Profile

Professor and Vice Chair for Faculty Development Department of Medicine
Professor of Cell & Developmental Biology
Professor of Molecular Physiology & Biophysics

Lab Url: http://www.mc.vanderbilt.edu/gannonlab 

B.S., Biology, Molloy College, 1985

M.S., Biology, Adelphi Univ, 1988

Ph.D., Cell Biology, Cornell Univ, 1996

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Onecut transcription factors in development and disease. Kropp PA, Gannon M (2016) Trends Dev Biol : 43-57
    › Primary publication · 28018056 (PubMed) · PMC5176019 (PubMed Central)
  2. Unexpected effects of the MIP-CreER transgene and tamoxifen on β-cell growth in C57Bl6/J male mice. Carboneau BA, Le TD, Dunn JC, Gannon M (2016) Physiol Rep 4(18)
    › Primary publication · 27670405 (PubMed) · PMC5037909 (PubMed Central)
  3. Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice. Pasek RC, Dunn JC, Elsakr JM, Aramandla M, Matta AR, Gannon M (2016) Am J Physiol Endocrinol Metab 311(3): E564-74
    › Primary publication · 27460898 (PubMed) · PMC5142004 (PubMed Central)
  4. Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice. Kodama S, Nakano Y, Hirata K, Furuyama K, Horiguchi M, Kuhara T, Masui T, Kawaguchi M, Gannon M, Wright CV, Uemoto S, Kawaguchi Y (2016) Sci Rep : 21211
    › Primary publication · 26887806 (PubMed) · PMC4758062 (PubMed Central)
  5. The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice. Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM (2016) Endocrinology 157(1): 220-32
    › Primary publication · 26485614 (PubMed) · PMC4701878 (PubMed Central)
  6. Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury. Riley KG, Pasek RC, Maulis MF, Dunn JC, Bolus WR, Kendall PL, Hasty AH, Gannon M (2015) Mol Metab 4(8): 584-91
    › Primary publication · 26266091 (PubMed) · PMC4529497 (PubMed Central)
  7. Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion. Golson ML, Dunn JC, Maulis MF, Dadi PK, Osipovich AB, Magnuson MA, Jacobson DA, Gannon M (2015) Diabetes 64(11): 3829-38
    › Primary publication · 26251404 (PubMed) · PMC4613976 (PubMed Central)
  8. Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo. Matsuoka TA, Kaneto H, Kawashima S, Miyatsuka T, Tochino Y, Yoshikawa A, Imagawa A, Miyazaki J, Gannon M, Stein R, Shimomura I (2015) J Biol Chem 290(12): 7647-57
    › Primary publication · 25645923 (PubMed) · PMC4367268 (PubMed Central)
  9. High-fat diet-induced β-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice. Mosser RE, Maulis MF, Moullé VS, Dunn JC, Carboneau BA, Arasi K, Pappan K, Poitout V, Gannon M (2015) Am J Physiol Endocrinol Metab 308(7): E573-82
    › Primary publication · 25628421 (PubMed) · PMC4385873 (PubMed Central)
  10. Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice. Riley KG, Pasek RC, Maulis MF, Peek J, Thorel F, Brigstock DR, Herrera PL, Gannon M (2015) Diabetes 64(4): 1284-98
    › Primary publication · 25392241 (PubMed) · PMC4375083 (PubMed Central)
  11. Activated FoxM1 attenuates streptozotocin-mediated β-cell death. Golson ML, Maulis MF, Dunn JC, Poffenberger G, Schug J, Kaestner KH, Gannon MA (2014) Mol Endocrinol 28(9): 1435-47
    › Primary publication · 25073103 (PubMed) · PMC4154244 (PubMed Central)
  12. Loss of HNF6 expression correlates with human pancreatic cancer progression. Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant NB, Maitra A, Means AL, Gannon MA (2014) Lab Invest 94(5): 517-27
    › Primary publication · 24638272 (PubMed) · PMC4068339 (PubMed Central)
  13. An assay for small scale screening of candidate β cell proliferative factors using intact islets. Mosser RE, Gannon M (2013) Biotechniques 55(6): 310-2
    › Primary publication · 24344680 (PubMed) · PMC4764137 (PubMed Central)
  14. Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling. Mundy C, Gannon M, Popoff SN (2014) J Cell Physiol 229(5): 672-81
    › Primary publication · 24127409 (PubMed) · PMC3946942 (PubMed Central)
