A general approach for identifying distant regulatory elements applied to the Gdf6 gene. Mortlock DP, Guenther C, Kingsley DM (2003) Genome Res 13: 2069-81 Control of BMP gene expression by long-range regulatory elements. Pregizer S, Mortlock DP (2009) Cytokine Growth Factor Rev 20: 509-15 Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome. Tassabehji M, Fang ZM, Hilton EN, McGaughran J, Zhao Z, de Bock CE, Howard E, Malass M, Donnai D, Diwan A, Manson FD, Murrell D, Clarke RA (2008) Hum Mutat 29: 1017-27 Extraocular ectoderm triggers dorsal retinal fate during optic vesicle evagination in zebrafish. Kruse-Bend R, Rosenthal J, Quist TS, Veien ES, Fuhrmann S, Dorsky RI, Chien CB (2012) Dev Biol 371: 57-65 The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development. Clendenning DE, Mortlock DP (2012) PLoS One 7: e36789 Comparative sequence analysis of the Gdf6 locus reveals a duplicon-mediated chromosomal rearrangement in rodents and rapidly diverging coding and regulatory sequences. Mortlock DP, Portnoy ME, Chandler RL, NISC Comparative Sequencing Program, Green ED (2004) Genomics 84: 814-23 Detection of potential GDF6 regulatory elements by multispecies sequence comparisons and identification of a skeletal joint enhancer. Portnoy ME, McDermott KJ, Antonellis A, Margulies EH, Prasad AB, NISC Comparative Sequencing Program, Kingsley DM, Green ED, Mortlock DP (2005) Genomics 86: 295-305 Identification of a distant cis-regulatory element controlling pharyngeal arch-specific expression of zebrafish gdf6a/radar. Reed NP, Mortlock DP (2010) Dev Dyn 239: 1047-60
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