Chin Chiang, Ph.D

Official Affiliation: Cell and Developmental Biology

Profile

Our research is focused on Sonic hedgehog (Shh) signaling in development and cancer. We study how Shh protein distribution and signaling are regulated and how this regulation affects the identity and number of neural progenitors/stem cells in the central nervous system. We use stem cell cultures and mouse genetics to address these crucial questions, with emphasis on 1) neural stem cells/progenitors involved in the establishment of the brain circuitry and 2) tumor stem cells in the initiation and progression of pediatric tumors.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Insight into the Etiology of Undifferentiated Soft Tissue Sarcomas from a Novel Mouse Model. Fleming JT, Brignola E, Chen L, Guo Y, Zhao S, Wang Q, Li B, Correa H, Ermilov AN, Dlugosz AA, Chiang C (2019) Mol Cancer Res 17(5): 1024-1035
    › Primary publication · 30683671 (PubMed) · PMC6497566 (PubMed Central)
  2. Bergmann glial Sonic hedgehog signaling activity is required for proper cerebellar cortical expansion and architecture. Cheng FY, Fleming JT, Chiang C (2018) Dev Biol 440(2): 152-166
    › Primary publication · 29792854 (PubMed) · PMC6014626 (PubMed Central)
  3. Lkb1 regulates granule cell migration and cortical folding of the cerebellar cortex. Ryan KE, Kim PS, Fleming JT, Brignola E, Cheng FY, Litingtung Y, Chiang C (2017) Dev Biol 432(1): 165-177
    › Primary publication · 28974424 (PubMed) · PMC5694378 (PubMed Central)
  4. The Purkinje neuron: A central orchestrator of cerebellar neurogenesis. Fleming J, Chiang C (2015) Neurogenesis (Austin) 2(1): e1025940
    › Primary publication · 27604220 (PubMed) · PMC4973588 (PubMed Central)
  5. BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma. Loganathan SN, Tang N, Fleming JT, Ma Y, Guo Y, Borinstein SC, Chiang C, Wang J (2016) Oncotarget 7(28): 43504-43517
    › Primary publication · 27259270 (PubMed) · PMC5190040 (PubMed Central)
  6. Consensus Paper: Cerebellar Development. Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerková G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawkes R (2016) Cerebellum 15(6): 789-828
    › Primary publication · 26439486 (PubMed) · PMC4846577 (PubMed Central)
  7. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC (2015) Cell Rep 11(1): 43-50
    › Primary publication · 25818300 (PubMed) · PMC4394042 (PubMed Central)
  8. Controlling COR competence: BCL-6 regulates neurogenesis and tumor suppression. Chiang C, Ihrie RA (2014) Cancer Cell 26(6): 773-774
    › Primary publication · 25490438 (PubMed)
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Featured Affiliation

  • Chiang Lab
    Professor of Cell and Developmental Biol
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Contact Information

4110 MRB III
465 21st Avenue South
Nashville, TN 37232-8240
United States
615-343-4922 (p)
615-343-4539 (f)
Email

Keywords & MeSH Terms

MeSH terms are retrieved from PubMed records. Learn more.

Key: MeSH Term Keyword

Apoptosis brain circuitry brain tumors cancer Cell Lineage central nervous system Cilia Culture Media, Serum-Free development Disease Models, Animal Endoderm Extracellular Signal-Regulated MAP Kinases Fetus Fibroblast Growth Factor 8 Flow Cytometry Gene Expression Regulation, Neoplastic Hippocampus Homeodomain Proteins Humans LIM-Homeodomain Proteins Lymphocytes MAP Kinase Kinase Kinases medulloblastoma Mutation Myelin Sheath neural progenitors neural progenitors/stem cells Neurons Oxazoles Rahbdomyosarcoma Rats Receptors, Cell Surface Resting Phase, Cell Cycle RNA-Binding Protein EWS Sarcoma Sarcoma Sonic hedgehog Stress, Physiological Trachea Tracheal Diseases Transplantation, Heterologous tumor stem cells Up-Regulation