  15. Advancements and challenges in generating accurate animal models of gestational diabetes mellitus. Pasek RC, Gannon M (2013) Am J Physiol Endocrinol Metab 305(11): E1327-38
    › Primary publication · 24085033 (PubMed) · PMC4073988 (PubMed Central)
  16. A physiological role for connective tissue growth factor in early wound healing. Alfaro MP, Deskins DL, Wallus M, DasGupta J, Davidson JM, Nanney LB, A Guney M, Gannon M, Young PP (2013) Lab Invest 93(1): 81-95
    › Primary publication · 23212098 (PubMed) · PMC3720136 (PubMed Central)
  17. The skeletal site-specific role of connective tissue growth factor in prenatal osteogenesis. Lambi AG, Pankratz TL, Mundy C, Gannon M, Barbe MF, Richtsmeier JT, Popoff SN (2012) Dev Dyn 241(12): 1944-59
    › Primary publication · 23073844 (PubMed) · PMC3752831 (PubMed Central)
  18. Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Henley KD, Gooding KA, Economides AN, Gannon M (2012) Am J Physiol Endocrinol Metab 303(6): E752-61
    › Primary publication · 22829579 (PubMed) · PMC3468431 (PubMed Central)
  19. Differential regulation of embryonic and adult β cell replication. Gunasekaran U, Hudgens CW, Wright BT, Maulis MF, Gannon M (2012) Cell Cycle 11(13): 2431-42
    › Primary publication · 22659844 (PubMed) · PMC3404874 (PubMed Central)
  20. Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. Reinert RB, Kantz J, Misfeldt AA, Poffenberger G, Gannon M, Brissova M, Powers AC (2012) PLoS One 7(3): e33529
    › Primary publication · 22470452 (PubMed) · PMC3314663 (PubMed Central)
  21. Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Guney MA, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M (2011) Proc Natl Acad Sci U S A 108(37): 15242-7
    › Primary publication · 21876171 (PubMed) · PMC3174622 (PubMed Central)
  22. Type 2 diabetes and the aging pancreatic beta cell. Gunasekaran U, Gannon M (2011) Aging (Albany NY) 3(6): 565-75
    › Primary publication · 21765202 (PubMed) · PMC3164365 (PubMed Central)
  23. Diet-induced impaired glucose tolerance and gestational diabetes in the dog. Moore MC, Menon R, Coate KC, Gannon M, Smith MS, Farmer B, Williams PE (2011) J Appl Physiol (1985) 110(2): 458-67
    › Primary publication · 21088210 (PubMed) · PMC3043793 (PubMed Central)
  24. Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG, Gannon M, Powers AC, Dempsey PJ (2010) Diabetes 59(12): 3090-8
    › Primary publication · 20802254 (PubMed) · PMC2992770 (PubMed Central)
  25. OASIS/CREB3L1 induces expression of genes involved in extracellular matrix production but not classical endoplasmic reticulum stress response genes in pancreatic beta-cells. Vellanki RN, Zhang L, Guney MA, Rocheleau JV, Gannon M, Volchuk A (2010) Endocrinology 151(9): 4146-57
    › Primary publication · 20668028 (PubMed) · PMC2940493 (PubMed Central)
  26. Regulation of pancreas plasticity and malignant transformation by Akt signaling. Elghazi L, Weiss AJ, Barker DJ, Callaghan J, Staloch L, Sandgren EP, Gannon M, Adsay VN, Bernal-Mizrachi E (2009) Gastroenterology 136(3): 1091-103
    › Primary publication · 19121634 (PubMed) · PMC2739876 (PubMed Central)
  27. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV (2006) Genes Dev 20(2): 253-66
    › Primary publication · 16418487 (PubMed) · PMC1356115 (PubMed Central)
  28. The proximal islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen promoter is sufficient to initiate but not maintain transgene expression in mouse islets in vivo. Frigeri C, Martin CC, Svitek CA, Oeser JK, Hutton JC, Gannon M, O'Brien RM (2004) Diabetes 53(7): 1754-64
    › Primary publication · 15220199 (PubMed)
  29. Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets. Brissova M, Fowler M, Wiebe P, Shostak A, Shiota M, Radhika A, Lin PC, Gannon M, Powers AC (2004) Diabetes 53(5): 1318-25
    › Primary publication · 15111502 (PubMed)
  30. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV (2002) Nat Genet 32(1): 128-34
    › Primary publication · 12185368 (PubMed)
