Dr. Crofford is a native of Nashville, TN and a graduate of VanderbiltUniversity and the University of Tennessee Center for the Health Sciences.  She served her internship and residency in Internal Medicine at WashingtonUniversity’s BarnesHospital.  Following training in Internal Medicine, she pursed research and clinical fellowships in Molecular Genetics and Rheumatology at the National Institutes of Health.  She joined the faculty of the University of Michigan in 1993 as Assistant Professor and rose to the rank of Professor in 2004.  She relocated to the University of Kentucky in 2004 as Gloria W. Singletary Professor of Internal Medicine, Chief of the Division of Rheumatology, and Director of the Center for the Advancement of Women’s Health.  She moved to Vanderbilt University in 2013 as Professor of Medicine in the Division of Rheumatology & Immunology 

Dr. Crofford’s research is focused on understanding inflammation, pain, and stress as mediators of rheumatic diseases.  She is best known for her work to define the role of prostaglandins in inflammatory arthritis.  She has maintained active research support the National Institutes of Health, Arthritis Foundation, and industry sources throughout her career.  More than 150 journal articles and book chapters have been published as a result of her research. 

Dr. Crofford is a past president of the American College of Rheumatology Research and Education Foundation.  She previously served on the American Board of Internal Medicine for Rheumatology.  Dr. Crofford served on the Advisory Council to the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health.  


The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Transcutaneous Electrical Nerve Stimulation Reduces Movement-Evoked Pain and Fatigue: A Randomized, Controlled Trial. Dailey DL, Vance CGT, Rakel BA, Zimmerman MB, Embree J, Merriwether EN, Geasland KM, Chimenti R, Williams JM, Golchha M, Crofford LJ, Sluka KA (2020) Arthritis Rheumatol 72(5): 824-836
    › Primary publication · 31738014 (PubMed) · PMC7188591 (PubMed Central)
  2. mPGES-1-Mediated Production of PGE and EP4 Receptor Sensing Regulate T Cell Colonic Inflammation. Maseda D, Banerjee A, Johnson EM, Washington MK, Kim H, Lau KS, Crofford LJ (2018) Front Immunol : 2954
    › Primary publication · 30619314 (PubMed) · PMC6302013 (PubMed Central)
  3. The Effects of Pain Severity, Pain Catastrophizing, Depression, and Exercise on Perceived Disability in Acute Low Back Pain Patients. Salt E, Wiggins AT, Hooker Q, Crofford L, Rayens MK, Segerstrom S (2018) Res Theory Nurs Pract 32(4): 436-448
    › Primary publication · 30567914 (PubMed)
  4. Phenome-wide association study identifies dsDNA as a driver of major organ involvement in systemic lupus erythematosus. Barnado A, Carroll RJ, Casey C, Wheless L, Denny JC, Crofford LJ (2019) Lupus 28(1): 66-76
    › Primary publication · 30477398 (PubMed) · PMC6389392 (PubMed Central)
  5. AAPT Diagnostic Criteria for Fibromyalgia. Arnold LM, Bennett RM, Crofford LJ, Dean LE, Clauw DJ, Goldenberg DL, Fitzcharles MA, Paiva ES, Staud R, Sarzi-Puttini P, Buskila D, Macfarlane GJ (2019) J Pain 20(6): 611-628
    › Primary publication · 30453109 (PubMed)
  6. Reply. Wilfong EM, Bayram KW, Crofford LJ (2019) Arthritis Rheumatol 71(4): 652-653
    › Primary publication · 30452119 (PubMed) · PMC6438712 (PubMed Central)
  7. Posttraumatic stress disorder in interstitial cystitis/bladder pain syndrome: Relationship to patient phenotype and clinical practice implications. McKernan LC, Johnson BN, Reynolds WS, Williams DA, Cheavens JS, Dmochowski RR, Crofford LJ (2019) Neurourol Urodyn 38(1): 353-362
    › Primary publication · 30350890 (PubMed) · PMC6310618 (PubMed Central)
  8. The Relationship Between Life Purpose With Depression and Disability in Acute Low Back Pain Patients. Salt E, Wiggins AC, Rayens MK, Johnson R, Hardy JK, Segerstrom S, Crofford LJ (2018) Orthop Nurs 37(5): 287-291
    › Primary publication · 30247411 (PubMed) · PMC6154802 (PubMed Central)
  9. Outpatient Engagement and Predicted Risk of Suicide Attempts in Fibromyalgia. McKernan LC, Lenert MC, Crofford LJ, Walsh CG (2019) Arthritis Care Res (Hoboken) 71(9): 1255-1263
