Profile

Kathleen (Kathy) DelGiorno, Ph.D. graduated with a B.S. in Biology from the United States Air Force Academy in 2005. She went on to serve as a Biological Research Officer in the U.S. Air Force for two years before working as a Research Associate studying pancreatic and adrenal cancers at the Translational Genomics Research Institute; simultaneously earning an M.S. from the University of Florida in Pharmacy. She earned her Ph.D. in Molecular Genetics and Microbiology from the State University of New York at Stony Brook in 2012, first studying pancreatic cancer development at Stony Brook University and then at Mayo Clinic Florida. She completed three years of Postdoctoral research at Fred Hutchinson Cancer Research Center investigating the role of interstitial fluid pressure to treatment resistance in pancreatic cancer. Dr. DelGiorno continued her research in pancreatic cancer in the Wahl laboratory at the Salk Institute for Biological Studies first as a Postdoctoral Fellow and then as a Staff Scientist. She recently opened her own laboratory as an Assistant Professor in the Department of Cell and Developmental Biology at Vanderbilt University.

 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D. DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM (2020) Gastroenterology 159(5): 1866-1881.e8
    › Primary publication · 32717220 (PubMed) · PMC7680354 (PubMed Central)
  2. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP (2020) Science 368(6486): 85-89
    › Primary publication · 32241947 (PubMed) · PMC7681911 (PubMed Central)
  3. Tuft Cell Formation Reflects Epithelial Plasticity in Pancreatic Injury: Implications for Modeling Human Pancreatitis. DelGiorno KE, Naeem RF, Fang L, Chung CY, Ramos C, Luhtala N, O'Connor C, Hunter T, Manor U, Wahl GM (2020) Front Physiol : 88
    › Primary publication · 32116793 (PubMed) · PMC7033634 (PubMed Central)
  4. Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T (2019) Nature 569(7754): 131-135
    › Primary publication · 30996350 (PubMed) · PMC6565370 (PubMed Central)
  5. Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM (2017) PLoS One 12(12): e0189051
    › Primary publication · 29211796 (PubMed) · PMC5718507 (PubMed Central)
  6. Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase. DuFort CC, DelGiorno KE, Carlson MA, Osgood RJ, Zhao C, Huang Z, Thompson CB, Connor RJ, Thanos CD, Scott Brockenbrough J, Provenzano PP, Frost GI, Michael Shepard H, Hingorani SR (2016) Biophys J 110(9): 2106-19
    › Primary publication · 27166818 (PubMed) · PMC4939548 (PubMed Central)
  7. Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma. DuFort CC, DelGiorno KE, Hingorani SR (2016) Gastroenterology 150(7): 1545-1557.e2
    › Primary publication · 27072672 (PubMed) · PMC4957812 (PubMed Central)
  8. Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Liou GY, Döppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, Storz P (2016) Cell Rep 14(10): 2325-36
    › Primary publication · 26947075 (PubMed) · PMC4794374 (PubMed Central)
  9. RUNX3 Controls a Metastatic Switch in Pancreatic Ductal Adenocarcinoma. Whittle MC, Izeradjene K, Rani PG, Feng L, Carlson MA, DelGiorno KE, Wood LD, Goggins M, Hruban RH, Chang AE, Calses P, Thorsen SM, Hingorani SR (2015) Cell 161(6): 1345-60
    › Primary publication · 26004068 (PubMed) · PMC4458240 (PubMed Central)
  10. PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC (2014) Gastroenterology 147(6): 1405-16.e7
    › Primary publication · 25311989 (PubMed) · PMC4252806 (PubMed Central)
  11. Response to Chauhan et Al.: interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning. DelGiorno KE, Carlson MA, Osgood R, Provenzano PP, Brockenbough JS, Thompson CB, Shepard HM, Frost GI, Potter JD, Hingorani SR (2014) Cancer Cell 26(1): 16-7
    › Primary publication · 25026210 (PubMed) · PMC4465109 (PubMed Central)
  12. Stromal reengineering to treat pancreas cancer. Stromnes IM, DelGiorno KE, Greenberg PD, Hingorani SR (2014) Carcinogenesis 35(7): 1451-60
    › Primary publication · 24908682 (PubMed) · PMC4076816 (PubMed Central)
  13. Persistent salmonellosis causes pancreatitis in a murine model of infection. DelGiorno KE, Tam JW, Hall JC, Thotakura G, Crawford HC, van der Velden AW (2014) PLoS One 9(4): e92807
    › Primary publication · 24717768 (PubMed) · PMC3981665 (PubMed Central)
  14. The secret origins and surprising fates of pancreas tumors. Bailey JM, DelGiorno KE, Crawford HC (2014) Carcinogenesis 35(7): 1436-40
    › Primary publication · 24583923 (PubMed) · PMC4076810 (PubMed Central)
  15. Identification and manipulation of biliary metaplasia in pancreatic tumors. Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC (2014) Gastroenterology 146(1): 233-44.e5
    › Primary publication · 23999170 (PubMed) · PMC3870045 (PubMed Central)
  16. Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment. Ali WH, Chen Q, Delgiorno KE, Su W, Hall JC, Hongu T, Tian H, Kanaho Y, Di Paolo G, Crawford HC, Frohman MA (2013) PLoS One 8(1): e55325
    › Primary publication · 23383154 (PubMed) · PMC3557251 (PubMed Central)
  17. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT (2012) Cancer Cell 22(3): 304-17
    › Primary publication · 22975374 (PubMed) · PMC3443395 (PubMed Central)
  18. Pancreas-specific ablation of beta1 integrin induces tissue degeneration by disrupting acinar cell polarity. Bombardelli L, Carpenter ES, Wu AP, Alston N, DelGiorno KE, Crawford HC (2010) Gastroenterology 138(7): 2531-40, 2540.e1-4
    › Primary publication · 20188101 (PubMed) · PMC2883624 (PubMed Central)