitz SA, Bis JC, Chung MK, Dörr M, Ozaki K, Roberts JD, Smith JG, Pfeufer A, Sinner MF, Lohman K, Ding J, Smith NL, Smith JD, Rienstra M, Rice KM, Van Wagoner DR, Magnani JW, Wakili R, Clauss S, Rotter JI, Steinbeck G, Launer LJ, Davies RW, Borkovich M, Harris TB, Lin H, Völker U, Völzke H, Milan DJ, Hofman A, Boerwinkle E, Chen LY, Soliman EZ, Voight BF, Li G, Chakravarti A, Kubo M, Tedrow UB, Rose LM, Ridker PM, Conen D, Tsunoda T, Furukawa T, Sotoodehnia N, Xu S, Kamatani N, Levy D, Nakamura Y, Parvez B, Mahida S, Furie KL, Rosand J, Muhammad R, Psaty BM, Meitinger T, Perz S, Wichmann HE, Witteman JC, Kao WH, Kathiresan S, Roden DM, Uitterlinden AG, Rivadeneira F, McKnight B, Sjögren M, Newman AB, Liu Y, Gollob MH, Melander O, Tanaka T, Stricker BH, Felix SB, Alonso A, Darbar D, Barnard J, Chasman DI, Heckbert SR, Benjamin EJ, Gudnason V, Kääb S (2012) Nat Genet 44(6): 670-5
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  242. Relation of the severity of obstructive sleep apnea in response to anti-arrhythmic drugs in patients with atrial fibrillation or atrial flutter. Monahan K, Brewster J, Wang L, Parvez B, Goyal S, Roden DM, Darbar D (2012) Am J Cardiol 110(3): 369-72
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  243. Clopidogrel: a case for indication-specific pharmacogenetics. Johnson JA, Roden DM, Lesko LJ, Ashley E, Klein TE, Shuldiner AR (2012) Clin Pharmacol Ther 91(5): 774-6
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  244. Characterization of genome-wide association-identified variants for atrial fibrillation in African Americans. Delaney JT, Jeff JM, Brown NJ, Pretorius M, Okafor HE, Darbar D, Roden DM, Crawford DC (2012) PLoS One 7(2): e32338
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  245. Genetic determinants of response to cardiovascular drugs. Wells QS, Delaney JT, Roden DM (2012) Curr Opin Cardiol 27(3): 253-61
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  246. Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Ramirez AH, Shi Y, Schildcrout JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M, Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC (2012) Pharmacogenomics 13(4): 407-18
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  247. A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Makita N, Seki A, Sumitomo N, Chkourko H, Fukuhara S, Watanabe H, Shimizu W, Bezzina CR, Hasdemir C, Mugishima H, Makiyama T, Baruteau A, Baron E, Horie M, Hagiwara N, Wilde AA, Probst V, Le Marec H, Roden DM, Mochizuki N, Schott JJ, Delmar M (2012) Circ Arrhythm Electrophysiol 5(1): 163-72
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  248. Modeling drug exposure data in electronic medical records: an application to warfarin. Liu M, Jiang M, Kawai VK, Stein CM, Roden DM, Denny JC, Xu H (2011) AMIA Annu Symp Proc : 815-23
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  249. A common β1-adrenergic receptor polymorphism predicts favorable response to rate-control therapy in atrial fibrillation. Parvez B, Chopra N, Rowan S, Vaglio JC, Muhammad R, Roden DM, Darbar D (2012) J Am Coll Cardiol 59(1): 49-56
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  250. Predicting clopidogrel response using DNA samples linked to an electronic health record. Delaney JT, Ramirez AH, Bowton E, Pulley JM, Basford MA, Schildcrout JS, Shi Y, Zink R, Oetjens M, Xu H, Cleator JH, Jahangir E, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC (2012) Clin Pharmacol Ther 91(2): 257-63
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  251. Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation. Gong IY, Schwarz UI, Crown N, Dresser GK, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Wells PS, Kim RB, Tirona RG (2011) PLoS One 6(11): e27808
