Profile

Dr. Billy G. Hudson, Ph.D., is the Elliot V. Newman Professor of Medicine, Biochemistry and Pathology, Microbiology and Immunology, and Director of the Center for Matrix Biology at Vanderbilt University. His research has focused on ancient collagen proteins that compose basement membranes, a specialized form of extracellular matrix that underlies epithelia cells. The matrix is essential for the development and maintenance of tissue architecture and function in all multi-cellular organisms from sponge to human. His research group discovered two collagen proteins, and named them alpha-3 and alpha-4 chains of collagen IV, and described how they, together with an alpha-5 chain, assemble into a complex α3α4α5 network that functions as a key component of the kidney filtration barrier. The network is directly involved in the pathogenic mechanisms underlying several diseases that cause kidney failure in millions of people: autoimmune Goodpasture syndrome; hereditary Alport syndrome; thin basement membrane nephropathy, Alport post-transplant nephritis, and diabetic renal disease. His work has defined the three-dimensional structure and antibody binding sites of the autoantigen of Goodpasture syndrome, and discovered a new sulfur-nitrogen chemical bond (=S=N-), named sulifilimine bond, that fastens the autoantigen together, uncovering clues to the pathogenesis of a prototype autoimmune disease, Science (2009).

Recently the Hudson team discovered the enzyme, named peroxidasin that forms the sulifilimine chemical bond, Nature Chemical Biology (2012), and the evolutionary origin of the sulfilimine chemical bond and peroxidasin, Proceedings of the National Academy of Sciences (2014). Just recently, they discovered that the trace element bromine is required for bond formation and that bromine is an essential trace element for tissue genesis throughout the animal kingdom, Cell (2014). These discoveries profile collagen IV scaffolds (suliflimine-crosslinked) as a primordial innovation that is essential for tissue evolution.

He is a co-founder of NephroGenex, a biotech company that is developing Pyridorin, a drug-candidate which was discovered in his laboratory for the prevention of diabetic kidney disease. A phase III clinical trial will begin 2014. He is also co-founder, along with wife, Dr. Julie Hudson, of “Aspirnaut”, an educational initiative that encourages students, kindergarten thru undergraduate, to pursue studies and careers in science, technology, engineering and mathematics.

Billy received his Ph.D. from the University of Iowa in 1966 and performed his postdoctoral training at Harvard University and the U.S. Army Research Institute of Environmental Medicine. He is the coauthor of over 200 scientific publications and 30 patents.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR (2017) Nature 545(7653): 243-247
    › Primary publication · 28467828 (PubMed)
  2. Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues. Fidler AL, Darris CE, Chetyrkin SV, Pedchenko VK, Boudko SP, Brown KL, Gray Jerome W, Hudson JK, Rokas A, Hudson BG (2017) Elife
    › Primary publication · 28418331 (PubMed)
  3. The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease. Xie LJ, Cui Z, Chen FJ, Pei ZY, Hu SY, Gu QH, Jia XY, Zhu L, Zhou XJ, Zhang H, Liao YH, Lai LH, Hudson BG, Zhao MH (2017) Immunology
    › Primary publication · 28342268 (PubMed)
  4. Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function. Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R (2016) Elife
    › Primary publication · 27929375 (PubMed) · PMC5207772 (PubMed Central)
  5. Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy. Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG (2016) Data Brief : 931-939
    › Primary publication · 27896299 (PubMed) · PMC5118616 (PubMed Central)
  6. Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane. Añazco C, López-Jiménez AJ, Rafi M, Vega-Montoto L, Zhang MZ, Hudson BG, Vanacore RM (2016) J Biol Chem 291(50): 25999-26012
    › Primary publication · 27770022 (PubMed)