    › Primary publication · 30192068 (PubMed) · PMC6405325 (PubMed Central)
  10. Physical activity is related to function and fatigue but not pain in women with fibromyalgia: baseline analyses from the Fibromyalgia Activity Study with TENS (FAST). Merriwether EN, Frey-Law LA, Rakel BA, Zimmerman MB, Dailey DL, Vance CGT, Golchha M, Geasland KM, Chimenti R, Crofford LJ, Sluka KA (2018) Arthritis Res Ther 20(1): 199
    › Primary publication · 30157911 (PubMed) · PMC6116369 (PubMed Central)
  11. Interstitial Pneumonia With Autoimmune Features: An Emerging Challenge at the Intersection of Rheumatology and Pulmonology. Wilfong EM, Lentz RJ, Guttentag A, Tolle JJ, Johnson JE, Kropski JA, Kendall PL, Blackwell TS, Crofford LJ (2018) Arthritis Rheumatol 70(12): 1901-1913
    › Primary publication · 30058242 (PubMed) · PMC6261671 (PubMed Central)
  12. Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation. Sullivan KM, Majhail NS, Bredeson C, Carpenter PA, Chatterjee S, Crofford LJ, Georges GE, Nash RA, Pasquini MC, Sarantopoulos S, Storek J, Savani B, St Clair EW (2018) Biol Blood Marrow Transplant 24(10): 1961-1964
    › Primary publication · 29953945 (PubMed) · PMC6239926 (PubMed Central)
  13. Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus. Barnado A, Carroll RJ, Casey C, Wheless L, Denny JC, Crofford LJ (2018) Arthritis Res Ther 20(1): 69
    › Primary publication · 29636090 (PubMed) · PMC5894248 (PubMed Central)
  14. Risk Factors for Transfusions Following Total Joint Arthroplasty in Patients With Rheumatoid Arthritis. Salt E, Wiggins AT, Rayens MK, Brown K, Eckmann K, Johannemann A, Wright RD, Crofford LJ (2018) J Clin Rheumatol 24(8): 422-426
    › Primary publication · 29538083 (PubMed) · PMC6136987 (PubMed Central)
  15. Phenome-Wide Association Studies Uncover a Novel Association of Increased Atrial Fibrillation in Male Patients With Systemic Lupus Erythematosus. Barnado A, Carroll RJ, Casey C, Wheless L, Denny JC, Crofford LJ (2018) Arthritis Care Res (Hoboken) 70(11): 1630-1636
    › Primary publication · 29481723 (PubMed) · PMC6109620 (PubMed Central)
  16. Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma. Sullivan KM, Goldmuntz EA, Keyes-Elstein L, McSweeney PA, Pinckney A, Welch B, Mayes MD, Nash RA, Crofford LJ, Eggleston B, Castina S, Griffith LM, Goldstein JS, Wallace D, Craciunescu O, Khanna D, Folz RJ, Goldin J, St Clair EW, Seibold JR, Phillips K, Mineishi S, Simms RW, Ballen K, Wener MH, Georges GE, Heimfeld S, Hosing C, Forman S, Kafaja S, Silver RM, Griffing L, Storek J, LeClercq S, Brasington R, Csuka ME, Bredeson C, Keever-Taylor C, Domsic RT, Kahaleh MB, Medsger T, Furst DE, SCOT Study Investigators (2018) N Engl J Med 378(1): 35-47
    › Primary publication · 29298160 (PubMed) · PMC5846574 (PubMed Central)
  17. mPGES1-Dependent Prostaglandin E (PGE) Controls Antigen-Specific Th17 and Th1 Responses by Regulating T Autocrine and Paracrine PGE Production. Maseda D, Johnson EM, Nyhoff LE, Baron B, Kojima F, Wilhelm AJ, Ward MR, Woodward JG, Brand DD, Crofford LJ (2018) J Immunol 200(2): 725-736
    › Primary publication · 29237778 (PubMed) · PMC5760456 (PubMed Central)
  18. When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data. Pulley JM, Jerome RN, Zaleski NM, Shirey-Rice JK, Pruijssers AJ, Lavieri RR, Chettiar SN, Naylor HM, Aronoff DM, Edwards DA, Niswender CM, Dugan LL, Crofford LJ, Bernard GR, Holroyd KJ (2017) Assay Drug Dev Technol 15(8): 354-361
    › Primary publication · 29193979 (PubMed) · PMC5731541 (PubMed Central)
  19. Secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis. Hanaoka BY, Ormseth MJ, Michael Stein C, Banerjee D, Nikolova-Karakashian M, Crofford LJ (2018) Clin Rheumatol 37(5): 1395-1399
    › Primary publication · 28914380 (PubMed) · PMC6050169 (PubMed Central)
  20. Daily Goals and Psychological Well-Being in Midlife and Older Women: Physical Pain Interacts with Goal Conflict. Segerstrom SC, Jones AC, Scott AB, Crofford LJ (2016) Res Hum Dev 13(4): 328-341
