No cell can survive or act without the appropriate nutrients and metabolic program. There has been a growing appreciation that metabolism is intimately linked to nearly all aspects of cell function and fate. The field of immunometabolism aims to understand how metabolic pathways are regulated in immune cells, how specific metabolic programs alter immune function, and how immunity in turn may influence metabolism. The Rathmell lab focuses on how metabolic pathways influence the function and fate of lymphocytes in inflammatory diseases, anti-tumor immunity, and in leukemia. Our work is highly interdisciplinary and involves the fields of immunology, cancer biology, and cell metabolism. Ultimately the goals of these projects are to exploit the specific metabolic programs of each cell type or activation state to selectively impact effector lymphocytes in inflammatory diseases and cancer.
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Key: MeSH Term KeywordAnimals Antineoplastic Agents, Immunological CD8-Positive T-Lymphocytes Cell Differentiation Cell Line, Tumor Glucose Glucose Transporter Type 1 Glut1 Glutaminase Glycolysis Hepatitis A Virus Cellular Receptor 2 Humans Immunoglobulin G Immunotherapy, Adoptive inflammation Lymphocyte Activation Lymphocytes, Tumor-Infiltrating Male Melanoma metabolism Mice Mice, Inbred C57BL Mice, Transgenic Phosphopyruvate Hydratase Programmed Cell Death 1 Receptor T cell Th1 Cells Th17 Cells tumor immunology