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  252. A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Kääb S, Crawford DC, Sinner MF, Behr ER, Kannankeril PJ, Wilde AA, Bezzina CR, Schulze-Bahr E, Guicheney P, Bishopric NH, Myerburg RJ, Schott JJ, Pfeufer A, Beckmann BM, Martens E, Zhang T, Stallmeyer B, Zumhagen S, Denjoy I, Bardai A, Van Gelder IC, Jamshidi Y, Dalageorgou C, Marshall V, Jeffery S, Shakir S, Camm AJ, Steinbeck G, Perz S, Lichtner P, Meitinger T, Peters A, Wichmann HE, Ingram C, Bradford Y, Carter S, Norris K, Ritchie MD, George AL, Roden DM (2012) Circ Cardiovasc Genet 5(1): 91-9
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  253. Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke RA, Rasmussen L, Wang X, Pacheco JA, Kho AN, Hayes MG, Weston N, Matsumoto M, Kopp PA, Newton KM, Jarvik GP, Li R, Manolio TA, Kullo IJ, Chute CG, Chisholm RL, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M (2011) Am J Hum Genet 89(4): 529-42
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  254. Genome-wide assessment for genetic variants associated with ventricular dysfunction after primary coronary artery bypass graft surgery. Fox AA, Pretorius M, Liu KY, Collard CD, Perry TE, Shernan SK, De Jager PL, Hafler DA, Herman DS, DePalma SR, Roden DM, Muehlschlegel JD, Donahue BS, Darbar D, Seidman JG, Body SC, Seidman CE (2011) PLoS One 6(9): e24593
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  255. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, Witte JS, Kwok PY, Roden DM, Wilke RA, McCarty CA, Davis RL, Giacomini KM (2011) Clin Pharmacol Ther 90(5): 674-84
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  256. Cardiovascular pharmacogenomics. Roden DM, Johnson JA, Kimmel SE, Krauss RM, Medina MW, Shuldiner A, Wilke RA (2011) Circ Res 109(7): 807-20
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  257. Pharmacogenomics: application to the management of cardiovascular disease. Johnson JA, Cavallari LH, Beitelshees AL, Lewis JP, Shuldiner AR, Roden DM (2011) Clin Pharmacol Ther 90(4): 519-31
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  258. Pharmacogenetics: call to action. Relling MV, Guchelaar HJ, Roden DM, Klein TE (2011) Clin Pharmacol Ther 90(4): 507; author reply 507-8
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  259. Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro. Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL, Roden DM (2011) Circulation 124(9): 1001-11
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  260. Atrial fibrillation and flutter outcomes and risk determination (AFFORD): design and rationale. Barrett TW, Storrow AB, Jenkins CA, Harrell FE, Miller KF, Moser KM, Russ S, Roden DM, Darbar D (2011) J Cardiol 58(2): 124-30
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  261. Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapy. Gong IY, Tirona RG, Schwarz UI, Crown N, Dresser GK, Larue S, Langlois N, Lazo-Langner A, Zou G, Roden DM, Stein CM, Rodger M, Carrier M, Forgie M, Wells PS, Kim RB (2011) Blood 118(11): 3163-71
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  262. Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapy. Scott SA, Sangkuhl K, Gardner EE, Stein CM, Hulot JS, Johnson JA, Roden DM, Klein TE, Shuldiner AR, Clinical Pharmacogenetics Implementation Consortium (2011) Clin Pharmacol Ther 90(2): 328-32
    › Primary publication · 21716271 (PubMed) · PMC3234301 (PubMed Central)
  263. Refining repolarization reserve. Roden DM, Abraham RL (2011) Heart Rhythm 8(11): 1756-7
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  264. Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC (2011) J Am Med Inform Assoc 18(4): 387-91
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  265. Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels. Tatonetti NP, Denny JC, Murphy SN, Fernald GH, Krishnan G, Castro V, Yue P, Tsao PS, Tsau PS, Kohane I, Roden DM, Altman RB (2011) Clin Pharmacol Ther 90(1): 133-42
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  266. The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions. Pirmohamed M, Aithal GP, Behr E, Daly A, Roden D (2011) Clin Pharmacol Ther 89(6): 784-5
