T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via a conserved T-box half-site. Tong Y, Aune T, Boothby M (2005) Proc Natl Acad Sci U S A 102: 2034-9 Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G (2020) Diabetes 69: 1219-1231 TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3. Wang L, Hiebert SW (2001) Oncogene 20: 3716-25 T-bet dependent removal of Sin3A-histone deacetylase complexes at the Ifng locus drives Th1 differentiation. Chang S, Collins PL, Aune TM (2008) J Immunol 181: 8372-81 Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Fenrick R, Amann JM, Lutterbach B, Wang L, Westendorf JJ, Downing JR, Hiebert SW (1999) Mol Cell Biol 19: 6566-74 Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Amann JM, Chyla BJ, Ellis TC, Martinez A, Moore AC, Franklin JL, McGhee L, Meyers S, Ohm JE, Luce KS, Ouelette AJ, Washington MK, Thompson MA, King D, Gautam S, Coffey RJ, Whitehead RH, Hiebert SW (2005) Mol Cell Biol 25: 9576-85 mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor. Huang S, Brandt SJ (2000) Mol Cell Biol 20: 2248-59 ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain. Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (2001) Mol Cell Biol 21: 6470-83 Recruitment of the SWI/SNF protein Brg1 by a multiprotein complex effects transcriptional repression in murine erythroid progenitors. Xu Z, Meng X, Cai Y, Koury MJ, Brandt SJ (2006) Biochem J 399: 297-304
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