Profile

The overall purpose of our research is to understand how glucose stimulates insulin secretion by pancreatic islet cells and to characterize and reverse abnormalities in this process that are present in diabetes. Insulin secretion by pancreatic islets is very tightly coupled to changes in the blood glucose; abnormalities in insulin secretion are a major factor in both type 1 and type 2 diabetes.  Our research utilizes a variety of research approaches including RNA and protein analysis, genetically modified mice, in vivo physiology, radioimmunoassay, adenovirus mediated gene transfer, transplantation of murine and human islets, confocal microscopy, and immunocytochemistry and involves collaborations with vascular biologists, development biologists, biomedical engineers, and transplant biologists.

 

More information is available on our lab's website:

https://www.powersresearch.org/