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  267. Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. Turner SD, Berg RL, Linneman JG, Peissig PL, Crawford DC, Denny JC, Roden DM, McCarty CA, Ritchie MD, Wilke RA (2011) PLoS One 6(5): e19586
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  268. Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel. Atack TC, Stroud DM, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM (2011) Circ Res 109(1): 38-46
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  269. Left atrial hypertension after repeated catheter ablations for atrial fibrillation. Shoemaker MB, Hemnes AR, Robbins IM, Langberg JJ, Ellis CR, Aznaurov SG, Fredi JL, Slosky DA, Roden DM, Murray KT, Piana RN, Mendes LA, Whalen SP (2011) J Am Coll Cardiol 57(19): 1918-9
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  270. Pharmacogenomics: the genetics of variable drug responses. Roden DM, Wilke RA, Kroemer HK, Stein CM (2011) Circulation 123(15): 1661-70
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  271. Personalized medicine and the genotype-phenotype dilemma. Roden DM (2011) J Interv Card Electrophysiol 31(1): 17-23
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  272. Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers. Kannankeril PJ, Norris KJ, Carter S, Roden DM (2011) Heart Rhythm 8(10): 1530-4
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  273. A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Holm H, Gudbjartsson DF, Sulem P, Masson G, Helgadottir HT, Zanon C, Magnusson OT, Helgason A, Saemundsdottir J, Gylfason A, Stefansdottir H, Gretarsdottir S, Matthiasson SE, Thorgeirsson GM, Jonasdottir A, Sigurdsson A, Stefansson H, Werge T, Rafnar T, Kiemeney LA, Parvez B, Muhammad R, Roden DM, Darbar D, Thorleifsson G, Walters GB, Kong A, Thorsteinsdottir U, Arnar DO, Stefansson K (2011) Nat Genet 43(4): 316-20
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  274. Pharmacogenomics at the tipping point: challenges and opportunities. Roden DM, Tyndale RF (2011) Clin Pharmacol Ther 89(3): 323-7
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  275. SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study. Jeff JM, Brown-Gentry K, Buxbaum SG, Sarpong DF, Taylor HA, George AL, Roden DM, Crawford DC (2011) Circ Cardiovasc Genet 4(2): 139-44
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  276. The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. McCarty CA, Chisholm RL, Chute CG, Kullo IJ, Jarvik GP, Larson EB, Li R, Masys DR, Ritchie MD, Roden DM, Struewing JP, Wolf WA, eMERGE Team (2011) BMC Med Genomics : 13
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  277. The emerging role of electronic medical records in pharmacogenomics. Wilke RA, Xu H, Denny JC, Roden DM, Krauss RM, McCarty CA, Davis RL, Skaar T, Lamba J, Savova G (2011) Clin Pharmacol Ther 89(3): 379-86
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  278. Genetic testing in subjects with no clinical abnormality: the tip of a huge iceberg. Roden DM (2011) J Am Coll Cardiol 57(1): 60-2
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  279. Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop. Fishman GI, Chugh SS, Dimarco JP, Albert CM, Anderson ME, Bonow RO, Buxton AE, Chen PS, Estes M, Jouven X, Kwong R, Lathrop DA, Mascette AM, Nerbonne JM, O'Rourke B, Page RL, Roden DM, Rosenbaum DS, Sotoodehnia N, Trayanova NA, Zheng ZJ (2010) Circulation 122(22): 2335-48
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  280. Visual integration of results from a large DNA biobank (BioVU) using synthesis-view. Pendergrass S, Dudek SM, Roden DM, Crawford DC, Ritchie MD (2011) Pac Symp Biocomput : 265-75
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  281. Pharmacogenomics: will the promise be fulfilled? Altman RB, Kroemer HK, McCarty CA, Ratain MJ, Roden D (2011) Nat Rev Genet 12(1): 69-73
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  282. Drug-induced long QT syndrome. Kannankeril P, Roden DM, Darbar D (2010) Pharmacol Rev 62(4): 760-81
