Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. Matsui Y, Halter SA, Holt JT, Hogan BL, Coffey RJ (1990) Cell 61: 1147-55 Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression. Biswas S, Guix M, Rinehart C, Dugger TC, Chytil A, Moses HL, Freeman ML, Arteaga CL (2007) J Clin Invest 117: 1305-13 Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL (2002) J Clin Invest 109: 1551-9 Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1. Pierce DF, Johnson MD, Matsui Y, Robinson SD, Gold LI, Purchio AF, Daniel CW, Hogan BL, Moses HL (1993) Genes Dev 7: 2308-17 Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators. Owens P, Pickup MW, Novitskiy SV, Chytil A, Gorska AE, Aakre ME, West J, Moses HL (2012) Proc Natl Acad Sci U S A 109: 2814-9 Mammary tumor suppression by transforming growth factor beta 1 transgene expression. Pierce DF, Gorska AE, Chytil A, Meise KS, Page DL, Coffey RJ, Moses HL (1995) Proc Natl Acad Sci U S A 92: 4254-8 Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice. Lenferink AE, Simpson JF, Shawver LK, Coffey RJ, Forbes JT, Arteaga CL (2000) Proc Natl Acad Sci U S A 97: 9609-14 Tumors initiated by constitutive Cdk2 activation exhibit transforming growth factor beta resistance and acquire paracrine mitogenic stimulation during progression. Corsino P, Davis B, Law M, Chytil A, Forrester E, Nørgaard P, Teoh N, Law B (2007) Cancer Res 67: 3135-44 Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Forrester E, Chytil A, Bierie B, Aakre M, Gorska AE, Sharif-Afshar AR, Muller WJ, Moses HL (2005) Cancer Res 65: 2296-302 Matrilysin (matrix metalloproteinase-7) selects for apoptosis-resistant mammary cells in vivo. Vargo-Gogola T, Fingleton B, Crawford HC, Matrisian LM (2002) Cancer Res 62: 5559-63 ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis. Cook RS, Garrett JT, Sánchez V, Stanford JC, Young C, Chakrabarty A, Rinehart C, Zhang Y, Wu Y, Greenberger L, Horak ID, Arteaga CL (2011) Cancer Res 71: 3941-51 Overexpression of the matrix metalloproteinase matrilysin results in premature mammary gland differentiation and male infertility. Rudolph-Owen LA, Cannon P, Matrisian LM (1998) Mol Biol Cell 9: 421-35 Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation. Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, Moses HL (2003) Am J Pathol 163: 1539-49 Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. Halter SA, Dempsey P, Matsui Y, Stokes MK, Graves-Deal R, Hogan BL, Coffey RJ (1992) Am J Pathol 140: 1131-46 Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment. Martin MD, Kremers GJ, Short KW, Rocheleau JV, Xu L, Piston DW, Matrisian LM, Gorden DL (2010) Mol Cancer Res 8: 1319-27 Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression. Fang WB, Jokar I, Chytil A, Moses HL, Abel T, Cheng N (2011) Clin Exp Metastasis 28: 351-66 Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth. Martin MD, Fingleton B, Lynch CC, Wells S, McIntyre JO, Piston DW, Matrisian LM (2008) Clin Exp Metastasis 25: 877-85 Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia. Hoshino A, Yee CJ, Campbell M, Woltjer RL, Townsend RL, van der Meer R, Shyr Y, Holt JT, Moses HL, Jensen RA (2007) Int J Biol Sci 3: 281-91 Inhibition of androgen action by dehydroepiandrosterone sulfotransferase transfected in PC-3 prostate cancer cells. Chan J, Song CS, Matusik RJ, Chatterjee B, Roy AK (1998) Chem Biol Interact 109: 267-78
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