Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Ericson J, Rashbass P, Schedl A, Brenner-Morton S, Kawakami A, van Heyningen V, Jessell TM, Briscoe J (1997) Cell 90: 169-80 Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Ashery-Padan R, Marquardt T, Zhou X, Gruss P (2000) Genes Dev 14: 2701-11 Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence. Breslin MB, Zhu M, Notkins AL, Lan MS (2002) Nucleic Acids Res 30: 1038-45 Inactivating the permanent neonatal diabetes gene Mnx1 switches insulin-producing β-cells to a δ-like fate and reveals a facultative proliferative capacity in aged β-cells. Pan FC, Brissova M, Powers AC, Pfaff S, Wright CV (2015) Development 142: 3637-48 Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS (1998) Development 125: 2213-21 Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain. Raum JC, Hunter CS, Artner I, Henderson E, Guo M, Elghazi L, Sosa-Pineda B, Ogihara T, Mirmira RG, Sussel L, Stein R (2010) Mol Cell Biol 30: 4234-44 Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Samaras SE, Cissell MA, Gerrish K, Wright CV, Gannon M, Stein R (2002) Mol Cell Biol 22: 4702-13 Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. Cissell MA, Zhao L, Sussel L, Henderson E, Stein R (2003) J Biol Chem 278: 751-6 Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1. Martin CC, Oeser JK, O'Brien RM (2004) J Biol Chem 279: 34277-89 DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Neely MD, Litt MJ, Tidball AM, Li GG, Aboud AA, Hopkins CR, Chamberlin R, Hong CC, Ess KC, Bowman AB (2012) ACS Chem Neurosci 3: 482-91 The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB, Madsen OD, Serup P (2004) Dev Biol 268: 123-34 Genetic determinants of pancreatic epsilon-cell development. Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P (2005) Dev Biol 286: 217-24 Molecular profiling indicates avian branchiomotor nuclei invade the hindbrain alar plate. Ju MJ, Aroca P, Luo J, Puelles L, Redies C (2004) Neuroscience 128: 785-96 Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. Grindley JC, Hargett LK, Hill RE, Ross A, Hogan BL (1997) Mech Dev 64: 111-26
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