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  283. Prospective, population-based long QT molecular autopsy study of postmortem negative sudden death in 1 to 40 year olds. Skinner JR, Crawford J, Smith W, Aitken A, Heaven D, Evans CA, Hayes I, Neas KR, Stables S, Koelmeyer T, Denmark L, Vuletic J, Maxwell F, White K, Yang T, Roden DM, Leren TP, Shelling A, Love DR, Cardiac Inherited Disease Group New Zealand (2011) Heart Rhythm 8(3): 412-9
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  284. Modulators of normal electrocardiographic intervals identified in a large electronic medical record. Ramirez AH, Schildcrout JS, Blakemore DL, Masys DR, Pulley JM, Basford MA, Roden DM, Denny JC (2011) Heart Rhythm 8(2): 271-7
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  285. Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Dumitrescu L, Ritchie MD, Brown-Gentry K, Pulley JM, Basford M, Denny JC, Oksenberg JR, Roden DM, Haines JL, Crawford DC (2010) Genet Med 12(10): 648-50
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  286. A clinical prediction model to estimate risk for 30-day adverse events in emergency department patients with symptomatic atrial fibrillation. Barrett TW, Martin AR, Storrow AB, Jenkins CA, Harrell FE, Russ S, Roden DM, Darbar D (2011) Ann Emerg Med 57(1): 1-12
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  287. Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Bezzina CR, Pazoki R, Bardai A, Marsman RF, de Jong JSSG, Blom MT, Scicluna BP, Jukema JW, Bindraban NR, Lichtner P, Pfeufer A, Bishopric NH, Roden DM, Meitinger T, Chugh SS, Myerburg RJ, Jouven X, Kääb S, Dekker LRC, Tan HL, Tanck MWT, Wilde AAM (2010) Nat Genet 42(8): 688-691
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  288. Responding to the clopidogrel warning by the US food and drug administration: real life is complicated. Roden DM, Shuldiner AR (2010) Circulation 122(5): 445-8
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  289. Principles of human subjects protections applied in an opt-out, de-identified biobank. Pulley J, Clayton E, Bernard GR, Roden DM, Masys DR (2010) Clin Transl Sci 3(1): 42-8
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  290. Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM (2010) Am J Hum Genet 86(4): 560-72
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  291. Voltage-gated sodium channels are required for heart development in zebrafish. Chopra SS, Stroud DM, Watanabe H, Bennett JS, Burns CG, Wells KS, Yang T, Zhong TP, Roden DM (2010) Circ Res 106(8): 1342-50
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  292. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W, American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, Council on Cardiovascular Nursing, American College of Cardiology Foundation (2010) J Am Coll Cardiol 55(9): 934-47
    › Primary publication · 20185054 (PubMed) · PMC3057430 (PubMed Central)
  293. Common variants in KCNN3 are associated with lone atrial fibrillation. Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA, Fox E, Darbar D, Smith NL, Smith JD, Schnabel RB, Soliman EZ, Rice KM, Van Wagoner DR, Beckmann BM, van Noord C, Wang K, Ehret GB, Rotter JI, Hazen SL, Steinbeck G, Smith AV, Launer LJ, Harris TB, Makino S, Nelis M, Milan DJ, Perz S, Esko T, Köttgen A, Moebus S, Newton-Cheh C, Li M, Möhlenkamp S, Wang TJ, Kao WH, Vasan RS, Nöthen MM, MacRae CA, Stricker BH, Hofman A, Uitterlinden AG, Levy D, Boerwinkle E, Metspalu A, Topol EJ, Chakravarti A, Gudnason V, Psaty BM, Roden DM, Meitinger T, Wichmann HE, Witteman JC, Barnard J, Arking DE, Benjamin EJ, Heckbert SR, Kääb S (2010) Nat Genet 42(3): 240-4
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  294. KCNH2 pharmacogenomics summary. Oshiro C, Thorn CF, Roden DM, Klein TE, Altman RB (2010) Pharmacogenet Genomics 20(12): 775-7
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  295. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W, American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology, the Council on Cardiovascular Nursing, and the American College of Cardiology Foundation (2010) Circulation 121(8): 1047-60
