Keyword Connections

•  Michael VanSaun

•  Richard Simerly

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Publications

• Intracellular signalling. Key enzyme in leptin-induced anorexia.
  Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG, Schwartz MW
  (2001) Nature 413: 794-5
• Hypothalamic CART is a new anorectic peptide regulated by leptin.
  Kristensen P, Judge ME, Thim L, Ribel U, Christjansen KN, Wulff BS, Clausen JT, Jensen PB, Madsen OD, Vrang N, Larsen PJ, Hastrup S
  (1998) Nature 393: 72-6
• Leptin regulation of bone resorption by the sympathetic nervous system and CART.
  Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G
  (2005) Nature 434: 514-20
• Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
  Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G
  (2005) Nat Genet 37: 1072-81
• Leptin regulates bone formation via the sympathetic nervous system.
  Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G
  (2002) Cell 111: 305-17
• Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
  van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB, INTERVAL, UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS
  (2019) Cell 176: 729-742.e18
• Effects of dietary composition on energy expenditure during weight-loss maintenance.
  Ebbeling CB, Swain JF, Feldman HA, Wong WW, Hachey DL, Garcia-Lago E, Ludwig DS
  (2012) JAMA 307: 2627-34
• Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
  Morton GJ, Gelling RW, Niswender KD, Morrison CD, Rhodes CJ, Schwartz MW
  (2005) Cell Metab 2: 411-20
• Leptin action in the forebrain regulates the hindbrain response to satiety signals.
  Morton GJ, Blevins JE, Williams DL, Niswender KD, Gelling RW, Rhodes CJ, Baskin DG, Schwartz MW
  (2005) J Clin Invest 115: 703-10
• Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents.
  Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ
  (2009) J Clin Invest 119: 2577-89
• Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells.
  Crossno JT, Majka SM, Grazia T, Gill RG, Klemm DJ
  (2006) J Clin Invest 116: 3220-8
• Role of leptin and melanocortin signaling in uremia-associated cachexia.
  Cheung W, Yu PX, Little BM, Cone RD, Marks DL, Mak RH
  (2005) J Clin Invest 115: 1659-65
• Obesity and the beta cell: lessons from leptin.
  Niswender KD, Magnuson MA
  (2007) J Clin Invest 117: 2753-6
• Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin.
  Ghamari-Langroudi M, Srisai D, Cone RD
  (2011) Proc Natl Acad Sci U S A 108: 355-60
• Serum leptin level is a regulator of bone mass.
  Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G
  (2004) Proc Natl Acad Sci U S A 101: 3258-63
• Common endocrine control of body weight, reproduction, and bone mass.
  Takeda S, Elefteriou F, Karsenty G
  (2003) Annu Rev Nutr 23: 403-11
• Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis.
  Niswender KD, Baskin DG, Schwartz MW
  (2004) Trends Endocrinol Metab 15: 362-9
• Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities.
  Niswender KD, Schwartz MW
  (2003) Front Neuroendocrinol 24: 1-10
• Leptin and inflammation-associated cachexia in chronic kidney disease.
  Mak RH, Cheung W, Cone RD, Marks DL
  (2006) Kidney Int 69: 794-7
• Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue.
  Coenen KR, Gruen ML, Chait A, Hasty AH
  (2007) Diabetes 56: 564-73
• Role of vascular oxidative stress in obesity and metabolic syndrome.
  Youn JY, Siu KL, Lob HE, Itani H, Harrison DG, Cai H
  (2014) Diabetes 63: 2344-55
• Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.
  Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG, Gannon M, Powers AC, Dempsey PJ
  (2010) Diabetes 59: 3090-8
• Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion.
  Stafford JM, Yu F, Printz R, Hasty AH, Swift LL, Niswender KD
  (2008) Diabetes 57: 1482-90
• Molecular pathways: adiponectin and leptin signaling in cancer.
  Vansaun MN
  (2013) Clin Cancer Res 19: 1926-32
• Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals.
  Lieb W, Sullivan LM, Harris TB, Roubenoff R, Benjamin EJ, Levy D, Fox CS, Wang TJ, Wilson PW, Kannel WB, Vasan RS
  (2009) Diabetes Care 32: 612-6
• Relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and insulin sensitivity in human obesity.
  Dunn JP, Kessler RM, Feurer ID, Volkow ND, Patterson BW, Ansari MS, Li R, Marks-Shulman P, Abumrad NN
  (2012) Diabetes Care 35: 1105-11
• Genetic markers at the leptin (OB) locus are not significantly linked to hypertension in African Americans.
  Rutkowski MP, Klanke CA, Su YR, Reif M, Menon AG
  (1998) Hypertension 31: 1230-4
• Longitudinal study of nutritional status, body composition, and physical function in hemodialysis patients.
  Johansen KL, Kaysen GA, Young BS, Hung AM, da Silva M, Chertow GM
  (2003) Am J Clin Nutr 77: 842-6
• Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample.
  Ingelsson E, Larson MG, Yin X, Wang TJ, Meigs JB, Lipinska I, Benjamin EJ, Keaney JF, Vasan RS
  (2008) J Clin Endocrinol Metab 93: 3149-57
• Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance?
  Schwartz MW, Niswender KD
  (2004) J Clin Endocrinol Metab 89: 5889-97
• Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice.
  Bodary PF, Gu S, Shen Y, Hasty AH, Buckler JM, Eitzman DT
  (2005) Arterioscler Thromb Vasc Biol 25: e119-22