Profile

Our primary interest is understanding how the central nervous system regulates energy stores. We are focused not only on the normal process, but also on the pathophysiological mechanisms that lead to common obesity, severe monogenic obesity, metabolic syndrome, cachexia or disease wasting, anorexia nervosa, and other eating disorders. A theme of the lab has been understanding the role of the central melanocortin system in these processes.

Because we are focused on a complex biological problem that impacts multiple physiological systems, we apply a wide variety of techniques including genetics, molecular biology, neuroantomy, and electrophysiology. Our work also spans a wide range of organisms, from zebrafish to mouse, to humans. New projects include development of the zebrafish as a model system for whole genome forward genetics of energy homeostasis, and identification of genes predisposing humans to anorexia nervosa.

Publications

The following timeline graph is generated from all co-authored publications.

Featured publications are shown below:

  1. Regulation of orexigenic AgRP neurons: A third way? Bingham NC, Cone RD (2015) Trends Endocrinol Metab 26(7): 339-40
    › Citation · 26033032 (PubMed)
  2. Neuroscience: a cellular basis for the munchies. Patel S, Cone RD (2015) Nature 519(7541): 38-40
    › Citation · 25707800 (PubMed)
  3. RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals. Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC (2015) J Clin Endocrinol Metab 100(4): 1639-45
    › Citation · 25675384 (PubMed) · PMC4399297 (PubMed Central)
  4. G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons. Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD (2015) Nature 520(7545): 94-8
    › Citation · 25600267 (PubMed) · PMC4383680 (PubMed Central)
  5. QnAs with Roger D. Cone. Cone RD (2013) Proc Natl Acad Sci U S A 110(24): 9618
    › Primary publication · 23716686 (PubMed) · PMC3683786 (PubMed Central)