Under pressure: stromal fibroblasts change their ways. Bierie B, Moses HL (2005) Cell 123: 985-7 Updated clinical classification of pulmonary hypertension. Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Krishna Kumar R, Landzberg M, Machado RF, Olschewski H, Robbins IM, Souza R (2013) J Am Coll Cardiol 62: D34-41 Scleroderma esophagus: a nonspecific entity. Schneider HA, Yonker RA, Longley S, Katz P, Mathias J, Panush RS (1984) Ann Intern Med 100: 848-50 Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma. Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL (2011) J Clin Invest 121: 4106-17 Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL (2006) Genes Dev 20: 3147-60 NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, Sorescu D (2005) Circ Res 97: 900-7 Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells. Guney MA, Petersen CP, Boustani A, Duncan MR, Gunasekaran U, Menon R, Warfield C, Grotendorst GR, Means AL, Economides AN, Gannon M (2011) Proc Natl Acad Sci U S A 108: 15242-7 Serological profiles in the connective tissue diseases in Zimbabwean patients. Davis P, Stein M, Ley H, Johnston C (1989) Ann Rheum Dis 48: 73-6 Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling the maintenance of highly enriched competitive repopulating stem cells. Szilvassy SJ, Weller KP, Lin W, Sharma AK, Ho AS, Tsukamoto A, Hoffman R, Leiby KR, Gearing DP (1996) Blood 87: 4618-28 DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition. Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, Brady HR (2003) Kidney Int 64: 2079-91 Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice. Riley KG, Pasek RC, Maulis MF, Peek J, Thorel F, Brigstock DR, Herrera PL, Gannon M (2015) Diabetes 64: 1284-98 Comparison of disease progression and mortality of connective tissue disease-related interstitial lung disease and idiopathic interstitial pneumonia. Kocheril SV, Appleton BE, Somers EC, Kazerooni EA, Flaherty KR, Martinez FJ, Gross BH, Crofford LJ (2005) Arthritis Rheum 53: 549-57 Thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase 2 inhibitors. A report of four cases. Crofford LJ, Oates JC, McCune WJ, Gupta S, Kaplan MJ, Catella-Lawson F, Morrow JD, McDonagh KT, Schmaier AH (2000) Arthritis Rheum 43: 1891-6 Biochemistry and turnover of lung interstitium. Davidson JM (1990) Eur Respir J 3: 1048-63 Hox11 genes are required for regional patterning and integration of muscle, tendon and bone. Swinehart IT, Schlientz AJ, Quintanilla CA, Mortlock DP, Wellik DM (2013) Development 140: 4574-82 Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts. Lopes LB, Furnish EJ, Komalavilas P, Flynn CR, Ashby P, Hansen A, Ly DP, Yang GP, Longaker MT, Panitch A, Brophy CM (2009) J Invest Dermatol 129: 590-8 Buschke-Ollendorff syndrome associated with elevated elastin production by affected skin fibroblasts in culture. Giro MG, Duvic M, Smith LT, Kennedy R, Rapini R, Arnett FC, Davidson JM (1992) J Invest Dermatol 99: 129-37 Parenteral Prostanoid Use at a Tertiary Referral Center: A Retrospective Cohort Study. Hay BR, Pugh ME, Robbins IM, Hemnes AR (2016) Chest 149: 660-6 Frequency of pleural effusions in patients with pulmonary arterial hypertension associated with connective tissue diseases. Luo YF, Robbins IM, Karatas M, Brixey AG, Rice TW, Light RW (2011) Chest 140: 42-47 Silicone breast implants and connective tissue disease: no association. Lipworth L, Holmich LR, McLaughlin JK (2011) Semin Immunopathol 33: 287-94 Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis. Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M (2009) Mol Endocrinol 23: 324-36 Ascorbate differentially regulates elastin and collagen biosynthesis in vascular smooth muscle cells and skin fibroblasts by pretranslational mechanisms. Davidson JM, LuValle PA, Zoia O, Quaglino D, Giro M (1997) J Biol Chem 272: 345-52 Connective tissue growth factor is critical for proper β-cell function and pregnancy-induced β-cell hyperplasia in adult mice. Pasek RC, Dunn JC, Elsakr JM, Aramandla M, Matta AR, Gannon M (2016) Am J Physiol Endocrinol Metab 311: E564-74 Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. Henley KD, Gooding KA, Economides AN, Gannon M (2012) Am J Physiol Endocrinol Metab 303: E752-61 Selective, α2β1 integrin-dependent secretion of il-6 by connective tissue mast cells. McCall-Culbreath KD, Li Z, Zhang Z, Lu LX, Orear L, Zutter MM (2011) J Innate Immun 3: 459-70 Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ (2013) Cell Signal 25: 2198-209 Transforming growth factor β induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. Ding ZY, Jin GN, Liang HF, Wang W, Chen WX, Datta PK, Zhang MZ, Zhang B, Chen XP (2013) Cell Signal 25: 1981-92 Connective tissue growth factor (CTGF/CCN2) negatively regulates BMP-2 induced osteoblast differentiation and signaling. Mundy C, Gannon M, Popoff SN (2014) J Cell Physiol 229: 672-81 Smad about elastin regulation. Davidson JM (2002) Am J Respir Cell Mol Biol 26: 164-6 A physiological role for connective tissue growth factor in early wound healing. Alfaro MP, Deskins DL, Wallus M, DasGupta J, Davidson JM, Nanney LB, A Guney M, Gannon M, Young PP (2013) Lab Invest 93: 81-95 Evidence of selection as a cause for racial disparities in fibroproliferative disease. Hellwege JN, Torstenson ES, Russell SB, Edwards TL, Velez Edwards DR (2017) PLoS One 12: e0182791 Fibroblast-specific plasminogen activator inhibitor-1 depletion ameliorates renal interstitial fibrosis after unilateral ureteral obstruction. Yao L, Wright MF, Farmer BC, Peterson LS, Khan AM, Zhong J, Gewin L, Hao CM, Yang HC, Fogo AB (2019) Nephrol Dial Transplant 34: 2042-2050 Clinical experience with specific COX-2 inhibitors in arthritis. Crofford LJ (2000) Curr Pharm Des 6: 1725-36 SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2(Akita) diabetic mice. Fujita H, Fujishima H, Takahashi K, Sato T, Shimizu T, Morii T, Shimizu T, Shirasawa T, Qi Z, Breyer MD, Harris RC, Yamada Y, Takahashi T (2012) Metabolism 61: 1714-24 A morbid course in a girl with mixed connective tissue disease. Essalah AA, Eddy AA (1999) Pediatr Nephrol 13: 54-6 A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model. Lopes LB, Brophy CM, Flynn CR, Yi Z, Bowen BP, Smoke C, Seal B, Panitch A, Komalavilas P (2010) J Vasc Surg 52: 1596-607 The spatial and temporal expression of the alpha 2 beta 1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis. Keely PJ, Wu JE, Santoro SA (1995) Differentiation 59: 1-13 A new approach to elastography using mutual information and finite elements. Miga MI (2003) Phys Med Biol 48: 467-80
Hints: (1) double-click or double-tap to navigate to a node. (2) Grab a node and move it to arrange the graph.