Keyword Connections

•  Ambra Pozzi
•  Bernard Rousseau

•  Bruce Carter
•  Rebecca Ihrie

Resources

• B6.129S-Tgfbr3{tm1.1Jba}/Vu

Communities

• Ihrie Lab

Publications

• Cardiovascular Toxic Effects of Targeted Cancer Therapies.
  Moslehi JJ
  (2016) N Engl J Med 375: 1457-1467
• Reversible cardiomyopathy associated with sunitinib and sorafenib.
  Uraizee I, Cheng S, Moslehi J
  (2011) N Engl J Med 365: 1649-50
• Mechanisms and management of retinopathy of prematurity.
  Hartnett ME, Penn JS
  (2012) N Engl J Med 367: 2515-26
• LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.
  Wang X, Abraham S, McKenzie JAG, Jeffs N, Swire M, Tripathi VB, Luhmann UFO, Lange CAK, Zhai Z, Arthur HM, Bainbridge J, Moss SE, Greenwood J
  (2013) Nature 499: 306-11
• Integrated genomic and molecular characterization of cervical cancer.
  Cancer Genome Atlas Research Network, Albert Einstein College of Medicine, Analytical Biological Services, Barretos Cancer Hospital, Baylor College of Medicine, Beckman Research Institute of City of Hope, Buck Institute for Research on Aging, Canada's Michael Smith Genome Sciences Centre, Harvard Medical School, Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services, HudsonAlpha Institute for Biotechnology, ILSbio, LLC, Indiana University School of Medicine, Institute of Human Virology, Institute for Systems Biology, International Genomics Consortium, Leidos Biomedical, Massachusetts General Hospital, McDonnell Genome Institute at Washington University, Medical College of Wisconsin, Medical University of South Carolina, Memorial Sloan Kettering Cancer Center, Montefiore Medical Center, NantOmics, National Cancer Institute, National Hospital, Abuja, Nigeria, National Human Genome Research Institute, National Institute of Environmental Health Sciences, National Institute on Deafness &Other Communication Disorders, Ontario Tumour Bank, London Health Sciences Centre, Ontario Tumour Bank, Ontario Institute for Cancer Research, Ontario Tumour Bank, The Ottawa Hospital, Oregon Health &Science University, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, SRA International, St Joseph's Candler Health System, Eli &Edythe L. Broad Institute of Massachusetts Institute of Technology &Harvard University, Research Institute at Nationwide Children's Hospital, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, University of Bergen, University of Texas MD Anderson Cancer Center, University of Abuja Teaching Hospital, University of Alabama at Birmingham, University of California, Irvine, University of California Santa Cruz, University of Kansas Medical Center, University of Lausanne, University of New Mexico Health Sciences Center, University of North Carolina at Chapel Hill, University of Oklahoma Health Sciences Center, University of Pittsburgh, University of São Paulo, Ribeir ão Preto Medical School, University of Southern California, University of Washington, University of Wisconsin School of Medicine &Public Health, Van Andel Research Institute, Washington University in St Louis
  (2017) Nature 543: 378-384
• Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling.
  Sampath K, Rubinstein AL, Cheng AM, Liang JO, Fekany K, Solnica-Krezel L, Korzh V, Halpern ME, Wright CV
  (1998) Nature 395: 185-9
• Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
  Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
  (1995) Nature 378: 584-92
• Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo.
  Thisse B, Wright CV, Thisse C
  (2000) Nature 403: 425-8
• Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75.
  Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV
  (1996) Nature 383: 716-9
• Production and auto-induction of transforming growth factor-alpha in human keratinocytes.
  Coffey RJ, Derynck R, Wilcox JN, Bringman TS, Goustin AS, Moses HL, Pittelkow MR
  (1987) Nature 328: 817-20
• Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
  Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS
  (2010) Nature 468: 973-7
• Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
  Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
  (2012) Nature 487: 505-9
• Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
  Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T, Stütz AM, Korshunov A, Reimand J, Schumacher SE, Beroukhim R, Ellison DW, Marshall CR, Lionel AC, Mack S, Dubuc A, Yao Y, Ramaswamy V, Luu B, Rolider A, Cavalli FM, Wang X, Remke M, Wu X, Chiu RY, Chu A, Chuah E, Corbett RD, Hoad GR, Jackman SD, Li Y, Lo A, Mungall KL, Nip KM, Qian JQ, Raymond AG, Thiessen NT, Varhol RJ, Birol I, Moore RA, Mungall AJ, Holt R, Kawauchi D, Roussel MF, Kool M, Jones DT, Witt H, Fernandez-L A, Kenney AM, Wechsler-Reya RJ, Dirks P, Aviv T, Grajkowska WA, Perek-Polnik M, Haberler CC, Delattre O, Reynaud SS, Doz FF, Pernet-Fattet SS, Cho BK, Kim SK, Wang KC, Scheurlen W, Eberhart CG, Fèvre-Montange M, Jouvet A, Pollack IF, Fan X, Muraszko KM, Gillespie GY, Di Rocco C, Massimi L, Michiels EM, Kloosterhof NK, French PJ, Kros JM, Olson JM, Ellenbogen RG, Zitterbart K, Kren L, Thompson RC, Cooper MK, Lach B, McLendon RE, Bigner DD, Fontebasso A, Albrecht S, Jabado N, Lindsey JC, Bailey S, Gupta N, Weiss WA, Bognár L, Klekner A, Van Meter TE, Kumabe T, Tominaga T, Elbabaa SK, Leonard JR, Rubin JB, Liau LM, Van Meir EG, Fouladi M, Nakamura H, Cinalli G, Garami M, Hauser P, Saad AG, Iolascon A, Jung S, Carlotti CG, Vibhakar R, Ra YS, Robinson S, Zollo M, Faria CC, Chan JA, Levy ML, Sorensen PH, Meyerson M, Pomeroy SL, Cho YJ, Bader GD, Tabori U, Hawkins CE, Bouffet E, Scherer SW, Rutka JT, Malkin D, Clifford SC, Jones SJ, Korbel JO, Pfister SM, Marra MA, Taylor MD
  (2012) Nature 488: 49-56
• Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus.
  Lowe LA, Supp DM, Sampath K, Yokoyama T, Wright CV, Potter SS, Overbeek P, Kuehn MR
  (1996) Nature 381: 158-61
• Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer.
  Bierie B, Moses HL
  (2006) Nat Rev Cancer 6: 506-20
• The roles of TGFβ in the tumour microenvironment.
  Pickup M, Novitskiy S, Moses HL
  (2013) Nat Rev Cancer 13: 788-99
• Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase.
  Jo D, Nashabi A, Doxsee C, Lin Q, Unutmaz D, Chen J, Ruley HE
  (2001) Nat Biotechnol 19: 929-33
• A TALE nuclease architecture for efficient genome editing.
  Miller JC, Tan S, Qiao G, Barlow KA, Wang J, Xia DF, Meng X, Paschon DE, Leung E, Hinkley SJ, Dulay GP, Hua KL, Ankoudinova I, Cost GJ, Urnov FD, Zhang HS, Holmes MC, Zhang L, Gregory PD, Rebar EJ
  (2011) Nat Biotechnol 29: 143-8
• Cytokine-driven beta-cell production in vivo.
  Worchel HN, Magnuson MA
  (2014) Nat Biotechnol 32: 63-4
• Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.
  Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H
  (2014) Nat Biotechnol 32: 76-83
• p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.
  Wildenberg GA, Dohn MR, Carnahan RH, Davis MA, Lobdell NA, Settleman J, Reynolds AB
  (2006) Cell 127: 1027-39
• HIF-1alpha is essential for myeloid cell-mediated inflammation.
  Cramer T, Yamanishi Y, Clausen BE, Förster I, Pawlinski R, Mackman N, Haase VH, Jaenisch R, Corr M, Nizet V, Firestein GS, Gerber HP, Ferrara N, Johnson RS
  (2003) Cell 112: 645-57
• Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.
  Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Schöler H, Smith A
  (1998) Cell 95: 379-91
• TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights.
  Moses HL, Yang EY, Pietenpol JA
  (1990) Cell 63: 245-7
• Oncogenic Signaling Pathways in The Cancer Genome Atlas.
  Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Cancer Genome Atlas Research Network, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N
  (2018) Cell 173: 321-337.e10
• Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.
  Fox MA, Sanes JR, Borza DB, Eswarakumar VP, Fässler R, Hudson BG, John SW, Ninomiya Y, Pedchenko V, Pfaff SL, Rheault MN, Sado Y, Segal Y, Werle MJ, Umemori H
  (2007) Cell 129: 179-93
• Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice.
  Matsui Y, Halter SA, Holt JT, Hogan BL, Coffey RJ
  (1990) Cell 61: 1147-55
• TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.
  Pietenpol JA, Stein RW, Moran E, Yaciuk P, Schlegel R, Lyons RM, Pittelkow MR, Münger K, Howley PM, Moses HL
  (1990) Cell 61: 777-85
• TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia.
  Bhowmick NA, Chytil A, Plieth D, Gorska AE, Dumont N, Shappell S, Washington MK, Neilson EG, Moses HL
  (2004) Science 303: 848-51
• Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.
  Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhäuser N, Böhm-Matthaei R, Baeuerle PA, Barde YA
  (1996) Science 272: 542-5