Profile

My laboratory studies the genomics and biology of pluripotent stem cells as model systems of cardiovascular cell differentiation.  Our group also investigates the role of canonical Wnt signaling in the specification and fate of cardiac stem cells.  The main goal is to optimize cardiac tissue repair and translate research findings to new therapeutic strategies for human patients of heart disease.  
 
We have performed transcriptome analysis of mouse embryonic stem cells at the pluripotent stage and after differentiation, and organized the Functional Genomics In Embryonic Stem Cells (FunGenES) public database.  Our group took part in the NHLBI Cardiovascular Cell Therapy Research Network (CCTRN) that recently completed three Clinical Trials using stem cell therapy in human patients of heart disease. Currently, I am the Director of the Vanderbilt Hub in the NHLBI Progenitor Cell Biology Consortium (PCBC) and I also  chair the PCBC Bioinformatics Committee, whose role is to establish quality indexes and standards for human embryonic, induced pluripotent, and adult stem cells.  The Bioinformatics Committee also coordinates genomics data analysis among PCBC research groups and provides training on Bioinformatics tools to investigators.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension. Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG (2016) Hypertension 67(2): 461-8
    › Primary publication · 26693821 (PubMed) · PMC4713264 (PubMed Central)
  2. Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis. Paik DT, Rai M, Ryzhov S, Sanders LN, Aisagbonhi O, Funke MJ, Feoktistov I, Hatzopoulos AK (2015) Circ Res 117(9): 804-16
    › Primary publication · 26338900 (PubMed) · PMC4600464 (PubMed Central)
  3. Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis. Fioret BA, Heimfeld JD, Paik DT, Hatzopoulos AK (2014) Cell Rep 8(1): 229-41
    › Primary publication · 25001281 (PubMed) · PMC4101892 (PubMed Central)
  4. Endothelial progenitor cells augment collateralization and hemodynamic rescue in a model of chronic cerebral ischemia. Hecht N, Schneider UC, Czabanka M, Vinci M, Hatzopoulos AK, Vajkoczy P, Woitzik J (2014) J Cereb Blood Flow Metab 34(8): 1297-305
    › Primary publication · 24780900 (PubMed) · PMC4126089 (PubMed Central)
  5. Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway. Tanwar V, Bylund JB, Hu J, Yan J, Walthall JM, Mukherjee A, Heaton WH, Wang WD, Potet F, Rai M, Kupershmidt S, Knapik EW, Hatzopoulos AK (2014) Stem Cells 32(7): 1774-88
    › Primary publication · 24648383 (PubMed) · PMC4123739 (PubMed Central)
  6. SDF-1 fused to a fractalkine stalk and a GPI anchor enables functional neovascularization. Stachel G, Trenkwalder T, Götz F, El Aouni C, Muenchmeier N, Pfosser A, Nussbaum C, Sperandio M, Hatzopoulos AK, Hinkel R, Nelson PJ, Kupatt C (2013) Stem Cells 31(9): 1795-805
    › Primary publication · 23744498 (PubMed)
  7. Stem cell therapy for chronic heart failure: an updated appraisal. Maltais S, Joggerst SJ, Hatzopoulos A, DiSalvo TG, Zhao D, Sung HJ, Wang X, Byrne JG, Naftilan AJ (2013) Expert Opin Biol Ther 13(4): 503-16
    › Primary publication · 23289619 (PubMed) · PMC4928684 (PubMed Central)
  8. Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm. Müller II, Melville DB, Tanwar V, Rybski WM, Mukherjee A, Shoemaker MB, Wang WD, Schoenhard JA, Roden DM, Darbar D, Knapik EW, Hatzopoulos AK (2013) Dis Model Mech 6(2): 332-41
    › Primary publication · 23223679 (PubMed) · PMC3597016 (PubMed Central)
  9. Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial. Traverse JH, Henry TD, Pepine CJ, Willerson JT, Zhao DX, Ellis SG, Forder JR, Anderson RD, Hatzopoulos AK, Penn MS, Perin EC, Chambers J, Baran KW, Raveendran G, Lambert C, Lerman A, Simon DI, Vaughan DE, Lai D, Gee AP, Taylor DA, Cogle CR, Thomas JD, Olson RE, Bowman S, Francescon J, Geither C, Handberg E, Kappenman C, Westbrook L, Piller LB, Simpson LM, Baraniuk S, Loghin C, Aguilar D, Richman S, Zierold C, Spoon DB, Bettencourt J, Sayre SL, Vojvodic RW, Skarlatos SI, Gordon DJ, Ebert RF, Kwak M, Moyé LA, Simari RD, Cardiovascular Cell Therapy Research Network (CCTRN) (2012) JAMA 308(22): 2380-9
