The overall purpose of our research is to understand how glucose stimulates insulin secretion by pancreatic islet cells and to characterize and reverse abnormalities in this process that are present in diabetes. Insulin secretion by pancreatic islets is very tightly coupled to changes in the blood glucose; abnormalities in insulin secretion are a major factor in both type 1 and type 2 diabetes. Our research utilizes a variety of research approaches including RNA and protein analysis, genetically modified mice, in vivo physiology, radioimmunoassay, adenovirus mediated gene transfer, transplantation of murine and human islets, confocal microscopy, and immunocytochemistry and involves collaborations with vascular biologists, development biologists, biomedical engineers, and transplant biologists.
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Key: MeSH Term KeywordAdenosine-5'-(N-ethylcarboxamide) Adult Animals, Laboratory Autoantibodies Brain Chromatin Immunoprecipitation Cystic Fibrosis Transmembrane Conductance Regulator diabetes Drug Evaluation, Preclinical Genes, Reporter Glucagon-Secreting Cells Glucose GSIS Heterozygote HLA-A2 Antigen Image Interpretation, Computer-Assisted imaging insulin Insulin Secretion islets Islets of Langerhans MafB Transcription Factor Mice, Inbred NOD Mitochondrial Proteins Paired Box Transcription Factors pancreas Pancreatitis PAX6 Transcription Factor Recombinant Fusion Proteins regeneration Single-Cell Analysis Species Specificity Spectrometry, Fluorescence Time Factors Trans-Activators vascularization Whole Body Imaging Zebrafish