The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis. Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD (2013) Nat Cell Biol 15: 677-87 Nfatc1 coordinates valve endocardial cell lineage development required for heart valve formation. Wu B, Wang Y, Lui W, Langworthy M, Tompkins KL, Hatzopoulos AK, Baldwin HS, Zhou B (2011) Circ Res 109: 183-92 Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM (2015) Gut 64: 720-30 Inhibition of epidermal growth factor receptor signaling elevates 15-hydroxyprostaglandin dehydrogenase in non-small-cell lung cancer. Yang L, Amann JM, Kikuchi T, Porta R, Guix M, Gonzalez A, Park KH, Billheimer D, Arteaga CL, Tai HH, DuBois R, Carbone DP, Johnson DH (2007) Cancer Res 67: 5587-93 Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. Liang A, Wang Y, Woodard LE, Wilson MH, Sharma R, Awasthi YC, Du J, Mitch WE, Cheng J (2012) J Pathol 228: 448-58 LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex. Duvall-Noelle N, Karwandyar A, Richmond A, Raman D (2016) Oncogene 35: 1122-33 Slug regulates E-cadherin repression via p19Arf in prostate tumorigenesis. Xie Y, Liu S, Lu W, Yang Q, Williams KD, Binhazim AA, Carver BS, Matusik RJ, Chen Z (2014) Mol Oncol 8: 1355-64 The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate. Dottori M, Gross MK, Labosky P, Goulding M (2001) Development 128: 4127-38 Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Speirs CK, Jernigan KK, Kim SH, Cha YI, Lin F, Sepich DS, DuBois RN, Lee E, Solnica-Krezel L (2010) Development 137: 1327-37 Smoking induces epithelial-to-mesenchymal transition in non-small cell lung cancer through HDAC-mediated downregulation of E-cadherin. Nagathihalli NS, Massion PP, Gonzalez AL, Lu P, Datta PK (2012) Mol Cancer Ther 11: 2362-72 SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. Mittal MK, Singh K, Misra S, Chaudhuri G (2011) J Biol Chem 286: 469-79 High motility of triple-negative breast cancer cells is due to repression of plakoglobin gene by metastasis modulator protein SLUG. Bailey CK, Mittal MK, Misra S, Chaudhuri G (2012) J Biol Chem 287: 19472-86 Signaling between transforming growth factor β (TGF-β) and transcription factor SNAI2 represses expression of microRNA miR-203 to promote epithelial-mesenchymal transition and tumor metastasis. Ding X, Park SI, McCauley LK, Wang CY (2013) J Biol Chem 288: 10241-53 Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. Tripathi MK, Misra S, Khedkar SV, Hamilton N, Irvin-Wilson C, Sharan C, Sealy L, Chaudhuri G (2005) J Biol Chem 280: 17163-71 Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan. Craig EA, Parker P, Austin AF, Barnett JV, Camenisch TD (2010) Cell Signal 22: 968-76 E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Schmidt CR, Gi YJ, Patel TA, Coffey RJ, Beauchamp RD, Pearson AS (2005) Surgery 138: 306-12 Epithelial-mesenchymal transition markers in pancreatic ductal adenocarcinoma. Cates JM, Byrd RH, Fohn LE, Tatsas AD, Washington MK, Black CC (2009) Pancreas 38: e1-6 Mode of action of the retrogene product SNAI1P, a SNAIL homolog, in human breast cancer cells. Mittal MK, Myers JN, Bailey CK, Misra S, Chaudhuri G (2010) Mol Biol Rep 37: 1221-7 Human SLUG does not directly bind to CtBP1. Bailey CK, Misra S, Mittal MK, Chaudhuri G (2007) Biochem Biophys Res Commun 353: 661-4 In vivo binding to and functional repression of the VDR gene promoter by SLUG in human breast cells. Mittal MK, Myers JN, Misra S, Bailey CK, Chaudhuri G (2008) Biochem Biophys Res Commun 372: 30-4 Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells. Tripathi MK, Misra S, Chaudhuri G (2005) Biochem Biophys Res Commun 329: 508-15 Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, Zhang H, Zhao Z, Marchand C, Weinstein JN, Cancer Genome Atlas Research Network, Bathe OF, Liang H (2018) Cell Rep 23: 255-269.e4
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.