Bertha C Elias, Ph.D

Official Affiliation: Medicine

Profile

Bertha Elias is a Research Instructor at the Vanderbilt University School of Medicine in Nashville, Tennessee. She is a member of the Brooks laboratory in the division of Nephrology.

She received her Ph.D in Zoology from the University of Pune in India. She started her career as a post-doctoral fellow at the Astra Research Centre (a center of excellence of the present AstraZeneca Pharmaceuticals) in Bangalore, India. She stayed on to work as an Associate Scientist with the company till 2001 with the cell biology group. She then did a couple more postdoctoral stints at the Mount Sinai School of Medicine, New York and the University of Tennessee, Memphis.

Her expertise is in using mammalian cell lines to study cell signaling events influenced by extracellular matrix and integrins in kidney development. Regulation of cellular tight and adherans junctions has been her main areas of focus in the recent past. She now focuses on the role of Cyclins G1 and G2  in cell cycle arrest leading to fibrosis. She uses biochemistry, cell biology, molecular biology, confocal microscopy as well as mass spectroscopy in her endeavors to answer interesting questions in her research.

 

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells. Elias BC, Mathew S, Srichai MB, Palamuttam R, Bulus N, Mernaugh G, Singh AB, Sanders CR, Harris RC, Pozzi A, Zent R (2014) J Biol Chem 289(12): 8532-44
    › Primary publication · 24509849 (PubMed) · PMC3961677 (PubMed Central)
  2. Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation. Elias BC, Bhattacharya S, Ray RM, Johnson LR (2010) Cell Adh Migr 4(3): 419-30
    › Primary publication · 20448461 (PubMed) · PMC2958619 (PubMed Central)
  3. PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Suzuki T, Elias BC, Seth A, Shen L, Turner JR, Giorgianni F, Desiderio D, Guntaka R, Rao R (2009) Proc Natl Acad Sci U S A 106(1): 61-6
    › Primary publication · 19114660 (PubMed) · PMC2629239 (PubMed Central)
  4. Phosphorylation of Tyr-398 and Tyr-402 in occludin prevents its interaction with ZO-1 and destabilizes its assembly at the tight junctions. Elias BC, Suzuki T, Seth A, Giorgianni F, Kale G, Shen L, Turner JR, Naren A, Desiderio DM, Rao R (2009) J Biol Chem 284(3): 1559-69
    › Primary publication · 19017651 (PubMed) · PMC2615497 (PubMed Central)
  5. Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer. Seth A, Sheth P, Elias BC, Rao R (2007) J Biol Chem 282(15): 11487-98
    › Primary publication · 17298946 (PubMed)
  6. MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide. Basuroy S, Seth A, Elias B, Naren AP, Rao R (2006) Biochem J 393(Pt 1): 69-77
    › Primary publication · 16134968 (PubMed) · PMC1383665 (PubMed Central)
  7. Phosphorylation of MdmX by CDK2/Cdc2(p34) is required for nuclear export of Mdm2. Elias B, Laine A, Ronai Z (2005) Oncogene 24(15): 2574-9
    › Primary publication · 15735705 (PubMed)
  8. Novel scintillation proximity assay for measuring membrane-associated steps of peptidoglycan biosynthesis in Escherichia coli. Chandrakala B, Elias BC, Mehra U, Umapathy NS, Dwarakanath P, Balganesh TS, deSousa SM (2001) Antimicrob Agents Chemother 45(3): 768-75
    › Primary publication · 11181358 (PubMed) · PMC90371 (PubMed Central)
  9. Mesoderm enhancing effect of human seminal plasma inhibin and its synthetic C-terminal nonapeptide fragment in the chick embryo. Ghaskadbi S, Elias B, Patwardhan V, Garde S, Sheth AR, Ghate HV (1994) Indian J Exp Biol 32(7): 450-7
    › Primary publication · 7959919 (PubMed)
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Keywords & MeSH Terms

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Key: MeSH Term Keyword

Animals Binding Sites Cell Line Cell Membrane Cell Movement Cell Nucleus Cells, Cultured Chromatography, Paper Claudin-2 Enzyme Activation Epidermal Growth Factor Epithelium Gene Expression Regulation, Enzymologic Guanine Nucleotide Exchange Factors Hydrogen Peroxide Inhibins Integrin beta1 Kidney Tubules, Proximal Mice Mitogen-Activated Protein Kinases Oxidants Oxidative Stress Protein Binding Protein Kinase C Reproducibility of Results RNA, Small Interfering Serine src-Family Kinases Tyrosine Urine