  7. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming. Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG (2016) Matrix Biol
    › Primary publication · 27619726 (PubMed)
  8. Extracellular chloride signals collagen IV network assembly during basement membrane formation. Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, Stothers C, Ero-Tolliver IA, McCall AS, Vanacore R, Bhave G, Santoro S, Blackwell TS, Zent R, Pozzi A, Hudson BG (2016) J Cell Biol 213(4): 479-94
    › Primary publication · 27216258 (PubMed) · PMC4878091 (PubMed Central)
  9. Pyridoxamine reduces postinjury fibrosis and improves functional recovery after acute kidney injury. Skrypnyk NI, Voziyan P, Yang H, de Caestecker CR, Theberge MC, Drouin M, Hudson B, Harris RC, de Caestecker MP (2016) Am J Physiol Renal Physiol 311(2): F268-77
    › Primary publication · 27194713 (PubMed) · PMC5008672 (PubMed Central)
  10. Antibodies to α5 chain of collagen IV are pathogenic in Goodpasture's disease. Cui Z, Zhao MH, Jia XY, Wang M, Hu SY, Wang SX, Yu F, Brown KL, Hudson BG, Pedchenko V (2016) J Autoimmun : 1-11
    › Primary publication · 27117167 (PubMed)
  11. Comprehensive Characterization of Glycosylation and Hydroxylation of Basement Membrane Collagen IV by High-Resolution Mass Spectrometry. Basak T, Vega-Montoto L, Zimmerman LJ, Tabb DL, Hudson BG, Vanacore RM (2016) J Proteome Res 15(1): 245-58
    › Primary publication · 26593852 (PubMed) · PMC4771517 (PubMed Central)
  12. Decellularization of intact tissue enables MALDI imaging mass spectrometry analysis of the extracellular matrix. Gessel M, Spraggins JM, Voziyan P, Hudson BG, Caprioli RM (2015) J Mass Spectrom 50(11): 1288-93
    › Primary publication · 26505774 (PubMed)
  13. The Ancient Immunoglobulin Domains of Peroxidasin Are Required to Form Sulfilimine Cross-links in Collagen IV. Ero-Tolliver IA, Hudson BG, Bhave G (2015) J Biol Chem 290(35): 21741-8
    › Primary publication · 26178375 (PubMed) · PMC4571896 (PubMed Central)
  14. Pyridoxamine protects proteins from damage by hypohalous acids in vitro and in vivo. Madu H, Avance J, Chetyrkin S, Darris C, Rose KL, Sanchez OA, Hudson B, Voziyan P (2015) Free Radic Biol Med : 83-90
    › Primary publication · 26159508 (PubMed) · PMC4684779 (PubMed Central)
  15. Hypohalous acids contribute to renal extracellular matrix damage in experimental diabetes. Brown KL, Darris C, Rose KL, Sanchez OA, Madu H, Avance J, Brooks N, Zhang MZ, Fogo A, Harris R, Hudson BG, Voziyan P (2015) Diabetes 64(6): 2242-53
    › Primary publication · 25605804 (PubMed) · PMC4439565 (PubMed Central)
  16. Supramolecular organization of the α121-α565 collagen IV network. Robertson WE, Rose KL, Hudson BG, Vanacore RM (2014) J Biol Chem 289(37): 25601-10
    › Primary publication · 25006246 (PubMed) · PMC4162165 (PubMed Central)
  17. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. McCall AS, Cummings CF, Bhave G, Vanacore R, Page-McCaw A, Hudson BG (2014) Cell 157(6): 1380-92
    › Primary publication · 24906154 (PubMed) · PMC4144415 (PubMed Central)
  18. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. Grove KJ, Voziyan PA, Spraggins JM, Wang S, Paueksakon P, Harris RC, Hudson BG, Caprioli RM (2014) J Lipid Res 55(7): 1375-85
    › Primary publication · 24864273 (PubMed) · PMC4076088 (PubMed Central)
  19. Propagating the nephrology research workforce: a Kidney Research National Dialogue training commentary. Kohan DE, Parker MG, Furth SL, Hudson BG, Warburton KM, Rys-Sikora KE, Rankin TL, Kidney Research National Dialogue (2014) Clin J Am Soc Nephrol 9(6): 1144-7
    › Primary publication · 24626430 (PubMed) · PMC4046718 (PubMed Central)
  20. Lens capsule as a model to study type IV collagen. Cummings CF, Hudson BG (2014) Connect Tissue Res 55(1): 8-12
    › Primary publication · 24437599 (PubMed) · PMC4138812 (PubMed Central)
  21. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT, Aspirnauts, Hudson JK, Hudson BG (2014) Proc Natl Acad Sci U S A 111(1): 331-6
    › Primary publication · 24344311 (PubMed) · PMC3890831 (PubMed Central)