    › Primary publication · 20142454 (PubMed) · PMC3056123 (PubMed Central)
  296. Brugada syndrome: lots of questions, some answers. Roden DM (2010) Heart Rhythm 7(1): 47-9
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  297. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Body SC, Collard CD, Shernan SK, Fox AA, Liu KY, Ritchie MD, Perry TE, Muehlschlegel JD, Aranki S, Donahue BS, Pretorius M, Estrada JC, Ellinor PT, Newton-Cheh C, Seidman CE, Seidman JG, Herman DS, Lichtner P, Meitinger T, Pfeufer A, Kääb S, Brown NJ, Roden DM, Darbar D (2009) Circ Cardiovasc Genet 2(5): 499-506
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  298. Arrhythmia pharmacogenomics: methodological considerations. Roden DM, Kannankeri PJ, Darbar D (2009) Curr Pharm Des 15(32): 3734-41
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  299. Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome. Yang T, Chung SK, Zhang W, Mullins JG, McCulley CH, Crawford J, MacCormick J, Eddy CA, Shelling AN, French JK, Yang P, Skinner JR, Roden DM, Rees MI (2009) Circ Arrhythm Electrophysiol 2(4): 417-26
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  300. Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM (2009) Circ Arrhythm Electrophysiol 2(3): 268-75
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  301. Close bidirectional relationship between chronic kidney disease and atrial fibrillation: the Niigata preventive medicine study. Watanabe H, Watanabe T, Sasaki S, Nagai K, Roden DM, Aizawa Y (2009) Am Heart J 158(4): 629-36
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  302. Cardiovascular effects of noncardiovascular drugs. Raj SR, Stein CM, Saavedra PJ, Roden DM (2009) Circulation 120(12): 1123-32
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  303. Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (www.brugadadrugs.org). Postema PG, Wolpert C, Amin AS, Probst V, Borggrefe M, Roden DM, Priori SG, Tan HL, Hiraoka M, Brugada J, Wilde AA (2009) Heart Rhythm 6(9): 1335-41
    › Primary publication · 19716089 (PubMed) · PMC2779019 (PubMed Central)
  304. Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization. Milan DJ, Kim AM, Winterfield JR, Jones IL, Pfeufer A, Sanna S, Arking DE, Amsterdam AH, Sabeh KM, Mably JD, Rosenbaum DS, Peterson RT, Chakravarti A, Kääb S, Roden DM, MacRae CA (2009) Circulation 120(7): 553-9
    › Primary publication · 19652097 (PubMed) · PMC2771327 (PubMed Central)
  305. ACE I/D polymorphism associated with abnormal atrial and atrioventricular conduction in lone atrial fibrillation and structural heart disease: implications for electrical remodeling. Watanabe H, Kaiser DW, Makino S, MacRae CA, Ellinor PT, Wasserman BS, Kannankeril PJ, Donahue BS, Roden DM, Darbar D (2009) Heart Rhythm 6(9): 1327-32
    › Primary publication · 19648063 (PubMed) · PMC2740737 (PubMed Central)
  306. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Gudbjartsson DF, Holm H, Gretarsdottir S, Thorleifsson G, Walters GB, Thorgeirsson G, Gulcher J, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Kucera G, Stubblefield T, Carter S, Roden D, Ng MC, Baum L, So WY, Wong KS, Chan JC, Gieger C, Wichmann HE, Gschwendtner A, Dichgans M, Kuhlenbäumer G, Berger K, Ringelstein EB, Bevan S, Markus HS, Kostulas K, Hillert J, Sveinbjörnsdóttir S, Valdimarsson EM, Løchen ML, Ma RC, Darbar D, Kong A, Arnar DO, Thorsteinsdottir U, Stefansson K (2009) Nat Genet 41(8): 876-8
    › Primary publication · 19597491 (PubMed) · PMC2740741 (PubMed Central)
  307. Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Bush WS, Crawford DC, Alexander C, George AL, Roden DM, Ritchie MD (2009) Pharmacogenomics 10(6): 1043-53
    › Primary publication · 19530973 (PubMed) · PMC2746955 (PubMed Central)
  308. The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM (2009) J Cardiovasc Pharmacol 54(1): 63-71
    › Primary publication · 19528813 (PubMed) · PMC3745652 (PubMed Central)
