Our primary interest is understanding how the central nervous
system regulates energy stores. We are focused not only on the
normal process, but also on the pathophysiological mechanisms that
lead to common obesity, severe monogenic obesity, metabolic
syndrome, cachexia or disease wasting, anorexia nervosa, and other
eating disorders. A theme of the lab has been understanding the
role of the central melanocortin system in these processes.
Because we are focused on a complex biological problem that impacts multiple physiological systems, we apply a wide variety of techniques including genetics, molecular biology, neuroantomy, and electrophysiology. Our work also spans a wide range of organisms, from zebrafish to mouse, to humans. New projects include development of the zebrafish as a model system for whole genome forward genetics of energy homeostasis, and identification of genes predisposing humans to anorexia nervosa.
The following timeline graph is generated from all co-authored publications.Featured publications are shown below:
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MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordAdipose Tissue, Brown Adiposity anorexia Arginine cachexia CHO Cells Colon Diet, Atherogenic Dietary Fats Disease Models, Animal energy homeostasis gamma-MSH Green Fluorescent Proteins Herpesvirus 1, Suid Humans hypothalamus Limbic System melanocortin Mutation Neurons Neuropeptides Nuclear Proteins Obesity Oligonucleotides Postprandial Period Promoter Regions, Genetic Rats Real-Time Polymerase Chain Reaction Receptor, Melanocortin, Type 3 Receptors, Cell Surface RNA, Messenger Sex Characteristics STAT3 Transcription Factor Transcription Factors Up-Regulation Ventral Tegmental Area