Keyword Connections

•  Albert Reynolds
•  Bih-Hwa Shieh
•  James Goldenring
•  Kathleen Gould

•  Mark de Caestecker
•  Randy Blakely
•  Robert Macdonald
•  Sandra Zinkel

•  Stephen Hann
•  Virginia Shepherd

Resources

• No matching connections

Communities

• Blakely Lab
• de Caestecker Lab
• Goldenring Lab
• Zinkel Lab

Publications

• Integrin-linked kinase is an adaptor with essential functions during mouse development.
  Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R
  (2009) Nature 461: 1002-6
• A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
  Rameh LE, Tolias KF, Duckworth BC, Cantley LC
  (1997) Nature 390: 192-6
• Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma.
  Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D'Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K
  (2010) Nature 467: 596-9
• Disruption of IRS-2 causes type 2 diabetes in mice.
  Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
  (1998) Nature 391: 900-4
• Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis.
  Gould KL, Nurse P
  (1989) Nature 342: 39-45
• Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction.
  Sy JC, Seshadri G, Yang SC, Brown M, Oh T, Dikalov S, Murthy N, Davis ME
  (2008) Nat Mater 7: 863-8
• Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.
  Silva JP, Köhler M, Graff C, Oldfors A, Magnuson MA, Berggren PO, Larsson NG
  (2000) Nat Genet 26: 336-40
• Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
  Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA
  (2013) Cell 155: 1624-38
• Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
  Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE
  (2017) Cell 170: 457-469.e13
• A role for proapoptotic BID in the DNA-damage response.
  Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ
  (2005) Cell 122: 579-91
• Single cell profiling of potentiated phospho-protein networks in cancer cells.
  Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud Ø, Gjertsen BT, Nolan GP
  (2004) Cell 118: 217-28
• Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5.
  de Bruin RA, McDonald WH, Kalashnikova TI, Yates J, Wittenberg C
  (2004) Cell 117: 887-98
• The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing.
  Muratani M, Kung C, Shokat KM, Tansey WP
  (2005) Cell 120: 887-99
• Protein kinase C phosphorylates pp60src at a novel site.
  Gould KL, Woodgett JR, Cooper JA, Buss JE, Shalloway D, Hunter T
  (1985) Cell 42: 849-57
• Roles of serine/threonine phosphatases in hippocampal synaptic plasticity.
  Winder DG, Sweatt JD
  (2001) Nat Rev Neurosci 2: 461-74
• Interleukin-4 and interleukin-13 signaling connections maps.
  Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD
  (2003) Science 300: 1527-8
• Phosphorylation and sequestration of serotonin transporters differentially modulated by psychostimulants.
  Ramamoorthy S, Blakely RD
  (1999) Science 285: 763-6
• A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
  Odom AR, Stahlberg A, Wente SR, York JD
  (2000) Science 287: 2026-9
• Suppression of aging in mice by the hormone Klotho.
  Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M
  (2005) Science 309: 1829-33
• Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase.
  Gould KL, Moreno S, Tonks NK, Nurse P
  (1990) Science 250: 1573-6
• A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
  Westphal RS, Anderson KA, Means AR, Wadzinski BE
  (1998) Science 280: 1258-61
• Structural insights into a circadian oscillator.
  Johnson CH, Egli M, Stewart PL
  (2008) Science 322: 697-701
• ATR and ATRIP: partners in checkpoint signaling.
  Cortez D, Guntuku S, Qin J, Elledge SJ
  (2001) Science 294: 1713-6
• Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer.
  Liu J, Ghanim M, Xue L, Brown CD, Iossifov I, Angeletti C, Hua S, Nègre N, Ludwig M, Stricker T, Al-Ahmadie HA, Tretiakova M, Camp RL, Perera-Alberto M, Rimm DL, Xu T, Rzhetsky A, White KP
  (2009) Science 323: 1218-22
• Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II.
  Karcher RL, Roland JT, Zappacosta F, Huddleston MJ, Annan RS, Carr SA, Gelfand VI
  (2001) Science 293: 1317-20
• Neurobiology. Dopamine's reversal of fortune.
  Blakely RD
  (2001) Science 293: 2407-9
• Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
  Cortez D, Wang Y, Qin J, Elledge SJ
  (1999) Science 286: 1162-6
• Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates.
  Kotecha N, Flores NJ, Irish JM, Simonds EF, Sakai DS, Archambeault S, Diaz-Flores E, Coram M, Shannon KM, Nolan GP, Loh ML
  (2008) Cancer Cell 14: 335-43
• Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.
  McCaffrey LM, Montalbano J, Mihai C, Macara IG
  (2012) Cancer Cell 22: 601-14
• Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
  Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, Cipolla AK, Wubbenhorst B, Xu X, Gimotty PA, Kee D, Santiago-Walker AE, Letrero R, D'Andrea K, Pushparajan A, Hayden JE, Brown KD, Laquerre S, McArthur GA, Sosman JA, Nathanson KL, Herlyn M
  (2010) Cancer Cell 18: 683-95
• HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
  Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL
  (2006) Cancer Cell 10: 25-38
• PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
  Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL
  (2002) Nat Med 8: 1145-52
• The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus.
  Hahn AS, Kaufmann JK, Wies E, Naschberger E, Panteleev-Ivlev J, Schmidt K, Holzer A, Schmidt M, Chen J, König S, Ensser A, Myoung J, Brockmeyer NH, Stürzl M, Fleckenstein B, Neipel F
  (2012) Nat Med 18: 961-6
• Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
  Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N
  (2007) Nat Med 13: 1193-202
• TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.
  Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N
  (2006) Nat Med 12: 107-13
• Calmodulin kinase II inhibition protects against structural heart disease.
  Zhang R, Khoo MS, Wu Y, Yang Y, Grueter CE, Ni G, Price EE, Thiel W, Guatimosim S, Song LS, Madu EC, Shah AN, Vishnivetskaya TA, Atkinson JB, Gurevich VV, Salama G, Lederer WJ, Colbran RJ, Anderson ME
  (2005) Nat Med 11: 409-17
• The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.
  Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD
  (2013) Nat Cell Biol 15: 677-87
• IQGAP1 makes PI(3)K signalling as easy as PIP, PIP, PIP.
  Rameh LE, Mackey AM
  (2016) Nat Cell Biol 18: 1263-1265
• Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation.
  Phillips N, Hayward RD, Koronakis V
  (2004) Nat Cell Biol 6: 618-25
• Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers.
  Bekaii-Saab T, Phelps MA, Li X, Saji M, Goff L, Kauh JS, O'Neil BH, Balsom S, Balint C, Liersemann R, Vasko VV, Bloomston M, Marsh W, Doyle LA, Ellison G, Grever M, Ringel MD, Villalona-Calero MA
  (2011) J Clin Oncol 29: 2357-63