Keyword Connections

•  Roger Cone

•  SAVANNAH WILLIAMS

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Communities

• Cone Lab

Publications

• G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
  Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD
  (2015) Nature 520: 94-8
• Leptin regulation of bone resorption by the sympathetic nervous system and CART.
  Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G
  (2005) Nature 434: 514-20
• Leptin regulates bone formation via the sympathetic nervous system.
  Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G
  (2002) Cell 111: 305-17
• Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.
  van der Klaauw AA, Croizier S, Mendes de Oliveira E, Stadler LKJ, Park S, Kong Y, Banton MC, Tandon P, Hendricks AE, Keogh JM, Riley SE, Papadia S, Henning E, Bounds R, Bochukova EG, Mistry V, O'Rahilly S, Simerly RB, INTERVAL, UK10K Consortium, Minchin JEN, Barroso I, Jones EY, Bouret SG, Farooqi IS
  (2019) Cell 176: 729-742.e18
• Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.
  Sebag JA, Zhang C, Hinkle PM, Bradshaw AM, Cone RD
  (2013) Science 341: 278-81
• Anatomy and regulation of the central melanocortin system.
  Cone RD
  (2005) Nat Neurosci 8: 571-8
• Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.
  Fan W, Ellacott KL, Halatchev IG, Takahashi K, Yu P, Cone RD
  (2004) Nat Neurosci 7: 335-6
• Studies on the physiological functions of the melanocortin system.
  Cone RD
  (2006) Endocr Rev 27: 736-49
• The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
  Panaro BL, Tough IR, Engelstoft MS, Matthews RT, Digby GJ, Møller CL, Svendsen B, Gribble F, Reimann F, Holst JJ, Holst B, Schwartz TW, Cox HM, Cone RD
  (2014) Cell Metab 20: 1018-29
• AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost.
  Zhang C, Forlano PM, Cone RD
  (2012) Cell Metab 15: 256-64
• Role of leptin and melanocortin signaling in uremia-associated cachexia.
  Cheung W, Yu PX, Little BM, Cone RD, Marks DL, Mak RH
  (2005) J Clin Invest 115: 1659-65
• QnAs with Roger D. Cone.
  Cone RD
  (2013) Proc Natl Acad Sci U S A 110: 9618
• Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin.
  Ghamari-Langroudi M, Srisai D, Cone RD
  (2011) Proc Natl Acad Sci U S A 108: 355-60
• Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.
  Panaro BL, Cone RD
  (2013) Proc Natl Acad Sci U S A 110: 7050-5
• Pineal-specific agouti protein regulates teleost background adaptation.
  Zhang C, Song Y, Thompson DA, Madonna MA, Millhauser GL, Toro S, Varga Z, Westerfield M, Gamse J, Chen W, Cone RD
  (2010) Proc Natl Acad Sci U S A 107: 20164-71
• Melanocortin-3 receptor regulates the normal fasting response.
  Renquist BJ, Murphy JG, Larson EA, Olsen D, Klein RF, Ellacott KL, Cone RD
  (2012) Proc Natl Acad Sci U S A 109: E1489-98
• Leptin and inflammation-associated cachexia in chronic kidney disease.
  Mak RH, Cheung W, Cone RD, Marks DL
  (2006) Kidney Int 69: 794-7
• The melanocortin-3 receptor is required for entrainment to meal intake.
  Sutton GM, Perez-Tilve D, Nogueiras R, Fang J, Kim JK, Cone RD, Gimble JM, Tschöp MH, Butler AA
  (2008) J Neurosci 28: 12946-55
• Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.
  Hatoum IJ, Stylopoulos N, Vanhoose AM, Boyd KL, Yin DP, Ellacott KL, Ma LL, Blaszczyk K, Keogh JM, Cone RD, Farooqi IS, Kaplan LM
  (2012) J Clin Endocrinol Metab 97: E1023-31
• RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals.
  Chen KY, Muniyappa R, Abel BS, Mullins KP, Staker P, Brychta RJ, Zhao X, Ring M, Psota TL, Cone RD, Panaro BL, Gottesdiener KM, Van der Ploeg LH, Reitman ML, Skarulis MC
  (2015) J Clin Endocrinol Metab 100: 1639-45
• The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models.
  Ellacott KL, Cone RD
  (2006) Philos Trans R Soc Lond B Biol Sci 361: 1265-74
• Creation of a genetic model of obesity in a teleost.
  Song Y, Cone RD
  (2007) FASEB J 21: 2042-9
• Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.
  Hohenadel MG, Thearle MS, Grice BA, Huang H, Dai MH, Tao YX, Hunter LA, Palaguachi GI, Mou Z, Kim RC, Tsang MM, Haack K, Voruganti VS, Cole SA, Butte NF, Comuzzie AG, Muller YL, Baier LJ, Krakoff J, Knowler WC, Yanovski JA, Han JC
  (2014) Int J Obes (Lond) 38: 1068-74
• Evaluation of genetic susceptibility loci for obesity in Chinese women.
  Shi J, Long J, Gao YT, Lu W, Cai Q, Wen W, Zheng Y, Yu K, Xiang YB, Hu FB, Zheng W, Shu XO
  (2010) Am J Epidemiol 172: 244-54
• Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity.
  Ghamari-Langroudi M, Vella KR, Srisai D, Sugrue ML, Hollenberg AN, Cone RD
  (2010) Mol Endocrinol 24: 2366-81
• Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue.
  Voss-Andreae A, Murphy JG, Ellacott KL, Stuart RC, Nillni EA, Cone RD, Fan W
  (2007) Endocrinology 148: 1550-60
• Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice.
  Lippert RN, Ellacott KL, Cone RD
  (2014) Endocrinology 155: 1718-27
• Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.
  Halatchev IG, Ellacott KL, Fan W, Cone RD
  (2004) Endocrinology 145: 2585-90
• Neuropeptide W: an anorectic peptide regulated by leptin and metabolic state.
  Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M
  (2010) Endocrinology 151: 2200-10
• Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.
  Srisai D, Gillum MP, Panaro BL, Zhang XM, Kotchabhakdi N, Shulman GI, Ellacott KL, Cone RD
  (2011) Endocrinology 152: 890-902
• Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling.
  Ellacott KL, Murphy JG, Marks DL, Cone RD
  (2007) Endocrinology 148: 6186-94