Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Barnard JA, Beauchamp RD, Russell WE, Dubois RN, Coffey RJ (1995) Gastroenterology 108: 564-80 Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Nam KT, Varro A, Coffey RJ, Goldenring JR (2007) Gastroenterology 132: 1804-19 Amphiregulin-deficient mice develop spasmolytic polypeptide expressing metaplasia and intestinal metaplasia. Nam KT, Lee HJ, Mok H, Romero-Gallo J, Crowe JE, Peek RM, Goldenring JR (2009) Gastroenterology 136: 1288-96 Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells. 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Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK, Coffey RJ (2008) Clin Cancer Res 14: 1182-91 From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease. Singh B, Coffey RJ (2014) Semin Cell Dev Biol 28: 12-21 Amphiregulin causes functional downregulation of adherens junctions in psoriasis. Chung E, Cook PW, Parkos CA, Park YK, Pittelkow MR, Coffey RJ (2005) J Invest Dermatol 124: 1134-40 Induction of lateral lumens through disruption of a monoleucine-based basolateral-sorting motif in betacellulin. Singh B, Bogatcheva G, Starchenko A, Sinnaeve J, Lapierre LA, Williams JA, Goldenring JR, Coffey RJ (2015) J Cell Sci 128: 3444-55 Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Damstrup L, Kuwada SK, Dempsey PJ, Brown CL, Hawkey CJ, Poulsen HS, Wiley HS, Coffey RJ (1999) Br J Cancer 80: 1012-9 Indian hedgehog, but not histidine decarboxylase or amphiregulin, is a progesterone-regulated uterine gene in hamsters. Khatua A, Wang X, Ding T, Zhang Q, Reese J, DeMayo FJ, Paria BC (2006) Endocrinology 147: 4079-92 Identification of a novel mono-leucine basolateral sorting motif within the cytoplasmic domain of amphiregulin. Gephart JD, Singh B, Higginbotham JN, Franklin JL, Gonzalez A, Fölsch H, Coffey RJ (2011) Traffic 12: 1793-804 Auto- and cross-induction within the mammalian epidermal growth factor-related peptide family. Barnard JA, Graves-Deal R, Pittelkow MR, DuBois R, Cook P, Ramsey GW, Bishop PR, Damstrup L, Coffey RJ (1994) J Biol Chem 269: 22817-22 Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form. Brown CL, Meise KS, Plowman GD, Coffey RJ, Dempsey PJ (1998) J Biol Chem 273: 17258-68 Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. Hinkle CL, Sunnarborg SW, Loiselle D, Parker CE, Stevenson M, Russell WE, Lee DC (2004) J Biol Chem 279: 24179-88 The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells. Brown CL, Coffey RJ, Dempsey PJ (2001) J Biol Chem 276: 29538-49 TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Lee DC, Sunnarborg SW, Hinkle CL, Myers TJ, Stevenson MY, Russell WE, Castner BJ, Gerhart MJ, Paxton RJ, Black RA, Chang A, Jackson LF (2003) Ann N Y Acad Sci 995: 22-38 Differential effects of amphiregulin and TGF-alpha on the morphology of MDCK cells. 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