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•  Stephen Brandt

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Publications

• In vivo reprogramming of adult pancreatic exocrine cells to beta-cells.
  Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA
  (2008) Nature 455: 627-32
• Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
  Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM
  (2001) Nature 413: 131-8
• Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
  Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, Cox NJ, Fajans SS, Signorini S, Stoffel M, Bell GI
  (1996) Nature 384: 458-60
• Heart repair by reprogramming non-myocytes with cardiac transcription factors.
  Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN
  (2012) Nature 485: 599-604
• Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
  Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R
  (2013) Nat Genet 45: 1044-9
• Generation of functional insulin-producing cells in the gut by Foxo1 ablation.
  Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D
  (2012) Nat Genet 44: 406-12, S1
• Control of pancreas and liver gene expression by HNF transcription factors.
  Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA
  (2004) Science 303: 1378-81
• Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
  Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA
  (2003) Cancer Cell 4: 437-50
• Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
  Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S
  (2005) Cancer Cell 8: 155-67
• A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
  Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ
  (2013) Nat Med 19: 1331-1337
• The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4.
  Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB
  (2003) Nat Med 9: 220-4
• TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
  Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N
  (2006) Nat Med 12: 107-13
• Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice.
  Ding M, Cui S, Li C, Jothy S, Haase V, Steer BM, Marsden PA, Pippin J, Shankland S, Rastaldi MP, Cohen CD, Kretzler M, Quaggin SE
  (2006) Nat Med 12: 1081-7
• EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity.
  Löf-Öhlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H
  (2017) Nat Cell Biol 19: 1313-1325
• Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
  Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG
  (2010) Circulation 122: 1004-16
• In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation.
  Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, Iliopoulos O
  (2013) Cell Metab 17: 372-85
• Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
  Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P
  (2013) Dev Cell 26: 86-100
• Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.
  Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin-Botton A
  (2007) Dev Cell 12: 457-65
• Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity.
  Liu J, Banerjee A, Herring CA, Attalla J, Hu R, Xu Y, Shao Q, Simmons AJ, Dadi PK, Wang S, Jacobson DA, Liu B, Hodges E, Lau KS, Gu G
  (2019) Dev Cell 48: 49-63.e7
• Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
  Zeng C, Matsuda K, Jia WH, Chang J, Kweon SS, Xiang YB, Shin A, Jee SH, Kim DH, Zhang B, Cai Q, Guo X, Long J, Wang N, Courtney R, Pan ZZ, Wu C, Takahashi A, Shin MH, Matsuo K, Matsuda F, Gao YT, Oh JH, Kim S, Jung KJ, Ahn YO, Ren Z, Li HL, Wu J, Shi J, Wen W, Yang G, Li B, Ji BT, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Brenner H, Schoen RE, Küry S, Colorectal Transdisciplinary (CORECT) Study, Gruber SB, Schumacher FR, Stenzel SL, Colon Cancer Family Registry (CCFR), Casey G, Hopper JL, Jenkins MA, Kim HR, Jeong JY, Park JW, Tajima K, Cho SH, Kubo M, Shu XO, Lin D, Zeng YX, Zheng W
  (2016) Gastroenterology 150: 1633-1645
• A molecular signature of gastric metaplasia arising in response to acute parietal cell loss.
  Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR
  (2008) Gastroenterology 134: 511-22
• It's about time: clock genes unveiled in the gut.
  Scheving LA, Russell WE
  (2007) Gastroenterology 133: 1373-6
• Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.
  Direnzo D, Hess DA, Damsz B, Hallett JE, Marshall B, Goswami C, Liu Y, Deering T, Macdonald RJ, Konieczny SF
  (2012) Gastroenterology 143: 469-80
• Hypoxia-inducible factor augments experimental colitis through an MIF-dependent inflammatory signaling cascade.
  Shah YM, Ito S, Morimura K, Chen C, Yim SH, Haase VH, Gonzalez FJ
  (2008) Gastroenterology 134: 2036-48, 2048.e1-3
• The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.
  Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL
  (2007) J Clin Invest 117: 1616-26
• Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis.
  Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L
  (2012) J Clin Invest 122: 3516-28
• The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.
  Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS
  (2009) J Clin Invest 119: 3373-83
• The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation.
  Capoccia BJ, Jin RU, Kong YY, Peek RM, Fassan M, Rugge M, Mills JC
  (2013) J Clin Invest 123: 1475-91
• Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas.
  Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF, Fujimoto K, Doi R, Kageyama R, Wright CV, Chiba T
  (2006) J Clin Invest 116: 1484-93
• Hepatic glucose sensing: does flux matter?
  Shiota M, Magnuson MA
  (2008) J Clin Invest 118: 841-4
• Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin.
  Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH
  (2016) J Clin Invest 126: 1926-38
• Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.
  Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K
  (2010) J Clin Invest 120: 4040-54
• Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis.
  Liu Q, Davidoff O, Niss K, Haase VH
  (2012) J Clin Invest 122: 4635-44
• Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.
  Kapitsinou PP, Sano H, Michael M, Kobayashi H, Davidoff O, Bian A, Yao B, Zhang MZ, Harris RC, Duffy KJ, Erickson-Miller CL, Sutton TA, Haase VH
  (2014) J Clin Invest 124: 2396-409
• Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
  Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH
  (2007) J Clin Invest 117: 1068-77
• von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.
  Hickey MM, Lam JC, Bezman NA, Rathmell WK, Simon MC
  (2007) J Clin Invest 117: 3879-89
• A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
  Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE
  (2008) Genes Dev 22: 166-78
• NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus.
  Miyata T, Maeda T, Lee JE
  (1999) Genes Dev 13: 1647-52
• Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
  Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ
  (2007) Genes Dev 21: 2629-43
• HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.
  Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B
  (2006) Genes Dev 20: 557-70