    › Primary publication · 28603467 (PubMed) · PMC5464603 (PubMed Central)
  21. The Mediating and Moderating Effect of Volunteering on Pain and Depression, Life Purpose, Well-Being, and Physical Activity. Salt E, Crofford LJ, Segerstrom S (2017) Pain Manag Nurs 18(4): 243-249
    › Primary publication · 28601476 (PubMed) · PMC7251856 (PubMed Central)
  22. Healthcare Costs Associated With Chronic Opioid Use and Fibromayalgia Syndrome. Painter JT, Crofford LJ, Butler JS, Talbert J (2014) Am J Pharm Benefits 6(6): e177-e184
    › Primary publication · 28553437 (PubMed) · PMC5444874 (PubMed Central)
  23. Impact of Moving From a Widespread to Multisite Pain Definition on Other Fibromyalgia Symptoms. Dean LE, Arnold L, Crofford L, Bennett R, Goldenberg D, Fitzcharles MA, Paiva ES, Staud R, Clauw D, Sarzi-Puttini P, Jones GT, Ayorinde A, Flüß E, Beasley M, Macfarlane GJ (2017) Arthritis Care Res (Hoboken) 69(12): 1878-1886
    › Primary publication · 28182834 (PubMed)
  24. Rheumatologists' perception of systemic lupus erythematosus quality indicators: significant interest and perceived barriers. Casey C, Chung CP, Crofford LJ, Barnado A (2017) Clin Rheumatol 36(1): 97-102
    › Primary publication · 27878408 (PubMed) · PMC5241104 (PubMed Central)
  25. Reply. Doss J, Mo H, Carroll RJ, Crofford LJ, Denny JC (2017) Arthritis Rheumatol 69(3): 680-681
    › Primary publication · 27860419 (PubMed)
  26. Reply. Nyhoff LE, Crofford LJ, Kendall PL (2017) Arthritis Rheumatol 69(2): 475-477
    › Primary publication · 27748073 (PubMed) · PMC5274625 (PubMed Central)
  27. Moderating effects of immunosuppressive medications and risk factors for post-operative joint infection following total joint arthroplasty in patients with rheumatoid arthritis or osteoarthritis. Salt E, Wiggins AT, Rayens MK, Morris BJ, Mannino D, Hoellein A, Donegan RP, Crofford LJ (2017) Semin Arthritis Rheum 46(4): 423-429
    › Primary publication · 27692433 (PubMed) · PMC5325817 (PubMed Central)
  28. Phenome-Wide Association Study of Rheumatoid Arthritis Subgroups Identifies Association Between Seronegative Disease and Fibromyalgia. Doss J, Mo H, Carroll RJ, Crofford LJ, Denny JC (2017) Arthritis Rheumatol 69(2): 291-300
    › Primary publication · 27589350 (PubMed) · PMC5274573 (PubMed Central)
  29. Dexamethasone-suppressed Salivary Cortisol and Pain Sensitivity in Female Twins. Godfrey KM, Herbert M, Strachan E, Mostoufi S, Crofford LJ, Buchwald D, Poeschla B, Succop A, Afari N (2017) Clin J Pain 33(3): 246-253
    › Primary publication · 27275736 (PubMed) · PMC5143218 (PubMed Central)
  30. Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. Dolan JM, Weinberg JB, O'Brien E, Abashian A, Procario MC, Aronoff DM, Crofford LJ, Peters-Golden M, Ward L, Mancuso P (2016) Am J Physiol Lung Cell Mol Physiol 310(11): L1111-20
    › Primary publication · 27059285 (PubMed) · PMC4935474 (PubMed Central)
  31. Causes of creatine kinase levels greater than 1000 IU/L in patients referred to rheumatology. Leverenz D, Zaha O, Crofford LJ, Chung CP (2016) Clin Rheumatol 35(6): 1541-7
    › Primary publication · 27041384 (PubMed) · PMC4871697 (PubMed Central)
  32. Perceived function and physical performance are associated with pain and fatigue in women with fibromyalgia. Dailey DL, Frey Law LA, Vance CG, Rakel BA, Merriwether EN, Darghosian L, Golchha M, Geasland KM, Spitz R, Crofford LJ, Sluka KA (2016) Arthritis Res Ther : 68
    › Primary publication · 26979999 (PubMed) · PMC4793621 (PubMed Central)
  33. Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis. Nyhoff LE, Barron BL, Johnson EM, Bonami RH, Maseda D, Fensterheim BA, Han W, Blackwell TS, Crofford LJ, Kendall PL (2016) Arthritis Rheumatol 68(8): 1856-68
    › Primary publication · 26945549 (PubMed) · PMC5668904 (PubMed Central)
  34. Endurance Exercise Improves Molecular Pathways of Aerobic Metabolism in Patients With Myositis. Munters LA, Loell I, Ossipova E, Raouf J, Dastmalchi M, Lindroos E, Chen YW, Esbjörnsson M, Korotkova M, Alexanderson H, Nagaraju K, Crofford LJ, Jakobsson PJ, Lundberg IE (2016) Arthritis Rheumatol 68(7): 1738-50
