DNA damage arising from exposure to environmental toxins and cellular metabolites thwarts DNA replication and leads to genome instability, cell death, and diseases including cancer. This laboratory uses the tools of structural biology and biochemistry to investigate molecular mechanisms of proteins involved in repairing DNA damage and maintaining replication fork progression. Current work focuses on base excision repair of DNA alkylation damage by DNA glycosylases and repair of stalled replication forks by structure-specific DNA translocases. The long-term goals are to understand the fundamental processes underlying genome maintenance and to develop new therapeutic strategies that target genetic diseases.
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- Vanderbilt-Ingram Cancer Center
Faculty Member
465 21st Ave S
5270A MRBIII
Nashville, TN 37232
United States
6159365233 (p)
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term Keyword
Alkylation Amino Acid Motifs Archaea Baculoviridae Base Sequence Blotting, Western Cell Survival Computer Simulation Deoxyguanosine DNA, Fungal DNA Adducts DNA Primase DNA repair DNA replication Endonucleases Enzyme Activation Extracellular Signal-Regulated MAP Kinases Genome Maintenance HEK293 Cells High-Throughput Nucleotide Sequencing Iron-Sulfur Proteins Mice Molecular Docking Simulation N-Glycosyl Hydrolases Naphthalenes Phylogeny Protein Binding Protein Conformation Protein Structure, Secondary Replication Protein A RNA Interference Structural Biology Surface Properties Thiazolidines X-ray crystallography