Keyword Connections

•  BethAnn McLaughlin
•  Bruce Carter
•  Ken Lau

•  Lawrence Marnett
•  Richard Peek
•  Sandra Zinkel

•  Stephen Hann
•  W. Jerome

Resources

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Communities

• Zinkel Lab

Publications

• Death, destruction, and the proteasome.
  Tansey WP
  (2004) N Engl J Med 351: 393-4
• Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
  Liu Z, Sun C, Olejniczak ET, Meadows RP, Betz SF, Oost T, Herrmann J, Wu JC, Fesik SW
  (2000) Nature 408: 1004-8
• Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.
  Hemann MT, Bric A, Teruya-Feldstein J, Herbst A, Nilsson JA, Cordon-Cardo C, Cleveland JL, Tansey WP, Lowe SW
  (2005) Nature 436: 807-11
• Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.
  Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV
  (1996) Nature 383: 716-9
• NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.
  Sun C, Cai M, Gunasekera AH, Meadows RP, Wang H, Chen J, Zhang H, Wu W, Xu N, Ng SC, Fesik SW
  (1999) Nature 401: 818-22
• NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.
  Eberstadt M, Huang B, Chen Z, Meadows RP, Ng SC, Zheng L, Lenardo MJ, Fesik SW
  (1998) Nature 392: 941-5
• Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis.
  Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ
  (1999) Nature 400: 886-91
• An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
  Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, Li C, Mitten MJ, Nettesheim DG, Ng S, Nimmer PM, O'Connor JM, Oleksijew A, Petros AM, Reed JC, Shen W, Tahir SK, Thompson CB, Tomaselli KJ, Wang B, Wendt MD, Zhang H, Fesik SW, Rosenberg SH
  (2005) Nature 435: 677-81
• Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
  Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN
  (2008) Nature 452: 98-102
• p19ARF directly and differentially controls the functions of c-Myc independently of p53.
  Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR
  (2004) Nature 431: 712-7
• Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
  Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, Beijersbergen RL, Bardelli A, Bernards R
  (2012) Nature 483: 100-3
• X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death.
  Muchmore SW, Sattler M, Liang H, Meadows RP, Harlan JE, Yoon HS, Nettesheim D, Chang BS, Thompson CB, Wong SL, Ng SL, Fesik SW
  (1996) Nature 381: 335-41
• Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration.
  Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R
  (2004) Nat Genet 36: 969-77
• Promoting apoptosis as a strategy for cancer drug discovery.
  Fesik SW
  (2005) Nat Rev Cancer 5: 876-85
• Helicobacter pylori and gastrointestinal tract adenocarcinomas.
  Peek RM, Blaser MJ
  (2002) Nat Rev Cancer 2: 28-37
• The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly.
  Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H
  (2004) Cell 118: 187-202
• Insights into programmed cell death through structural biology.
  Fesik SW
  (2000) Cell 103: 273-82
• A role for proapoptotic BID in the DNA-damage response.
  Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ
  (2005) Cell 122: 579-91
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.
  Lowe SW, Ruley HE, Jacks T, Housman DE
  (1993) Cell 74: 957-67
• Junction adhesion molecule is a receptor for reovirus.
  Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell FJ, Nusrat A, Parkos CA, Dermody TS
  (2001) Cell 104: 441-51
• Structural basis for the inhibition of caspase-3 by XIAP.
  Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS
  (2001) Cell 104: 791-800
• Bid plays a role in the DNA damage response.
  Zinkel SS, Hurov KE, Gross A
  (2007) Cell 130: 9-10; author reply 10-1
• Perp is a p63-regulated gene essential for epithelial integrity.
  Ihrie RA, Marques MR, Nguyen BT, Horner JS, Papazoglu C, Bronson RT, Mills AA, Attardi LD
  (2005) Cell 120: 843-56
• Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer.
  Liu J, Ghanim M, Xue L, Brown CD, Iossifov I, Angeletti C, Hua S, Nègre N, Ludwig M, Stricker T, Al-Ahmadie HA, Tretiakova M, Camp RL, Perera-Alberto M, Rimm DL, Xu T, Rzhetsky A, White KP
  (2009) Science 323: 1218-22
• p53 status and the efficacy of cancer therapy in vivo.
  Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T
  (1994) Science 266: 807-10
• The invasive chytrid fungus of amphibians paralyzes lymphocyte responses.
  Fites JS, Ramsey JP, Holden WM, Collier SP, Sutherland DM, Reinert LK, Gayek AS, Dermody TS, Aune TM, Oswald-Richter K, Rollins-Smith LA
  (2013) Science 342: 366-9
• Structural biology. Controlling the caspases.
  Fesik SW, Shi Y
  (2001) Science 294: 1477-8
• Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
  Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW
  (1997) Science 275: 983-6
• SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages.
  Berger SB, Romero X, Ma C, Wang G, Faubion WA, Liao G, Compeer E, Keszei M, Rameh L, Wang N, Boes M, Regueiro JR, Reinecker HC, Terhorst C
  (2010) Nat Immunol 11: 920-7
• p53 and MDM2: antagonists or partners in crime?
  Eischen CM, Lozano G
  (2009) Cancer Cell 15: 161-2
• HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors.
  Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL
  (2006) Cancer Cell 10: 25-38
• Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis.
  Yang L, DeBusk LM, Fukuda K, Fingleton B, Green-Jarvis B, Shyr Y, Matrisian LM, Carbone DP, Lin PC
  (2004) Cancer Cell 6: 409-21
• Targeting nonclassical oncogenes for therapy in T-ALL.
  Subramaniam PS, Whye DW, Efimenko E, Chen J, Tosello V, De Keersmaecker K, Kashishian A, Thompson MA, Castillo M, Cordon-Cardo C, Davé UP, Ferrando A, Lannutti BJ, Diacovo TG
  (2012) Cancer Cell 21: 459-72
• Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
  Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S
  (2005) Cancer Cell 8: 155-67
• LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.
  Wang J, An H, Mayo MW, Baldwin AS, Yarbrough WG
  (2007) Cancer Cell 12: 239-51