  22. Site-specific AGE modifications in the extracellular matrix: a role for glyoxal in protein damage in diabetes. Voziyan P, Brown KL, Chetyrkin S, Hudson B (2014) Clin Chem Lab Med 52(1): 39-45
    › Primary publication · 23492568 (PubMed) · PMC4104777 (PubMed Central)
  23. The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN. Ooi JD, Chang J, O'Sullivan KM, Pedchenko V, Hudson BG, Vandenbark AA, Fugger L, Holdsworth SR, Kitching AR (2013) J Am Soc Nephrol 24(3): 419-31
    › Primary publication · 23411782 (PubMed) · PMC3582203 (PubMed Central)
  24. Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice. Steenhard BM, Vanacore R, Friedman D, Zelenchuk A, Stroganova L, Isom K, St John PL, Hudson BG, Abrahamson DR (2012) PLoS One 7(12): e50745
    › Primary publication · 23236390 (PubMed) · PMC3517557 (PubMed Central)
  25. Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis. Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A (2012) J Biol Chem 287(42): 35139-52
    › Primary publication · 22888006 (PubMed) · PMC3471707 (PubMed Central)
  26. Inhibition of integrin α2β1 ameliorates glomerular injury. Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A (2012) J Am Soc Nephrol 23(6): 1027-38
    › Primary publication · 22440900 (PubMed) · PMC3358756 (PubMed Central)
  27. Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130). Revert-Ros F, López-Pascual E, Granero-Moltó F, Macías J, Breyer R, Zent R, Hudson BG, Saadeddin A, Revert F, Blasco R, Navarro C, Burks D, Saus J (2011) J Biol Chem 286(40): 35030-43
    › Primary publication · 21832087 (PubMed) · PMC3186396 (PubMed Central)
  28. Pyridoxamine protects protein backbone from oxidative fragmentation. Chetyrkin S, Mathis M, Hayes McDonald W, Shackelford X, Hudson B, Voziyan P (2011) Biochem Biophys Res Commun 411(3): 574-9
    › Primary publication · 21763683 (PubMed) · PMC3153140 (PubMed Central)
  29. Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues. Chetyrkin S, Mathis M, Pedchenko V, Sanchez OA, McDonald WH, Hachey DL, Madu H, Stec D, Hudson B, Voziyan P (2011) Biochemistry 50(27): 6102-12
    › Primary publication · 21661747 (PubMed) · PMC3140462 (PubMed Central)
  30. Goodpasture's disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis. Pedchenko V, Vanacore R, Hudson B (2011) Curr Opin Nephrol Hypertens 20(3): 290-6
    › Primary publication · 21378566 (PubMed) · PMC3159420 (PubMed Central)
  31. Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes. Parkin JD, San Antonio JD, Pedchenko V, Hudson B, Jensen ST, Savige J (2011) Hum Mutat 32(2): 127-43
    › Primary publication · 21280145 (PubMed) · PMC4800984 (PubMed Central)
  32. Stem cell therapy for Alport syndrome: the hope beyond the hype. Gross O, Borza DB, Anders HJ, Licht C, Weber M, Segerer S, Torra R, Gubler MC, Heidet L, Harvey S, Cosgrove D, Lees G, Kashtan C, Gregory M, Savige J, Ding J, Thorner P, Abrahamson DR, Antignac C, Tryggvason K, Hudson B, Miner JH (2009) Nephrol Dial Transplant 24(3): 731-4
    › Primary publication · 19110486 (PubMed) · PMC3888105 (PubMed Central)
  33. Interaction of Dr adhesin with collagen type IV is a critical step in Escherichia coli renal persistence. Selvarangan R, Goluszko P, Singhal J, Carnoy C, Moseley S, Hudson B, Nowicki S, Nowicki B (2004) Infect Immun 72(8): 4827-35
    › Primary publication · 15271945 (PubMed) · PMC470682 (PubMed Central)
  34. Crescentic glomerulonephritis and subepidermal blisters with autoantibodies to alpha5 and alpha6 chains of type IV collagen. Ghohestani RF, Rotunda SL, Hudson B, Gaughan WJ, Farber JL, Webster G, Uitto J (2003) Lab Invest 83(5): 605-11
    › Primary publication · 12746470 (PubMed)
  35. Seventy-year-old man with pulmonary problems and renal failure: a clinicopathologic correlation conference from the University of Oklahoma College of Medicine. Kinasewitz G, Fine D, Good TD, Eaton B, Silva F, Hudson B (1997) J Okla State Med Assoc 90(8): 431-41
    › Primary publication · 9816389 (PubMed)
  36. Rapidly Progressive Renal Failure in a Young Woman. Scarpelli DG (1975) N Engl J Med 293(18): 922-7
    › Primary publication · 1177991 (PubMed)