    › Primary publication · 26867141 (PubMed)
  35. The role of Bruton's tyrosine kinase in autoimmunity and implications for therapy. Crofford LJ, Nyhoff LE, Sheehan JH, Kendall PL (2016) Expert Rev Clin Immunol 12(7): 763-73
    › Primary publication · 26864273 (PubMed) · PMC5070917 (PubMed Central)
  36. At the Bedside: Neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases. Barnado A, Crofford LJ, Oates JC (2016) J Leukoc Biol 99(2): 265-78
    › Primary publication · 26658004 (PubMed) · PMC6608010 (PubMed Central)
  37. Public and personal depression stigma in a rural American female sample. Simmons LA, Yang NY, Wu Q, Bush HM, Crofford LJ (2015) Arch Psychiatr Nurs 29(6): 407-12
    › Primary publication · 26577555 (PubMed)
  38. Risk Factors for Targeted Fungal and Mycobacterial Infections in Patients Taking Tumor Necrosis Factor Inhibitors. Salt E, Wiggins AT, Rayens MK, Huaman MA, Mannino D, Schwieterman P, Merkley SA, Jones AR, Crofford LJ (2016) Arthritis Rheumatol 68(3): 597-603
    › Primary publication · 26474379 (PubMed) · PMC5548176 (PubMed Central)
  39. Psychological aspects of chronic musculoskeletal pain. Crofford LJ (2015) Best Pract Res Clin Rheumatol 29(1): 147-55
    › Primary publication · 26267008 (PubMed) · PMC5061342 (PubMed Central)
  40. Examining rheumatoid arthritis patients' trust in their provider over time: the effects of demographic factors and accessing sources of information. Salt E, Rayens MK, Kerr AM, Alikhan M, Crofford LJ (2015) Orthop Nurs 34(3): 159-65
    › Primary publication · 25989126 (PubMed)
  41. Does computed tomography-based muscle density predict muscle function and health-related quality of life in patients with idiopathic inflammatory myopathies? Cleary LC, Crofford LJ, Long D, Charnigo R, Clasey J, Beaman F, Jenkins KA, Fraser N, Srinivas A, Dhaon N, Hanaoka BY (2015) Arthritis Care Res (Hoboken) 67(7): 1031-40
    › Primary publication · 25623494 (PubMed) · PMC5207482 (PubMed Central)
  42. Parasympathetic reactivity in fibromyalgia and temporomandibular disorder: associations with sleep problems, symptom severity, and functional impairment. Eisenlohr-Moul TA, Crofford LJ, Howard TW, Yepes JF, Carlson CR, de Leeuw R (2015) J Pain 16(3): 247-57
    › Primary publication · 25542636 (PubMed) · PMC4352401 (PubMed Central)
  43. Physical impairment in patients with idiopathic inflammatory myopathies is associated with the American College of Rheumatology functional status measure. Hanaoka BY, Cleary LC, Long DE, Srinivas A, Jenkins KA, Bush HM, Starnes CP, Rutledge M, Duan J, Fan Q, Fraser N, Crofford LJ (2015) Clin Rheumatol 34(11): 1929-37
    › Primary publication · 25388646 (PubMed) · PMC5244815 (PubMed Central)
  44. Effect of transcutaneous electrical nerve stimulation on pain, function, and quality of life in fibromyalgia: a double-blind randomized clinical trial. Noehren B, Dailey DL, Rakel BA, Vance CG, Zimmerman MB, Crofford LJ, Sluka KA (2015) Phys Ther 95(1): 129-40
    › Primary publication · 25212518 (PubMed) · PMC4295083 (PubMed Central)
  45. Sources of health information among rural women in Western Kentucky. Simmons LA, Wu Q, Yang N, Bush HM, Crofford LJ (2015) Public Health Nurs 32(1): 3-14
    › Primary publication · 24905745 (PubMed)
  46. New insights into the benefits of exercise for muscle health in patients with idiopathic inflammatory myositis. Alemo Munters L, Alexanderson H, Crofford LJ, Lundberg IE (2014) Curr Rheumatol Rep 16(7): 429
    › Primary publication · 24879535 (PubMed) · PMC4133148 (PubMed Central)
  47. Regulation of B lymphocytes and plasma cells by innate immune mechanisms and stromal cells in rheumatoid arthritis. Maseda D, Bonami RH, Crofford LJ (2014) Expert Rev Clin Immunol 10(6): 747-62
    › Primary publication · 24734886 (PubMed) · PMC5073792 (PubMed Central)
  48. Modeling Bivariate Longitudinal Hormone Profiles by Hierarchical State Space Models. Liu Z, Cappola AR, Crofford LJ, Guo W (2014) J Am Stat Assoc 109(505): 108-118
    › Primary publication · 24729646 (PubMed) · PMC3979568 (PubMed Central)
  49. Use of NSAIDs in treating patients with arthritis. Crofford LJ (2013) Arthritis Res Ther : S2
