My basic research focuses on the clinical and molecular pharmacology of adenosine, and its role in normal physiology and disease states. In particular, we are interested in the role of adenosine A2B receptors in pulmonary (inflammation, asthma) and cardiovascular (angiogenesis, cell base therapies) disorders. Our studies vary from whole animal studies, inclusing genetic ablation models, to cell cultures and intracellular pathways. Our ultimate goal is to develop therapies that target adenosine receptors.


The following timeline graph is generated from all co-authored publications.

  1. Renal impairment of pure autonomic failure. Garland EM, Gamboa A, Okamoto L, Raj SR, Black BK, Davis TL, Biaggioni I, Robertson D (2009) Hypertension 54(5): 1057-61
    › Primary publication · 19738158 (PubMed) · PMC2796115 (PubMed Central)
  2. Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more. Raj SR, Black BK, Biaggioni I, Paranjape SY, Ramirez M, Dupont WD, Robertson D (2009) Circulation 120(9): 725-34
    › Primary publication · 19687359 (PubMed) · PMC2758650 (PubMed Central)
  3. Adenosine receptors in wound healing, fibrosis and angiogenesis. Feoktistov I, Biaggioni I, Cronstein BN (2009) Handb Exp Pharmacol (193): 383-97
    › Primary publication · 19639289 (PubMed) · PMC3729032 (PubMed Central)
  4. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout mice. Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS, Biaggioni I, Feoktistov I (2010) Am J Respir Cell Mol Biol 42(5): 564-71
    › Primary publication · 19556606 (PubMed) · PMC2874442 (PubMed Central)
  5. Differential role of the carboxy-terminus of the A(2B) adenosine receptor in stimulation of adenylate cyclase, phospholipase Cbeta, and interleukin-8. Ryzhov S, Zaynagetdinov R, Goldstein AE, Matafonov A, Biaggioni I, Feoktistov I (2009) Purinergic Signal 5(3): 289-98
    › Primary publication · 19125355 (PubMed) · PMC2717310 (PubMed Central)
  6. Nocturnal blood pressure dipping in the hypertension of autonomic failure. Okamoto LE, Gamboa A, Shibao C, Black BK, Diedrich A, Raj SR, Robertson D, Biaggioni I (2009) Hypertension 53(2): 363-9
    › Primary publication · 19047577 (PubMed) · PMC2665259 (PubMed Central)
  7. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ, JUPITER Study Group (2008) N Engl J Med 359(21): 2195-207
    › Primary publication · 18997196 (PubMed)
  8. Psychiatric profile and attention deficits in postural tachycardia syndrome. Raj V, Haman KL, Raj SR, Byrne D, Blakely RD, Biaggioni I, Robertson D, Shelton RC (2009) J Neurol Neurosurg Psychiatry 80(3): 339-44
    › Primary publication · 18977825 (PubMed) · PMC2758320 (PubMed Central)
  9. Circadian clocks, autonomic rhythms, and blood pressure dipping. Biaggioni I (2008) Hypertension 52(5): 797-8
    › Primary publication · 18779437 (PubMed) · PMC2692022 (PubMed Central)
  10. Host A(2B) adenosine receptors promote carcinoma growth. Ryzhov S, Novitskiy SV, Zaynagetdinov R, Goldstein AE, Carbone DP, Biaggioni I, Dikov MM, Feoktistov I (2008) Neoplasia 10(9): 987-95
    › Primary publication · 18714400 (PubMed) · PMC2517644 (PubMed Central)