Profile

The central goal of my lab is to understand how inflammatory microenvironments affect epithelial cell behaviors in the context of human diseases, specifically, in inflammatory bowel diseases and colorectal cancer. Aberrant cell specification is now recognized to be a major factor in various intestinal diseases. For example, dysfunctional Goblet and Paneth cells in the intestine contribute to barrier defects, while progenitor-like colorectal cancer cells are prone to therapeutic resistance and metastasis. Devising ways to control these aberrant behaviors may lead to effective therapeutic strategies to combat these complex diseases. My lab is interested in understanding the signaling mechanisms that control the differentiating cell populations in the intestine (defined loosely as transit amplifying cells) as they become exposed to various in vivo environments. We want to characterize the degree of heterogeneity and plasticity in such populations, and to leverage such properties for reversing pathological behaviors.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM (2015) Sci Signal 8(407): ra129
    › Primary publication · 26671150 (PubMed) · PMC4812576 (PubMed Central)
  2. Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo. Simmons AJ, Banerjee A, McKinley ET, Scurrah CR, Herring CA, Gewin LS, Masuzaki R, Karp SJ, Franklin JL, Gerdes MJ, Irish JM, Coffey RJ, Lau KS (2015) Mol Syst Biol 11(10): 835
    › Primary publication · 26519361 (PubMed) · PMC4631206 (PubMed Central)
  3. Multiscale analysis of the murine intestine for modeling human diseases. Lyons J, Herring CA, Banerjee A, Simmons AJ, Lau KS (2015) Integr Biol (Camb) 7(7): 740-57
    › Primary publication · 26040649 (PubMed) · PMC4569017 (PubMed Central)
  4. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α. Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM (2013) Integr Biol (Camb) 5(11): 1355-65
    › Primary publication · 24084984 (PubMed) · PMC3966991 (PubMed Central)
  5. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM (2013) Integr Biol (Camb) 5(7): 940-63
    › Primary publication · 23685806 (PubMed) · PMC3759823 (PubMed Central)
  6. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium. Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM (2012) PLoS Biol 10(9): e1001393
    › Primary publication · 23055830 (PubMed) · PMC3463506 (PubMed Central)
  7. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. Lau KS, Zhang T, Kendall KR, Lauffenburger D, Gray NS, Haigis KM (2012) PLoS One 7(7): e41343
    › Primary publication · 22815993 (PubMed) · PMC3399817 (PubMed Central)
  8. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M (2011) Nat Commun : 334
    › Primary publication · 21629267 (PubMed) · PMC3133923 (PubMed Central)
  9. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs. Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM (2011) Sci Signal 4(165): ra16
    › Primary publication · 21427409 (PubMed) · PMC3963028 (PubMed Central)
  10. Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer. Lau KS, Haigis KM (2009) Mol Cells 28(4): 315-20
    › Primary publication · 19812895 (PubMed) · PMC3976423 (PubMed Central)
  11. Adaptive regulation at the cell surface by N-glycosylation. Dennis JW, Lau KS, Demetriou M, Nabi IR (2009) Traffic 10(11): 1569-78
    › Primary publication · 19761541 (PubMed)
  12. N-Glycans in cancer progression. Lau KS, Dennis JW (2008) Glycobiology 18(10): 750-60
    › Primary publication · 18701722 (PubMed)
  13. Inhibition of the sodium/potassium ATPase impairs N-glycan expression and function. Beheshti Zavareh R, Lau KS, Hurren R, Datti A, Ashline DJ, Gronda M, Cheung P, Simpson CD, Liu W, Wasylishen AR, Boutros PC, Shi H, Vengopal A, Jurisica I, Penn LZ, Reinhold VN, Ezzat S, Wrana J, Rose DR, Schachter H, Dennis JW, Schimmer AD (2008) Cancer Res 68(16): 6688-97
    › Primary publication · 18701493 (PubMed)
  14. Genome-scale identification of UDP-GlcNAc-dependent pathways. Lau KS, Khan S, Dennis JW (2008) Proteomics 8(16): 3294-302
    › Primary publication · 18646010 (PubMed)
  15. Increased efficiency for performing colony formation assays in 96-well plates: novel applications to combination therapies and high-throughput screening. Katz D, Ito E, Lau KS, Mocanu JD, Bastianutto C, Schimmer AD, Liu FF (2008) Biotechniques 44(2): ix-xiv
    › Primary publication · 18422490 (PubMed)
  16. Complex N-glycan and metabolic control in tumor cells. Mendelsohn R, Cheung P, Berger L, Partridge E, Lau K, Datti A, Pawling J, Dennis JW (2007) Cancer Res 67(20): 9771-80
    › Primary publication · 17942907 (PubMed)
  17. Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation. Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M, Dennis JW (2007) Cell 129(1): 123-34
    › Primary publication · 17418791 (PubMed)
  18. Genome-wide detection of segmental duplications and potential assembly errors in the human genome sequence. Cheung J, Estivill X, Khaja R, MacDonald JR, Lau K, Tsui LC, Scherer SW (2003) Genome Biol 4(4): R25
    › Primary publication · 12702206 (PubMed) · PMC154576 (PubMed Central)