    › Primary publication · 24267197 (PubMed) · PMC3891482 (PubMed Central)
  50. Prostaglandin E2 induction during mouse adenovirus type 1 respiratory infection regulates inflammatory mediator generation but does not affect viral pathogenesis. McCarthy MK, Levine RE, Procario MC, McDonnell PJ, Zhu L, Mancuso P, Crofford LJ, Aronoff DM, Weinberg JB (2013) PLoS One 8(10): e77628
    › Primary publication · 24147040 (PubMed) · PMC3797793 (PubMed Central)
  51. Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells. Kojima F, Frolov A, Matnani R, Woodward JG, Crofford LJ (2013) J Immunol 191(10): 4979-88
    › Primary publication · 24127557 (PubMed) · PMC5061343 (PubMed Central)
  52. Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice. Frolov A, Yang L, Dong H, Hammock BD, Crofford LJ (2013) Prostaglandins Leukot Essent Fatty Acids 89(5): 351-8
    › Primary publication · 24055573 (PubMed) · PMC3897272 (PubMed Central)
  53. Intrauterine group A streptococcal infections are exacerbated by prostaglandin E2. Mason KL, Rogers LM, Soares EM, Bani-Hashemi T, Erb Downward J, Agnew D, Peters-Golden M, Weinberg JB, Crofford LJ, Aronoff DM (2013) J Immunol 191(5): 2457-65
    › Primary publication · 23913961 (PubMed) · PMC3750066 (PubMed Central)
  54. Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. Frolov A, Dong H, Jiang M, Yang L, Cook EC, Matnani R, Hammock BD, Crofford LJ (2013) J Biol Chem 288(33): 23696-703
    › Primary publication · 23814065 (PubMed) · PMC3745317 (PubMed Central)
  55. Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women. Srikuea R, Symons TB, Long DE, Lee JD, Shang Y, Chomentowski PJ, Yu G, Crofford LJ, Peterson CA (2013) Arthritis Rheum 65(2): 519-28
    › Primary publication · 23124535 (PubMed) · PMC3558634 (PubMed Central)
  56. Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia. Shang Y, Gurley K, Symons B, Long D, Srikuea R, Crofford LJ, Peterson CA, Yu G (2012) Arthritis Res Ther 14(6): R236
    › Primary publication · 23116302 (PubMed) · PMC3674608 (PubMed Central)
  57. Linking disease symptoms and subtypes with personalized systems-based phenotypes: a proof of concept study. Aschbacher K, Adam EK, Crofford LJ, Kemeny ME, Demitrack MA, Ben-Zvi A (2012) Brain Behav Immun 26(7): 1047-56
    › Primary publication · 22687333 (PubMed) · PMC3725324 (PubMed Central)
  58. Predictors of survival in a cohort of patients with polymyositis and dermatomyositis: effect of corticosteroids, methotrexate and azathioprine. Schiopu E, Phillips K, MacDonald PM, Crofford LJ, Somers EC (2012) Arthritis Res Ther 14(1): R22
    › Primary publication · 22284862 (PubMed) · PMC3392815 (PubMed Central)
  59. Goal conflict, distress, and pain in women with fibromyalgia: a daily diary study. Hardy JK, Crofford LJ, Segerstrom SC (2011) J Psychosom Res 70(6): 534-40
    › Primary publication · 21624576 (PubMed)
  60. mPGES-1 null mice are resistant to bleomycin-induced skin fibrosis. McCann MR, Monemdjou R, Ghassemi-Kakroodi P, Fahmi H, Perez G, Liu S, Shi-Wen X, Parapuram SK, Kojima F, Denton CP, Abraham DJ, Martel-Pelletier J, Crofford LJ, Leask A, Kapoor M (2011) Arthritis Res Ther 13(1): R6
    › Primary publication · 21266028 (PubMed) · PMC3546456 (PubMed Central)
  61. Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration. Monrad SU, Kojima F, Kapoor M, Kuan EL, Sarkar S, Randolph GJ, Crofford LJ (2011) Prostaglandins Leukot Essent Fatty Acids 84(3-4): 113-21
    › Primary publication · 21190819 (PubMed) · PMC3072052 (PubMed Central)
  62. Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation. Csepeggi C, Jiang M, Kojima F, Crofford LJ, Frolov A (2011) J Biol Chem 286(3): 2078-87
    › Primary publication · 21084287 (PubMed) · PMC3023505 (PubMed Central)
  63. Rheumatoid arthritis and salivary biomarkers of periodontal disease. Mirrielees J, Crofford LJ, Lin Y, Kryscio RJ, Dawson DR, Ebersole JL, Miller CS (2010) J Clin Periodontol 37(12): 1068-74
    › Primary publication · 20880053 (PubMed) · PMC2980566 (PubMed Central)