  31. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Samaras SE, Cissell MA, Gerrish K, Wright CV, Gannon M, Stein R (2002) Mol Cell Biol 22(13): 4702-13
    › Primary publication · 12052878 (PubMed) · PMC133887 (PubMed Central)
  32. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR (2002) Mol Cell Biol 22(11): 3864-74
    › Primary publication · 11997520 (PubMed) · PMC133833 (PubMed Central)
  33. Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Gannon M, Gamer LW, Wright CV (2001) Dev Biol 238(1): 185-201
    › Primary publication · 11784003 (PubMed)
  34. Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC (2002) J Biol Chem 277(13): 11225-32
    › Primary publication · 11781323 (PubMed)
  35. Molecular genetic analysis of diabetes in mice. Gannon M (2001) Trends Genet 17(10): S23-8
    › Primary publication · 11585673 (PubMed)
  36. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy M (2001) Proc Natl Acad Sci U S A 98(3): 1065-70
    › Primary publication · 11158595 (PubMed) · PMC14709 (PubMed Central)
  37. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV (2000) Development 127(13): 2883-95
    › Primary publication · 10851133 (PubMed)
  38. TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium. Gannon M, Gilday D, Rifkind AB (2000) Toxicol Appl Pharmacol 164(1): 24-37
    › Primary publication · 10739741 (PubMed)
  39. Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Gannon M, Herrera PL, Wright CV (2000) Genesis 26(2): 143-4
    › Primary publication · 10686611 (PubMed)
  40. Analysis of the Cre-mediated recombination driven by rat insulin promoter in embryonic and adult mouse pancreas. Gannon M, Shiota C, Postic C, Wright CV, Magnuson M (2000) Genesis 26(2): 139-42
    › Primary publication · 10686610 (PubMed)
  41. Pancreatic beta cell-specific transcription of the pdx-1 gene. The role of conserved upstream control regions and their hepatic nuclear factor 3beta sites. Gerrish K, Gannon M, Shih D, Henderson E, Stoffel M, Wright CV, Stein R (2000) J Biol Chem 275(5): 3485-92
    › Primary publication · 10652343 (PubMed)
  42. Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Wright CV, Leach SD (1999) Gastroenterology 117(6): 1416-26
    › Primary publication · 10579983 (PubMed)
  43. Avian cardiac progenitors: methods for isolation, culture, and analysis of differentiation. Gannon M, Bader D (1997) Methods Cell Biol : 117-32
    › Primary publication · 9379947 (PubMed)
  44. Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R (1997) Mol Cell Biol 17(10): 6002-13
    › Primary publication · 9315659 (PubMed) · PMC232449 (PubMed Central)
  45. Molecular cloning and expression of two novel avian cytochrome P450 1A enzymes induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Gilday D, Gannon M, Yutzey K, Bader D, Rifkind AB (1996) J Biol Chem 271(51): 33054-9
    › Primary publication · 8955152 (PubMed)
  46. Commitment, differentiation, and diversification of avian cardiac progenitor cells. Melnik N, Yutzey KE, Gannon M, Bader D (1995) Ann N Y Acad Sci : 1-8
    › Primary publication · 7755245 (PubMed)
  47. Initiation of cardiac differentiation occurs in the absence of anterior endoderm. Gannon M, Bader D (1995) Development 121(8): 2439-50
    › Primary publication · 7671808 (PubMed)
  48. Diversification of cardiomyogenic cell lineages in vitro. Yutzey K, Gannon M, Bader D (1995) Dev Biol 170(2): 531-41
    › Primary publication · 7649381 (PubMed)
  49. Arachidonic acid metabolism by dioxin-induced cytochrome P-450: a new hypothesis on the role of P-450 in dioxin toxicity. Rifkind AB, Gannon M, Gross SS (1990) Biochem Biophys Res Commun 172(3): 1180-8
    › Primary publication · 2123101 (PubMed)
  50. Beta-naphthoflavone induction of a cytochrome P-450 arachidonic acid epoxygenase in chick embryo liver distinct from the aryl hydrocarbon hydroxylase and from phenobarbital-induced arachidonate epoxygenase. Nakai K, Ward AM, Gannon M, Rifkind AB (1992) J Biol Chem 267(27): 19503-12
    › Primary publication · 1527070 (PubMed)