  309. Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac I(Ks) block by protein kinase A-mediated I(Ks) phosphorylation. Yang T, Kanki H, Zhang W, Roden DM (2009) Br J Pharmacol 157(6): 952-61
    › Primary publication · 19522859 (PubMed) · PMC2737654 (PubMed Central)
  310. Clopidogrel and the concept of high-risk pharmacokinetics. Roden DM, Stein CM (2009) Circulation 119(16): 2127-30
    › Primary publication · 19398674 (PubMed)
  311. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC (2009) Nat Med 15(4): 380-3
    › Primary publication · 19330009 (PubMed) · PMC2904954 (PubMed Central)
  312. A genotype-dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation genotype ECG-phenotype correlation in atrial fibrillation. Husser D, Stridh M, Sörnmo L, Roden DM, Darbar D, Bollmann A (2009) Circ Arrhythm Electrophysiol 2(1): 24-8
    › Primary publication · 19305639 (PubMed) · PMC2658819 (PubMed Central)
  313. Estimation of the warfarin dose with clinical and pharmacogenetic data. International Warfarin Pharmacogenetics Consortium, Klein TE, Altman RB, Eriksson N, Gage BF, Kimmel SE, Lee MT, Limdi NA, Page D, Roden DM, Wagner MJ, Caldwell MD, Johnson JA (2009) N Engl J Med 360(8): 753-64
    › Primary publication · 19228618 (PubMed) · PMC2722908 (PubMed Central)
  314. Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Kääb S, Darbar D, van Noord C, Dupuis J, Pfeufer A, Newton-Cheh C, Schnabel R, Makino S, Sinner MF, Kannankeril PJ, Beckmann BM, Choudry S, Donahue BS, Heeringa J, Perz S, Lunetta KL, Larson MG, Levy D, MacRae CA, Ruskin JN, Wacker A, Schömig A, Wichmann HE, Steinbeck G, Meitinger T, Uitterlinden AG, Witteman JC, Roden DM, Benjamin EJ, Ellinor PT (2009) Eur Heart J 30(7): 813-9
    › Primary publication · 19141561 (PubMed) · PMC2663727 (PubMed Central)
  315. Repolarization reserve: a moving target. Roden DM (2008) Circulation 118(10): 981-2
    › Primary publication · 18765386 (PubMed)
  316. Keep the QT interval: it is a reliable predictor of ventricular arrhythmias. Roden DM (2008) Heart Rhythm 5(8): 1213-5
    › Primary publication · 18675237 (PubMed) · PMC3212752 (PubMed Central)
  317. Rate-independent QT shortening during exercise in healthy subjects: terminal repolarization does not shorten with exercise. Kannankeril PJ, Harris PA, Norris KJ, Warsy I, Smith PD, Roden DM (2008) J Cardiovasc Electrophysiol 19(12): 1284-8
    › Primary publication · 18665873 (PubMed) · PMC2811883 (PubMed Central)
  318. International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes. Bass AS, Darpo B, Breidenbach A, Bruse K, Feldman HS, Garnes D, Hammond T, Haverkamp W, January C, Koerner J, Lawrence C, Leishman D, Roden D, Valentin JP, Vos MA, Zhou YY, Karluss T, Sager P (2008) Br J Pharmacol 154(7): 1491-501
    › Primary publication · 18663380 (PubMed) · PMC2492102 (PubMed Central)
  319. Cellular basis of drug-induced torsades de pointes. Roden DM (2008) Br J Pharmacol 154(7): 1502-7
    › Primary publication · 18552874 (PubMed) · PMC2492095 (PubMed Central)
  320. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Cooper GM, Johnson JA, Langaee TY, Feng H, Stanaway IB, Schwarz UI, Ritchie MD, Stein CM, Roden DM, Smith JD, Veenstra DL, Rettie AE, Rieder MJ (2008) Blood 112(4): 1022-7
    › Primary publication · 18535201 (PubMed) · PMC2515139 (PubMed Central)
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Keywords & MeSH Terms

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Key: MeSH Term Keyword

Acute Kidney Injury Adult Antibodies, Monoclonal Antineoplastic Agents Antipsychotic Agents Apolipoprotein L1 Atrial Natriuretic Factor Calcium Conserved Sequence Coronary Thrombosis Data Interpretation, Statistical Drug Evaluation, Preclinical Drug Prescriptions Ether-A-Go-Go Potassium Channels Evolution, Molecular Flecainide Genotype Heart Failure, Diastolic Hemostasis Heterozygote Histamine Antagonists Inheritance Patterns Mixed Function Oxygenases Multiplex Polymerase Chain Reaction Mutation, Missense Polypharmacy Population Groups Proto-Oncogene Proteins c-akt Receptors, G-Protein-Coupled Retrospective Studies