  64. Self-regulatory deficits in fibromyalgia and temporomandibular disorders. Nes LS, Carlson CR, Crofford LJ, de Leeuw R, Segerstrom SC (2010) Pain 151(1): 37-44
    › Primary publication · 20561749 (PubMed)
  65. Adverse effects of chronic opioid therapy for chronic musculoskeletal pain. Crofford LJ (2010) Nat Rev Rheumatol 6(4): 191-7
    › Primary publication · 20357788 (PubMed)
  66. Impaired sleep quality in fibromyalgia: Detection and quantification with ECG-based cardiopulmonary coupling spectrograms. Thomas RJ, Mietus JE, Peng CK, Goldberger AL, Crofford LJ, Chervin RD (2010) Sleep Med 11(5): 497-8
    › Primary publication · 20015685 (PubMed) · PMC2854867 (PubMed Central)
  67. Objective measures of disordered sleep in fibromyalgia. Chervin RD, Teodorescu M, Kushwaha R, Deline AM, Brucksch CB, Ribbens-Grimm C, Ruzicka DL, Stein PK, Clauw DJ, Crofford LJ (2009) J Rheumatol 36(9): 2009-16
    › Primary publication · 19684146 (PubMed) · PMC2909463 (PubMed Central)
  68. Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP. Kunisch E, Jansen A, Kojima F, Löffler I, Kapoor M, Kawai S, Rubio I, Crofford LJ, Kinne RW (2009) J Immunol 183(2): 1328-36
    › Primary publication · 19542367 (PubMed) · PMC5074557 (PubMed Central)
  69. Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA. Kojima F, Kapoor M, Kawai S, Yang L, Aronoff DM, Crofford LJ (2009) Prostaglandins Other Lipid Mediat 89(1-2): 26-33
    › Primary publication · 19464664 (PubMed) · PMC2738595 (PubMed Central)
  70. Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice. Kojima F, Kapoor M, Yang L, Fleishaker EL, Ward MR, Monrad SU, Kottangada PC, Pace CQ, Clark JA, Woodward JG, Crofford LJ (2008) J Immunol 180(12): 8361-8
    › Primary publication · 18523303 (PubMed) · PMC2435291 (PubMed Central)
  71. Sleep stage dynamics in fibromyalgia patients and controls. Burns JW, Crofford LJ, Chervin RD (2008) Sleep Med 9(6): 689-96
    › Primary publication · 18314389 (PubMed)
  72. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study. Nash RA, McSweeney PA, Crofford LJ, Abidi M, Chen CS, Godwin JD, Gooley TA, Holmberg L, Henstorf G, LeMaistre CF, Mayes MD, McDonagh KT, McLaughlin B, Molitor JA, Nelson JL, Shulman H, Storb R, Viganego F, Wener MH, Seibold JR, Sullivan KM, Furst DE (2007) Blood 110(4): 1388-96
    › Primary publication · 17452515 (PubMed) · PMC1939909 (PubMed Central)
  73. Sequential induction of pro- and anti-inflammatory prostaglandins and peroxisome proliferators-activated receptor-gamma during normal wound healing: a time course study. Kapoor M, Kojima F, Yang L, Crofford LJ (2007) Prostaglandins Leukot Essent Fatty Acids 76(2): 103-12
    › Primary publication · 17239574 (PubMed) · PMC1847382 (PubMed Central)
  74. Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway. Kapoor M, Kojima F, Qian M, Yang L, Crofford LJ (2007) J Biol Chem 282(8): 5356-66
    › Primary publication · 17186945 (PubMed)
  75. Polymyositis evolving after rhabdomyolysis associated with HMG-CoA reductase inhibitors: a report of two cases. Gupta S, Blaivas M, Ike RW, Crofford LJ (2001) J Clin Rheumatol 7(5): 332-5
    › Primary publication · 17039165 (PubMed)
  76. Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis. Kapoor M, Kojima F, Qian M, Yang L, Crofford LJ (2006) FASEB J 20(13): 2387-9
    › Primary publication · 17023389 (PubMed) · PMC4415996 (PubMed Central)
  77. Major enzymatic pathways in dermal wound healing: current understanding and future therapeutic targets. Kapoor M, Kojima F, Appleton I, Kawai S, Crofford LJ (2006) Curr Opin Investig Drugs 7(5): 418-22
    › Primary publication · 16729717 (PubMed)
  78. Cardiovascular effects of selective COX-2 inhibition: is there a class effect? The International COX-2 Study Group. Crofford LJ, Breyer MD, Strand CV, Rushitzka F, Brune K, Farkouh ME, Simon LS (2006) J Rheumatol 33(7): 1403-8
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  79. Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia. McLean SA, Williams DA, Harris RE, Kop WJ, Groner KH, Ambrose K, Lyden AK, Gracely RH, Crofford LJ, Geisser ME, Sen A, Biswas P, Clauw DJ (2005) Arthritis Rheum 52(11): 3660-9