    › Primary publication · 23129008 (PubMed) · PMC3652242 (PubMed Central)
  10. Recent Progress on Chemical Biology of Pluripotent Stem Cell Self-renewal, Reprogramming and Cardiomyogenesis. Hao J, Sawyer DB, Hatzopoulos AK, Hong CC (2011) Recent Pat Regen Med 1(3): 263-274
    › Primary publication · 22787575 (PubMed) · PMC3392203 (PubMed Central)
  11. Combinatorial polymer electrospun matrices promote physiologically-relevant cardiomyogenic stem cell differentiation. Gupta MK, Walthall JM, Venkataraman R, Crowder SW, Jung DK, Yu SS, Feaster TK, Wang X, Giorgio TD, Hong CC, Baudenbacher FJ, Hatzopoulos AK, Sung HJ (2011) PLoS One 6(12): e28935
    › Primary publication · 22216144 (PubMed) · PMC3246450 (PubMed Central)
  12. Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. Wang WD, Melville DB, Montero-Balaguer M, Hatzopoulos AK, Knapik EW (2011) Dev Biol 360(1): 173-85
    › Primary publication · 21963426 (PubMed) · PMC3236700 (PubMed Central)
  13. Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells. Rai M, Walthall JM, Hu J, Hatzopoulos AK (2012) Stem Cells Dev 21(1): 54-66
    › Primary publication · 21861760 (PubMed) · PMC3245675 (PubMed Central)
  14. The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Melville DB, Montero-Balaguer M, Levic DS, Bradley K, Smith JR, Hatzopoulos AK, Knapik EW (2011) Dis Model Mech 4(6): 763-76
    › Primary publication · 21729877 (PubMed) · PMC3209646 (PubMed Central)
  15. Preconditioned endothelial progenitor cells reduce formation of melanoma metastases through SPARC-driven cell-cell interactions and endocytosis. Defresne F, Bouzin C, Grandjean M, Dieu M, Raes M, Hatzopoulos AK, Kupatt C, Feron O (2011) Cancer Res 71(14): 4748-57
    › Primary publication · 21616936 (PubMed)
  16. Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Wu B, Wang Y, Lui W, Langworthy M, Tompkins KL, Hatzopoulos AK, Baldwin HS, Zhou B (2011) Circ Res 109(2): 183-92
    › Primary publication · 21597012 (PubMed) · PMC3132827 (PubMed Central)
  17. Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition. Aisagbonhi O, Rai M, Ryzhov S, Atria N, Feoktistov I, Hatzopoulos AK (2011) Dis Model Mech 4(4): 469-83
    › Primary publication · 21324930 (PubMed) · PMC3124051 (PubMed Central)
  18. Stem cell therapy: pieces of the puzzle. Schoenhard JA, Hatzopoulos AK (2010) J Cardiovasc Transl Res 3(1): 49-60
    › Primary publication · 20119487 (PubMed) · PMC2810366 (PubMed Central)
  19. Stem cell therapy for cardiac repair: benefits and barriers. Joggerst SJ, Hatzopoulos AK (2009) Expert Rev Mol Med : e20
    › Primary publication · 19586557 (PubMed)
  20. Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Boudoulas KD, Hatzopoulos AK (2009) Dis Model Mech 2(7-8): 344-58
    › Primary publication · 19553696 (PubMed) · PMC2707103 (PubMed Central)
  21. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. Hao J, Daleo MA, Murphy CK, Yu PB, Ho JN, Hu J, Peterson RT, Hatzopoulos AK, Hong CC (2008) PLoS One 3(8): e2904
    › Primary publication · 18682835 (PubMed) · PMC2483414 (PubMed Central)
  22. Adenosine receptor-mediated adhesion of endothelial progenitors to cardiac microvascular endothelial cells. Ryzhov S, Solenkova NV, Goldstein AE, Lamparter M, Fleenor T, Young PP, Greelish JP, Byrne JG, Vaughan DE, Biaggioni I, Hatzopoulos AK, Feoktistov I (2008) Circ Res 102(3): 356-63
    › Primary publication · 18032734 (PubMed) · PMC2803108 (PubMed Central)
  23. Biologic properties of endothelial progenitor cells and their potential for cell therapy. Young PP, Vaughan DE, Hatzopoulos AK (2007) Prog Cardiovasc Dis 49(6): 421-9
    › Primary publication · 17498522 (PubMed) · PMC1978244 (PubMed Central)
  24. The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Montero-Balaguer M, Lang MR, Sachdev SW, Knappmeyer C, Stewart RA, De La Guardia A, Hatzopoulos AK, Knapik EW (2006) Dev Dyn 235(12): 3199-212
    › Primary publication · 17013879 (PubMed)
  25. Expression of the protein related to Dan and Cerberus gene--prdc--During eye, pharyngeal arch, somite, and swim bladder development in zebrafish. Müller II, Knapik EW, Hatzopoulos AK (2006) Dev Dyn 235(10): 2881-8
    › Primary publication · 16921498 (PubMed)