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Alzheimer Disease Amyloid beta-Peptides Animals Brain Injuries, Traumatic Cognitive Dysfunction Disease Models, Animal Disks Large Homolog 4 Protein Glycogen Synthase Kinase 3 beta Hippocampus Male Maze Learning Memory Metformin Mice Neuroprotective Agents Oligonucleotides, Antisense Peptide Fragments Pyrrolidines Thiophenes Treatment Outcome