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  80. Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumonia. Kocheril SV, Appleton BE, Somers EC, Kazerooni EA, Flaherty KR, Martinez FJ, Gross BH, Crofford LJ (2005) Arthritis Rheum 53(4): 549-57
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  81. Memory beliefs and function in fibromyalgia patients. Glass JM, Park DC, Minear M, Crofford LJ (2005) J Psychosom Res 58(3): 263-9
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  82. Immunomodulatory therapy for SSc: will high-intensity immunosuppression with stem cell rescue improve outcome? Crofford LJ (2005) Curr Rheumatol Rep 7(2): 142-9
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  83. Management of fibromyalgia syndrome. Goldenberg DL, Burckhardt C, Crofford L (2004) JAMA 292(19): 2388-95
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  84. Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome. Crofford LJ, Young EA, Engleberg NC, Korszun A, Brucksch CB, McClure LA, Brown MB, Demitrack MA (2004) Brain Behav Immun 18(4): 314-25
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  85. Nephrogenic fibrosing dermopathy: a novel cutaneous fibrosing disorder in patients with renal failure. Swartz RD, Crofford LJ, Phan SH, Ike RW, Su LD (2003) Am J Med 114(7): 563-72
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  86. Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizing. Geisser ME, Casey KL, Brucksch CB, Ribbens CM, Appleton BB, Crofford LJ (2003) Pain 102(3): 243-250
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  87. High-dose immunosuppressive therapy for severe systemic sclerosis: initial outcomes. McSweeney PA, Nash RA, Sullivan KM, Storek J, Crofford LJ, Dansey R, Mayes MD, McDonagh KT, Nelson JL, Gooley TA, Holmberg LA, Chen CS, Wener MH, Ryan K, Sunderhaus J, Russell K, Rambharose J, Storb R, Furst DE (2002) Blood 100(5): 1602-10
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  88. Use of actigraphy for monitoring sleep and activity levels in patients with fibromyalgia and depression. Korszun A, Young EA, Engleberg NC, Brucksch CB, Greden JF, Crofford LA (2002) J Psychosom Res 52(6): 439-43
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  89. Prostaglandin biology. Crofford LJ (2001) Gastroenterol Clin North Am 30(4): 863-76
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  90. Cognitive function in fibromyalgia patients. Park DC, Glass JM, Minear M, Crofford LJ (2001) Arthritis Rheum 44(9): 2125-33
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  91. Effects of selective cyclooxygenase-2 inhibition on vascular responses and thrombosis in canine coronary arteries. Hennan JK, Huang J, Barrett TD, Driscoll EM, Willens DE, Park AM, Crofford LJ, Lucchesi BR (2001) Circulation 104(7): 820-5
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  92. Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. Stichtenoth DO, Thorén S, Bian H, Peters-Golden M, Jakobsson PJ, Crofford LJ (2001) J Immunol 167(1): 469-74
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  93. Cyclooxygenase inhibition and thrombogenicity. Catella-Lawson F, Crofford LJ (2001) Am J Med : 28S-32S
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  94. Critical role of C/EBPdelta and C/EBPbeta factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1beta in articular chondrocytes. Thomas B, Berenbaum F, Humbert L, Bian H, Béréziat G, Crofford L, Olivier JL (2000) Eur J Biochem 267(23): 6798-809
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  95. Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four cases. Crofford LJ, Oates JC, McCune WJ, Gupta S, Kaplan MJ, Catella-Lawson F, Morrow JD, McDonagh KT, Schmaier AH (2000) Arthritis Rheum 43(8): 1891-6
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  96. Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. Crofford LJ, Lipsky PE, Brooks P, Abramson SB, Simon LS, van de Putte LB (2000) Arthritis Rheum 43(1): 4-13
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  97. Cyclooxygenase-2 expression in gastric antral mucosa before and after eradication of Helicobacter pylori infection. McCarthy CJ, Crofford LJ, Greenson J, Scheiman JM (1999) Am J Gastroenterol 94(5): 1218-23
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  98. Cyclooxygenase in biology and disease. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE (1998) FASEB J 12(12): 1063-73
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  99. The neuroscience and endocrinology of fibromyalgia. Pillemer SR, Bradley LA, Crofford LJ, Moldofsky H, Chrousos GP (1997) Arthritis Rheum 40(11): 1928-39
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  100. Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis. Crofford LJ, Kalogeras KT, Mastorakos G, Magiakou MA, Wells J, Kanik KS, Gold PW, Chrousos GP, Wilder RL (1997) J Clin Endocrinol Metab 82(4): 1279-83
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  101. Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Crofford LJ, Tan B, McCarthy CJ, Hla T (1997) Arthritis Rheum 40(2): 226-36
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  102. Local expression of corticotropin-releasing hormone in inflammatory arthritis. Crofford LJ, Sano H, Karalis K, Webster EA, Friedman TC, Chrousos GP, Wilder RL (1995) Ann N Y Acad Sci : 459-71
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  103. Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arthritis and osteoarthritis. Crofford LJ, Sano H, Karalis K, Friedman TC, Epps HR, Remmers EF, Mathern P, Chrousos GP, Wilder RL (1993) J Immunol 151(3): 1587-96
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  104. Tissue-specific regulation of IL-6 production by IL-4. Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts. Donnelly RP, Crofford LJ, Freeman SL, Buras J, Remmers E, Wilder RL, Fenton MJ (1993) J Immunol 151(10): 5603-12
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  105. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. Crofford LJ, Wilder RL, Ristimäki AP, Sano H, Remmers EF, Epps HR, Hla T (1994) J Clin Invest 93(3): 1095-101
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  106. Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Crofford LJ, Pillemer SR, Kalogeras KT, Cash JM, Michelson D, Kling MA, Sternberg EM, Gold PW, Chrousos GP, Wilder RL (1994) Arthritis Rheum 37(11): 1583-92
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  107. Glucocorticoid and/or glucocorticoid antagonist effects in inflammatory disease-susceptible Lewis rats and inflammatory disease-resistant Fischer rats. Karalis K, Crofford L, Wilder RL, Chrousos GP (1995) Endocrinology 136(7): 3107-12
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  108. Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. Wilborn J, Crofford LJ, Burdick MD, Kunkel SL, Strieter RM, Peters-Golden M (1995) J Clin Invest 95(4): 1861-8
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  109. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. Ben-Av P, Crofford LJ, Wilder RL, Hla T (1995) FEBS Lett 372(1): 83-7
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  110. L-tryptophan implicated in human eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis rat. Crofford LJ, Rader JI, Dalakas MC, Hill RH, Page SW, Needham LL, Brady LS, Heyes MP, Wilder RL, Gold PW (1990) J Clin Invest 86(5): 1757-63
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  111. In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. Sano H, Hla T, Maier JA, Crofford LJ, Case JP, Maciag T, Wilder RL (1992) J Clin Invest 89(1): 97-108
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  112. Pituitary-adrenal axis responsiveness to ovine corticotropin releasing hormone in patients with rheumatoid arthritis treated with low dose prednisone. Cash JM, Crofford LJ, Gallucci WT, Sternberg EM, Gold PW, Chrousos GP, Wilder RL (1992) J Rheumatol 19(11): 1692-6
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  113. Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis. Crofford LJ, Sano H, Karalis K, Webster EL, Goldmuntz EA, Chrousos GP, Wilder RL (1992) J Clin Invest 90(6): 2555-64
    › Primary publication · 1281840 (PubMed) · PMC443415 (PubMed Central)